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Abstract

Volume 21, Issue 1 (January 2019) 21, 19–23; DOI:10.4103/aja.aja_24_17

Contemporary grading of prostate cancer: 2017 update for pathologists and clinicians

Silvia Gasparrini1, Alessia Cimadamore1, Marina Scarpelli1, Francesco Massari2, Andrea Doria1, Roberta Mazzucchelli1, Liang Cheng3, Antonio Lopez-Beltran4, Rodolfo Montironi1

1 Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
2 Division of Oncology, S. Orsola-Malpighi Hospital, Bologna, Italy
3 Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
4 Department of Pathology and Surgery, Faculty of Medicine, Cordoba, Spain

Correspondence: Dr. R Montironi (r.montironi@univpm.it)

Date of Submission 17-Feb-2017 Date of Acceptance 26-May-2017 Date of Web Publication 04-Aug-2017

Abstract

The Gleason grading system for prostate cancer (PCa) was developed in the 1960s by DF Gleason. Due to changes in PCa detection and treatment, the application of the Gleason grading system has changed considerably in pathology routine practice. Two consensus conferences were held in 2005 and in 2014 to update PCa Gleason grading. This review provides a summary of the changes in the grading of PCa from the original Gleason grading system to the prognostic grade grouping, as well as a discussion of the clinical significance of the percentage of Gleason patterns 4 and 5.

Keywords: Gleason grading; Gleason system; prognostic grade grouping; prostate cancer; tertiary pattern

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