Home  |  Archive  |  Online Submission  |  News & Events  |  Subscribe  |  APFA  |  Society  |  Links  |  Contact Us  |  中文版
Search   
 
Journal

Ahead of print
Authors' Accepted
    Manuscripts
new!
Current Issue
Archive
Acknowledgments
Special Issues
Browse by Category

Manuscript Submission

Online Submission
Online Review
Instruction for Authors
Instruction for Reviewers
English Corner new!

About AJA

About AJA
Editorial Board
Contact Us
News

Resources & Services

Advertisement
Subscription
Email alert
Proceedings
Reprints

Download area

Copyright licence
EndNote style file
Manuscript word template
Guidance for AJA figures
    preparation (in English)

Guidance for AJA figures
    preparation (in Chinese)

Proof-reading for the
    authors

AJA Club (in English)
AJA Club (in Chinese)

Links

Meetings
Journals
Societies & Institutes
Hospitals
Databases & Libraries
Companies
Websites
Other links

 
Abstract

Volume 20, Issue 5 (September 2018) 20, 479–487; DOI:10.4103/aja.aja_26_18

Stimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesis

Hai-Tao Ma1,2, Chang-Min Niu1,2, Jing Xia1,2, Xue-Yi Shen1,2, Meng-Meng Xia1,2, Yan-Qiu Hu3, Ying Zheng1,2

1 Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225001, China
2 Jiangsu Key Laboratory of Experimental and Translational Noncoding RNA Research, Yangzhou 225001, China
3 Clinicial Medical College, Yangzhou University, Yangzhou 225001, China

Correspondence: Dr. Y Zheng (yzzkl@163.com)

Date of Submission 31-Oct-2017 Date of Acceptance 27-Feb-2018 Date of Web Publication 29-May-2018

Abstract

To clarify the functions and mechanism of stimulated by retinoic acid gene 8 (Stra8) in spermatogenesis, we analyzed the testes from Stra8 knockout and wild-type mice during the first wave of spermatogenesis. Comparisons showed no significant differences in morphology and number of germ cells at 11 days postpartum, while 21 differentially expressed genes (DEGs) associated with spermatogenesis were identified. We speculate that Stra8 performs many functions in different phases of spermatogenesis, such as establishment of spermatogonial stem cells, spermatogonial proliferation and self-renewal, spermatogonial differentiation and meiosis, through direct or indirect regulation of these DEGs. We therefore established a preliminary regulatory network of Stra8 during spermatogenesis. These results will provide a theoretical basis for further research on the mechanism underlying the role of Stra8 in spermatogenesis.

Keywords: differentiation; meiosis; proliferation; spermatogenesis; spermatogonia; Stra8

Full Text | PDF |

 
Browse:  167
 
Copyright 1999-2017  Shanghai Materia Medica, Shanghai Jiao Tong University.  All rights reserved