Wai-Yee Chan, Ph.D.

 

Professor, Department of Pediatrics,

Georgetown University Children's Medical Center,

3800 Reservoir Road, NW,

                                    Washington, DC 20007.

Tel: (202) 687-7068

                                    E-mail: chanw@georgetown.edu

 

Adjunct Investigator,

Laboratory of Clinical Genomics

National Institute of Child Health and Human Development,

National Institutes of Health

Tel: (301) 451-8821

Fax: (301) 480-4700

Email: chanwy@mail.nih.gov

 

NATIONALITY:            Naturalized US Citizen, 1984.

 

EDUCATION:

1970-74       B. Sc., Hon., 1st Class (Major: Chemistry; Minor: Biochemis­try), the Chinese University of Hong Kong, Hong Kong.

1974-77       Ph.D. (Biochemistry), University of Florida, Gainesville, FL. Advisor: Dr. Owen M. Rennert.

1977-79       Fellow, Division of Genetics, Endocrinology & Metabolism, Depart­ment of Pediatrics, University

                     of Oklahoma, Oklaho­ma City, OK. Director: Owen M. Rennert, MD.

1982            Visiting Scientist, Department of Biochemistry, University of Washingto­n, Seattle, WA. Supervisor: Earl W. Davie, Ph.D. 

 

APPOINTMENTS:

1979-82                      Director, Clinical Trace Metals Diagnostic Lab, Department of Pediatrics, University of             Oklaho­ma, Oklahoma City, OK.

1979-89           Assistant to Associate Professor, Department of Pediatrics (Tenured 1983) and Department of Biochemistry & Molecular Biology (Adjunct), University of Oklahoma, Oklahoma City, OK.

1980-87           Scientific Director, Biochemical Genetics Lab, Oklahoma Children's Hospital, Okla City, OK.

1981-87           Consultant, Medical Service, Veteran's Administration Medical Center, Oklahoma City, OK.

1982-88                       Scientific Director, Trace Metals Diagnostic Lab, State of Oklahoma Teaching Hospi­tals, Oklahoma City, OK.

1987-89           Associate Member, Oklahoma Medical Research Foundation, Oklahoma City, OK.

1989-Present   Affiliate Member, Oklahoma Medical Research Founda­tion, Oklahoma City, OK.

1989-Present   Professor, Department of Pediatrics (Tenured 1990), Departments of Biochemist­ry & Molecular Biology and Cell Biology (Sec­ondary), Georgetown University, Washington, DC.

1990-Present   Member, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, DC.

1993-2000       Director, Molecular Genetic Diagnostic Lab, Georgetown Universi­ty Children's Medical Center, Washington­, DC.

1998-2000       Chief, Division of Genetics and Metabolic Diseases, Department of Pediatrics, Georgetown University, Washington, DC.

2001-Present   Adjunct Investigator, Laboratory of Clinical Genomics, NICHD, NIH, Bethesda, MD.

 

BOARD CERTIFICATION:

1. Certified Nutrition Specialist, Certificate # 00049,

    The Certification Board for Nutrition Specialists, August 1993.

2. Director, Molecular Genetic Diagnostic Laboratory, CLIA ID#: 09D0903844, Health Care Financing

    Administration, DHHS, 1995-2000.

 

PATENT:

1. Pregnancy Specific Proteins Applications

    Sole Inventor

    US Patent No. 5,169,835; Issue date: December 8, 1992.

    Australian Patent No. 645965; Issue date: December 6, 1993.

    Canadian Patent No. 805-105; European Patent No. 90902488.7; Japanese Patent No. 4-504655.

2. Retinoic Acid Inducible DNA Sequences and Polypeptides Expressed Thereby and Their Use in Promoting 

    Alveolar Development

    U.S.S.N. 09/330,004, European Patent No. 99930221.9-2107; Japanese Patent No. 2000-553125

    Inventor: 60%.  Co-Inventors: Donald Massaro 20%, Gloria Massaro 20%

3. In Vivo Assay for Identifying Nucleic Acid Sequences Involved in Alveolar Loss, Development and Nucleic

    Acid Sequences Identified Thereby

Inventors: Donald Massaro 40%, Gloria Massaro 40%, Wai-Yee Chan 20%.

4. Method Evolved for Recognition of Thrombophilia (MERT)

    Inventors: Cigdem Dogulu, Owen M. Rennert, Wai-Yee Chan

    US patent application filed: January 15, 2004. DHHS reference no. E-282-2003/0-us-01

 

 

SOCIETY MEMBERSHIPS:

American Society of Human Genetics, 1977

Society for Pediatric Research, 1980

American College of Nutrition, 1981

American Society for Biochemistry and Molecular Biology, 1982

Society of Chinese Bioscientists in America, (Oklahoma Representative, 1985-89), 1985

American Institute of Immunology, 1987

Endocrine Society, 1990

Association of Chinese Geneticists in America, (President-elect 2002-03, President 2003-04) 1999

 

CONSULTANTSHIP:

1.   Mitsubishi Kasei Corporation, Yokohama, Japan. 1993-1994.

2.   Bayer Corporation, Pharmaceutical Division, Berkeley, California. 1998-2000.

3.   AstraZeneca Pharmaceuticals LP, Wilmington, Delaware. 2000-2004.

 

HONORS AND AWARDS:

Awards:

1.   Scholarship for Chemistry, the Chinese University of Hong Kong, 1972‑74.

2.   Tak Shing Scholarship for Biochemistry, the Chinese University of Hong Kong, 1973‑74.

3.   Honors, First Class, Chemistry, the Chinese Univer­sity of Hong Kong, 1974.

4.      Listed in : American Men and Women of Science, 1982; Who's Who in the World, 1984, 1998;

      International Who's Who in Medicine, 1986; Who's Who in Science and Engineering, 1991;

      Who's Who in Medicine and Healthcare, 1997.

5.   Merrick Award for Outstanding Biomedical Research, Oklahoma Medical Research Founda­tion, Oklahoma City, Oklahoma, 1988.

6.   Service Award, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, July, 1989.

7.      Honorary Member, Chinese American Medical Association, New York, 1992.

8.      Distinguished Faculty Tutor, School of Medicine, Georgetown University, 1997.

 

Visiting Professorship:

1.      Visiting Professor, Cancer Institute, Chinese Academy of Medical Sciences, and Institute of Basic Clinical

      Sciences, China-Japan Friendship Hospital, Beijing, China, May 12-15, 1987.

2.  Visiting Professor, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, March 18-20, 1991.

3.   Visiting Scholar, Shaw College, Chinese University of Hong Kong, Hong Kong, June 29-July 5, 1993.

 

Invited Participation in Delegations:

1. American Delegate to the First U.S.‑China Bilateral Conference on Protein in Biology and Medicine. Shanghai and Beijing, China, May 24‑June 12, 1981. 

2. American Delegate, the Second U.S.‑China Bilateral Conference on Protein in Biology and Medicine. Oklahoma City, OK, June 11‑13, 1983.  

3. American Delegate, U.S.A.-P.R.C. Tumor Biology Conference. Oklahoma Medical Research Foundation, Oklahoma City, OK, April 21-22, 1986.

4. Delegation from the Oklahoma Medical Research Foundation to SunYet-sen University of Medical Sciences, Guangzhou, Insti­tute of Biochemistry, Academia Sinica, Shanghai, and Chinese Academy of Medical Sciences, and China-Japan Friendship Hospital, Beijing, China, June to August, 1986.

5. US Delegate, Briefing on Medical Application of Modern Biotechnology to Norwe­gian Parliamentary Committee on Health and Social Affairs. Royal Norwegian Embassy, Washington, DC. September 7, 1990.

6. Centennial Reunion Conference of the US-China Bilateral Meeting on Proteins in Biology and Medicine, 

     Maui, Hawaii, June 20-24, 1992.

Conference Organizer, Session Chair, and Invited Presentation in Symposia:

 

1.   Scientific Working Conference on Cystic Fibrosis.  Cystic Fibrosis Foundation and National Institutes of Health, Padre Island, TX, March 4-7, 1979. 

2.   Ross Clinical Research Conference on Meeting Nutritional Goals for Low-Birth-Weight Infants. Ross Laboratories, Tarpon Springs, FL, October 2‑4, 1980.

3.   Manganese in Metabolism and Enzyme Function Confer­ence. Pennsylvania State Universi­ty, University Park, PA, October 7-10, 1984.

4.   Symposium on Manganese Nutrition. American Chemical Society, Anaheim, CA. September 7-12, 1986.

5.   The First International CEA Workshop.  McGill Cancer Center, McGill University, Montreal, Canada, June 11-14, 1990.

6.   The Second International PSG/CEA Workshop (Co-Organizer). NIH/Georgetown University, Washington, DC, June 17-20, 1991.

7.   The Third International PSG/CEA Workshop. University of Umea, Umea, Sweden, June 14-17, 1992.

8.   The Fourth International PSG/CEA Workshop, Deaconess Hospital, Harvard Medical School, Boston, August 22-25, 1993.

9.   The Fifth International PSG/CEA Workshop, Freiburg University, Freiburg, Germany, July 18-21, 1994.

10. The Sixth International PSG/CEA Workshop, McGill Cancer Center, McGill University, Montreal, Canada, September 6-8, 1995.

11. Symposium on the Chemistry and Molecular Biology of Blood Coagulation, Battelle Conference Center,    Seattle, WA, October 24, 1997.

12. Molecular abnormalities of LH action. Symposium on Disorders of Gonadotropin Secretion and Action, 80th Annual Meeting of the Endocrine Society, June 24, 1998.

13. The Impact of Culture on Health Seeking Behavior Panel. (Panelist) Washington DC Area Geriatric Education Center Consortium Spring 1999 Enrichment Series: Multicultural Issues in Aging.  Howard University, Washington, DC, May 27, 1999.

14. Spirituality of Aging for Minority Population (Panelist).  Washington DC Area Geriatric Education Center

      Consortium Spring 2000 Enrichment Series: Multicultural Issues in Aging.  Howard University,

      Washington, DC.  June 2, 2000.

15. TWGH-CUHK Eddie Wang Symposium on Complementary Chinese and Western Medicine Symposium – Integrated Approach, Hong Kong, Feb 27-28, 2004.

16. International Conference on Medical Genetics, Advances on Birth Defect: Diagnosis, Prevention, and

      Intervention. (Scientific Committee); Session on Molecular Basis of Genetic Disorders (Chair), Beijing, China, July 15-17, 2004.

17. Session on Y Chromosome Evolution, Population and Molecular Genetics (Co-Chair), 10th SCBA International Conference, Beijing, China, July 18-23, 2004.

