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Abstract

Volume 10, Issue 1 (January 2008) 10, 36–43; 10.1111/j.1745-7262.2008.00375.x

Hypogonadism and erectile dysfunction: an overview

Nilgun Gurbuz, Elnur Mammadov and Mustafa Faruk Usta

Section of Andrology, Department of Urology, Akdeniz University School of Medicine, Antalya 07070, Turkey

Correspondence: Dr Mustafa Faruk Usta, Section of Andrology, Department of Urology, Akdeniz University School of Medicine, Dumlupinar Bulvari, Kampus 07070, Antalya, Turkey. Fax: +90-242-237-6343. E-mail: musta@akdeniz.edu.tr; mususuta53@hotmail.com

Abstract

In humans androgen decline is presented as a clinical picture which includes decreased sexual interest, diminished erectile capasity, delayed or absent orgasms and reduced sexual pleasure. Additionally, changes in mood, diminished well being, fatigue, depression and irritability are also associated with androgen insufficiency. The critical role of androgens on the development, growth, and maintanence of the penis has been widely accepted. Although, the exact effect of androgens on erectile physiology still remains undetermined, recent experimental studies have broaden our understanding about the relationship between androgens and erectile function. Preclinical studies showed that androgen deprivation leads to penile tissue atrophy and alterations in the nerve structures of the penis. Furthermore, androgen deprivation caused to accumulation of fat containing cells and decreased protein expression of endothelial and neuronal nitric oxide synthases (eNOS and nNOS), and phosphodiesterase type-5 (PDE-5), which play crucial role in normal erectile physiology. On the light of the recent literature, we aimed to present the direct effect of androgens on the structures, development and maintanence of penile tissue and erectile physiology as well. Furhermore, according to the clinical studies we conclude the aetiology, pathophysiology, prevalance, diagnosis and treatment options of hypogonadism in aging men.

Keywords: testosterone, erectile physiology, symptomatic late onset hypogonadism

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.