Anna-Maria
Andersson
phone +45 35424252, e-mail: anna@rh.dk
Education
1988 Master
of Science in Cell Biology from University of Copenhagen.
1992 Ph.D.
from University of Copenhagen.
Employment
1988-1992 Research Fellow at the Protein Laboratory, University of Copenhagen.
1992- Present appointment: Director of the Hormone
Laboratory at the Department of Growth and Reproduction, The National
University Hospital. Senior research fellow.
1998-2000 EU project: Uncovering the role of inhibin and
activin through the development and application of new improved immuno-assays
(contract nr. BMH4-CT98-9574)
2000-2004
EU
project: Increasing incidence of human male reproductive health disorders in
relation to environmental effects on growth- and sex steroid-induced
alterations in programmed development (contract nr. QLK4-1999-01422)
2002-2005
EU project: Exposure-outcome relationships
in male urogenital malformations with special reference to endocrine
disrupters. (contract nr. QLRT-2001-00269)
2002-2006
EU project: EDEN: Endocrine disrupters: Exploring novel endpoints, exposure,
low-dose- and mixture-effects in humans, aquatic wildlife and laboratory
animals (contract nr. QLK4-CT-2002-00603)
Anna-Maria Andersson, publications pr. August 2004
1. Andersson AM, Petersen JH, Jørgensen N, Jensen TK, Skakkebæk NE. Serum inhibin B and follicle- stimulating hormone levels as tools in the evaluation of infertile men: significance of adequate reference values from proven fertile men. J Clin Endocrinol Metab, 2004 89:2873-79.
2. Andersson AM, Jørgensen N, Frydelund-Larsen L, Rajpert-De Meyts E, Skakkebæk NE. Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls. J Clin Endocrinol Metab 2004 89:3161-67.
3. Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, Wulf HC. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans J Invest. Dermatol. 2004, 123 (1): 57-61.
4. Chellakooty M, Vangsgaard K, Larsen T, Scheike T, Falck-Larsen J, Legarth J, Andersson AM, Main KM, Skakkebæk NE, Juul A. A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: Association between placental GH and fetal growth. J Clin Endocrin Metab. 2004 89:384-91.
5. Carlsen E, Petersen JH, Andersson AM, Skakkebæk NE. Effects of ejaculation frequency and season on variations in semen quality. Fert Steril, 2004 82:358-66.
6. Carlsen E, Andersson AM, Petersen JH, Skakkebæk NE. History of febrile illness and variation in semen quality. Hum Reprod, 2003 Oct; 18(10):2089-92.
7. Holm M, Rajpert-De Meyts E, Andersson AM, Skakkebaek NE. Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio. J Pathol. 2003 Mar; 199(3):378-86.
8.
Andersson AM, Carlsen E, Petersen JH, Skakkebaek NE. Variation in
levels of serum inhibin B, testosterone, estradiol, luteinizinghormone,
follicle-stimulating hormone, and sex hormone-binding globulin inmonthly
samples from healthy men during a 17-month period: possible effects of seasons.
J Clin Endocrinol Metab. 2003 Feb; 88(2):932-7.
9.
Christiansen P, Andersson
AM, Skakkebaek NE. Longitudinal studies of inhibin B levels in boys and
young adults withKlinefelter syndrome.J Clin Endocrinol Metab. 2003
Feb;88(2):888-91.
10. Lonberg U, Damm P, Andersson AM, Main KM,
Chellakooty M, Lauenborg J,Skakkebaek NE, Juul A. Increase in maternal placental growth hormone during
pregnancy anddisappearance during parturition in normal and growth
hormone-deficientpregnancies.Am J Obstet Gynecol. 2003 Jan;188(1):247-51.
11. Popovic-Todorovic B, Loft A, Lindhard A, Bangsboll S, Andersson
AM, Andersen AN. A prospective
study of predictive factors of ovarian response in 'standard' IVF/ICSI patients
treated with recombinant FSH. A suggestion for a recombinant FSH dosage
normogram. Hum Reprod. 2003 Apr;18(4):781-7.
12. Frydelund-Larsen L, Krausz C, Leffers H, Andersson
AM, Carlsen E, BangsboellS, McElreavey K, Skakkebaek NE, Rajpert-De Meyts
E. Inhibin B: a marker for the
functional state of the seminiferous epithelium inpatients with azoospermia
factor C microdeletions.J Clin Endocrinol Metab. 2002 Dec;87(12):5618-24.
13. Jorgensen N, Carlsen E, Nermoen I, Punab M, Suominen
J, Andersen AG, Andersson AM, Haugen TB, Horte A, Jensen TK, Magnus O,
Petersen JH, Vierula M,Toppari J, Skakkebaek NE. East-West gradient in semen quality in the Nordic-Baltic
area: a study of menfrom the general population in Denmark, Norway, Estonia and
Finland.Hum Reprod. 2002 Aug;17(8):2199-208.
