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Volume 13, Issue 5 (September 2011) 13, 673–676; 10.1038/aja.2011.18
TRP channels in prostate cancer: the good, the bad and the ugly?
Dimitra Gkika1,2 and Natalia Prevarskaya1,2
1 Inserm U1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, France
2 Université des Sciences et Technologies de Lille (USTL), Villeneuve d'Ascq, France
Correspondence: Dr D Gkika, (dimitra.gkika@univ-lille1.fr)
Received 18 February 2011; Revised 20 March 2011; Accepted 11 April 2011; Published online 30 May 2011
| Abstract |
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During the last decade, transient receptor potential (TRP) channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TRP channels, notably TRP melastatin 8 (TRPM8), TRP vanilloid 6 (TRPV6),TRP canonical (TRPC6) and TRPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.
Keywords: ion channel; lysophospholipids; migration; neuroendocrine; prostate cancer; PSA; transient receptor potential (TRP) channels; TRP channels; TRPM8; TRPV6; TRPV2
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