18. Wuhan Frontier of Biomedical Science Satellite Workshop of SCBA, Wuhan, China, July 25-26, 2004.

 

SERVICE ACTIVITIES:

 

Professional Service

I. Grant Review and Study Sections:

A. International:

1. Research Grants Council, University Grants Committee (Formerly University and Polytech­nic Grants  

    Committee), Hong Kong, Overseas Reviewer, 1991-93, 1995-98.

     2. Lottery Health Research, New Zealand Lottery Grants Board, Department of Internal Affairs, New

         Zealand, Reviewer, 1993.

     3. Health Research Council of New Zealand, Reviewer, 1996-present.

     4. USDA Research & Scientific Exchanges/Portuguese Ministry of Science and Technology/European Community, USDA, Reviewer, 1997.

     5. The Wellcome Trust and Health Research Board, United Kingdom, Reviewer, 1999.

B. National:

    1. Site Visit Committee, National Institute of Arthritis, Diabet­es, Digestive and Kidney Diseases, NIH, for            Hepatobiliary Center in Denver, Colorado, August, 1984.

 2. Special Study Section, Physiology of Lactation and Biology of Human Milk, National Institute of Child

        Health and Human Development, NIH, July, 1985.

 3. Biochemistry Subcommittee, Drug Abuse Biomedical Re­search Review Committee, National Institute of

        Drug Abuse, NIH, Ad Hoc Reviewer, October, 1993, 1994.

    4. Reproductive Biology Study Section, National Institutes of Health, Ad Hoc Reviewer, October, 1994.

5. Special Emphasis Panel, National Institutes of Child Health and Human Development, NIH, April 23,

   1998.

6. Endocrinology, Metabolism, Nutritional and Reproductive Sciences Study Section, ZRG1 F06-20, NIH,

October, 2001 - present.

7. Ad Hoc Reviewer, Neonatal Research Network, National Institute of Child Health and Human

    Development, NIH, April, 2004.

 

II. Journal Editorial Activities:

 A. Editorial Boards:

      1. Journal of the American College of Nutrition, 1982 ‑ Present.

      2. Journal of Endocrine Genetics, 1999 - present.

      3. Journal of Current Molecular Medicine, 1999 - present.

      4. Annals of Traditional Chinese Medicine, 2004 – present.

 B. Reviewer:

     Science, Proceedings of the National Academy of Sciences, USA, Biochemistry, New England Journal of

     Medicine, American Journal of Medical Genetics, Journal of Immunology, Journal of Clinical

     Endocrinology and Metabolism, Gene, Human Genetics,  European Journal of Biochemistry, Biochimica et

     Biophysica Acta, Pediatrics, Life Sciences,  American Journal of Clinical Nutrition, DNA and Cell Biology,

     Journal of Nutritional Biochemistry, Proceedings for the Society of Experimental Biology and Medicine,

     DNA Sequences, Molecular Reproduction and Development, Asian Journal of Andrology.

 

III. Other Review Activities:

1. Literature Selection Technical Review Committee, National Library of Medicine, Guest Reviewer, 1996.

2. Selection Committee, Japanese Society for the Promotion of Science (JSPS) Fellowship Program, Fogarty

    International Center, National Institutes of Health, December 2, 1996.

3. Selection Committee, Asia Pacific Economic Council (APEC) Youth Science Festival, International

    Directorate, American Association for the Advancement of Sciences, 2000, 2003.

4. Review Panel, the Korea-U.S. Science and Engineering Summer Camp in Seoul, South Korea, American

Association for the Advancement of Science, April, 2002.

 

IV. Activities at Foreign Academic Institutes:

1. Dissertation/Thesis External Reviewer, Master of Philosophy and Doctor of Philosophy, Division of

    Biochemistry, the Chinese University of Hong Kong, 1984, 1989-1994, 1998, 2001-present.

2. External/Visiting Examiner, Undergraduate Program of Biochemistry, Undergraduate Examination Board,   

    the Chinese University of Hong Kong, Hong Kong, 1994-97.

3. External Assessor, Personnel Department, the Chinese University of Hong Kong, Hong Kong S.A.R., China,

    1995, 1997, 1999-2002, 2004.

4. External Examiner, First Professional Degree, the Chinese University of Hong Kong School of Medicine,         Hong Kong S.A.R., China, 2001-present.

5. Special Advisor to the Chancellor (2001-present) and Member, College Council (2002-present), the Macau       Millennium College, Macau S.A.R., China.

6. Member, Scientific Advisory Board, Area of Excellence in Chinese Medicine Research and Further Development, Hong Kong S.A.R., China, 2002-2007.

7. Liaison, Montgomery College-Millennium College Faculty/Student Exchange Program, 2003-present.

NIH/University Service:

I. National Institutes of Health:

1. Coordinator, Graduate Supervisory Committee, NICHD-CUHK Graduate Partnership Program, NICHD,       2003-present.

II. Georgetown University:

  1. Genetics Graduate Program Committee, 1989-95.

  2. Genetics Clinical Fellowship Committee, 1989-95.

  3. Neuroscience Task Force, 1990-93.

  4. Subcommittee on Reproductive Failure/Genetics, Perinatal Task Force, 1990-93.

  5. Georgetown University Hospital Molecular Diagnostic Laboratory Committee, 1993-97.

  6. Institutional Biosafety Committee, 1996–2002.

  7. Medical Center Research Committee, 1998-2001.

  8. Sub-committee on Pre-Clinical Education of the Committee on Medical Education, 1998-present.

  9. Executive Committee, Department of Biochemistry & Molecular Biology, 2003-present.

10. Committee on Appointment and Promotion, Georgetown University Medical Center, 2003-present.

11. Development and Child Health Research Initiative Task Force, Georgetown University, 2004.

 III. Oklahoma Medical Research Foundation:

  1. Recombinant DNA subcommittee, 1987-88.

  2. Library Advisory committee, 1988-89.

III. University of Oklahoma:

  1.Graduate Curriculum Committee (1981-83), Graduate Admissions and Student Recruitment Committee

     (1986-89), and Faculty Advisory Committee (1988-89), Department of Biochemistry & Molecu­lar                      Biology.

 2.  Research and Education Computer Advisory Committee, 1983‑86.

 3.  Affirmative Action Committee, 1984‑87.

 4.  Planning Committee, Mid‑American Molecular Biology Colloquium, 1986‑87.

 5.  Medical Alumni Association Research Award Committee, 1989.

 

Public Service:

I. National and International Scientific Organizations:

1.  American Biographical Institute, Inc., Honorary Educational Advisory Board, 1984‑89.

2.  Society of Sigma Xi, University of Oklahoma Chapter, Award Committee, 1984‑85; Treasurer, 1985‑88.

3.  Society of Chinese Bioscientist in Ameri­ca, Oklahoma Representative, 1985‑89.

4.  American Association for the Advancement of Science, Advisory Committee, Pacific Rim Initiative,             1997-2003.

5.  Association of Chinese Geneticists in America, Board of Directors, 2000-2002, President-Elect, 2002-2003,      President 2003-2004,.

 

SCHOLARSHIP AND RESEARCH:

 

A. RESEARCH SUPPORT:

 

Past Support from NIH (Foundation and Industrial Support Not Listed):

1.   Identification and Quantitation of Cystic Fibrosis Factors. (Co-Investigator) RFP‑NHLBI‑HR‑77‑3, NIH. 1977 – 1981.

2.   Human Milk Peptide, Metallo‑Peptides and Trace Metals (Co-PI). RO1 HD 12465, NIH. 1978 – 1981.     

3.   Nutritional Role of Manganese Binding Molecules in Milk (PI). RO1 HD 16730, NIH. 1983 – 1986.           

4.   Genetic Studies of Pregnancy Specific b1 Glycoprotein (PI). RO1 HD 21793, NIH. 1986 – 1993. 

5.     Project 1: Role of PSG Proteins in the Testis (PI). Program Project: Cell Biology of Testis. PO1HD24633,   NIH, 1992 - 1996          

6.      Molecular Genetics of Pregnancy Specific Glycoproteins (PI). IPA, NCHGRI, NIH. 1995.  

7.   The Promonocyte Receptor for PSG11s. (PI) RO1 HD31553, NIH. 1995 - 1998                

8.   Experimental Emphysema: Studies on Remediation. (Co-Investigator)  RO1 HL59432, NIH. 1997 - 1999.

9.   Research Training in Developmental Immunology.T32 HD07185-11. NIH. 1994 – 1999.             

10. Remediation of Emphysema: Mechanism, Characterization. (Co-Investigator) 1RO1 HL60115-01A, NIH, 1998 – 2002.

 

Current Support:

 

1.  Establishment of a developmental genomics program in NICHD. IPA, NICHD, NIH. 100%,

     01/01/2001 – 09/30/2005.   $ 942,143.00, current year $ 228,652.50.     

2.  Section on Developmental Genomics, NICHD intramural support for the laboratory, 100%,

     01/01/2001 – 09/30/2005.   (Excluding personnel) $ 2,072,350, current year $  575,170.

3. Fate of Spermatogonial Stem Cells. 2 R01-HD33728-05A1.   10% effort. (no monetary support requested)

    PI: Martin Dym, Ph.D.

    12/01/2002 – 11/30/2007    $ 1,250,000 (Total Direct) ($250,000, 1st Year Direct)

Goal: To understand the regulation of the initial steps of spermatogenesis.          

 

 

              

B. PUBLICATIONS:

 

Dissertation:

 

To Purify and Characterize Metallothionein from Human Tissues, and to Investigate Its Roles in Mammalian Copper Metabolism and in the Menkes Kinky Hair Disease.     Ph.D. Dissertation, Department of Bio­chemistry and Molecular Biology, University of Florida, Gainesville, Florida, 1977.

 

Books and Monographs:

 

 1.  Rennert OM and Chan WY.  (Editors) Metabolism of Trace Metals in Man: Volume 1. Develop­mental Aspects.   CRC Press, Inc., Boca Raton, FL. 1984.

 2.  Rennert OM, and Chan WY.  (Editors) Metabolism of Trace Metals in Man:  Volume 2. Genetic Implications. CRC Press, Inc., Boca Raton, FL. 1984.

 3.  Garnica AD, Chan WY, and Rennert OM.  Trace Elements in Development and Disease.  Current  Problems in Pediatrics.  Volume XVI, Number 2. Year Book Medical Publishers, Inc., Chicago, IL. 1986.

4.   Chris YF Lau, Chan WY. (Editors) Y Chromosome, Germ Cell Development and Fertility. World Scientific Publishing Co. Pte. Ltd., Singapore, 2004 (In preparation).

