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Zhi-Ming Cai
Education:
1. Shantou University, BS, 1984;
2. Sun Yat-sen University, M.D., 1993;
3. Huazhong University of Science & Technology, Ph.D. in Management, 2004.
Professional and Academic Experience:
1. 1984-1989 Shenzhen Women and Children Health Care Hospital, Dept. of Urology, Physician;
2. 1993-1996 Shenzhen Municipal Health Office, Assistant Director;
3. 1996-1999 Shenzhen Luohu Hospital, president;
4. 1999-2010 Peking University Shenzhen Hospital, president; Chief of Guangdong Key Laboratory of Male Reproductive Medicine and Genetics; Chairman of Shenzhen Medical Association Professional Committee for Reproductive Medicine.
5. 2011- Shenzhen Second People's Hospital, president. Chief of Guangdong Key Laboratory of Male Reproductive Medicine and Genetics; Chairman of Shenzhen Medical Association Professional Committee for Reproductive Medicine.
Awards & Honors:
1. 2009 The Third Prize of Chinese Medical Prize;
2. 2008 The Third Prize of Guangdong Science and Technology Progress Award;
3. 2008 Shenzhen Science & Technology Innovation Award;
4. 2006 Shenzhen Science & Technology Innovation Award.
Research Projects Ongoing:
1. National High-tech R&D Program (863 Program), No. 2009AA022707;
2. National High-tech R&D Program (863 Program), No. 2006AA02A302;
3. The National Natural Science Foundation of China, No. 81070529;
4. The National Natural Science Foundation of China, No. 30972992;
5. Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, No. 2008A060301001.
Research interests:
1. Mechanisms of male infertility;
2. Genomic study of genitourinary cancers.
Selected Publications:
Han Y, Chen J, Zhao X, Liang C, Wang Y, Sun L, Jiang Z, Zhang Z, Yang R, Chen J, Li Z, Tang A, Li X, Ye J, Guan Z, Gui Y, Cai Z*. MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS One. 2011 Mar 28;6(3):e18286. Chen H, Fok KL, Yu S, Jiang J, Chen Z, Gui Y, Cai Z*, Chan HC. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Mol Hum Reprod. 2011 Jul;17(7):405-14. Li Z, Li W, Xie J, Wang Y, Tang A, Li X, Ye J, Gui Y, Cai Z*. Epigenetic inactivation of PCDH10 in human prostate cancer cell lines. Cell Biol Int. 2011 Jul 1;35(7):671-6. Zhou L, Chen J, Li Z, Li X, Hu X, Huang Y, Zhao X, Liang C, Wang Y, Sun L, Shi M, Xu X, Shen F, Chen M, Han Z, Peng Z, Zhai Q, Chen J, Zhang Z, Yang R, Ye J, Guan Z, Yang H, Gui Y, Wang J, Cai Z*, Zhang X. Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma. PLoS One. 2010 Dec 30;5(12):e15224. Li Z, Xie J, Li W, Tang A, Li X, Jiang Z, Han Y, Ye J, Jing J, Gui Y, Cai Z*. Identification and characterization of human PCDH10 gene promoter. Gene. 2011 Apr1;475(1):49-56. Chen J, Wang Y, Wei B, Lai Y, Yan Q, Gui Y, Cai Z*. Functional expression of ropporin in human testis and ejaculated spermatozoa. J Androl. 2011 Jan-Feb;32(1):26-32. Lai Y, Ye J, Chen J, Zhang L, Wasi L, He Z, Zhou L, Li H, Yan Q, Gui Y, Cai Z*, Wang X, Guan Z. UPK3A: a promising novel urinary marker for the detection of bladder cancer. Urology. 2010 Aug;76(2):514.e6-11. Cui G, Qi Z, Guo X, Qin J, Gui Y, Cai Z*. Rat bone marrow derived mesenchymal progenitor cells support mouse ES cell growth and germ-like cell differentiation. Cell Biol Int. 2009 Mar;33(3):434-41. Zhou Y, Qin D, Tang A, Zhou D, Qin J, Yan B, Diao R, Jiang Z, Cai Z*, Gui Y.Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis. Mol Hum Reprod. 2009 Apr;15(4):223-30. Zhou DR, Zhou YC, Cui GH, Guo X, Qin J, Gui YT，Cai ZM*. Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of connexin43. Toxicology in Vitro，2008, 22(7):1719-1725. Guo X, Gui Y, Tang A, Lu L, Gao X, Cai Z*. Differential Expression of VASA gene in ejaculated spermatozoa from Normozoospermic men and the patients with oligozoospermia. Asian Journal of Andrology. 2007, 9(3): 339-344.
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