Aleksander Giwercman

Aleksander Giwercman
>Professor in Andrology
>Scanian Andrology Centre
>Fertility Centre
>Malm ö University Hospital
>SE 205 02 Malmö, Sweden
>Phone No: +46 40 337904 (office)
>+46 70 6837904 (mobile)
>Fax No: +46 40 337043
>e-mail: aleksander.giwercman@kir.mas.lu.se

Current Position

Chairman, Fertility Centre, Malmö University Hospital

 

Academic History

M.D. University of Copenhagen, Denmark (1981);

PhD, University of Copenhagen, Denmark (1992);

Associate Professor, Lunds University (2001);

Professor, Lunds University (2002)

 

Professional experience

July 1991-July 1994: senior registrar, University Dept. of Growth and Reproduction, Rigshospitalet, Copenhagen.

September 1997-December 1997: registrar, Dept. of Endocrinology, Karolinska Hospital, Stockholm

August 1994- August 1999: consultant, University Dept. of Growth and Reproduction, Rigshospitalet, Copenhagen.

March 1994: Authorized as Clinical Androlog by European Academy of Andrology

Spetember 1999-  Senior Consultant in Andrology, Malmö University Hospital

June 2001 – Chairman, Fertility Centre, Malmö University Hospital

 

Teaching and supervising experience, dissertations

SUPERVISION

Previous:

Graduated PhD students: PhD Niels Jørgensen, PhD Tina Kold Jensen, PhD Fan-Jing Meng (main supervisor), PhD Peter M. Petersen (main supervisor);

Biology students: Susanne Neergaard Poll, Charlotte Andersen

Medical students: Jesper Gyllenborg, Marla Chellakooty, Vibeke Jensen, Marie Frimodt-Møller, Stine Fredslund,  Ahmad M. Issa,  Morten Nielsen, Charlotte Giwercman;

Ongoing:

PhD students: Jonas Richthoff, MD; Tarmo Tiido, Kristina Lundin, Jakob Eberhard, Olof Ståhl, Saad ElZanaty, Yasir Ruhayel, Mona Bungum.

TEACHING

1978                Teaching in histology of medical students at University of Copenhagen, Institute of Anatomy;

1979-81,  1989-90 Teaching of laboratory technicians, School of laboratory technicians, Copenhagen;

1994-                Teaching at pre- and postgraduate level in Denmark as well as abroad in:

                                clinical andrology, semen analysis,testis histology;

1999-                Teaching in andrology, medical students, Lunds University;

Organiser of 5 postgraduate courses and 5 international meetings.

Other

Member, European Academy of Andrology;

President, Nordic Association of Andrology (1997-2001);

Secretary, examination committee, European Academy of Andrology;

Chairman, educational committee, European Academy of Andrology;

Referee for 21 scientific journals;

Member of Project Managing Group, ASCLEPIOS (EU Biomed) project (1993-1997);

Main co-ordinator: NorFA's Nordic-Baltic network for study of semen quality among army conscripts (1997-2000);

Member of Project Managing Group, INUEND0 (EU project) (2002-);

Member of Project Managing Group, EMAS (EU project) (2002-).

Scientiffic work

Leader of a research group (2 post-docs, 8 PhD students, 1 pre-graduated student, 6 laboratory technicians, 2 research nurses) focusing on “Gene-Environment-Lifestyle interaction and male reproductive function).

 

More than 160 papers published in international, peer-reviewed journals.

Previous clinical trials

Co-principal investigator, trial of recombinant FSH for Organon (according to GCP), Rigshospitalet, Copenhagen, Denmark, 1995-1997.

 

 

 

Peer-reviewed original papers

 

119.Giwercman A, Kledal TS, Schwartz M, Giwercman Y, Leffers H, Zazzi H, Wedell A, Skakkebæk NE. Preserved male fertility despite decreased androgen sensitivity due to a mutation in the ligand binding domain of the androgen receptor gene.  J Clin Endocrinol Metab 2000; 85:2253-9.

120.Giwercman A, Lundgaard Hansen L, Skakkebaek NE. Initiation of sperm production after bilateral orchiopexy performed in two adult men. Clinical and biological implications.  J Urol 2000; 163:1255-1256.

121.Larsen L, Scheike T, Jensen TK, Bonde JP, Ernst E, Hjøllund H, Zhou Y, Skakkebæk NE, Giwercman A. CASA parameters as predictors for fertility of men from general population.  Hum Reprod 2000; 15:1552-1556.

