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Abstract

Volume 19, Issue 6 (November 2017) 19, 617–618; 10.4103/1008-682X.190324

The impact of autophagy in spermiogenesis

Nihan Ozturk, Klaus Steger, Undraga Schagdarsurengin

Clinic of Urology, Pediatric Urology and Andrology, Section Molecular Andrology, Justus-Liebig-University Giessen, Schubertstrasse 81, 35392 Giessen, Germany

Correspondence: Dr.U Schagdarsurengin(undraga.schagdarsurengin@chiru.med.uni-giessen.de)

2016-11-29

Abstract

Autophagy is an evolutionarily conserved self-digestion process which is essential to keep basal homeostasis in a cell. During this process, degradation and recycling of many cytoplasmic components including the long-lived, unnecessary or aggregated proteins and damaged organelles is achieved through lysosomal machinery. Autophagy has a critical role for lower eukaryotic organisms such as yeast to survive and adapt to nutrient starvation conditions. In addition to this primary function, autophagy appears as a crucial mechanism for cell differentiation and development enabling the cells to modify their content and morphology in response to environmental and hormonal cues. A recent study by Shang et al.[1] shed more light on the molecular mechanisms of how autophagy regulates spermiogenesis.

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