HUHTANIEMI,
Ilpo Tapani
CURRENT
POSITIONS
Professor
of Physiology, Medical Faculty University of Turku, Finland
1986 –
(from
April 2002 part time)
Professor
of Reproductive Biology, Institute of Reproductive
and
Developmental Biology, Imperial College, Faculty of Medicine, 1
Apr 2002
London,
UK
EDUCATIONAL
TRAINING
-
Licentiate of Medicine, University of Helsinki 30
Oct 1972
-
Licensed physician in Finland 1
Nov 1972
-
Doctor of Medical Science, University of Helsinki 12
Feb 1974
-
Specialist in Clinical Chemistry (Chemical Pathology) 9
Nov 1978
FOREIGN
TRAINING
-
Postdoctoral Fellow (Dept. Obstetr., Gyn. and Reprod. Sci., Univ. of 1975
– 1976
Calif.
San Francisco, CA), total 20 months
-
Visiting Associate (Natl. Inst. of Child Health and Human Developm., 1979
- 1980
NIH,
Bethesda, MD), total 20 months
-
Visiting Professor, Zentrum für Molekulare Biologie, Univ. of Heidelberg, 1990
- 1991
Germany,
12 months
-
Visiting Professor, MRC Reproductive Biology Unit, Edinburgh, UK 1999
- 2000
8
months
RESEARCH
AWARDS, HONOURS, LECTURES AND MAJOR STIPENDIARY SUPPORT
-
NIH International Postdoctoral Research Fellow (Fogarty Foundation) 1975
- 1976
Univ.
of Calif. San Francisco, Dept. Ob./Gyn., 20 months
-
Visiting Associate, Natl. Inst. of Child Health and Human Developm., 1979
- 1980
NIH, Bethesda, MD, 20 months
-
Senior Fellow of The Academy of Finland 1981
- 1983
-
Research Grants and contracts from the Academy of Finland 1981
- 2007
-
Continuous funding from The Sigrid Jusélius Foundation 1987
- 2005
-
3-yr Research Contract from the Finnish Life and Pension Insurance 1989
- 1991
Companies
-
Grant from the Rockefeller/E. Schering/CONRAD Fdn. 1997
- 2006
-
Advanced Scientist Grant from The Academy of Finland 1990
- 1991
1994
– 1995
1999
- 2000
-
Young Investigator Award of The American Society of Andrology 1987
-
The Finnish Academy of Science and Letters (Suomalainen Tiedeakatemia)
-
elected member 1993
-
Nordic Society for Andrology
-
The Erik Blom Lecture 1994
-.Australian
Society for Reproductive Biology
-
The Goding Lecture 1994
-
The Finnish Endocrine Society
-
Honorary Member 1997
-
The Finnish Medical Society DUODECIM
- Matti Äyräpää Award 1999
-
Society for the Study of Fertility (UK)
-
Parkes lecture
1999
-
Honorary Member of The Romanian Academy of Medical Sciences 2001
-
Laboratory granted status of ‘Centre of Excellence’ of The Academy 2002
of Finland
-
Society for Endocrinology (UK), European Medal Lecture 2002
-
Fellow of The Academy of Medical Sciences (UK) 2003
-
German Endocrine Society, The Berthold Lecture 2004
EDITORSHIPS
IN SCIENTIFIC JOURNALS
Kliin-Lab,
Editor-in-Chief 1983 - 1985
Acta
Endocrinologica, Editor 1985 - 1992
The
Society for the European Journal of Endocrinology
-
Member of Executive Committee 1993
- 1996
Journal
of Andrology
-
International Associate Editor 1994
- 1997
Trends
in Physiological Sciences, Associate Editor 1995
- 1999
Molecular
and Cellular Endocrinology,
-
Editorial Board 1994
– 1999
-
Managing Chief Editor 1999-
Endocrinology,
Editorial Board 1996
– 1999
Journal
of Endocrinology, Scientific Editor 1996
- 1999
Clinical
Endocrinology, Editorial Board 1997
- 2002
Pathophysiology,
Editorial Board 1997
–
Cell
and Tissue Research, Editorial Board 2000-
2002
Reproduction,
Associate Editor 2004
-
ACTIVITIES
IN SCIENTIFIC SOCIETIES
-
Nordic Association of Physiology
-
member of board 1993
- 1997
-
WHO Special Programme of Research, Development and Research
Training
in Human Reproduction
-
temporary advisor 1987
- 1990
-
Member of the Task Force for Male Contraception 1993
-
-
International Society of Andrology
-
Secretary 1989
- 1997
-
Member of Executive Council 1988
-
-
President 1997
- 2001
-
Society for the Study of Reproduction (U.S.A.)
