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Abstract

Volume 8, Issue 2 (March 2006) 8, 183–187; 10.1111/j.1745-7262.2006.00121.x

DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men

Yuan Yang, Cui-Ying Xiao, Zhou-Cun A, Si-Zhong Zhang, Xiang Li and Si-Xiao Zhang

1.Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China
2.Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
3.Division of Human Morbid Genomics, National Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China

Correspondence: Prof. Si-Zhong Zhang, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China. Fax: +86-28-8516-4009. E-mail: szzhang@mcwcums.com

Received 15 September 2005; Accepted 29 November 2005.

Abstract

Aim: To explore the possible effect of the deleted in azoospermia (DAZ) copy cluster deletion on spermatogenesis in the Chinese population, the deletion of the azoospermia factor c (AZFc) region was analyzed in 346 normozoospermic men.

Methods: Three DAZ single nucleotide variant loci and seven AZFc-specific sequence-tagged sites were examined with polymerase chain reaction (PCR)-restriction fragment length polymorphism and routine PCR.

Results: Five (1.4%) of the normozoospermic men were found to have deletion of gr/gr-DAZ1/DAZ2. None of the men were found to have b2/b4-entire DAZ deletion.

Conclusion: The presence of gr/gr-DAZ1 /DAZ2 deletion in five men with normozoospermia suggests that this deletion per se may not be sufficient for spermatogenic impairment in Chinese men.

Keywords: azoospermia factor c, deleted in azoospermia, gene deletion, normozoospermia

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.