NIELS JØRGENSEN,MD, Ph.D.
Telephone
(+45) 35 45 50 85 (work)
E-mail
njcph@rh.dk (work)
June 1991 Medical
doctor, University of Copenhagen.
February 1996 Medical
Ph.D., University of Copenhagen. Thesis ”Immature Germ Cells and their
Relation
to Germ Cell Cancer – Immunohistochemical and DNA Densitometric
Studies”.
October 2003 Certified
clinical andrologist, European Academy of Andrology.
October 2004 Certified
specialist in medical endocrinology.
EMPLOYMENTS
July 1989 – Aug 1990 Scholarship,
Laboratory of Male Reproduction, National University Hospital,
Denmark.
July 1991 – Sept 1994 Ph.D.-student.
University Department of Growth and Reproduction, National Uni-
versity
Hospital, Denmark.
Oct 1994 – March 1996 Internship
(general surgery 6 months, general internal medicine 6 months, and ge-
neral
practice 6 months). Copenhagen County Hospitals.
Oct 1994 – March 1996 Part
time Registrar, University Department of Growth and Reproduction, National
University
Hospital, Denmark.
April 1996 – Sept 1996 Registrar,
training in andrology. University Department of Growth and Reproduc-
tion,
National University Hospital, Denmark.
Oct 1996 – Sept 1997 Registrar,
training in internal medicine, part 1A, University Department of Cardio-
logy
and Endocrinology. Frederiksberg Municipality Hospital, Denmark.
Oct 1996 – Sept 1997 Part
time Registrar, University Department of Growth and Reproduction, National
University
Hospital, Denmark.
Oct 1997 – Jan 1998 Registrar,
training in andrology. University Department of Growth and Reproduc-
tion,
National University Hospital, Denmark.
Feb 1998 – Jan 1999 Registrar,
training in internal medicine, part 1B, University Department of Cardio-
logy
and Endocrinology. Frederiksberg Municipality Hospital, Denmark.
Feb 1998 – Jan 1999 Part
time Registrar, University Department of Growth and Reproduction, National
University
Hospital, Denmark.
Feb 1999 – Aug 1999 Registrar,
training in andrology. University Department of Growth and Reproduc-
tion,
National University Hospital, Denmark.
Sept 1999 – Aug 2000 Registrar,
training in internal medicine, part 2A, University Department of Ne-
phrology,
National University Hospital, Denmark.
Sept 2000 – Feb 2001 Registrar,
training in internal medicine, part 2B, University Department of Haema-
tology,
National University Hospital, Denmark.
March 2001 – Aug 2001 Registrar,
training in internal medicine, part 2C, University Department of Infec-
tious
Diseases, National University Hospital, Denmark.
Sept 1999 – Aug 2001 Part
time Registrar, University Department of Growth and Reproduction, National
University
Hospital, Denmark.
Sept 2001 – April 2002 Registrar,
training in andrology. University Department of Growth and Reproduc-
tion,
National University Hospital, Denmark.
May 2002 – Nov 2003 Senior
Registrar, training in internal medicine-endocrinology, part 3. University
Department
of Endocrinology, National University Hospital, Denmark.
Dec 2003 – (Oct 2003) Senior
Registrar, training in internal medicine-endocrinology, part 3. University
Department
of Endocrinology, Hvidovre Hospital, Denmark.
Nov 2004 - Present Consultant,
Andrology and Medical Endocrinology, University Department of
Growth
and Reproduction, National University Hospital, Denmark.
1.
Jørgensen N, Giwercman A, Müller J and Skakkebæk NE: Clinical and biological
significance of carcinoma-in-situ of the human testis. Cancer Surveys, 1990; 9:
287-302.
2.
Clausen OPF, Giwercman A, Jørgensen N, Bruun E,
Frimodt-Møller C and Skakkebæk NE: DNA distribution in maldescended testes. Hyperdiploid
aneuploidy without evidence of germ cell neoplasia. Cytometry, 1991; 12: 77-81.
3.
Jørgensen N, Giwercman A, Hansen SW and Skakkebæk NE: Testicular cancer after
vasectomy: Origin from carcinoma-in-situ of the testis. European Journal of
Cancer, 1993; 29A: 1062-1064.
4.
Jørgensen N, Giwercman A, Hansen SW and Skakkebæk NE: Testicular cancer after
vasectomy: Origin from carcinoma-in-situ of the testis. Urology/Nephrology
Digest, 1993: 10. “Abstract publication” based on European Journal of Cancer,
1993; 29A: 1062-1064 (publication no. 3).