14. Gravholt CH, Naeraa RW, Andersson AM,
Christiansen JS, Skakkebaek NE.
Inhibin A and B in adolescents and young adults with Turner's syndrome
and nosign of spontaneous puberty.Hum Reprod. 2002 Aug;17(8):2049-53.
15. Lajer H, Daugaard G, Andersson AM, Skakkebaek
NE. Clinical use of serum TRA-1-60
as tumor marker in patients with germ cellcancer.Int J Cancer. 2002 Jul
10;100(2):244-6.
16. Christiansen P, Andersson AM, Skakkebaek NE,
Juul A. Serum inhibin B, FSH, LH
and testosterone levels before and after humanchorionic gonadotropin
stimulation in prepubertal boys with cryptorchidism.Eur J Endocrinol. 2002
Jul;147(1):95-101.
17. Chellakooty M, Skibsted L, Skouby SO, Andersson AM,
Petersen JH, Main KM,Skakkebaek NE, Juul A. Longitudinal study of serum placental GH in 455 normal
pregnancies: correlationto gestational age, fetal gender, and weight.J Clin
Endocrinol Metab. 2002 Jun;87(6):2734-9.
18. Mol NM, Sorensen N, Weihe P, Andersson AM,
Jorgensen N, Skakkebaek NE,Keiding N, Grandjean P. Spermaturia and serum hormone concentrations at the age of
puberty in boysprenatally exposed to polychlorinated biphenyls.Eur J
Endocrinol. 2002 Mar;146(3):357-63.
19. Andersson AM. Inhibin B in the
assessment of seminiferous tubular function.Baillieres Best Pract Res Clin
Endocrinol Metab. 2000 Jun;14(3):389-97. Review.
20. Andersson AM, Skakkebaek NE. Serum
inhibin B levels during male childhood and puberty.Mol Cell Endocrinol. 2001
Jun 30;180(1-2):103-7. Review.
21. Schmiegelow M, Lassen S, Poulsen HS, Schmiegelow K, Hertz
H, Andersson AM, Skakkebaek NE, Muller J. Gonadal status in male survivors following childhood brain
tumors.J Clin Endocrinol Metab. 2001 Jun;86(6):2446-52.
22. Mikkelsen AL, Andersson AM, Skakkebaek NE,
Lindenberg S. Basal concentrations
of oestradiol may predict the outcome of in-vitromaturation in regularly
menstruating women.Hum Reprod. 2001 May;16(5):862-7.
23. Ishoy T, Andersson AM, Suadicani P, Guldager B,
Appleyard M, Gyntelberg F,Skakkebaek NE.
Major reproductive health characteristics in male Gulf War Veterans. The
DanishGulf War Study.Dan Med Bull. 2001 Feb;48(1):29-32.
24. Sehested A, Andersson AM, Muller J, Skakkebaek
NE. Serum inhibin A and inhibin B
in central precocious puberty before and duringtreatment with GnRH
agonists.Horm Res. 2000;54(2):84-91.
25. Andersen AG, Jorgensen N, Andersson AM, Carlsen
E, Skakkebaek NE, JensenTK, Keiding N, Swan SH. Serum levels of testosterone do not provide evidence of
selection bias instudies of male reproductive health.Epidemiology. 2000
Mar;11(2):232-4. No abstract available.
26. Hjollund NH, Jensen TK, Bonde JP, Henriksen TB, Andersson
AM, Kolstad HA,Ernst E, Giwercman AJ, Skakkebaek NE, Olsen J. [Stress and fertility. A follow-up
study among couples planning the firstpregnancy]Ugeskr Laeger. 2000 Sep
18;162(38):5081-6. Danish.
27. Muller J, Juul A, Andersson AM, Sehested A,
Skakkebaek NE. Hormonal changes
during GnRH analogue therapy in children with centralprecocious puberty.J
Pediatr Endocrinol Metab. 2000 Jul;13 Suppl 1:739-46. Review.
28. Hjollund NH, Bonde JP, Jensen TK, Henriksen TB, Andersson
AM, Kolstad HA,Ernst E, Giwercman A, Skakkebaek NE, Olsen J. Male-mediated spontaneous abortion
among spouses of stainless steel welders.Scand J Work Environ Health. 2000
Jun;26(3):187-92.
29. Sehested A, Juul AA, Andersson AM, Petersen JH,
Jensen TK, Muller J,Skakkebaek NE.
Serum inhibin A and inhibin B in healthy prepubertal, pubertal, and
adolescentgirls and adult women: relation to age, stage of puberty, menstrual
cycle,follicle-stimulating hormone, luteinizing hormone, and estradiol levels.J
Clin Endocrinol Metab. 2000 Apr;85(4):1634-40.