 

Chapter in Book:

 

 1.  Chan WY, Leung KK.  Body fluid glucose determination - An o‑toluidine method.  Journal of the Science Society of the Chinese University of Hong Kong. Vol 3,  pp. 40‑44, 1971.

 2.  Rennert OM, Garnica AD, Chan WY.  Hyperornithinemia and hyper­ammonemia: a rare disorder of ammonia metabolism.  In:  The Liver-Quantitative Aspects of Structure and Function. Preisig R, Qaum­gartner G. (eds.). Gstaad, Switzerland. pp.198‑303, 1975.

 3.  Chan WY, Griesmann GE, Rennert OM.  Polyamine deriva­tives in growing cells.  In:  Advances in Polyamine Research Caldarera CM, Zappia V, Bachrach U. (eds.). Vol. 3, Raven Press, New York, NY. pp. 213‑­223, 1981.

 4.  Rennert OM, Chan WY, Seale TW, Perlman M.  Polyamine metabolism in humans:  Clinical implications.  In:  Polyamines in Biology and Medicine. Morris DR, Marton LJ. (eds.). Marcel Dekker, New York, NY. Chapter 20, pp.384‑400, 1981.

 5.  Chan WY, Ramadan TZ, Perlman M, McCaffree MA, Rennert OM. Manganese and copper metabolism  in the mother and in the neonate.  In:  Nutrition and Child Health Perspectives for the 1980's. Tsang RC, Nichols BL Jr. (eds.). Alan R. Liss, New York, NY. p.191, 1981.

 6.  Rennert OM, Chan WY, Ramadan TZ, McCaffree MA.  Trace metal concentra­tion in the term and premature infant.  In:  Proceedings of the Second Ross Clinical Research Conference.  Meeting Nutritional Goals for Low-Birth Weight Infants. Sauls HS, Bachhuber WL, Lewis LA. (eds.). Ross Laboratories, Columbus, OH. pp.122‑124, 1982.

 7.  McCaffree MA, Chan WY, Rennert OM.  Evaluation of trace metal homeos­tasis in low‑birth-weight infants.  In Proceedings of the Second Ross Clinical Research Conference.  Meeting Nutritional Goals for Low-Birth Weight Infants. Sauls HS, Bachhuber WL, Lewis LA (eds.). Ross Laboratories, Columbus, OH. pp.125‑127, 1982.

 8.  Chan WY, Tease LA, Liu HC, Rennert OM.  Cell culture studies of Wilson's disease (Hepatolenticular 

      Degeneration). In: Biolog­ical Aspects of Metals and Metal Related Diseases. Sarkar B. (ed.). Raven Press, New York, NY. pp.147‑158, 1983.

9.   Chan WY, Bates J Jr, Rennert OM.  Trace metals in milk, In: Metabo­lism of Trace Metals in Man. Vol.  1: Developmental As­pects. Rennert OM, Chan WY. (eds.). CRC Press, Boca Raton, FL. pp. 63‑78, 1984.

10. Sarale C, Chan WY, Rennert OM.  Wilson's disease:  Recent advances, In: Metabolism of Trace Metals in Man. Vol. 2: Genetic Implica­tions. Rennert OM, Chan WY. (eds.). CRC Press, Boca Raton, FL. pp.53‑70, 1984.

11. Rennert OM, Chan WY.  Genetic diseases: model for the study of trace metals,  In: Metabolism of Trace Metals in Man.  Vol. 2: Genetic Implications. Rennert OM, Chan WY (eds.).  CRC Press, Boca Raton, FL. pp.133‑140, 1984.

12. Chan WY, Bates JM Jr, Raghib MH, Rennert OM. Bioavailability of manganese in milk studied with in vitro and in vivo systems. In: Manganese in Metabolism and Enzyme Function. Wedler FC, Schramm VL. (eds.). Academic Press, New York, NY. pp.17‑34, 1986.

13. Chan WY.  Enzymology, In: Oklahoma Notes: Biochemistry.  Briggs T, Chandler A. (eds.). Springer‑  Verlag, New York, NY. pp.18‑32, 1987.

14. Chan WY.  Human biochemical genetics.  In: Oklahoma Notes:  Biochemistry. Briggs T, Chandler A. (eds.). Springer‑Verlag, New York, NY. pp.175‑194, 1987.

15. Chan WY, Raghib MH. Absorption studies of manganese from various milk diets in suckling rats. In: Nutritional Bioavailability of Manganese. Kies C. (ed.). ACS, Washington, D.C. pp. 80-89, 1987.

16. Chan WY. Pregnancy-specific b1-glycoproteins: Laboratory findings and clinical potential. Georgetown   Medicine. Georgetown University, Vol 1, pp. 11-15, 1991.

17. Laue L, Wu SM, Kudo M, Hsueh AJW, Griffin JE, Wilson JD, Grant DB, Berry AC, Cutler GB Jr, Chan WY. The Gene defect that causes genetically XY males to develop as apparent females (Leydig cell hypoplasia). In: Third Annual Press Book. American Society for Cell Biology, Bethesda, MD. pp. 1-3, 1994.

18. Chan WY, Garnica AD, Rennert OM.  Genetic trace metal disturbances. In: Handbook of Metal-Ligand  Interactions in Biological Fluids. Berthon G. (ed.). Volume 2: Bioinorganic Medicine, Part 4, Chapter 2, Section A, Marcel Dekker, Inc., New York, NY. pp. 792-802, 1995.

19. Chan WY. Education, R&D, and the Biotech Industry in Hong Kong. In: Biotechnology in Hong Kong.   Chan, AWK. (ed.), US-China Intellectual Property Institute, New York, pp. 451-471, 1999.

 

Peer-Reviewed Articles:

 

 1.  Ho WKK, Chan WY.  Serum lipid and lipoprotein levels in normal Chinese.  Clin Chim Acta. 7:149‑154, 1974.

 2.  Ho WKK, Chan WY.  Evaluation of serum lipid and lipopro­tein levels in normal Chinese.  The influence of dietary habit, body weight, exercise and familial record of coronary heart disease.  Clin Chim Acta.  61:19‑ 25, 1975.

 3. Garnica AD, Chan WY, Rennert OM.  The role of the metal­lothioneins in intracellular copper transport:    Studies using skin fibroblasts of patients with Menkes' Syndrome.  Ann Clin Lab Sci. 8:302‑ 309, 1978.

 4.  Chan WY, Garnica AD, Rennert OM.  Metal binding studies of metal­lo­thioneins in Menkes' Kinky Hair   Disease.  Clin Chim Acta. 88:221‑ 228, 1978.

 5.  Chan WY, Garnica AD, Rennert OM.  Cell culture studies of Menkes' Kinky Hair Disease.  Clin Chim Acta.  88:495‑507, 1978.

 6.  Chan WY, Seale TW, Shukla JB, Rennert OM.  Polyamine conjugates and total polyamine concentration in human amniotic fluid. Clin Chim Acta.  91:233‑242, 1979.

 7.  Chan WY, Garnica AD, Rennert OM.  Inducibility of metal­lothionein biosyn­thesis in cultured normal and Menkes' Kinky Hair Disease fibroblasts:  Effects of copper and cadmium.  Pediat Res. 13(4):197‑­203, 1979.

 8.  Rennert OM, Chan WY.  Menkes' metallothionein and copper metabolism.  Pediat Res. 13(4):204‑­205,   1979.

 9.  Seale TW, Chan WY, Shukla JB, Rennert OM.  Isolation and charac­teriza­tion of a polyamine‑peptide conjugate from human amniot­ic fluid.  Clin Chim Acta.  95:461‑472, 1979.

10. Seale TW, Chan WY, Shukla JB, Rennert OM.  A poly­amine­-peptide conjugate isolated from normal human plasma.  Arch  Biochem Biophys. 189:164‑174, 1979.

11. Chan WY, Seale TW, Rennert OM.  Fluorescence micro-disc electro­phoresis in sodium dodecylsulfate: A  simple and sensitive method applicable for routine laboratory analysis.  J Chromat. 181(2):259­‑265, 1980.

12. Chan WY, Cushing W, Coffman MA, Rennert OM.  Genetic expression of Wilson's Disease in cell culture: A diagnostic marker.  Science.  208:299‑300, 1980.

13. Rennert OM, Chan WY, Hildago H, Cushing W, Griesmann GE.  Poly­amines in Menkes' Kinky Hair Disease.  Clin Chim Acta. 103:375‑ 380, 1980.

14. Chan WY, Rennert OM.  Comparative study of Menkes' and Wilson's Disease.  Cien Biol.  5(2):73‑75,    1980.

15. Chan WY, Richichi J, Griesmann GE, Cushing W, Kling OR, Rennert OM.  Copper and ceruloplasmin  

        activity in human amniotic fluid.  Am J Obstet Gynecol.  138(3):257‑259, 1980.

16.  Chan WY, Ramadan TZ, Perlman M, McCaffree MA, Rennert OM. Copper and manganese in the mother

       and  in the neonate.  Nutr Rep Internat.  22(6):939‑948, 1980.

17.  Rennert OM, Chan WY, Griesmann GE.  Polyamine‑peptide conjugates:  Proposed functions.  Physiol  

       Chem  Phys. 12(5):441‑­450, 1980.

18.  Chan WY, Rennert OM.  The role of copper in iron metabo­lism. Ann Clin Lab Sci.  10(4):338‑­344, 1980.

19.  Chan WY,  Rennert OM.  Cadmium nephropathy.  Ann Clin Lab Sci.  11(3):229‑238, 1981.

20.  Chan WY, Mosca P, Rennert OM.  Lithium nephrotoxicity: A review. Ann Clin Lab Sci. 11(4):343‑349,   1981.

21.  Perlman M, Chan WY, Ramadan TZ, Rennert OM.  Urinary polyamine in preterm infants.  Clin Chim    Acta.   113:1‑6, 1981.

22.  Chan WY, Chung KW, Bates J, Blomberg LA, Rennert OM. Organ specific zinc deficiency in testicular

       feminization rats:  Hormone­‑me­tal interaction.  Biochem Biophys Res Comm. 102(2):630‑­635, 1981.

23. Seiler N, Knodgen B, Gittos MW, Chan WY, Griesmann GE, Rennert OM.  On the formation of amino    acids deriving from spermi­dine and spermine.  Biochem J. 200(1):123‑132, 1981.

24. Chan WY, Bates J, Rennert OM.  Comparative studies of manganese binding in human breast milk, bovine  milk and infant formula.  J Nutr.  112(4):642‑651, 1982.

