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Abstract

Volume 19, Issue 4 (July 2017) 19, 425–432; DOI:10.4103/1008-682X.179532

Superparamagnetic iron oxide nanoparticle targeting of adipose tissue-derived stem cells in diabetes-associated erectile dysfunction

Lei-Lei Zhu, Zheng Zhang, He-Song Jiang, Hai Chen, Yun Chen, Yu-Tian Dai

Department of Andrology, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, China

Correspondence: Dr. YT Dai (13913957628@163.com)

Date of Submission 23-Sep-2015 Date of Decision 17-Nov-2015 Date of Acceptance 23-Feb-2016 Date of Web Publication 06-May-2016

Abstract

Erectile dysfunction (ED) is a major complication of diabetes, and many diabetic men with ED are refractory to common ED therapies. Adipose tissue-derived stem cells (ADSCs) have been shown to improve erectile function in diabetic animal models. However, inadequate cell homing to damaged sites has limited their efficacy. Therefore, we explored the effect of ADSCs labeled with superparamagnetic iron oxide nanoparticles (SPIONs) on improving the erectile function of streptozotocin-induced diabetic rats with an external magnetic field. We found that SPIONs effectively incorporated into ADSCs and did not exert any negative effects on stem cell properties. Magnetic targeting of ADSCs contributed to long-term cell retention in the corpus cavernosum and improved the erectile function of diabetic rats compared with ADSC injection alone. In addition, the paracrine effect of ADSCs appeared to play the major role in functional and structural recovery. Accordingly, magnetic field-guided ADSC therapy is an effective approach for diabetes-associated ED therapy.

Keywords: erectile dysfunction; magnetic targeting; stem cells; superparamagnetic iron oxide nanoparticles

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Asian Journal of Andrology CN 31-1795/R ISSN 1008-682X  Copyright © 2023  Shanghai Materia Medica, Chinese Academy of Sciences.  All rights reserved.