5.
Jørgensen N, Giwercman A, Hansen SW and Skakkebæk NE: Testicular cancer after
vasectomy: Origin from carcinoma-in-situ of the testis. Urology Digest, 1994:
1. Abstract publication based on European Journal of Cancer, 1993; 29A:
1062-1064 (publication no. 3).
6.
Jørgensen N, Giwercman A, Müller J and Skakkebæk NE: Immunohistochemical markers of
carcinoma-in-situ of the testis also expressed in normal infantile germ cells.
Histopathology, 1993; 22: 373-378.
7.
Giwercman A, Andrews PW, Jørgensen N, Müller J, Græm N and
Skakkebæk NE: Immunohistochemical expression of embryonal marker TRA-1-60 in
carcinoma-in-situ germ cells and in testicular germ cell tumours. Cancer, 1993;
72: 1308-1314.
8.
Visfeldt J, Jørgensen N; Müller J, Møller H
and Skakkebæk NE: Testicular germ cell tumours of childhood in Denmark,
1943-1989: Incidence and evaluation of histology using immunohistochemical techniques.
The Journal of Pathology, 1994; 174: 39-47.
9.
Jørgensen N, Rajpert-De Meyts E, Græm N, Müller J, Giwercman A and Skakkebæk NE:
Expression of immunohistochemical markers for testicular carcinoma in situ by
normal human foetal germ cells. Laboratory Investigations, 1995; 72: 223-231.
10. Jørgensen
N, Müller J, Giwercman A,
Visfeldt J, Møller H and Skakkebæk NE: DNA content and expression of tumour
markers in germ cells adjacent to germ cell tumours in childhood: Probably a
different origin of the infantile and adolescent germ cell tumours. The Journal
of Pathology, 1995; 176: 269-278.
11. Møller H, Jørgensen
N and Forman D: Trends in incidence of testicular cancer in boys and
adolescent men. International Journal of Cancer, 1995; 61: 761-765.
12. Møller H, Jørgensen
N and Forman D: Trends in incidence of testicular cancer in boys and
adolescent men. Focus and Opinion: Pediatrics, 1996; 2: 150-151. Abstract
publication based on International Journal of Cancer, 1995; 61: 761-765
(publication no. 9).
13. Yue Z, Meng FJ, Jørgensen
N, Ziebe S and Andersen AN: Sperm morphology using strict criteria
after percoll density separation: Influence on fertilization and pregnancy
rates after in-vitro fertilization. Human Reproduction, 1995; 10: 1781-1785.
14. Jahnukainen K, Jørgensen
N, Pöllänen P, Giwercman A and Skakkebæk NE: Testicular mononuclear
cell infiltrates in normal human males and in patients with germ cell
neoplasia. International Journal of Andrology, 1995; 18: 312-320.
15. Yding Andersen C and Jørgensen N: Improvement of sperm motility by adding
progesterone to the Percoll media during sperm purification. Human Reproduction,
1995; 10: 3183-3185.
16. Rajpert-De Meyts E, Jørgensen N, Müller J, Nielsen OH and Skakkebæk NE:
Prolonged expression of the c-kit
receptor in germ cells of intersex foetal testes. The Journal of Pathology,
1996; 178: 166-169.
17. Rajpert-De Meyts E, Jørgensen N, Müller J, Giwercman A and Skakkebæk NE: Origin
of germ cell tumours. In Sex Differentiation: Clinical and biological aspects.
Ed. IA Hughes. Serono Symposia Series. Frontiers in Endocrinology, 1996; 20:
45-54.
18. Jørgensen
N, Müller J, Jaubert F, Clausen
OP and Skakkebæk NE: Heterogeneity of gonadoblastoma germ cells. Similarities
with immature germ cells, spermatogonia and testicular carcinoma in situ cells.
Histopathology, 1997; 30: 177-186.
19. Jørgensen
N, Auger J, Giwercman A,
Irvine DS, Jensen TK, Jouannet P, Keiding N, Le Bon C, Macdonald E, Pekuri A,
Scheike T, Simonsen M, Suominen J and Skakkebæk NE: Semen analysis performed by
different laboratory teams: An intervariation study. International Journal of
Andrology, 1997; 20: 201-208.
20. Skakkebæk NE, Rajpert-De Meyts E, Jørgensen N, Carlsen E, Petersen PM, Giwercman A, Andersen
A-G, Jensen TK and Müller J: Germ cell cancer and disorders of spermatogenesis:
An environmental connection? APMIS, 1998; 106: 3-11.