25. Chan WY, Rennert OM.  Prenatal and postnatal diagnosis of diseases of copper metabolism. Ann Clin Lab Sci.  12(5):372‑380, 1982.

26. Griesmann GE, Chan WY, Rennert OM.  Determination of gamma‑aminobutyric acid by reverse‑­phase HPLC and pre‑column labeling for fluorescence detection.  J Chromat.  230:121‑124, 1982.

27. Perlman M, Chan WY, Ramadan TZ, McCaffree MA, Rennert OM.  Serum copper and ceruloplas­min in  preterm infants:  Prospective study.  J Am Coll Nutr.  1:155‑163, 1982.

28. Liu HC, Chan WY, Rennert OM.  Histochemical studies of fibroblasts from patients with Menkes' Kinky Hair Disease and Wilson's Disease.  Histochem J.  14:781‑789, 1982.

29. Chan WY, Chung KW, Bates JM Jr, LeBlanc M, Tease LA, Griesmann GE, Rennert OM. Zinc metabolism in testicular feminiza­tion and cryptorchid testes in rats.  Life Sci. 32(11):1279‑­1284, 1983.

30. Chung KW, Chan WY, Dressler JB, Allison JE, Rennert OM. Androgen receptors in the brain of neonatal normal male and androgen insensitive rats.  Biochem Biophys Res Comm. 111(2):717‑722, 1983.

31. Rixon MW, Chan WY, Davie EW, Chung DW.  Character­iza­tion of a cDNA coding for a‑chain of human fibrinogen. Biochemistry.  22(13): 3237‑3244, 1983.

32. Chung DW, Chan WY, Davie EW.  Characterization of a cDNA coding for the g‑chain of human fibrinogen.  Biochemistry.  22(13): 3250‑3256, 1983.

33. Fan MZ, Chan WY, Griesmann G, Rennert OM.  Polyamine metabolism in McCoy cells:  I. Comparative studies of extracel­lular polyamine conjugated proteins of human fibroblast and McCoy cultures. Physiol Chem Phys. 15(1):57‑68, 1983.

34. Fan MZ, Chan WY, Rennert OM.  Polyamine metabolism in McCoy cells:  II. Cellular origin of excreted    polyamine conjugated proteins.  Physiol Chem Phys.  15(1):69‑80, 1983.

35. Fan MZ, Chan WY, Griesmann G, Rennert OM.  Polyamine metabolism in McCoy cells: III. Comparative studies of metabolic fate of exogenous putrescine in human fibroblast cultures and McCoy cultures.  Physiol Chem Phys.  15(1):81‑86, 1983.

36. Wang CS, Chan WY, Kloer H‑U.  Comparative studies on the chemical and immunochemical properties of human milk, human pancre­atic juice and bovine milk lacto­ferrin.  Comp Biochem Physiol. 78B(3):575­-580, 1984.

37. Blackett PR, Lee DM, Donaldson DL, Fesmire JD, Chan WY, Holcombe JH, Rennert OM.  Studies of lipids, lipoproteins and apolipoproteins in Menkes Disease.  Pediat Res.  18(9):864‑870, 1984.

38. Chan WY, Bates JM. Jr, Rennert OM, Mamood A, Tor­res‑Pinedo R.  Intestinal transport of manganese from human milk, bovine milk and infant formula in rats.  Life Sci.  35(24):2415‑2­419,1984.

39. Raghib H, Chan WY, Rennert OM.  Effect of age, method of feeding and prior fasting on the absorption of milk manganese in suck­ling rats.  Nutr Rep Internat.  32(5):1201‑1210, 1985.

40. Garnica AD, Chan WY, Rennert OM.  Trace metals in genetic disease.  Trace Metals Med. 2(2):47‑58, 1985.

41. Chan WY, Rennert OM.  Genetic trace metal disturbances.  J Am Coll Nutr.  4(1):39‑48, 1985.

42. Chung KW, Kim SY, Chan WY, Rennert OM.  Androgen receptors in prostate glands of zinc deficient rats. Life Sci.  38(1):351­356, 1986.

43. Raghib MH, Chan WY, Rennert OM.  Comparative bioavailabil­ity of manganese from extrinsically labeled milk diets using suckling rats as a model.  Brit J Nutr.  55(1):49‑58, 1986.

44. Chan WY, Bates JM Jr, Rennert OM, Chung KW.  Abnormal zinc metabolism in unilateral maldescended testes of a mutant rat strain.  Proc Soc Expt Biol Med.  182(4):549‑558, 1986.

45. Raghib H, Chan WY, Rennert OM.  Comparative studies of selenium‑75 (Selenite and Seleno­methionine) absorption from various milk diets in suckling rats. J Nutr.  116(8):1456‑1463, 1986.

46. Chan PK, Chan WY, Yung BY‑M, Cook RG, Aldrich MB, Ku D, Goldknopf LL, Busch H. Amino acid  sequence of a specif­ic antigenic peptide of protein B23.  J Biol Chem.  261(30):14335‑1­4341, 1986.

47. Chan WY, Bates JM Jr, Rennert OM, Chung KW.  Absence of a 23kd protein in testes of testicular feminization rats.  Life Sci. 40(22):2169-2173, 1987.

48. Raghib HM, Chan WY, Rennert OM. Absorption of milk manganese in suckling rats.  Nutr Rep Internat. 35(6):1111-1121, 1987.

49. Chan WY, Tease LA, Borjigin J, Chan PK, Rennert OM, Srinivasan B, Shupert WL, Cook RG. Pregnancy-specific b1-glycoprotein mRNA is present in placental as well as non-placental tissues. Hum Reprod. 3(5):677-686, 1988.

50. Chan WY, Tease LA, Bates JM Jr, Borjigin J, Shupert WL.  Pregnancy-specific b1-glycoprotein in rats:  Tissue distribution of the mRNA and identification of testicular cDNA clones.   Hum Reprod. 3(5):687-692, 1988.

51. Chan WY, Qiu WR.  Human Pregnancy-specific b1-glycoprotein is encoded by multiple genes localized on two chromosomes.  Am J Hum Genet. 43(2):152-159, 1988.

52. Chan WY, Borjigin J, Zheng QX, Shupert WL. Character­iza­tion of cDNA encoding human pregnancy-specific b1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. DNA. 7(8):545-555, 1988.

53. Chan WY, Liu QR, Borjigin J, Busch H, Rennert OM, Tease LA, Chan PK. Characterization of a cDNA encoding human nucleophosmin and studies of its function in normal and abnormal growth. Biochemistry.  28(3):1033-1039, 1989.

54. Tease LA, Fazleabas AG, Chan WY. Expression of pregnan­cy-specific b1-glycoprotein in baboon placenta.  Biol Reprod. 41:1113-1121, 1989.

55. Borjigin J, Tease LA, Barnes W, Chan WY.  Expression of pregnan­cy-specific b1-glycoprotein in human testis. Biochem Biophys Res Comm. 166(2):622-629, 1990.

56. Ogilvie S, Shiverick KT, Larkin LH, Romrell LJ, Shupert WL, Chan WY. Pregnancy-specific b1-glycoprotein mRNA and immuno­re­active-protein in the testis of rat.  Endocrinology. 126(1):292-298,1990.

57. Zheng QX, Tease LA, Shupert WL, Chan WY. Character­iza­tion of cDNAs of the human pregnancy-specific b1-glycoprotein fami­ly - A new subfamily of the immunoglobu­lin gene superfamily. Biochemis­try. 29(11): 2845-2852, 1990.

58. Jose P, Felder RA, Felder CC, Chan WY.  Molecular  biology of adrener­gic and dopamine receptors and  the  study of develop­mental nephrology.  Pediat Nephrol. 4:679-685, 1990.

59. Ho WKK, Liu SC, Shaw PC, Yeung HW, Ng TB, Chan WY. Cloning of the cDNA of a-momorcharin: A ribosome inactivating protein. Biochim Biophys Acta  1088:311-314, 1991.

60.  Chan WY,  Zheng QX, McMahon J, Tease LA. Character­iza­tion of new members of the pregnancy specific b1-glycoprotein family.  Mol Cell Biochem. 106:161-170, 1991.

61. Richardson LL, Chan WY, Dym M. Localization of a "preg­nan­cy-specific" b1-glycoprotein in the male      reproductive tract of the rat by in situ hybridization. Biol Reprod. 45: 704-710, 1991.

62. Chan WY.  The pregnancy-specific b1-glycoprotein family. Adv Contr Deliv Syst.  7:21-52, 1991.

63. Shupert WL, Chan WY. Pregna­ncy-specific b1-glycoprotein (PSG) in human intestine. Mol Cell Biochem. 120:159-170, 1993.

64. Wu SM, Bazar L, Cohn M J, Cahill R, Chan WY.  Expression of pregnancy-specific b1-glycoproteins in   hematopoietic cells.  Mol Cell Biochem. 122:147-158, 1993.

65. Ida H, Rennert OM, Eto Y, Chan WY. Identification of a cDNA encoding human acid sphingomyelinase with a new mutation that renders the enzyme inactive.  J Biochem. 114:15-20, 1993.

66. Chen H, Chan WY, Chen C-L, Mansfield, BC, Chou JY. The carboxyl-terminal domain of the human pregnancy specific glycopro­tein specifies intracellular retention and stability. J Biol Chem. 268(29):22­066-22075, 1993.

67. Pan C-J, Chamberlin ME, Wu SM, Chan WY, Chou JY. Pregnancy-specific b1-glycopro­tein genes expression and their induction by 5-bromo-2'-deoxy-uridine. Biochemistry. 33(23):7260-7266, 1994.

68. Garnica AD, Chan WY, Rennert OM. Copper-histidine treatment of Menkes' disease. J Pediat. 125(2):336-338, 1994.

69. Rennert OM, Chan WY, Garnica AD.  Menkes kinky hair disease - A glimpse from the past into the future. Menkes disease: The study of copper metabolism.  Internat Pediat. 9(Supp. 2):69-73, 1994.

70. Laue L, Chan WY, Hsueh AJW, Kudo M, Hsu SY, Wu SM, Blomberg LA, Cutler GB Jr. Genetic heterogeneity of constitutively activating mutations of the luteinizing hormone receptor in familial male-  limited precocious puberty. Proc Natl Acad Sci, USA. 92(6):1906-1910, 1995.

71. Laue L, Wu SM, Kudo M., Hsueh AJW, Griffin JE, Wilson JD, Grant DB, Brain C, Berry EC, Cutler GB Jr, Chan WY. A nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasia. Hum Mol Genet. 4(8):1429-1433, 1995.

