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Abstract

Volume 16, Issue 2 (March 2014) 16, 274–279; 10.4103/1008-682X.123664

Differential expression of 5-alpha reductase isozymes in the prostate and its clinical implications

Kai Wang, Dong-Dong Fan, Song Jin, Nian-Zeng Xing, Yi-Nong Niu

Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

Correspondence: Dr YN Niu

Received: 9 July 2013; Revised: 6 September 2013; Accepted: 1 December 2013

Abstract

The development of human benign or malignant prostatic diseases is closely associated with androgens, primarily testosterone (T) and dihydrotestosterone (DHT). T is converted to DHT by 5-alpha reductase (5-AR) isozymes. Differential expression of 5-AR isozymes is observed in both human benign and malignant prostatic tissues. 5-AR inhibitors (5-ARI) are commonly used for the treatment of benign prostatic hyperplasia (BPH) and were once promoted as chemopreventive agents for prostate cancer (PCa). This review discusses the role of the differential expression of 5-AR in the normal development of the human prostate and in the pathogenesis and progression of BPH and PCa.

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