Volume 18, Issue 4 (July 2016) 18, 650–653; 10.4103/1008-682X.160261
The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study
Yumeng Zhang, Qiang Fu, Xiong Zhang
Department of Urology, Shanghai Jiao Tong University Affi liated Sixth People's Hospital, Shanghai,
Department of Burn and Plastic Surgery, Shanghai Jiaotong University, School of Medicine Affililated Ruijin Hospital, Shanghai,
Correspondence: Prof. Q Fu
Received: 15 March 2015; Revised: 19 April 2015; Accepted: 30 June 2015
This study aimed to investigate the presence of human papillomavirus and Epstein–Barr virus in male lichen sclerosus patients.
We extracted DNA from formalin‑fixed paraffin‑embedded foreskin tissue blocks of 47 male LS patients and 30 healthy men and
performed real‑time PCR test to detect HPV and EBV. None of the 47 LS patients and 30 healthy men had detectable HPV infection.
EBV was detected in 18 LS patients (38.3%) and four healthy men (13.3%), the difference is significant (P < 0.05). Tissue blocks
with significant inflammatory reaction tend to have higher EBV load. HPV has no significant relationship with LS. Male LS patients
have higher EBV infection rate, but the role of EBV in the pathogenesis of LS needs further investigate.
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