122.Hjollund NH, Jensen TK, Bonde JP, Henriksen TB, Andersson AM, Kolstad HA, Ernst E, Giwercman A, Skakkebæk NE, Olsen J. Stress and fertility. A follow-up study among couples planning the first pregnancy. Ugeskr Laeger 2000; 162: 5081-6.

 

123.Hjollund NH, Bonde JP, Jensen TK, Henriksen TB, Andersson AM, Kolstad HA, Ernst E, Giwercman A, Skakkebaek NE, Olsen J. Male-mediated spontaneous abortion among spouses of stainless steel welders. Scand J Work Environ Healthh 2000; 26:187-92.

 

124.Hjollund NH, Jensen TK, Bonde JP, Henriksen TB, Andersson AM, Kolstad HA, Ernst E, Giwercman A, Skakkebaek NE, Olsen J. Spontaneous abortion and physical strain around implantation: a follow-up study of first-pregnancy planners. Epidemiology 2000; 11:18-23.

 

125.Bonde JP, Joffe M, Apostoli P, Dale A, Kiss P, Spano M, Caruso F, Giwercman A, Bisanti L, Porru S, Vanhoorne M, Comhaire F, Zschiesche W. Sperm count and chromatin structure in men exposed to inorganic lead: lowest adverse effect levels. Occup Environ Med 2002; 59: 234-242.

 

126.ELzanaty S, Richthoff J, Malm J, Giwercman A. The impact of epididymis and accessory sex glands on sperm motility. Hum Reprod 2002; 17: 2904-2011.

 

127.Petersen PM, Giwercman A, Daugaard G, Rørth M, Petersen JH, Skakkebæk NE, Hansen SW, von der Maase, H. Effect of graded testiscular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis. J Clin Oncol 2002; 20:1537-1543.

 

128.Richthoff J, Rylander L, Hagmar L, Malm J, Giwercman A. Higher sperm counts in Southern Sweden as compared to Denmark. Hum Reprod 2002; 17: 2468-2073.

129.Richthoff J, Spano M, Giwercman YL, Frohm B, Jepson K, Malm J, Stridsberg M, Giwercman A. The impact of testicular and accessory sex gland function on sperm chromatin integrity. Hum Reprod 2002; 17: 3162-3169.

130.Bouloux PM, Nieschlag E, Burger HG, Skakkebæk NE, Wu FC, Handelsman DJ, Baker GH, Ochsenkuehn R, Syska A, McLachlan R, Giwercman A, Conway AJ, Turner L, van Kuijk JH, Vortman G. Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermi men who failed to respond to human chorionic gonadotropin alone. J Androl 2003, 24; 604-1.

131.Giwercman A, Richthoff J, Hjøllund H, Bonde JP, Jepson K, Frohm B, Spano M. Correlation between sperm motility and Sperm Chromatin Structure Assay parameters. Fertil Steril, 2003; 80: 1404-12.

132.Loft S, Kold-Jensen T, Hjøllund NH, Giwercman A, Gyllenborg J, Ernst E, Olsen J, Scheike T, Poulsen HE, Bonde JP. Oxidative DNA damage in human sperm influences time to pregnancy. Hum Reprod 2003, 9; 375-9.

133.Lundin, BK, Giwercman, A, Richthoff, J, Abrahamsson, P-A, Giwercman, YL. No association between mutations in the human androgen receptor GGN repeat and inter-sex conditions. Molec Hum Reprod 2003; 9; 375-9.

 

134.Lundwall A, Giwercman A, Ruhayel Y, Giwercman Y, Lilja H, Halldén C, Malm J. A frequent allele codes for a truncated variant of semenogelin I, the major protein component of human coagulum. Molec Hum Reprod 2003; 9; 345-50.

135.Richthoff J, Rylander L, Jönsson B, Mårtensson H, Hagmar L, Nilsson-Ehle P, Stridsberg M, Giwercman A. Exposure to persistent organochlorines in relation to markers of reproductive function in young males from the general Swedish population. Environ Health Perspect 2003; 111: 409-13.

136.Giwercman YL, Ivarsson SA, Richthoff J, Lundin KB, Giwercman A. A Novel Mutation in the D-Box of the Androgen Receptor Gene (S597R) in Two Unrelated Individuals Is Associated with both Normal Phenotype and Severe PAIS. Horm Res 2004; 61:58-62.