21. Rajpert-De Meyts E, Jørgensen N, Nielsen KB, Müller J and Skakkebæk NE:
Developmental arrest of germ cells in the pathogenesis of germ cell neoplasia.
APMIS, 1998; 106: 198-206.
22. Skakkebæk NE, Giwercman A, Jensen TK, Jørgensen N, and Keiding N:
Selection biases in semen study? Fertility and Sterility, 1998; 69: 1158-1159.
(Letter).
23. Jørgensen
N, Toppari J, Grandjean P, and
Skakkebæk NE: Environment and male reproductive function. In Male Reproductive
Function. Ed. Christina Wang. Kluwer Academic Publishers, 1999: 321-337.
24. Rajpert-De Meyts E, Jørgensen N, Græm N, Müller J, Cate R, Skakkebæk NE:
Expression of Anti-Müllerian Hormone during Normal and Pathological Gonadal
Development: Association with Differentiation of Sertoli and Granulosa Cells.
The Journal of Clinical Endocrinology and Metabolism, 1999; 84: 3836-3844.
25. Andersen AG, Jensen TK, Carlsen E, Jørgensen N, Andersson AM, Krarup
T, Keidinig N and Skakkebæk NE: High frequency of sub-optimal semen quality in
an unselected population of young men. Human Reproduction, 2000; 15: 366-372.
26. Andersen AG, Jørgensen
N, Jensen TK, Andersson AM, Carlsen E, Keiding N, Swan SH and Skakkebæk
NE: Serum Levels of Testosterone do not Provide Evidence of Selection Bias in
Studies of Male Reproductive Health. Epidemiology, 2000; 11: 232-233. (Letter).
27. Carlsen E, Andersen AG, Buchreitz L, Jørgensen N, Magnus Ø,
Matulevicius V, Nerrmoen I, Holm Petersen J, Punab M, Suominen J, Zilaitiene B
and Giwercman A: Inter-observer variation in the results of the clinical
andrological examination including estimation of testicular size. International
Journal of Andrology, 2000; 23: 248-253.
28. Jørgensen
N, Andersen AG, Eustache F,
Irvine DS, Suominen J, Petersen JH, Andersen AN, Auger J, Cawood EHH, Horte A,
Jensen TK, Jouannet P, Keiding N, Vierula M, Toppari and Skakkebæk NE: Regional
Differences in Semen Quality in Europe. Human Reproduction, 2001; 16:
1012-1019.
29. Krausz C, Quintana-Murci L, Rajpert-De Meyts E,
Jobling M, Jørgensen N, Larsen
LF, Skakkebæk NE and McElreavey K: Identification of an Y-chromosome haplogroup
associated with reduced sperm counts. Human Molecular Genetics, 2001; 10:
1873-1877.
30. Jensen TK, Slama R, Ducot B, Suominen J, Cawood EHH,
Andersen AG, Eustache F, Irvine DS, Auger J, Jouannet P, Vierula M, Jørgensen N, Toppari J, Skakkebæk
NE, Keiding N and Spira A: Regional differences in waiting time to pregnancy
among fertile couples from four European cities. Human Reproduction, 2001; 16:
2697-2704.
31. Auger J, Eustache F, Andersen AG, Irvine DS, Jørgensen N, Skakkbæk NE,
Suominen J, Toppari J, Vierula M and Jouannet P: Sperm morphological defects
related to environment, lifestyle and medical history of 1001 male partners of
pregnant women from four European cities. Human Reproduction, 2001; 16:
2710-2717.
32. Andersen AG, Ziebe S, Jørgensen N, Petersen JH, Skakkebæk NE and Andersen AN: Time
to pregnancy in relation to semen quality assessed by CASA before and after
sperm separation. Human Reproduction, 2002; 17: 173-177.
33.
Rajpert-De Meyts E, Leffers
H, Petersen JH, Andersen AG, Carlsen E, Jørgensen
N and Skakkebæk NE: CAG repeat length in androgen-receptor gene and
reproductive variables in fertile and infertile men. Lancet, 2002; 359: 44-46.
34.
Slama R, Eustache F, Ducot B,
Jensen TK, Jørgensen N, Horte
A, Irvine S, Suominen J, Andersen AG, Auger J, Vierula M, Toppari J, Andersen
AN, Keiding N, Skakkebæk NE, Spira A and Jouannet P: Time to pregnancy and
semen parameters: A cross sectional study among fertile couples from four
European cities. Human Reproduction, 2002; 17: 503-515.