72. Garnica AD, Chan WY. The role of the placenta in fetal nutrition and growth.  J Am Coll Nutr. 15(3):206 -222, 1996.

73. Bano M, Prasad S, Dickson RB, Chan WY. Detection of pregnancy-specific b1-glycoprotein in human milk. Breast. 5:61-66, 1996.

74. Laue LL, Wu SM, Kudo M, Bourdony CJ, Cutler GB Jr, Hsueh AJW, Chan WY. Compound heterozygous mutations of the luteiniz­ing hormone receptor gene in Leydig Cell Hypoplasia. Mol Endocrinol. 10(8): 987-997, 1996.

75. Laue L, Wu SM, Kudo M, Hsueh AJW, Cutler GB Jr, Jelly DH, Diamond FB, Chan WY. Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty. Biochem Mol Med. 58:192-198, 1996.

76. Wu SM, Blomberg LA, Chan WY. Recovery of PCR products from polyacrylamide gel for sequencing. BioTechniques. 21(3):358-362, 1996.

77. Garnica AD, Chan WY. Placenta and growth factors in fetal growth and nutrition. Nutrition  13(4):384-385, 1997.

78. Stratakis CA, Lin J-P, Pras E, Rennert OM, Bourdony CJ, Chan WY. Allgrove (Triple-A) syndrome in Puerto Rican kindreds maps to chromosome 12 (12q13). Proc Assoc Am Physicians. 109(5):478-482,1997.

79. Wu SM, Jose M, Hallermeier K, Rennert OM, Chan WY.  Polymorphisms in the coding exons of the human luteinizing hormone receptor. Hum Mut. 11(4):333-334 and Mutation in Brief #124, On-line,1997.

80. Blomberg LA, Wu SM, Dirami G, Dym M, Chou JY, Chan WY. Characterization and cellular localization of pregnancy-specific b1-glycoproteins in rat testis. Mol Cell Biochem. 177:229-237, 1997.

81. Chan WY, Cutler GB Jr. Molecular aspects of precocious puberty. Adv Mol Cell Endocrinol 2:121-141, 1998.

82. Blomberg LL, Cohn MJ, Cahill RA, Chan WY. Effect of human pregnancy-specific b1 glycoprotein on blood cell regeneration after bone marrow transplant. Proc Soc Expt Biol Med. 217:212-218, 1998.

83. Chan WY, Cutler GB Jr. Mutations of gonadotrophin receptors leading to loss or gain of function. Top  Endocrinol. 8:9-12, 1998.

84. Chan WY. Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations.   Mol Genet Metab. 63(2):75-84, 1998.

85. Martin MM, Wu SM, Martin ALA, Rennert OM, Chan WY. Testicular seminoma in a patient with a constitutively activating mutation of the luteinizing hormone/chorionic gonadotropin receptor. Euro J Endocrinol. 139:101-106, 1998.

86. Wu SM, Stratakis CA, Chan CHY, Hallermeier K, Bourdony CJ, Chan WY. Genetic heterogeneity of ACTH resistance syndromes: A novel mutation of the ACTH receptor gene in hereditary glucocorticoid deficiency. Mol Gen Metab. 64:256-265, 1998.

87. Wu SM, Hallermeier MK, Laue L, Brain C, Berry EC, Grant DB, Griffin JE, Wilson JD, Cutler GB Jr, Chan WY. Inactivation of the luteinizing hormone/chorionic gonadotro­pin receptor by insertional mutation in Leydig cell hypoplasia. Mol Endocrinol. 12(11):1651-1660, 1998.   

88. Wu SM, Arnold LL, Rone J, Trivedi M, Chan WY.  Effect of pregnancy-specific b1-glycoprotein on the preimplantation embryo. Proc Soc Expt Biol Med. 220:169-177,1999.

89. Wu SM, Leschek EW, Brain C, Chan WY. A novel mutation of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty – effect of the size of a critical amino acid on receptor activity. Mol Genet Metab. 66:68-73 1999.

90. Arnold LL, Doherty TM, Flor WA, Simon JA, Chou JY, Chan WY, Mansfield BC.  Pregnancy-specific glycoprotein gene expression in recurrent aborters: A potential correlation to interleukin-10 expression. Amer J Reprod Immunol. 41:174-182, 1999.

91. Wu SM, Chan WY. Male pseudohermaphroditism due to inactivating luteinizing hormone receptor mutations. Arch Med Res. 30(6):495-500, 1999.

92. Wu SM, Leschek EW, Rennert OM, Chan WY. Luteinizing hormone receptor mutations in disorders of

      sexual development and cancer. Frontiers Biosci. 5:D342-352, 2000.

93. Wu SM, Leschek EW, Rennert OM, Chan WY. Luteinizing hormone receptor mutations in sexual development and cancer. J Pediat Path Mol Med. 19(1):21-40, 2000.

94. Massaro GD, Massaro D, Chan WY, Clerch LB, Ghyselinck N, Chambon P, Chandraratna RAS. Signalling via retinoic acid receptor b mediates endogenous inhibition of the perinatal formation of pulmonary alveoli. Physiol Genomics. 4(1):51-57, 2000.

95. Leschek EW, Chan WY, Diamond D, Laefer M, Jones J, Barnes KM, Cutler GB Jr. Nodular Leydig cell

      hyperplasia in a boy with Familial male-limited precocious puberty (FMPP).  J Pediatr. 138(6):949-951, 2001.

96. Sandrini F, Farmakidis C, Kirschner LS, Wu SM, Tullio-Pelet A, Lyonnet S, Metzger DL, Bourdony CJ, Hochberg Z, Chan WY, Stratakis CA. Spectrum of mutations of the AAAS gene and genotype-phenotype correlation in patients with isolated resistance to corticotropin or Allgrove syndrome. J Clin Endocrinol Metab. 86: 5433-5437, 2001.

97. Chan WY, Rennert OM. Molecular aspects of sexual differentiation. Curr Mol Med. 2:25-37, 2002.

98.    Bastain TM, Lewczyk CM, Sharp WS, James RS, Long RT, Eagen PB, Ebens CL, Meck JM, Chan WY,    Sidransky ER, Rapoport JL, Castellanos FX. Cytogenetic abnormalities in Attention- Deficit/ 

         Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 41(7):1-5, 2002.

99.   Blomberg LA, Chan WY, Clerch L, Massaro G, Massaro D. Molecular cloning and characterization of         two genes up-regulated early in lung development. Biochim Biophys Acta, 1574(3):391-398, 2002.

100.  Pang ALY, Taylor HC, Johnson W, Alexander S, Chen Y, Su YA, Li X, Ravindranath N, Dym M,

    Rennert OM, Chan WY. Identification of differentially expressed genes in spermatogenesis in the      

    mouse. J Androl. 24(6):899-911, 2003.

101.  Dogulu CF, Kansu T, Leung MYK, Baxendale V, Wu SM, Ozguc M, Chan WY, Rennert OM. Evidence    for genetic susceptibility to thrombosis in Pseudotumor Cerebri. Thromb Res, 111(6):389-395, 2003.

102.  Leung MLY, Al-Muslim O, Wu SM, Azizs A, Inam S, Awadh M, Rennert OM, Chan WY.  A novel 

         missense homozygous inactivating mutation in the fourth transmembrane helix of the luteinizing

         hormonereceptor in Leydig Cell Hypoplasia. Amer J Med Genet, 130A:146-153, 2004.

103.    Ohta S, Lai EW, Pang ALY, Brouwers FM, Chan WY,  Eisenhofer G, de Krijger R,  Ksinantova L, Blazicek P, Breza J, Kvetnansky R, Wesley RA, Pacak K. Down-regulation of metastasis suppressor gene in malignant pheochromocytoma. Internat J Cancer, 2004 (in press).

104.    Wu SM, Baxendale V, Chen Y, Li X, ALY Pang, Stitely T, Munson PJ, Leung MYK, Ravindranath N, Dym M, Rennert OM, Chan WY.  Analysis of mouse germ cell transcriptome at different stages of spermatogenesis: Biological significance. Genomics, 2004 (in press).

105.    Ifon ET, Pang ALY, Johnson W, Cashman K, Zimmerman S, Muralidhar S, Chan WY, Casey J, Rosenthal LJ. U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3. Cancer Cell International, 2004 (in press).

106.    Salameh W, Shoucair M, Guo TB, Zahed L, Wu SM, Rennert, O.M., and Chan WY.  Leydig cell hypoplasia due to inactivation of luteinizing hormone receptor by a novel homozygous nonsense truncation mutation in the seventh transmembrane domian.  Molecular and Cellular Endocrinology. 2004 (in press).

 

Manuscript Submitted:

 

1.   Lowenthal ED, Chan WY, Wu SM, Karaviti LP. A Case of Familial Testotoxicosis:  Unexpected tall      

      stature attained by untreated boys with Familial Testotoxicosis. Clinical Genetics. 2003.

2.      Liu Y, Yao ZX, Bendavid C, Borgmeyer C, Han Z, Cavalli LR, Gallicano I, Chan WY, Folmer J, Zirkin BR, Haddad BR, and Papadopoulos V. Cytochrome P450 17a-hydroxylase/17,20 lyase (CYP17) gene deletion causes infertility in mice. Molecular Endocrinology, 2004.

3.      Pang ALY, Johnson W, Dym M, Rennert OM, Chan WY. Expression profiling of purified male germ cells: stage specific expression patterns related to meiosis and post-meiotic development. Physiological Genomics, 2004.

4.      Pang ALY, Johnson W, Dym M, Rennert OM, Chan WY. A survey of house-keeping gene expression during male germ cell development. Biology of Reproduction, 2004.

5.      Vong QP, Lau CYF, Dym M, Rennert OM, Chan WY. Differential expression of Ddx3y, PL10 and Ddx3 in germ cell and gonad development in mouse. Biology of Reproduction, 2004.

6.      Leung MYK, Bellan D, Steinback P, Baxendale V, Wu SM, Rennert OM, Chan WY. Mutation of the conserved hydrophobic amino acid residues of the leucine-rich repeats of human luteinizing hormone receptor deformed the LRR coils and reduced the availability of beta-strand to ligand-receptor interaction. Journal of Biological Chemistry, 2004.

 

Manuscript In Preparation:

 

1.   Chan WY, Wu SM, Ruszcyzk L, Stitely T, Law E, Baxendale V, Pang ALY, Rennert OM.   

Spermatogenesis: Model for antisense transcription?  Nature Genetics, 2004.

