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Abstract

Volume 16, Issue 1 (January 2014) 16, 107–111; 10.4103/1008-682X.122194

Fertility outcome of Patients with Testicular Tumor: before and after treatment Running title: Fertility of Testicular Cancer Survivors

Ping Ping1, Ben-Hong Gu2, Peng Li3, Yi-Ran Huang1, Zheng Li3

1 Department of Urology, Shanghai Human Sperm Bank, Shanghai Institute of Andrology, Renji
Hospital Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
2 Department of Surgery, Shanghai Pudong District Traditional Chinese Medicine Hospital,
Shanghai 201200, China
3 Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai
201200, China

Correspondence: Dr. Z Li

Received: 07-05-2013; Revised: 05-07-2013; Accepted: 26-09-2013

Abstract

Testicular cancer (TC) is the most curable type of cancer, with a survival rate of more than 95%. Oncologists are faced with the
challenge that gonadotoxic cancer treatments can compromise future fertility, either temporarily or permanently. Our aim was to
investigate the long-term effects of TC treatments on male fertility and on the offspring of patients who had received these treatments.
Between January 1996 and December 2010, 125 eligible patients, ranging from 18 to 54 years (median age 36.3 ± 15.7), with
unilateral TC underwent surgery, chemotherapy or radiotherapy at our center. Some of these patients had their semen samples
cryopreserved in the Shanghai Human Sperm Bank. The clinical data were evaluated, and questionnaire and telephone follow-up
surveys were given to all patients. The data were analyzed to determine the patients’ fertility status pre- and posttreatment. Of the
125 eligible patients, 93.6% (117/125) were accessible and were evaluated. Among 81 men who were married before diagnosis,
21 had conceived successfully before diagnosis and six reported azoospermia. Posttreatment conception was attempted by 73 men;
of these, 16 conceived naturally and 19 conceived by artifi cial reproductive techniques, resulting in 37 healthy babies with no
congenital malformations. Of the patients who had not conceived before treatment, 21.9% (21/96) banked their sperm and
23.8% of these patients (5/21) subsequently used the banked sperm. Retroperitoneal lymph node dissection, chemotherapy and
radiotherapy were the most highly correlated with lack of conception post-TC treatment. Sperm banking should be recommended
to TC patients with the desire for biological conception. There is no evidence to suggest that TC treatments are associated with
birth defects or childhood malignancies.

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.