Home  |   Archive  |   Online Submission  |   News & Events  |   Subscribe  |   APFA  |   Society  |   Contact Us  |   中文版
Search   
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

 
Abstract

Volume 11, Issue 4 (July 2009) 11, 508–516; 10.1038/aja.2009.29

Stereological study of the effects of vitamin E on testis structure in rats treated with para-nonylphenol

M Soleimani Mehranjani1, A Noorafshan2, HR Momeni1, MH Abnosi1, M Mahmoodi1, M Anvari3 and SM Hoseini11

1 Biology Department, Arak University, Arak 38156, Iran
2 Anatomy Department, Shiraz University of Medical Sciences, Shiraz 71348, Iran
3 Anatomy Department, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd 89195-999, Iran

Correspondence: Dr Soleimani Mehranjani M, E-mail: m-soleimani@araku.ac.ir

Received 7 November 2008; Revised 10 April 2009; Accepted 28 April 2009; Published online 29 June 2009

Abstract

This study was organized to see whether vitamin E, as a strong antioxidant, could affect the abnormalities of testis structure caused by para-nonylphenol (p-NP) during its development. A total of 32 female Wistar rats after mating were divided into four groups (n = 8): control, vitamin E (100 mg kg-1 per day), p-NP (250 mg kg-1 per day) and p-NP + vitamin E. The rats were treated from the seventh day of pregnancy till the twenty-first day. After weaning, the male pups were divided into the same groups and were treated orally for 90 days. Finally, the right testis was fixed, processed, stained and studied using stereological methods. The weight and volume of testis, volume of seminiferous tubules and its diameter, thickness of the basement membrane, height of the germinal epithelium, total number of types A and B spermatogonia, spermatocyte, spermatid and Sertoli cells were significantly reduced in p-NP group when compared with other groups. Co-administration of vitamin E and p-NP compensated for the adverse effects of p-NP on the above parameters. In addition, treatment with only vitamin E caused a significant increase in diameter, basement membrane thickness and height of germinal epithelium, number of spermatogonia and spermatocytes. Co-administration of vitamin E with p-NP could prevent the adverse effects of p-NP on the testis structure during its development.

Keywords: development, para-nonylphenol, stereology, testis, vitamin E

PDF | PDF |

 
Browse:  3670
 
Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.