 

Published Abstracts:

 

 1. Rennert OM, Garnica AD, Chan WY.  Hyperornithinemia and hyper­ammonemia:  A rare disorder of ammonia metabolism. Proc 2nd Internat Gstaad Symp. 1975. (podium)

 2.  Garnica AD, Rennert OM, Chan WY.  Ornithine ketoacid transaminase deficiency associated with  

      hyperammonemia and or­nithinemia.  Pediat Res.  10(4):365, 1976.

 3.  Chan WY, Garnica AD, Rennert OM.  Defective metallo­thionein in Kinky Hair Syndrome fibroblasts. Pediat Res.  11(4):453, 1977.

 4.  Chan WY, Garnica AD, Rennert OM.  Studies of 64Cu and 109Cd efflux and uptake in Menkes' Kinky Hair (MKHS) fibroblasts.  Pediat Res.  11(4):453, 1977.

 5. Chan WY, Garnica AD, Rennert OM.  Defective metallo­thionein and copper accumulation in Menkes' Kinky Hair Syndrome (MKHS) fibroblasts. Am J Hum Genet.  29(6):29A, 1977. (podium)

 6.  Rennert OM, Seale TW, Chan WY, Flux M.  No differences detected spectro­photometrically between blood peptides of Cystic Fibrosis and normal individuals frac­tionated by column chromatog­raphy.  Pediat Res. 12(4): 511, 1978.

 7.  Chan WY, Seale TW, Shukla JB, Blackett P, Rennert OM.  Character­ization of a polyamine‑conjugated l low molecular weight polypeptide in human third trimester amniotic fluid. Pediat Res.  12(4):392, 1978.

 8.  Seale TW, Chan WY, Shukla JB, Rennert OM.  Human plasma polyamine-conjugated peptide, putrescinin. Pediat Res.  12(4):512, 1978.

 9.  Chan WY, Seale TW, Shukla JB, Rennert OM.  Polyamines in human amniotic fluid.  Clin Res. 26:812A, 1978.

10. Garnica AD, Chan WY, Rennert OM.  Accumulation of infused protein bound copper in the Kinky Hair  Syndrome. Clin Res.  26:820A, 1978.

11. Chan WY, Garnica AD, Rennert OM.  Abnormal accumulation of copper in cultured fibroblasts as in vitro genetic marker for Wilson's Disease.  Pediat Res.  13(4):418, 1979.

12. Chan WY, Perlman M, Kling OR, Seale TW, Rennert OM. Variation of trace element contents of human amniotic fluid with gestation. Pediat Res.  13(4):35­6­, 1979.

13. Seale TW, Smith DJ, Chan WY, Rennert OM.  Detection and properties of a sodium reabsorption inhibitor in serum from Cystic Fibrosis patients. Genetics  91:s113, 1979.

14.  Chan WY, Garnica AD, Rennert OM.  Abnormal copper metabolism in cultured fibroblasts ‑ A genetic marker for Wilson's Disease. Am J Hum Genet.  31(6):41A, 1979.

15.  Perlman M, Ramadan T, Chan WY, Rennert OM.  Serial copper and cerulo­plasmin values in serum of preterm infants. Clin Res. 27(5):799A, 1979.

16.   Seale TW, Chan WY, Martinez R, Rennert OM.  Detection and properties of sodium inhibition in serum from Cystic Fibrosis patients.  Proc Joint Meet Genet Soc Canada Am Soc Nat.  1979.   

17.  Chan WY, Cushing W, Coffman MA, Rennert OM.  Genetic expression of Wilson's Disease in culture. Pediat Res. 14(4):520, 1980.

18.  Perlman M, Chan WY, Ramadan T, Griesmann G, Rennert OM. Urinary polyamines in preterm infants.  Pediat Res.  14(4):578, 1980.

19.  Chan WY, Ramadan TZ, Perlman M, McCaffree MA, Rennert OM. Manganese and copper metabolism in the mother and the neonate. Proc Am Coll Nutr. #29, 1980.

20.  Chan WY, Ramadan TW, McCaffree MA, Perlman M, Rennert OM. Manganese and copper in full‑term and preterm newborns.  Clin Res.  28(5):853A, 1980.

21.   Pineda JL, Rennert OM, Chan WY.  Zinc metallopeptide in human milk.  Clin Res.  28(5):867A, 1980.

22.  Chan WY, Chung KW, Bates J, Blomberg LA, Rennert OM. Hormonal‑metal ion interaction in testicular feminization.  Pediat Res.  15(4):505, 1981.

23.  Chan WY, Coffman MA, Rennert OM.  Wilson's Disease fibroblasts‑mutants of intracellular copper transport. Pediat Res. 15(4):560, 1981.

24.   McCaffree MA, Chan WY, Costiloe P, Rennert OM.  Levels of copper and ceruloplasmin in infants fed two different formulas.  Pediat Res.  15(4):540, 1981.

25.   McCaffree MA, Chan WY, Ramadan TZ, Perlman M, Rennert OM. Copper and manganese levels in infants following exchange trans­fusion.  Pediat Res.  15(4):540, 1981.

26.  Blackett P, Donaldson D, Lee D, Chan WY, Holcombe JH, Rennert OM.  Hyperlipidemia and glucose intolerance with hypocuprinemia in Menkes' Disease.  Pediat Res.  15(4):626, 1981.

27.  Chan WY, Bates J, Pineda J, Rennert OM.  Manganese binding proteins in human breast milk. J Am Coll Nutr. 1(1):113, 1982. (podium)

28.  Chan WY, Bates JM Jr, Rennert OM.  Manganese binding ligands in human milk and its substitutes. Fed Proc. 41(3):360, 1982. (podium)

29.  Fan MZ, Chan WY, Griesmann GE, Rennert OM.  Polyamine conjugated protein in medium of McCoy cultures. Fed Proc.  41(3):519, 1982.

30.  Griesmann GE, Fan MZ, Chan WY., and Rennert, O.M.  Metabolic fate of exogenous putrescine in McCoy cultures. Fed Proc.  41(3):877, 1982.

31.  Rennert OM, Fan MZ, Chan WY.  Cellular origin of excreted polyamine conjugated protein in McCoy culture. Fed Proc.  41(4):1431, 1982.

32.  Chan WY, Tease,LA, Rennert OM.  Kinetic studies of copper metabolism in Wilson's Disease fibroblast culture.  Pediat Res. 16(4):256A, 1982.

33.  Chan WY, Bates JM Jr, Rennert OM.  Molecular localiza­tion of manganese in human breast milk, bovine milk and infant formula.  Pediat Res.  16(4):158A, 1982.

34.  Liu HC, Chan WY, Rennert OM.  Diseases of copper metabo­lism:  Histochemical studies of Wilson's and Menkes' Disease fibroblasts. Pediat Res.  16(4):193A, 1982.

35.  Chan WY, Tease LA, Bates JM Jr, Rennert OM.  Zinc metabolism in Testicular Feminiza­tion Syndrome cultured fibroblas­ts. Pediat Res.  16(4):136A, 1982.

36.  Germer M, Griesmann G, Garison R, Chan WY, Rennert OM.  Chemical diagnosis of Reye's Syndrome‑ determination of g‑aminobut­yric acid and lysine.  Pediat Res.  16(4):257A, 1982.

37.  Chung KW, Chan WY, Dressler JB, Allison JE, Rennert OM. Androgen receptors in the brain of neonatal normal male and androgen insensitive rat. Endocrinology.  110(Suppl):200, 1982.

38.  Bates JM Jr, Chan WY, Mahmood A, Rennert OM.  Human milk, bovine milk and infant formula ligand‑ bound manganese transport in rat.  Fed Proc.  42(4):817, 1983.

39.  Rixon MW, Que BG, Chan WY, Chung DW, Davie EW.  Isolation and characterization of cDNAs coding for the a, b and g chains of human fibrinogen. Fed Proc.  42(7):1761, 1983.

40.  Chung DW, Rixon MW, Que BG, Chan WY, Davie EW.  Isolation and characterization of cDNAs for the a and g  chains of human fibrinogen. Proc. IX Internat Congr Thromb Haem. 1983. (podium)

41.  Bates JM Jr, Chan WY, Rennert OM.  Characterization of manganese binding ligand in Human breast milk. Fed Proc. 43(3):489, 1984.

42.   Raghib HM, Chan WY, Rennert OM.  Comparative bioavailabil­ity of manganese in human milk, cow's milk and infant formula. Fed Proc.  43(3):489, 1984.

43.  Raghib HM, Chan WY, Rennert OM.  Effect of age on absorption of manganese from human milk, cow's milk and infant formula.  Pediat Res.  18(4):209A, 1984.

44.  Chan WY, Rennert OM.  Immunological screening for the cDNA of the oncodevelopmental protein bSP1 from a human placental expression library. Fed Proc.  44(5):1461, 1985.

45.      Bates JM Jr, Chan WY, Chung KW, Rennert OM.  Abnormal zinc metabolism in heritable maldescended testes of a mutant rat strain. Fed Proc.  44(4):933, 1985.

46.  Raghib HM, Chan WY, Rennert OM.  Changes associated with advancing age of suckling rats. Fed. Proc. 44(6):1­850, 1985.

47.  Chan WY, Rennert OM.  Cloning of the cDNA of human pregnancy­‑­specific b1‑glyco­protein. Pediat Res. 19(4):152A, 1985.

48.  Bates JM Jr, Chan WY, Chung KW, Rennert OM.  Aberrant zinc binding in testes of Testicular Feminization rats. Pediat Res.  19(4):149A, 1985.

49.  Chung KW, Chan WY, Rennert OM. Influence of zinc deficiency upon androgen receptor binding in the rat prostate gland. Proc 67th Ann Meet Endocr Soc.  p.666, 1985.

50.  Tease LA, Kim, SY, Garnica AD, Chan WY, Rennert OM.  Molecular cloning of human apoferritin light chain cDNA.  Am J Hum Genet.  37(4):178A, 1985.

51.  Raghib HM, Chan WY, Rennert OM.  Selenium bioavailability of infant milk diets. Fed Proc.  45(3):589, 1986.

52.  Chan WY, Raghib, H.M., and Rennert, O.M.  Factors affecting selenium absorption from infant milk diets. Pediat Res. 20(4):237A, 1986.

53.  Garnica AD, Chan WY, Rennert OM.  Ceruloplasmin infusion in Menke's Syndrome. Pediat Res. 20(4): 264A, 1986.

54.  Chan WY, Chan PK, Rennert OM, Busch H.  Identification and charac­teriza­tion of cloned cDNAs coding for the nucleolar phosphopro­tein B23. Fed Proc.  45(6):1589, 1986.

