Home  |  Archive  |  Online Submission  |  News & Events  |  Subscribe  |  APFA  |  Society  |  Links  |  Contact Us  |  中文版
Search
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

Links

Meetings
Journals
Societies & Institutes
Hospitals
Databases & Libraries
Companies
Websites
Other links

 
Abstract

Volume 8, Issue 1 (January 2006) 8, 11–29; 10.1111/j.1745-7262.2006.00112.x

Sperm chromatin structure and male fertility: biological and clinical aspects

J Erenpreiss, M Spano, J Erenpreisa, M Bungum and A Giwercman

1.University of Lund, Fertility Centre, Malmö University Hospital, Malmö SE 205 02, Sweden
2.Latvian University Biomedicine Centre, Ratsupites 1, Riga LV 1067, Latvia
3.Section of Toxicology and Biomedical Sciences, BIOTEC-MED, ENEA CR Casaccia, Via Anguillarese 301, Rome 00060, Italy
4.Fertility Clinic, Viborg Hospital (Skive), Resenvej 25, DK 7800 Skive, Denmark

Correspondence: Dr Juris Erenpreiss, Fertility Centre, Malmö University Hospital, Malmö SE 205 02 Sweden. Fax: +46-4033-7043. E-mail: Juris.Erenpreiss@med.lu.se

Received 18 April 2005; Accepted 12 November 2005

Abstract

Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.

Keywords: infertility, sperm, DNA damage, human

Full Text | PDF |

 
Browse:  999
Copyright 1999-2014    Shanghai Materia Medica, Shanghai Jiao Tong University.    All rights reserved