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Volume 13, Issue 5 (September 2011) 13, 698–701; 10.1038/aja.2011.32
Is XMRV a causal virus for prostate cancer?
Zhen-Zhen Zhang1,2, Bao-Feng Guo3, Zhuang Feng4, Ling Zhang2 and Xue-Jian Zhao2
1 Department of Epidemiology, Michigan State University, East Lansing, MI 48224, USA
2 Research Center of Prostate Diseases, Department of Reproductive Pathophysiology, School of Basic Medicine, Jilin University, Changchun 130021, China
3 Department of Surgery, China-Japan Union Hospital, Norman Bethune Medical School, Jilin University, Changchun 130031, China
4 Department of Pathology, Wayne State University, Detroit, MI 48201, USA
Correspondence: Professor XJ Zhao, (zhaoxuejian2007@yahoo.com.cn)
Received 16 January 2011; Revised 13 February 2011; Accepted 22 March 2011; Published online 18 July 2011
| Abstract |
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The potential association between xenotropic murine leukaemia virus-related gammaretrovirus (XMRV) and prostate cancer (PCa) has been documented since 2006. It is important for furthering our understanding of the biological mechanisms of PCa to ascertain whether this association is causal. To summarize the available information on the epidemiological and laboratory findings of the association, we conducted a literature search of the PubMed electronic database (from March 2006 to February 2011) to identify relevant published studies that examined the association between XMRV and PCa. Although several studies showed the positive association between XMRV and PCa, more recent studies did not support this conclusion. The positive findings might be due to contamination of human samples. Further studies are needed to clarify this association.
Keywords: prostate cancer; review; XMRV
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