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Abstract

Volume 9, Issue 2 (March 2007) 9, 229–233; 10.1111/j.1745-7262.2007.00187.x

Associations among benign prostate hypertrophy, atypical adenomatous hyperplasia and latent carcinoma of the prostate

Konstantinos Stamatiou, Alevizos Alevizos, Mohamed Natzar, Constantinos Mihas, Anargiros Mariolis, Emmanouel Michalodimitrakis and Fragiskos Sofras

1.Department of Urology, University Hospital, Medical School, University of Crete, Heraklion 71110, Greece
2.Department of Urology, Tzaneion General Hospital, Piraeus18536, Greece
3.Department of Medical Research, Health Center of Vyronas, Athens 16231, Greece
4.Department of Forensic Sciences, University Hospital, Medical School, University of Crete, Heraklion 71110, Greece

Correspondence: Dr Konstantinos Stamatiou, Department of Urology, University Hospital, Medical School, University of Crete, Heraklion 71110, Greece. Fax: +30-210-760-8053. E-mail: stamatiouk@gmail.com

Received 27 December 2005; Accepted 20 April 2006.

Abstract

Aim: To investigate the frequency of atypical adenomatous hyperplasia (AAH) and its associations with benign prostate hypertrophy (BPH) and latent histological carcinoma of the prostate (LPC) in autopsy material.

Methods: Two hundred and twelve prostate specimens obtained from autopsy material were subjected to whole mount analysis in an attempt to investigate the associations among BPH, AAH and LPC.

Results: Most histological carcinomas and AAH lesions were found in enlarged prostates with intense hypertrophy. No statistically significant relation was found between BPH and the main characteristics of LPC, such as tumor volume, histological differentiation and biological behavior. Our data regarding multi-focal tumors showed a tendency for multi-focal carcinomas to develop in larger prostates, and a tendency of AAH lesions to develop in larger prostates. No statistically significant relation was found between AAH and LPC.

Conclusion: There seems not any causative aetiopathogenetical or topographical relation between AAH lesions and prostate adenocarcinoma. AAH lesion seems to be a well-defined mimicker of prostatic adenocarcinoma, and the reported association of AAH with prostatic carcinoma could probably be an epiphenomenon.

Keywords: atypical adenomatous hyperplasia, histological prostate cancer, benign prostate hypertrophy

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.