HUHTANIEMI, Ilpo Tapani

CURRENT POSITIONS

Professor of Physiology, Medical Faculty University of Turku, Finland               1986 –

(from April 2002 part time)

Professor of Reproductive Biology, Institute of Reproductive

and Developmental Biology, Imperial College, Faculty of Medicine,                       1 Apr 2002

London, UK

 

EDUCATIONAL TRAINING

- Licentiate of Medicine, University of Helsinki                               30 Oct 1972

- Licensed physician in Finland                                                       1 Nov 1972

- Doctor of Medical Science, University of Helsinki                          12 Feb 1974

- Specialist in Clinical Chemistry (Chemical Pathology)                     9 Nov 1978

 

FOREIGN TRAINING

- Postdoctoral Fellow (Dept. Obstetr., Gyn. and Reprod. Sci., Univ. of                   1975 – 1976

Calif. San Francisco, CA), total 20 months

- Visiting Associate (Natl. Inst. of Child Health and Human Developm.,                   1979 - 1980

NIH, Bethesda, MD), total 20 months

- Visiting Professor, Zentrum für Molekulare Biologie, Univ. of Heidelberg,                   1990 - 1991

Germany, 12 months

- Visiting Professor, MRC Reproductive Biology Unit, Edinburgh, UK                   1999 - 2000

8 months

 

RESEARCH AWARDS, HONOURS, LECTURES AND MAJOR STIPENDIARY SUPPORT

 

- NIH International Postdoctoral Research Fellow (Fogarty Foundation)                   1975 - 1976

Univ. of Calif. San Francisco, Dept. Ob./Gyn., 20 months

- Visiting Associate, Natl. Inst. of Child Health and Human Developm.,                   1979 - 1980

 NIH, Bethesda, MD, 20 months

- Senior Fellow of The Academy of Finland                               1981 - 1983

- Research Grants and contracts from the Academy of Finland                       1981 - 2007

- Continuous funding from The Sigrid Jusélius Foundation                    1987 - 2005

- 3-yr Research Contract from the Finnish Life and Pension Insurance                   1989 - 1991

   Companies

- Grant from the Rockefeller/E. Schering/CONRAD Fdn.                       1997 - 2006

- Advanced Scientist Grant from The Academy of Finland                           1990 - 1991

                                                                                      1994 – 1995

                                                                                      1999 - 2000

- Young Investigator Award of The American Society of Andrology                        1987

- The Finnish Academy of Science and Letters (Suomalainen Tiedeakatemia)

                   - elected member                                         1993

- Nordic Society for Andrology

                   - The Erik Blom Lecture                                          1994

-.Australian Society for Reproductive Biology

                   - The Goding Lecture                                          1994

- The Finnish Endocrine Society

                   - Honorary Member                                         1997

- The Finnish Medical Society DUODECIM

                   -  Matti Äyräpää Award                                            1999

- Society for the Study of Fertility (UK)

                   - Parkes lecture                                           1999

- Honorary Member of The Romanian Academy of Medical Sciences            2001

- Laboratory granted status of ‘Centre of Excellence’ of The Academy         2002

   of Finland    

- Society for Endocrinology (UK), European Medal Lecture        2002

- Fellow of The Academy of Medical Sciences (UK)        2003

- German Endocrine Society, The Berthold Lecture        2004

 

 

EDITORSHIPS IN SCIENTIFIC JOURNALS

Kliin-Lab, Editor-in-Chief                                               1983 - 1985

Acta Endocrinologica, Editor                                      1985 - 1992

The Society for the European Journal of Endocrinology

                   - Member of Executive Committee                          1993 - 1996

Journal of Andrology

                   - International Associate Editor                                  1994 - 1997

Trends in Physiological Sciences, Associate Editor                                  1995 - 1999

Molecular and Cellular Endocrinology,

                   - Editorial Board                                            1994 – 1999

                   - Managing Chief Editor                                           1999-

Endocrinology, Editorial Board                                            1996 – 1999

Journal of Endocrinology, Scientific Editor                                  1996 - 1999

Clinical Endocrinology, Editorial Board                                            1997 - 2002

Pathophysiology, Editorial Board                                                    1997 –

Cell and Tissue Research, Editorial Board                                       2000- 2002

Reproduction, Associate Editor                                                     2004 -

 

