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Abstract

Volume 13, Issue 1 (January 2011) 13, 53–58; 10.1038/aja.2010.63

Diagnostic tools in male infertility—the question of sperm dysfunction

Christopher LR Barratt1,2, Steven Mansell1, Catherine Beaton1, Steve Tardif1 and Senga K Oxenham1

1 Reproductive and Developmental Biology, Maternal and Child Health Science Laboratories, Centre for Oncology and Molecular Medicine, Ninewells Hospital, University of Dundee, Dundee, DD1 9SY, Scotland, UK
2 Assisted Conception Unit, NHS Tayside, Ninewells Hospital, Dundee, DD1 9SY, Scotland, UK

Correspondence: Dr CLR Barratt, (c.barratt@dundee.ac.uk)

Abstract

Sperm dysfunction is the single most common cause of infertility, yet what is remarkable is that, there is no drug a man can take or add to his spermatozoa in vitro to improve fertility. One reason for the lack of progress in this area is that our understanding of the cellular and molecular workings of the mature spermatazoon is limited. However, over the last few years there has been considerable progress in our knowledge base and in addressing new methods to diagnose sperm dysfunction. We review the current state of the field and provide insights for further development. We conclude that: (i) there is little to be gained from more studies identifying/categorizing various populations of men using a basic semen assessment, where an effort is required in making sure the analysis is performed in an appropriate high quality way; (ii) technological development is likely to bring the reality of sperm function testing closer to implementation into the clinical pathways. In doing this, these assays must be robust, cheap (or more appropriately termed cost effective), easy to use and clinically useful; and (iii) clinical necessity, e.g., the need to identify the highest quality spermatozoon for injection is driving basic research forward. This is an exciting time to be an andrologist and, likely, a fruitful one.

Keywords: gamete biomarker; male fertility; sperm biomarker; sperm dysfunction

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.