35. Mol NM, Sørensen N, Weihe P, Andersson AM, Jørgensen N, Skakkebæk NE,
Keiding N and Grandjean P: Spermaturia and serum hormone concentrations at
puberty age in boys prenatally exposed to polychlorinated biphenyls. European
Journal of Endocrinology, 2002; 146: 357-363.
36. Jensen TK, Carlsen E, Jørgensen N, Berthelsen JG, Keiding N, Christensen K,
Petersen JH, Knudsen LB and Skakkeæk NE: Hypothesis; Poor semen quality may
contribute to recent decline in fertility rates. Human Reproduction, 2002; 17:
1437-1440.
37.
Jørgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen AG, Andersson AM,
Haugen TB, Horte A, Jensen TK, Magnus Ø, Petersen JH, Vierula M, Toppari J and
Skakkebæk NE: East-west gradient in semen quality in the Nordic-Baltic area: A
study of men from the general population in Denmark, Norway, Estonia and
Finland. Human Reproduction, 2002; 17: 2199-2208.
38.
Punab M, Zilaitiene B, Jørgensen N, Horte A,
Matulevicius V, Peetsalu A and Skakkebæk NE: Regional differences in semen
qualities in the Baltic region. International Journal of Andrology, 2002; 25:
243-252.
39. Jørgensen N
and Skakebæk NE: Dårlig sædkvalitet hos unge danske mænd – resultat af en
ændret miljøpåvirkning med mulige fertilitetskonsekvenser. Månedsskrift for
Praktisk Lægegerning, 2003; 2:169-175.
40. Skakkebæk NE, Holm M, Hoei-Hansen C, Jørgensen N, and Rajpert-De Meyts
E: Association between testicular dysgenesis syndrome (TDS) and testicular
neoplasia: Evidence from 20 adult patients with signs of maldevelopment of the
testis. APMIS, 2003; 111: 1-11.
41. Skakkebæk
NE, Juul A, Jørgensen N and
Rajpert-De Meyts E: Andrologisk endokrinologi. Medicinsk kompendium, 2003,
chapter 56.
42. Jensen M, Leffers H, Jørgensen N, Petersen JH, Andersen AN, Skakkebæk NE and
Rajpert-De Meyts E: Frequent polymorphism of the mitochondrial DNA polymerase gamma
gene (POLG) in patients with normal
spermiograms and unexplained subfertility. Human Reproduction, 2004; 19: 65-70.
43.
Jensen TK, Jørgensen N, Punab M, Haugen TB,
Suominen J, Zilaitiene B, Andersen AG, Carlsen E, Magnus Ø, Matulevicius V,
Nermoen I, Vierula M, Keiding N, Toppari J and Skakkebæk NE: In utero exposure
to maternal smoking associated with reduced semen quality and testis size in
adulthood; A cross sectional study of 2069 young men from the general
population in five European countries. American Journal of Epidemiology, 2004;
159: 49-58.
44. Asklund C, Jørgensen
N, Jensen TK and Skakkebæk NE: Biology and epidemiology of testicular
dysgenesis syndrome. British Journal of Urology, 2004; 93 (suppl 3), 6-11.
45. Andersson AM, Petersen JH, Jørgensen N, Jensen TK and Skakkeæk NE: Serum inhibin B and
Follicle-Stimulating Hormone Levels as tools in the evaluation of infertile
men: Significance of adequate reference values from proven fertile men. Journal
of Clinical Endocrinology and Metabolism, 2004; 89: 2873-2879.
46.
Andersson AM, Jørgensen N, Larsen LF,
Rajpert-De Meyts E and Skakkebæk NE: Impaired Leydig cell function in infertile
men: A study of 357 idiopathic infertile men and 318 proven fertile controls.
Journal of Clinical Endocrinology and Metabolism, 2004; 89: 3161-3167.
47. Rajpert-De Meyts E, Hanstein R, Jørgensen N, Græm N, Vogt P and Skakkebæk NE: Differential
development of the OCT-3/4 (POU5F1) in normal and dysgenetic human gonads.
Human Reproduction, 2004; 19: 1338-1344.
48. Jensen TK, Andersson AM, Jørgensen N,
Andersen AG, Carlsen E, Petersen JH and Skakkebæk NE: Body mass index in
relation to semen quality and reproductive hormones among 1,558 Danish men.
Fertility and Sterility, 2004; 82: 863-870.
PEER
REVIEW
Peer review recent year for
Asian Journal of Andrology
Human Reproduction
International Journal of Andrology