ACTIVITIES IN SCIENTIFIC SOCIETIES

- Nordic Association of Physiology

                   - member of board                                                     1993 - 1997

- WHO Special Programme of Research, Development and Research

Training in Human Reproduction

                   - temporary advisor                                                  1987 - 1990

                   - Member of the Task Force for Male Contraception                    1993 -

- International Society of Andrology

                   - Secretary                                                    1989 - 1997

                   - Member of Executive Council                               1988 -

                   - President                                                    1997 - 2001

- Society for the Study of Reproduction (U.S.A.)                               1989 -

- European Study Group for Mol. and Cell. Endocrinology of the Testis

                   - member of permanent scientific committee                           1986 -

- Committee of The Acta Endocrinologica Societies 

                   - member                                                      1985 - 1992

- The Finnish Endocrine Society                                                                        1970 -

                   - treasurer                                                                             1982 - 1985

                   - member of board                                                                       1982 - 1993

                   - chairman                                                                              1988 - 1990

- The Finnish Society of Developmental Biology                                                    1981 -

                   - member of board                                                                       1981 - 1984

- The Finnish Physiological Society                                                                    1985 -

                   - member or board                                                             1991 - 1993

- The Finnish Andrological Society                                                                     1988 -

                   - founding member

                   - chairman                                                    1995 -1998

- The European Academy of Andrology                           1992 -

                   - founding member

                   - member of executive committee                           1992 - 2002

- The European Federation of Endocrine Societies

                   - member of Executive Council                               1994 -2001

 

Reviewer of doctoral dissertation 20 times

Referee for docentship application 8 times

Supervisor for 32 doctoral dissertations

Official Opponent for 18 doctoral dissertations

Invited speaker and/or chairman in about 160 international scientific meetings

Member of organizing committee of about 20 international scientific congresses

 

SCIENTIFIC PUBLICATIONS

About 460 peer-reviewed papers and over 100 book chapters in the field of reproductive endocrinology, andrology and molecular biology.

 

Ten representative publications:

 

1.        Clayton R.N. and Huhtaniemi I.T.: Absence of gonadotropin-releasing hormone receptors in human gonadal tissue.  Nature 1982; 299: 56-59.

2.        Aittomäki K., Dieguez Lucena J.L., Pakarinen P., Sistonen P., Tapanainen J., Gromoll J., Kaskikari R., Sankila E.-M., Lehväslaiho H., Reyes Engel A., Nieschlag E., Huhtaniemi I. and de la Chapelle A.: Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell 1995; 82: 959-968.

3.        Tapanainen J.S., Aittomäki K., Jiang M., Vaskivuo T. and Huhtaniemi I.T.: Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nature Genet 1997; 15: 205-206.

4.        Manna P.R., Tena-Sempere M. and Huhtaniemi I.T.: Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse Leydig tumor cells; Involvement of the steroidogenic acute regulatory (StAR) protein. J Biol Chem 1999; 274: 5909-5918.

5.        Jiang M., Pakarinen P., Zhang F.-P., El-Hefnawy T., Koskimies P., Pettersson K. and Huhtaniemi I.: A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence. Hum Mol Genet 1999; 8: 2037-2046.

6.        Kero J., Poutanen M., Zhang F.-P., Rahman N., McNicol A.-M., Huhtaniemi I., Nilson J. and Keri R.: Elevated luteinizing hormone (LH) in transgenic mice induces functional LH receptor expression and steroidogenesis in adrenal cortex.  J Clin Invest 2000; 105: 633-641.

7.        Themmen A.P.N. and Huhtaniemi I.T.: Mutations of gonadotropins and gonadotropin receptors: Elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 2000; 21: 551-583.

8.        Zhang F.-P., Poutanen M., Wilbertz J. and Huhtaniemi I.: Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout mice. Mol Endocrinol 2001; 18: 182-193.

9.        Manna P.R., Joshi L., Reinhold V.N., Aubert M.L., Suganuma N., Pettersson K. and Huhtaniemi I.: Synthesis, purification, and structural and functional characterization of recombinant form of a common genetic variant of human luteinizing hormone. Hum Mol Genet, 2002; 11: 301-315.

10.    Zhang F.-P., Pakarainen T., Poutanen M., Toppari J. and Huhtaniemi I.: The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Proc Natl Acad Sci USA 2003; 100: 13692-13697.