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Abstract

Volume 20, Issue 4 (July 2018) 20, 355–359; 10.4103/aja.aja_4_18

Differences in sympathetic nervous system activity and NMDA receptor levels within the hypothalamic paraventricular nucleus in rats with differential ejaculatory behavior

Jia-Dong Xia1, Jie Chen2, Bai-Bing Yang3, Hai-Jian Sun4, Guo-Qing Zhu4, Yu-Tian Dai3, Jie Yang1, Zeng-Jun Wang1

1 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
2 Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing 210000, China
3 Department of Andrology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing 210000, China
4 Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing 210000, China

Correspondence: Dr. ZJ Wang (zengjunwang@njmu.edu.cn) or Dr. J Yang (yj197912@163.com)

Date of Submission 10-Sep-2017 Date of Acceptance 27-Dec-2017 Date of Web Publication 06-Mar-2018

Abstract

Differences in intravaginal ejaculation latency reflect normal biological variation, but the causes are poorly understood. Here, we investigated whether variation in ejaculation latency in an experimental rat model is related to altered sympathetic nervous system (SNS) activity and expression of N-methyl-D-aspartic acid (NMDA) receptors in the paraventricular nucleus of the hypothalamus (PVN). Male rats were classified as “sluggish,” “normal,” and “rapid” ejaculators on the basis of ejaculation frequency during copulatory behavioral testing. The lumbar splanchnic nerve activity baselines in these groups were not significantly different at 1460 ± 480 mV, 1660 ± 600 mV, and 1680 ± 490 mV, respectively (P = 0.71). However, SNS sensitivity was remarkably different between the groups (P < 0.01), being 28.9% ± 8.1% in “sluggish,” 48.4% ± 7.5% in “normal,” and 88.7% ± 7.4% in “rapid” groups. Compared with “normal” ejaculators, the percentage of neurons expressing NMDA receptors in the PVN of “rapid” ejaculators was significantly higher, whereas it was significantly lower in “sluggish” ejaculators (P = 0.01). In addition, there was a positive correlation between the expression of NMDA receptors in the PVN and SNS sensitivity (r = 0.876, P = 0.02). This study shows that intravaginal ejaculatory latency is associated with SNS activity and is mediated by NMDA receptors in the PVN.

Keywords: ejaculation; N-methyl-D-aspartic acid receptor; paraventricular nucleus; sympathetic nervous system

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.