55.   Tease LA, Chan WY, Rennert OM.  Characterization of the cDNA clones of human pregnancy-specific b1- glycoprotein. Fed Proc. 45(6):1512, 1986. (podium)

56. Chung KW, Kim SY, Giger NM, Chan WY, Rennert OM.  Ultra-­structure of Sertoli cells and concentration of androgen binding protein in testes and epidi­dymids of zinc deficient rats. Anat Rec.  214(3):22A, 1986.

57.   Chan WY, Raghib HM, Rennert OM.  Absorption studies of manganese from milk diets in suckling rats.  Abs 192nd Am Chem Soc Div Agri Food Chem.  #13, 1986.

58.  Tease LA, Chan PK, Cook RG, Rennert OM, Srinivasan B, Chan WY.  Nucleotide sequence of cDNA coding for the N‑terminal portion for human pregnancy-specific b1-glycoprotein. Fed Proc.  46(6):1949, 1987.

59.   Qiu W, Tease LA, Chan WY.  Cloning of human pregnancy-specific b1-glycoprotein gene. Fed Proc. 46(6): 1986, 1987.

60.  Chan WY, Qiu WR, Rennert OM, Tease LA.  Human pregnancy-specific b1 glycoprotein is coded by a multigene family.  Am J Hum Genet.  41(3):A149, 1987.

61.   Chan WY, Bates JM Jr, Tease LA.  Presence of pregnancy-specific b1- glycoprotein mRNA in placental as well as non‑placental tissues of rat. J Cell Biol.  105(4):258a, 1987.

62.     Chan WY, Borjigin J, Shupert WL.  Cloning and characteriza­tion of Schwan­gers­chaftsprotein 1 cDNAs of human testis and HeLa cells. FASEB J. 2(6):A1686, 1988. (podium)

63.     Tease LA, Bates JM. Jr, Borjigin J, Shupert WL, Chan WY. Presence of a protein homologous to human Schwangerschaftsprotein 1 in rat testis. FASEB J. 2(6):A1686, 1988. (podium)

64.  Venkataraman PS, Chan WY, Fugate R.  Cellular calcium responses to calcitonin in mouse hepatocytes: comparison of neonatal vs adult mice. Pediat Res.  23(4):254A, 1988.

65.  Chan WY, Sung S-S L.  Differential expression of human pregnancy-specific b1-glycoprotein in erythroid and myeloid cell lines. FASEB J.  3(3):A323, 1989.

66.     Tease LA, Fazleabas AT, Chan WY. Animal model for the studies of human pregnancy-specific b1 glycoprotein. Pediat Res. 25(4):61A, 1989.

67.     Ogilvie S, Larkin LH, Romrell LJ, Shiverick KT, Shupert WL, Chan WY. Localization of proteins immunochemically related to human pregnancy-specific b1-glycoprotein in the testes of rats.  Proc Endocr Soc 71st Ann Meet. P.155, 1989.

68.   Zheng QX, Borjigin J, Shupert WL, Tease LA, Sung JSS, Chan WY. Differential expression of multiple forms of SP1 in human tissues. Proc XVIIth Meet Internat Soc Onco­develop Biol Med. P.12, 1989.      (podium)

69. Tease LA, Shupert WL, Fazleabas AT, Zavy MT, Chan WY.  Presence of pregnancy-specific b1-glycoprotein in different species of animal. Proc XVIIth Meet Internat Soc Oncodevelop Biol Med. P.62, 1989. (podium)

70.  Ho WKK, Liu SC, Chan WY. Cloning of the anti-HIV plant protein a-momorcharin cDNA. FASEB J. 4(3):A491, 1990.

71.  Richardson LL, Chan WY, Dym M. Expression of the "pregnan­cy-specific" b1-glycoprotien (SP1) in the male reproductive tract of the rat. J Androl. 11:32-P, 1990.

72.  Shupert WL,Chan WY. Expression of pregnancy-specific b1-glycopro­teins in human intestine. Proc CEA Workshop. p.7, 1990.

73. Wu SM, Bazar LS, Cohn ML, Burstein SA, Cahill R, Tease LA, Chan WY. Pregnancy-specific b1-glycoprotein in blood cells - expression and potential functions. Proc 2nd  Internat PSG/CEA Workshop. p. 9, 1991. (podium)

74.  Tease LA, Wu SM, Chan WY. Stable expression of human pregnancy-specific b1-glycoprotein in CHO cells. Proc 2nd Internat PSG/CEA Workshop. p. 11, 1991.

75.  Wu M, Tease LA, Chan WY. In vitro expression of human pregnancy-specific b1-glycoprotein (PSG) in CHO cells. FASEB J. 6(1):A231, 1992.

76.  Chan WY, Wu SM, Silavin S. Expression of the pregnancy-specific b1-glycoprotein gene family in cultured trophoblasts. FASEB J. 6(1):A450, 1992.

77.  Chan WY, Wu SM, Pan CJ, Chou JY. Transformed trophoblasts as in vitro models for studying PSG expression. Proc 3rd Internat CEA/PSG Workshop. p. 8, 1992.

78.  Wu SM, Thompson E, Hartmann D-P, Chan WY. Pregnancy-specific b1-glycoprotein in human breast tumor. Proc 4th Internat CEA/PSG Workshop. p. 22, 1993. (podium)

79.  Laue L, Hsueh AJW, Cutler GB Jr, Chan WY. Multiple constitutively activating mutations of the human luteinizing hormone receptor (hLHR) in Familial Male Precocious Puberty (FMPP). FASEB J. 8(7):A1320, 1994.

80.  Chan WY, Blomberg LA, Vornberger W, Suarez-Quian C. Distribution of pregnancy specific glycoprotein in the normal and azoospermic testis. Biol Reprod. 50(Supp 1):91, 1994. (podium)

81.  Blomberg LA, Chen H-W, Dirami G, Chou JY, Dym M, Chan WY.  Cloning and identification of specific cellular location of pregnancy-specific b1-glycoprotein (PSG) transcripts in rat testis. Biol Reprod. 50(Suppl 1): 120, 1994.

82.  Arnold LL, Wu SM, Simon JA, Chan WY. Expression of pregnancy-specific b1-glycoprotein mRNA in human endometrial tissue. Biol Reprod. 50(Suppl 1):177, 1994.

83.  Laue L, Chan WY, Hsueh AJW, Kudo M, Hsu SY, Wu SM, Blomberg LA, Cutler GB Jr. Genetic heterogeneity of activating mutations of the luteinizing hormone receptor gene in familial male-limited precocious puberty. Am J Hum Genet. 55:A228, 1994.

84. Wu SM, Chan WY. The expression of pregnancy-specific b1-glycoprotein genes in Meckel-Gruber syndrome fibroblasts. Am J Hum Genet. 55:A290, 1994.

85.  Gursel DG, Blomberg, LA, Flor A, Garnica AD, Chan WY, Rennert OM. Characterization of a cDNA clone from human kidney sharing high homology with the cDNA sequence of placental sphingomyelinase. Am J Hum Genet. 55:A326, 1994.

 86. Laue L, Wu SM, Hsueh AJW, Griffin J, Grant DB, Barry C, Cutler GB Jr, Chan WY. An inactivation mutation of the human luteinizing hormone receptor (hLHR) gene in Leydig Cell Hypoplasia (LCH). Mol Biol Cell. 5 (Suppl):68A, 1994.

87.  Wu SM, Arnold LL, Rone J, Blomberg LA, Trivedi J, Chan WY.  The novel effects of recombinant pregnancy -specific b1-glycoprotein on the preimplantation embryo. Mol Biol Cell.  5(Suppl):352A, 1994.

88.  Arnold LL, Wu SM, Flor AW, Simons JA, Chan WY. Pattern of pregnancy-specific b1-glycoprotein gene expression in women with recurrent spontaneous abortion. J Soc Gynecol Invest. 2(2):P293, 1995.

89.  Laue L, Wu SM, Jelly DH, Cutler GB Jr, Chan WY. A novel constitutively activating mutation of the human luteinizing hormone receptor (hLHR) gene in an African American patient with "sporadic" male-limited precocious puberty. Proc 77th Ann Meet Endocr Soc. p. 477, 1995.

90.  Laue L, Wu SM, Kudo M, Hsueh AJW, Bourdony CJ, Cutler GB Jr, Chan WY. Heterogeneity of human luteinizing hormone receptor (hLHR) gene mutations in Leydig Cell Hypoplasia.  Proc 77th Ann. Meet. Endocr. Soc. p. 478, 1995.

91.  Arnold LL, Wu SM, Rone J, Simons JA, Chan WY. A prospective randomized comparison of mouse embryo development during Chinese Hamster Ovary (CHO) cell co-culture: Impact of pregnancy specific b1 glycoprotein. Proc 51st Ann Meet Am Soc Reprod Med. 1995.

92.   Laue L, Wu SM, Kudo M, Hsueh AJW, Cutler GB Jr, Chan WY. Missense mutations in exons 10 and 11 of the human luteinizing hormone receptor gene cause Leydig Cell Hypoplasia. Am J Hum Genet.  57(4):A217, 1995.

93.   Laue L, Wu SM, Kudo M, Hsueh AJW, Cutler GB Jr, Bourdony CJ, Chan WY. Heterozygous mutations of the luteinizing hormone receptor gene in a patient with Leydig cell hypoplasia. Prog Abst Interna­t Congr Endocrinol 96. p.747, 1996. (podium)

94.  Blomberg LA, Rone J, Rennert OM,  Chan WY. Molecular cloning and characterization of novel embryonic genes. Pediat Res. 41(4):41A, 1997.

95.   Hallermeier K, Wu SM, Laue LL, Griffin JE, Wilson JD, Brain C, Berry AC, Grant DB, Cutler GB Jr, Chan WY. Compound heterozygous mutations of the luteinizing hormone/chorionic gonadotropin receptor gene in a family with two children affected by Leydig cell hypoplasia (LCH). Pediat Res. 41(4):67A, 1997. (podium)

96.   Martin MM, Wu SM, Martin ALA, Rennert OM, Chan WY. Constitutive activation of the hLH receptor: A proposed etiology for seminoma. Pediat Res. 41(4):70A, 1997.

97.   Flor WA, Chan WY, Rennert OM. Delayed motor and mental development in a male with an intermediate allele in the FMR-1 gene.  Pediat Res. 41(4):102A, 1997.

98.  Stratakis CA, Lin J-P, Pras E, Wu SM, Bourdony CJ, Rennert OM, Chan WY. Allgrove (Triple-A)   syndrome in Puerto Rican kindreds maps to chromosome 12 (12q13). Pediat Res. 41(4):107A, 1997.

