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Abstract

Volume 19, Issue 2 (March 2017) 19, 230–233; DOI:10.4103/1008-682X.171575

A possible relationship between serum sex hormones and benign prostatic hyperplasia/lower urinary tract symptoms in men who underwent transurethral prostate resection

Yu Wu, Hong Pan, Wei-Ming Wang, Ding Xu, Liang Zhang, Zheng-Qin Gu, Qiang Bai, Jun Qi, He-Feng Huang

1Department of Urology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China; 2Department of Gynecology, Xinhua Hospital,
School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China; 3Department of Assisted Reproduction Medicine, International Peace Maternity and Child
Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.

Correspondence: Dr. J Qi (jasonqi@sh163.net) or Dr. HF Huang (huanghefg@hotmail.com)

Date of Submission 07-May-2015 Date of Decision 31-Jul-2015 Date of Acceptance 20-Nov-2015 Date of Web Publication 12-Jan-2016

Abstract

In this study, we examined the relationship between sex hormone levels and lower urinary tract symptoms (LUTS) in men with
benign prostatic hyperplasia (BPH) who underwent transurethral surgery. The study was conducted in 158 patients who came to our
hospital for surgery. Clinical conditions were assessed by body mass index (BMI), digital rectal examination, International Prostate
Symptom Score (IPSS) and transrectal ultrasound (TRUS). The levels of sex hormones (including total testosterone (TT), estradiol (E2),
progesterone (P), luteinizing hormone (LH), follicle‑stimulating hormone (FSH) and prolactin (PRL)) and prostate‑specific
antigen (PSA) were reviewed. Correlations were determined through statistical analysis. The mean age was 72.06 ± 8.68 years.
The total IPSS was significantly associated with the TT level (r = −0.21, P = 0.01). Other sex hormone levels were not correlated
with total IPSS. However, some ratios such as E2/ TT (r = 0.23, P = 0.00) and FSH/LH (r = −0.17, P = 0.04) were associated with
total IPSS. Further analysis showed that the nocturia was associated with age (r = 0.16, P = 0.04), BMI (r = 0.21, P = 0.01),
and TT (r = −0.19, P = 0.02). Moreover, we divided the patients into two subgroups based on IPSS severity (<20 or ≥20). The
mean TT level was in the normal range, but it was significantly related to the presence of severe LUTS. In summary, our study
has shown that the severity of LUTS is associated with TT, E2/ TT and FSH/LH in men who underwent prostate surgery. Increasing
nocturia was observed in lower testosterone patients. Additional larger studies are needed to elucidate the potential mechanisms.

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