30. Andersen AG, Jensen TK, Carlsen E, Jorgensen N, Andersson
AM, Krarup T,Keiding N, Skakkebaek NE. High frequency of sub-optimal semen quality in an unselected
population ofyoung men.Hum Reprod. 2000 Feb;15(2):366-72.
31. PHjollund NH, Jensen TK, Bonde JP, Henriksen TB, Andersson
AM, Kolstad HA,Ernst E, Giwercman A, Skakkebaek NE, Olsen J. Spontaneous abortion and physical
strain around implantation: a follow-up studyof first-pregnancy planners.Epidemiology.
2000 Jan;11(1):18-23.
32. Hjollund NH, Jensen TK, Bonde JP, Henriksen TB, Andersson
AM, Kolstad HA,Ernst E, Giwercman A, Skakkebaek NE, Olsen J. Distress and reduced fertility: a
follow-up study of first-pregnancy planners.Fertil Steril. 1999 Jul;72(1):47-53.
33. Andersson AM, Skakkebaek NE. Exposure
to exogenous estrogens in food: possible impact on human developmentand
health.Eur J Endocrinol. 1999 Jun;140(6):477-85. Review.
34. Hjollund NH, Jensen TK, Bonde JP, Henriksen TB, Andersson
AM, SkakkebaekNE. Is
glycosylated haemoglobin a marker of fertility? A follow-up study
offirst-pregnancy planners.Hum Reprod. 1999 Jun;14(6):1478-82.
35. Carlsen E, Olsson C, Petersen JH, Andersson AM,
Skakkebaek NE. Diurnal rhythm in
serum levels of inhibin B in normal men: relation totesticular steroids and
gonadotropins.J Clin Endocrinol Metab. 1999 May;84(5):1664-9.
36. Andersen HR, Andersson AM, Arnold SF, Autrup H,
Barfoed M, Beresford NA,Bjerregaard P, Christiansen LB, Gissel B, Hummel R,
Jorgensen EB, Korsgaard B,Le Guevel R, Leffers H, McLachlan J, Moller A,
Nielsen JB, Olea N, Oles-KaraskoA, Pakdel F, Pedersen KL, Perez P, Skakkeboek
NE, Sonnenschein C, Soto AM, etal.
Comparison of short-term estrogenicity tests for identification
ofhormone-disrupting chemicals.Environ Health Perspect. 1999 Feb;107 Suppl
1:89-108.
37. Andersson AM, Skakkeboek NE. [Serum
inhibin B as a marker of spermatogenesis]Ugeskr Laeger. 1999 Jan 4;161(1):51.
Danish. No abstract available.
38. Petersen PM, Andersson AM, Rorth M, Daugaard G,
Skakkebaek NE. Undetectable
inhibin B serum levels in men after testicular irradiation.J Clin Endocrinol
Metab. 1999 Jan;84(1):213-5.
39. Hjollund NH, Kold Jensen T, Bonde JP, Henriksen TB,
Kolstad HA, AnderssonAM, Ernst E, Giwercman A, Skakkebaek NE, Olsen J. Job strain and time to pregnancy.Scand
J Work Environ Health. 1998 Oct;24(5):344-50.
40. Andersson AM, Muller J, Skakkebaek NE.
Different roles of prepubertal and postpubertal germ cells and Sertoli
cells inthe regulation of serum inhibin B levels.J Clin Endocrinol Metab. 1998
Dec;83(12):4451-8.
41. Juul A, Andersson AM, Pedersen SA, Jorgensen
JO, Christiansen JS, GroomeNP, Skakkebaek NE. Effects of growth hormone replacement therapy on IGF-related
parameters and onthe pituitary-gonadal axis in GH-deficient males. A double-blind,placebo-controlled
crossover study.Horm Res. 1998;49(6):269-78.
42. Jorgensen M, Hummel R, Bevort M, Andersson AM,
Skakkebaek NE, Leffers H.
Detection of oestrogenic chemicals by assaying the expression level
ofoestrogen regulated genes.APMIS. 1998 Jan;106(1):245-51. Review.
43. Skakkebaek NE, Rajpert-De Meyts E, Jorgensen N,
Carlsen E, Petersen PM,Giwercman A, Andersen AG, Jensen TK, Andersson AM,
Muller J. Germ cell cancer and
disorders of spermatogenesis: an environmental connection?APMIS. 1998
Jan;106(1):3-11; discussion 12. Review.
44. Andersson AM, Toppari J, Haavisto AM, Petersen JH, Simell T, Simell O,Skakkebaek
NE. Longitudinal reproductive
hormone profiles in infants: peak of inhibin B levelsin infant boys exceeds
levels in adult men.J Clin Endocrinol Metab. 1998 Feb;83(2):675-81.
