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Volume 16, Issue 4 (July 2014) 16, 561–564; 10.4103/1008-682X.126396
Androgen receptor functions in prostate cancer development and progression
Steven P Balk
Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Correspondence: Dr. SP Balk (sbalk@bidmc.harvard.edu)
2014-4-11
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The androgen receptor (AR) is critical for the normal development of prostate and for its differentiated functions. The consistent expression of AR in prostate cancer (PCa), and its continued activity in PCa that relapse after androgen deprivation therapy (castration-resistant prostate cancer (CRPC)), indicate that at least a subset of these genes are also critical for PCa development and progression. This review addressed AR regulated genes that may be critical for PCa, and how AR may acquire new functions during PCa development and progression.
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