1989
-
-
European Study Group for Mol. and Cell. Endocrinology of the Testis
-
member of permanent scientific committee 1986
-
-
Committee of The Acta Endocrinologica Societies
-
member 1985
- 1992
-
The Finnish Endocrine Society
1970
-
-
treasurer
1982
- 1985
-
member of board
1982
- 1993
-
chairman
1988
- 1990
-
The Finnish Society of Developmental Biology 1981
-
-
member of board
1981
- 1984
-
The Finnish Physiological Society
1985
-
-
member or board 1991
- 1993
-
The Finnish Andrological Society
1988
-
-
founding member
-
chairman 1995
-1998
-
The European Academy of Andrology 1992
-
-
founding member
-
member of executive committee 1992
- 2002
-
The European Federation of Endocrine Societies
-
member of Executive Council 1994
-2001
Reviewer
of doctoral dissertation 20 times
Referee
for docentship application 8 times
Supervisor
for 32 doctoral dissertations
Official
Opponent for 18 doctoral dissertations
Invited
speaker and/or chairman in about 160 international scientific meetings
Member
of organizing committee of about 20 international scientific congresses
SCIENTIFIC
PUBLICATIONS
About
460 peer-reviewed papers and over 100 book chapters in the field of
reproductive endocrinology, andrology and molecular biology.
Ten representative publications:
1.
Clayton R.N. and Huhtaniemi I.T.: Absence of
gonadotropin-releasing hormone receptors in human gonadal tissue. Nature
1982; 299: 56-59.
2.
Aittomäki K., Dieguez Lucena J.L., Pakarinen P.,
Sistonen P., Tapanainen J., Gromoll J., Kaskikari R., Sankila E.-M.,
Lehväslaiho H., Reyes Engel A., Nieschlag E., Huhtaniemi I. and de la Chapelle
A.: Mutation in the follicle-stimulating hormone receptor gene causes
hereditary hypergonadotropic ovarian failure. Cell 1995; 82: 959-968.
3.
Tapanainen J.S., Aittomäki K., Jiang M., Vaskivuo T.
and Huhtaniemi I.T.: Men homozygous for an inactivating mutation of the
follicle-stimulating hormone (FSH) receptor gene present variable suppression
of spermatogenesis and fertility. Nature
Genet 1997; 15: 205-206.
4.
Manna P.R., Tena-Sempere M. and Huhtaniemi I.T.:
Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse
Leydig tumor cells; Involvement of the steroidogenic acute regulatory (StAR)
protein. J Biol Chem 1999; 274:
5909-5918.
5.
Jiang M., Pakarinen P., Zhang F.-P., El-Hefnawy T.,
Koskimies P., Pettersson K. and Huhtaniemi I.: A common polymorphic allele of
the human luteinizing hormone beta-subunit gene: additional mutations and
differential function of the promoter sequence. Hum Mol Genet 1999; 8: 2037-2046.
6.
Kero J., Poutanen M., Zhang F.-P., Rahman N., McNicol
A.-M., Huhtaniemi I., Nilson J. and Keri R.: Elevated luteinizing hormone (LH)
in transgenic mice induces functional LH receptor expression and
steroidogenesis in adrenal cortex.
J Clin Invest 2000; 105:
633-641.
7.
Themmen A.P.N. and Huhtaniemi I.T.: Mutations of
gonadotropins and gonadotropin receptors: Elucidating the physiology and
pathophysiology of pituitary-gonadal function. Endocr Rev 2000; 21: 551-583.
8.
Zhang F.-P., Poutanen M., Wilbertz J. and Huhtaniemi
I.: Normal prenatal but arrested postnatal sexual development of luteinizing
hormone receptor knockout mice. Mol
Endocrinol 2001; 18: 182-193.
9.
Manna P.R., Joshi L., Reinhold V.N., Aubert M.L.,
Suganuma N., Pettersson K. and Huhtaniemi I.: Synthesis, purification, and
structural and functional characterization of recombinant form of a common
genetic variant of human luteinizing hormone. Hum Mol Genet, 2002; 11: 301-315.
10.
Zhang F.-P., Pakarainen T., Poutanen M., Toppari J.
and Huhtaniemi I.: The low gonadotropin-independent constitutive production of
testicular testosterone is sufficient to maintain spermatogenesis. Proc Natl Acad Sci USA 2003; 100:
13692-13697.