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Abstract

Volume 15, Issue 6 (November 2013) 15, 711–712; 10.1038/aja.2013.109

Chromoplexy: a new paradigm in genome remodeling and evolution

Kendric Wang1, Yuzhuo Wang1,2 and Colin C Collins1

1Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada
2Department of Experimental Therapeutics, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada

Correspondence: Dr CC Collins, (ccollins@prostatecentre.com)

26 August 2013

Abstract

Early massively-parallel sequencing studies have revealed the mutational landscape of protein-coding genes in prostate cancer. However, most of these studies have not explored the extensive influence of genomic rearrangement in prostate cancer. In a recent Cell article, Baca and colleagues used whole-genome sequencing to tackle this issue, comprehensively surveying the abundance of genomic rearrangements present in a large cohort of 57 prostate cancers. They characterized a wide-spread phenomenon termed ‘chromoplexy’, which may drive cancer evolution through the phenomena of punctuated equilibrium by concurrently dysregulating numerous cancer genes across multiple chromosomes. While the causes of this event still require elucidation, this defining discovery undoubtedly offers an important glimpse into the evolutionary process of prostate cancer.

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