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Abstract

Volume 18, Issue 3 (May 2016) 18, 471–474; 10.4103/1008-682X.157398

The effect of the degree of left renal vein constriction on the development of adolescent varicocele in Sprague-Dawley rats

Bing Yao, Wen-Liang Zhou, Da-Yu Han, Bin Ouyang, Xu Chen, Sheng-Fu Chen, Chun-Hua Deng, Xiang-Zhou Sun

Department of Urology, The First Affiliated Hospital; The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
School of Life Sciences, Sun Yat-Sen University, Guangzhou, China
Department of Urology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China
Department of Urology, Guangzhou First People's Hospital, Guangzhou, China
Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

Correspondence: Dr. XZ Sun (sunxzh08@qq.com)

07-Aug-2015

Abstract

Experimental models have allowed inquiry into the pathophysiology of varicocele (VC) beyond that possible with human patients. A randomized controlled study in rats was designed to clarify the influence of the degree of left renal vein constriction on the development of adolescent VC. Fifty adolescent male Sprague-Dawley rats (Rattus norvegicus) were randomly assigned to five groups of 10: the experimental groups (I-IV) underwent partial ligation of left renal veins with 0.5-, 0.6-, 0.7-, and 0.8-mm diameter needles, respectively. The control group (V) underwent a sham operation. The diameter of the left spermatic vein (LSV) was measured at baseline and 30 days postoperatively. In addition, the lesion of the left kidney was examined with the naked eye and assessed by Masson's trichrome staining. VC was successfully induced in 2 (20%), 4 (40%), 7 (70%), and 10 (100%) rats in groups I-IV, respectively. The other rats failed to develop VCs primarily due to left renal atrophy. No VC was observed in group V. The postsurgical LSV diameters in VC rats in groups III and IV were 1.54 ± 0.16 and 1.49 ± 0.13 mm, respectively (P > 0.05), and their increments were 1.36 ± 0.10 and 1.31 ± 0.10 mm, respectively (P > 0.05). These results suggest that suitable constriction of the left renal vein is critical for adolescent VC development. In addition, the 0.8-mm diameter needle may be more suitable for inducing left renal vein constriction in adolescent rat models.

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