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Abstract

Volume 16, Issue 2 (March 2014) 16, 290–294; 10.4103/1008-682X.122347

Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk

Fiore Pelliccione1, Anatolia D’Angeli1, Settimio D’Andrea1, Arcangelo Barbonetti1, Alfonso Pezzella1, Stefano Necozione2, Stefano Falone3, Fernanda Amicarelli3, Felice Francavilla1 and Sandro Francavilla1

1Department of Life, Health and Environmental Sciences, Section of Andrology, 2Department of Life, Health and Environmental Sciences, Section of Epidemiology,
3Department of Life, Health and Environmental Sciences, Section of Biological and Biotechnological Sciences, University of L’Aquila, L’Aquila, Italy.

Correspondence: Dr. S Francavilla

23 December 2013

Abstract

The number of the circulating angiogenic cells (CACs) and colony forming units (CFUs) derived from cultured circulating mononuclear
cells (MNCs) represents a laboratory surrogate for endothelial cell repair ability. The serum of men with erectile dysfunction (ED)
and vascular risk factors (VRFs) showed an increased level of endothelial cell damage/dysfunction markers and reduced the numbers
of CACs and CFUs derived from the cells of healthy men. We analyzed whether treating men with ED and VRFs with the selective
phosphodiesterase type 5 inhibitor tadalafi l improved the endothelial cell repair ability and reduced the levels of the serum markers
of endothelial cell damage/dysfunction. MNCs from healthy men were cultured with 20% serum from 36 ED patients to obtain
CACs and CFUs. The ED patients were evaluated before and after 4 weeks of treatment with tadalafi l (20 mg every other day) or
with a placebo. The tadalafi l treatment improved erectile function (P = 0.0028), but had no effect on the inhibitory effects of
serum from ED patients on the CACs and CFUs derived from healthy men. The levels of endothelin-1 (P = 0.011) and tissue type
plasminogen activator (P = 0.005) were reduced after treatment compared to baseline and those of the placebo group, whereas
no changes were observed in the E-selectin levels. The tadalafi l treatment in the ED patients with VRFs resulted in only a modest
effect on the laboratory measures of the endothelial cell damage/dysfunction and repair ability. The proposed benefi cial effect of phosphodiesterase type 5 inhibition on vascular homeostasis requires further analysis.

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.