45. Bonde JP, Hjollund NH, Jensen TK, Ernst E, Kolstad H,
Henriksen TB,Giwercman A, Skakkebaek NE, Andersson AM, Olsen J. A follow-up study of environmental and
biologic determinants of fertility among430 Danish first-pregnancy planners:
design and methods.Reprod Toxicol. 1998 Jan-Feb;12(1):19-27.
46. Juul A, Scheike T, Pedersen AT, Main KM, Andersson
AM, Pedersen LM,Skakkebaek NE.
Changes in serum concentrations of growth hormone, insulin, insulin-like
growthfactor and insulin-like growth factor-binding proteins 1 and 3 and
urinarygrowth hormone excretion during the menstrual cycle.Hum Reprod. 1997
Oct;12(10):2123-8.
47. Jensen TK, Andersson AM, Hjollund NH, Scheike
T, Kolstad H, Giwercman A,Henriksen TB, Ernst E, Bonde JP, Olsen J, McNeilly A,
Groome NP, Skakkebaek NE. Inhibin
B as a serum marker of spermatogenesis: correlation to differences insperm
concentration and follicle-stimulating hormone levels. A study of 349Danish
men.J Clin Endocrinol Metab. 1997 Dec;82(12):4059-63.
48. Andersson AM, Juul A, Petersen JH, Muller J, Groome NP, Skakkebaek NE. Serum inhibin B in healthy pubertal and
adolescent boys: relation to age, stageof puberty, and follicle-stimulating
hormone, luteinizing hormone, testosterone,and estradiol levels.J Clin Endocrinol
Metab. 1997 Dec;82(12):3976-81.
49. Larsen T, Main K, Andersson AM, Juul A, Greisen
G, Skakkebaek NE. Growth hormone,
insulin-like growth factor I and its binding proteins 1 and 3in last trimester
intrauterine growth retardation with increased pulsatilityindex in the
umbilical artery.Clin Endocrinol (Oxf). 1996 Sep;45(3):315-9.
50. Andersson AM, Skakkebaek NE. [A new
ultrasensitive bioanalysis of estrogen]Ugeskr Laeger. 1996 Feb
19;158(8):1091-2. Danish. No abstract available.
51. Andersson AM, Orskov H, Ranke MB, Shalet S, Skakkebaek NE. Interpretation of growth hormone provocative tests:
comparison of cut-offvalues in four European laboratories.Eur J Endocrinol.
1995 Mar;132(3):340-3.
52. Andersson AM, Edvardsen K, Skakkebaek NE.
Expression and localization of N- and E-cadherin in the human testis
andepididymis.Int J Androl. 1994 Aug;17(4):174-80.
53. Gegelashvili G, Andersson AM, Schousboe A, Bock
E. Cyclic AMP regulates NCAM
expression and phosphorylation in cultured mouseastrocytes.Eur J Cell Biol.
1993 Dec;62(2):343-51.
54. Gegelashvili G, Andersson AM, Schousboe A, Bock
E. Characterization of NCAM
diversity in cultured neurons.FEBS Lett. 1993 Jun 21;324(3):337-40.
55. Gaardsvoll H, Krog L, Zhernosekov D, Andersson AM,
Edvardsen K, Olsen M,Bock E, Linnemann D.
Age-related changes in expression of neural cell adhesion molecule
(NCAM) inheart: a comparative study of newborn, adult and aged rats.Eur J Cell
Biol. 1993 Jun;61(1):100-7.
56. Skakkebaek NE, Andersson AM. [Physiology of growth hormone during
pregnancy]Ugeskr Laeger. 1993 Apr 12;155(15):1144-5. Danish. No abstract
available.
57. Andersson AM, Olsen M, Zhernosekov D, Gaardsvoll H, Krog L, Linnemann D,Bock E. Age-related changes in expression of
the neural cell adhesion molecule inskeletal muscle: a comparative study of newborn,
adult and aged rats.Biochem J. 1993 Mar 15;290 ( Pt 3):641-8.
58. Gaardsvoll H, Andersson AM, Bock E. Demonstration of L1-related mRNAs in
rat brain using DNA oligonucleotideprobes.FEBS Lett. 1991 Dec 2;294(1-2):94-6.
59. Andersson AM, Moran N, Gaardsvoll H, Linnemann D, Bjerkvig R, Laerum OD,Bock E. Characterization of NCAM expression and
function in BT4C and BT4Cn gliomacells.Int J Cancer. 1991 Jan 2;47(1):124-9.
60. Andersson AM, Gaardsvoll H, Giladi E, Dahl B, Bock E. Characterization of rat brain NCAM mRNA using DNA
oligonucleotide probes.FEBS Lett. 1990 Apr 24;263(2):385-8.
61. Dalseg AM, Andersson AM, Bock E. Characterization of N-cadherin mRNA in
chicken brain and heart by means ofoligonucleotide probes.FEBS Lett. 1990 Mar
26;262(2):234-6.