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Volume 13, Issue 1 (January 2011) 13, 18–23; 10.1038/aja.2010.71

Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility

Xiao-Yan Huang and Jia-Hao Sha

Lab of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, China

Correspondence: Professor JH Sha, (shajh@njmu.edu.cn)


Proteomic technologies have undergone significant development in recent years, which has led to extensive advances in protein research. Currently, proteomic approaches have been applied to many scientific areas, including basic research, various disease and malignant tumour diagnostics, biomarker discovery and other therapeutic applications. In addition, proteomics-driven research articles examining reproductive biology and medicine are becoming increasingly common. The key challenge for this field is to move from lists of identified proteins to obtaining biological information regarding protein function. The present article reviews the available scientific literature related to spermatogenesis. In addition, this study uses two-dimensional electrophoresis mass spectrometry (2DE-MS) and liquid chromatography (LC)-MS to construct a series of proteome profiles describing spermatogenesis. This large-scale identification of proteins provides a rich resource for elucidating the mechanisms underlying male fertility and infertility.

Keywords: infertility; male fertility; proteomics; spermatogenesis

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