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Abstract

Volume 23, Issue 1 (January 2021) 23, 97–102; 10.4103/aja.aja_31_20

Establishment and internal validation of preoperative nomograms for predicting the possibility of testicular salvage in patients with testicular torsion

Wan-Xiang Zheng1, Guang-Dong Hou1, Wei Zhang2, Di Wei1, Xue-Lin Gao1, Mei-Hong Chen1, Lu-Guang Huang3, Fei Yan1, Geng Zhang1, Lei Yu1, Fei Liu1, Bo Zhang2, Jian-Lin Yuan1

1 Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China
2 Department of Urology, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China
3 Information Center, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China

Correspondence: Dr. JL Yuan (jianliny@fmmu.edu.cn) or Dr. B Zhang (zhangbo@fmmu.edu.cn)

Date of Submission 28-Sep-2019 Date of Acceptance 27-Apr-2020 Date of Web Publication 17-Jul-2020

Abstract

This study aimed to establish nomograms to preoperatively predict the possibility of testicular salvage (TS) in patients with testicular torsion. The clinical data of 204 patients with testicular torsion diagnosed at Xijing Hospital and Tangdu Hospital (Xi'an, China) between August 2008 and November 2019 were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to determine the independent predictors of TS. Based on multivariate regression coefficients, nomograms to predict possibility of TS were established. The predictive ability of the nomograms was internally validated by receiver operating characteristic (ROC) curves and calibration plots. The duration of symptoms ranged from 2 h to 1 month, with a median of 3.5 days. Thirty (14.7%) patients underwent surgical reduction and contralateral orchiopexy, while the remaining 174 (85.3%) underwent orchiectomy and contralateral orchiopexy. Finally, long symptom duration was an independent risk predictor for TS, while visible intratesticular blood flow and homogeneous testicular echotexture under color Doppler ultrasound were independent protective predictors. Internal validation showed that the nomograms, which were established by integrating these three predictive factors, had good discrimination ability in predicting the possibility of TS (areas under the ROC curves were 0.851 and 0.828, respectively). The calibration plots showed good agreement between the nomogram-predicted possibility of TS and the actual situation. In conclusion, this brief preoperative prediction tool will help clinicians to quickly determine the urgency of surgical exploration.

Keywords: nomogram; testicular salvage; testicular torsion

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.