137.Giwercman YL. Richthoff J, Lundin KB, Abrahamsson P-A, Lilja H, Giwercman A.  The length of the androgen receptor CAG repeat regulates prostatic activity in adolescence, Prostate, 2004, 59:227-33;

 

138.Hjollund NH, Bonde JP, Henriksen TB, Giwercman A, Olsen J, The Danish First Pregnancy Planner Study Team.  . Reproductive effects of male psychological distress. Epidemiology 2004; 15: 21-7.

139.Hjollund NH, Bonde JP, Henriksen TB, Giwercman A, Olsen J, The Danish First Pregnancy Planner Study Team.  Job strain and male fertility. Epidemiology 2004; 15: 114-7.

140.Ståhl O, Eberhard J, Cwikiel M, Cavallin-Ståhl E, Spano M, Giwercman A. The impact of testicular cancer and its therapy on sperm DNA integrity, Cancer 2004, 100:1137-44.

 

141.ElZanaty S, Malm J, Giwercman A. Viscosity of the seminal fluid in relation to the epididymal and accessory sex gland function and its impact on sperm motility. Int J Androl, 2004, 27:94-100.

 

142.Eberhard J, Ståhl O, Giwecman YL, Cwikiel M, Cavallin-Ståhl E, Lundin KB, Giwercman A. Impact of therapy and androgen receptor polymorphism on semen quality in men treated for testicular germ cell cancer: a prospective, longitudinal study. Hum Reprod 2004; 19:1418-25.

 

143.Bungum M, Humeidan P, Spano M Jepson K, Bungum L, Giwercman A The predictive value of Sperm Chromatin Structure Assay (SCSA®) parameters for the outcome of intrauterine insemination, IVF and ICSI. Hum Reprod, 2004;19:1401-8

 

144.Ruhayel Y, Lundin KB, Giwercman YL,Halldén  C, Willén M, Giwercman A. Androgen Receptor Gene GGN and CAG Repeat Tract Polymorphism and Y Chromosome Microdeletions among Swedish Severely Oligozoospermic and Azoospermic Men. Hum Reprod, 2004;19:2076-83;

 

145.Rignell-Hydbom A, Rylander L, Giwercman A, Jönsson B, Nilsson-Ehle P, Hagmar L. Effect of dietary exposure to CB-153 and p,p´-DDE on reproductive function in Swedish fishermen. Hum Reprod; 2004;19:2066-75;.

 

146.Giwercman A, Lundin KB, Eberhard J, Ståhl O, Cwikiel M, Cavallin-Ståhl E, Giwercman YL. testicular germ cell cancer pathogenesis and the androgen receptor polymorphism. Eur J Cancer, 2004;40:2152-8;

 

147.Malm G, Haugen TB, Henrichsen T, Bjørsvik C, Grotmol T, Sæther T, Malm J, Figenschau Y, Hagmar L, Rylander L, Levine RJ, Giwercman A. Reproductive function during summer and winter in Norwegian men living north and south of the Arctic Circle. J Clin Endocrinol Metab, 2004;89:4397-402;

 

148.Erenpreiss J, Giwercman A, Erenpreissa J, Spano M. Toluidine blue cytometry test for sperm DNA conformation; comparison with the flow cytometric sperm chromatin structure and TUNEL assays. Hum Reprod, 2004;19:2277-2282;

 

149.Aschim EL, Nordenskjöld A, Giwercman A, Lundin KB, RuhayelY, Haugen TB, Grotmol T,Giwercman YL. Linkage between cryptorchidism, hypospadias and GGN trinucleotide repeat length in the androgen receptor gene. J Clin Endocrinol Metab, 2004;89:5105-9;

 

150.Toft, G, Rignell-Hydbom, A, Tyrkiel, E, Shvets, M, Giwercman, A. Quality control workshops in standardization of sperm concentration and motility assessment in multi-centre studies. Int J Androl, in press.

 

151.Giwercman Richiardi L, Kaijser M, Ekbom A, Akre O. Number of children and risk for prostate cancer. Submitted.

 

 

Reviews and book chapters:

 

 

152.Giwercman A. Gonadotoxic treatment in males – a reason for andrological counseling? Radiother Oncol 2003, 68; 213-5.

153.Giwercman YL, Giwercman A. Epidemiology of male reproductive disorders. Endotext, in press.

154.Giwercman A. Male Infertility. Review Series in Urology, in press.

155.Toft G, Hagmar L, Giwercman A, Bonde JP. Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reprod Toxicol, 2004, 19:5-26.