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Abstract

Volume 16, Issue 2 (March 2014) 16, 256–261; 10.4103/1008-682X.122339

Selective Androgen Receptor Modulators for the Treatment of Late Onset Male Hypogonadism

Christopher C Coss, Amanda Jones, Michael L. Hancock, Mitchell S. Steiner and James T. Dalton

GTx, Inc., Memphis TN 38163, USA

Correspondence: Dr. JT Dalton

2013-10-16

Abstract

Several testosterone preparations are used in the treatment of hypogonadism in the ageing male. These therapies differ in their convenience, flexibility, regional availability and expense but share their pharmacokinetic basis of approval and dearth of long-term safety data. The brevity and relatively reduced cost of pharmacokinetic based registration trials provides little commercial incentive to develop improved novel therapies for the treatment of late onset male hypogonadism. Selective androgen receptor modulators (SARMs) have been shown to provide anabolic benefit in the absence of androgenic effects on prostate, hair and skin. Current clinical development for SARMs is focused on acute muscle wasting conditions with defi ned clinical endpoints of physical function and lean body mass. Similar regulatory clarity concerning clinical deficits in men with hypogonadism is required before the beneficial pharmacology and desirable pharmacokinetics of SARMs can be employed in the treatment of late onset male hypogonadism.

Keywords: hypogonadism; late onset hypogonadism; selective androgen receptor modulators; testosterone

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