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Abstract

Volume 10, Issue 2 (March 2008) 10, 214–218; 10.1111/j.1745-7262.2008.00335.x

Relationship between testosterone and indexes indicating endothelial function in male coronary heart disease patients

Lu Fu, Qian-Ping Gao and Jing-Xia Shen

Cardiovascular Department, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Correspondence: Dr Qian-Ping Gao, the First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, China. Fax: +86-451-5367-0428. E-mail: gaoqianping@sohu.com

Received 17 March 2007; Accepted 20 August 2007.

Abstract

Aim: To investigate the relationship between androgen level and the indexes indicating endothelial function in male patients with coronary heart disease (CHD).

Methods: We registered the following data for 106 50-70-year-old men: age, weight, blood lipid, including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride, whether a smoker, sugar levels, blood pressure, free testosterone (FT), vascular cell adhesion molecule-1 (VCAM-1) and the intima-media thickness (IMT) of common carotid artery, common carotid diameter, maximum velocity in systolic phase, minimum velocity in diastolic phase and resistent index. Among the 106 men, 51 were patients with CHD. The relationships between FT level, VCAM-1 concentration and IMT were examined, respectively, using a stepwise linear regression technique among all the 106 men.

Results: There was no statistical difference in terms of age, blood pressure, whether a smoker, sugar levels, HDL-C, minimum velocity in diastolic phase, resistent index between male CHD patients and controls; whereas results for weight, total cholesterol, low density lipoprotein cholesterol, triglyceride, VCAM-1 and IMT of male CHD patients were higher than those of controls; FT level and maximum velocity in systolic phase were lower. It was found that among all the objects, FT level was inversely correlated with IMT and VCAM-1 concentration.

Conclusion: FT level was inversely correlated with VCAM-1 concentration and IMT which are indicators of endothelial function.

Keywords: testosterone, coronary heart disease, endothelial function

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