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Abstract

Volume 10, Issue 2 (March 2008) 10, 313–318; 10.1111/j.1745-7262.2008.00313.x

Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice

Sahdeo Prasad, Neetu Kalra, Madhulika Singh and Yogeshwer Shukla

Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226001, India

Correspondence: Dr Yogeshwer Shukla, Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, PO Box 80, M.G. Marg, Lucknow 226001, India. Fax: +91-522-2628227. Email: yogeshwer_shukla@hotmail.com/shukla_y@rediffmail.com

Received 27 January 2007; Accepted 20 May 2007.

Abstract

Aim: To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice.

Methods: Oral treatment of lupeol (1 mg/animal) and MPE (1 mL [20% w/v]/ animal) was given separately to animals along with subcutaneous injection of testosterone (5 mg/kg body weight) consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species (ROS) levels, lipid peroxidation and antioxidant enzymes status (catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase).

Results: In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes.

Conclusion: The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer.

Keywords: mango pulp extract, lupeol, testosterone, oxidative stress, antioxidant enzymes, prostate cancer

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