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Volume 20, Issue 2 (March 2018) 20, 138–144; DOI:10.4103/aja.aja_25_17
Testosterone treatment and cardiovascular events in prescription database studies
Molly M Shores
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, VA Puget Sound Health Care System, 1660 South Columbian Way Seattle, WA 98108, USA
Correspondence: Dr. MM Shores (molly.shores@va.gov)
Date of Submission 09-Dec-2016 Date of Acceptance 15-May-2017 Date of Web Publication 11-Aug-2017
| Abstract |
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Over the past decade, there has been a substantial increase in the number of men who are treated with testosterone. Despite this increase in the use of testosterone, the risks of adverse cardiovascular events are unclear as meta-analyses have reported conflicting findings and no clinical studies have been large enough or long enough to adequately assess for cardiovascular risks. The goal of this paper is to review large prescription database studies of testosterone treatment and adverse cardiovascular events and mortality with the aim of providing some guidance for clinicians and researchers in this controversial area.
Keywords: cardiovascular diseases; cohort studies; myocardial infarction; stroke; testosterone/adverse effects; thrombosis
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