99.  Wu SM, Jose M, Hallermeier K, Rennert OM, Chan WY. Polymorphisms in the coding exons of the human luteinizing hormone/chorio­nic gonadotropin receptor gene. Pediat Res. 41(4):109A, 1997.

100. Jose M, Wu SM, Rennert OM, Chan WY.  Expression of the LH receptor in cultured human skin fibroblasts.  Prog Abst 79th Ann Meet Endocr Soc. p. 553, 1997.

101. Wu SM, Jose M, Hallermeier K, Rennert OM, Chan WY. Polymorphisms of the coding exons of the hLH receptor.  Prog Abst 79th Ann Meet Endocr Soc. p. 553, 1997.

102.Stratakis CA, Wu SM, Bourdony CJ, Cohen D, Rennert OM, Chan WY. Hereditary isolated glucocorticoid deficiency: Description of a kindred with adrenocorticotropin (ACTH) unresponsiveness and identifi­cation of a novel mutation (P237H) of the ACTH-receptor (MC2R); absence of MC2R defects in 4 kindreds with Allgrove syndrome. Prog Abst 79th Ann Meet Endocr Soc. p. 557, 1997.

103. Wu SM, Hallermeier K, Laue L, Griffin JE, Wilson JD, Grant DB, Brain C, Berry EC, Cutler GB Jr, Chan WY.  Insertional mutation in exon 1 inactivates the LH/hCG­ receptor in a patient with Leydig Cell  Hypoplasia. Prog Abst 79th Ann Meet Endocr Soc. p. 553, 1997.

104. Martin MM, Wu SM, Martin ALA, Rennert OM, Chan WY. Malignant seminoma in a patient with a constitutive activating mutation of the hLH receptor gene. Horm Res. 48(Suppl 2):118, 1997.

105. Wu SM, Stratakis CA,  Bourdony CJ, Rennert OM, Chan WY. Molecular genetics of syndromes of Adrenocorticotropin (ACTH) resistance: Novel mutations of the ACTH receptor gene in hereditary glucocorticoid resistance patient and refinement of the Allgrove syndrome locus. Amer J Hum Genet. 61(4): A351, 1997.

106. Chan WY, Blomberg LA, Massaro GD, Massaro D. Identification of retinoic acid (RA)-induced genes in emphysematous rat lung. Amer J Resp Crit Care Med. 157(3):A433, 1998.

107. Chan WY, Blomberg LA, Massaro GD, Massaro D. Identification of differentially expressed genes involved in lung development in the rat. Amer J Resp Crit Care Med. 157(3):A547, 1998.

108. Zimmerman TN, Chan WY, Wu SM, Stratakis CA. Hereditary isolated glucocorticoid deficiency associated with Reye’s syndrome. Pediat Res. 43(4):89A, 1998. (podium).

109. Chan WY. Molecular abnormalities of LH action. . Prog Abs 80th Ann Meet Endo Soc. p. 27, 1998. (podium)

110. Wu SM, Brain C, Leschek E, Chan WY. A new mutation of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty. Prog Abs 80th Ann Meet Endocr Soc. p. 283, 1998.

111. Prakasam G, Castro-Magana M, Arguello R, Angulo M, Canas A, Kam R, Vitollo P, and Chan WY.     Hormonal profile during treatment in familial male-limited precocious puberty due to a novel heterozygous activating mutation of the LH receptor. Prog Abs 80th Ann Meet Endocr Soc. p. 283, 1998.

112. Chan WY, Blomberg LA, Massaro GD, Massaro D. Molecular cloning and characterization of two          differentially expressed genes in rat lung. Amer J Resp Crit Care Med. 159(3):A665, 1999.

113.    Massaro GD, Massaro D, Chan WY, Clerch LB, Ghyselinck N, Chambon P. Retinoids and the regulation of alveolus formation. FASEB J. 13(4):A353, 1999.

114.  Colon AR, Chan WY. The Pediatric Ishimpo. Pediat Res. 47(4):182A, 2000.

115.  Chan WY, Blomberg LA, Eckart M, Massaro D. Identification of retinoic-acid-modulated genes in        emphysematous rat lungs by subtraction hybridization. FASEB J, 15(4)A156, 2001. (podium)

116. Blomberg LA, Chan WY, Clerch L, Massaro D. Cloning and characterization of two genes                              differentially expressed during postnatal rat lung alveolus formation. FASEB J, 15(4)A164, 2001.

117.    Blomberg LA, Massaro D, Clerch L, Chan WY. Identification of a gene up-regulated in emphysematous rat lung during retinoic acid-induced alveolus regeneration and during spontaneous postnatal alveolus formation. FASEB J, 15(4)A165, 2001.

118.    Leschek EW, Jones J, Chan WY, Barnes KM, Jones JC, Cutler GB Jr. Effect of spironolactone, testolactone, and deslorelin treatment on the final height of boys with familial male-limited precocious puberty (FMPP). Lawson-Wilkens – Euro Pediat Endocr Soc Meet, 2001.

119.    Wu SM, Leschek EW, Chan WY. A novel constitutive activating mutation of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty (FMPP). Prog Abst, Endocr Soc 83rd Ann Meet, p. 567, 2001.

120.    Sandrini F, Farmakidis C, Kirschner LS, Tullio-Pelet A, Lyonnet S, Bourdony CJ, Chan WY, Stratakis CA. Spectrum of mutations of the AAAS gene and genotype-phenotype correlation in a patients with isolated resistance to corticotropin or Allgrove Syndrome. Prog Abst, Endocr Soc 83rd Ann Meet, p. 568, 2001.

121.    Abbasi V, Chan WY, Wu SM, Dowse J, Ali S. Clinical, biochemical, radiological, and genetic studies in a unique case of 46 XY gonadal dysgenesis. Pediat Res. 51(4)119A, 2002.

122.    Wu SM, Al-Muslim O, Aziz A, Inam  S, Awadh M, Rennert OM, Chan WY.  A novel mutation in TM IV of the luteinizing hormone/chorionic gonadotropin receptor in a patient with the severe form of Leydig Cell Hypoplasia. Prog Abst, Endocr Soc 84th Annu Meet, p.316, 2002.

123.    Chan WY, Chen Y, Pang LY, Li X, Su Y, Dym M, Rennert OM. Changes in germ cell gene expression during spermatogenesis in the mouse. Prog Abst, Endocr Soc 84th Annu Meet, p. 539, 2002.

124.    Wu SM, Chen Y, Baxendale V, Dym M, Rennert OM, Chan WY. Elucidation of the transcriptome of mouse pachytene spermatocyte by Serial Analysis of Gene Expression (SAGE) analysis. Prog Abst, Endocr Soc 84th Annu Meet, p. 539, 2002.

125.    Leschek EW, Chan WY, Jones J, Jones JC, Barnes KM, Cutler GB Jr. Gonadotropin-independent precocious puberty in a girl with an activating mutation of the Luteinizing Hormone Receptor (LHR). Prog Abst, Endocr Soc 84th Annu Meet, p. 483, 2002.

126.    Li X, Ravindranath N, Chan WY, Manickam P, Dym M. Microarray analysis of spermatogonial responsiveness to stem cell factor. Prog Abst, Soc Study Reprod 35th Ann Meet, p. 141, 2002.

127.    Dogulu CF, Kansu T, Baxendale V, Wu SM, Ozguc M, Chan WY, Rennert OM. Evidence for genetic susceptibility for Pseudotumor cerebri in Turkish population. Amer J Human Genet., 71(4)369, 2002.

128.    Wu SM, Baxendale V, Chen Y, Leung MYK, Ravindranath N, Dym M, Rennert OM, and Chan WY. Identification of genes differentially expressed at different stages of spermatogenesis in mice using SAGE. Prog Abst 3rd International Symposium on Differential Gene Expression, p. 33, 2002.

129.    Pang ALY, Chen Y, Su Y, Ravindranath N, Dym M, Rennert OM, and Chan WY. Identification of genes differentially expressed at different stages of spermatogenesis in mice using cDNA microarray hybridization. Prog Abst 3rd International Symposium on Differential Gene Expression, p. 25, 2002 (podium)

130.    Chan WY, Wu SM, Baxendale V, Chen Y, Li X, Leung MYK, Ravindranath N, Dym M, and Rennert OM. Functional genomics of spermatogenesis: Profile of the transcriptome of mouse germ cells. North America Testis Workshop, Society of Andrology,  March 26-29, 2003, Phenoix, AZ.

131.    Ray R, Wu SM, Sellers EAC, Dean H, Taback S, Chan WY, Chudley AE. A multi-generation French Canadian kindred with familial male-limited precocious puberty caused by a C1118T mutation in the luteinizing hormone/choriogonadotropin receptor (LHCGR) gene. Annual Clinical Genetics Meeting, American College of Medical Genetics, San Diego, CA, March 13-15, 2003.

132.    Leung MYK, Baxendale V, Leschek E, Wu SM, Fichman K, Chan WY, Rennert OM. A novel polymorphic site at the mutation hot-spot (TM VI) of the luteinizing hormone receptor in a patient with familial male-limited precocious puberty. Amer J Human Genet., 73(5):294, 2003.

133.    Vong QP, Wu SM, Dym M, Rennert OM, and Chan WY.  Dby expression and germ cell development.  Amer J Human Genet. 73(5):328, 2003.

134.    Tayebi N, Feng LX, Baxendale V, Wu SM, Pang ALY, Dym M, Chan WY, Rennert OM. Using SAGE to confirm a telomerase immortalized spermatogonial cell line as an experimental model. Amer J Human Genet. 73(5):329, 2003.

135.  Pang ALY, Johnson W, Ravindranath N, Dym M, Rennert OM, Chan WY. A survey of housekeeping

         gene expression during germ cell development. Amer J Human Genet. 73(5):429, 2003.

136.    Ravindranath N, Nalbandian A, Pang ALY, Djakiew DD, Chan WY. Identification of p75NTR-responsive genes in the human prostate cancer cells by cDNA microarray.  American Association of Cancer Research, 2004.

137.    Pang ALY, Johnson W, Rennert OM, and Chan WY. Characterization of a potential sense-antisense transcript pair that is differentially expressed in male germ cells. European Testis Workshop, Edingburgh, Scotland, 2004.

138.  Chan WY. Functional Genomics – an efficient approach to identify gene targets in cancer and development.

         4th TWGHs – CUHK Eddie Wang Symposium. (podium)

139.  Chan WY, Wu SM, and Rennert OM. Molecular genetics of human diseases caused by mutation of the LH receptor.  Beijing 2004 International Conference on Medical Genetics. Abstract book, p. 37,  2004. (podium)

140. Chan WY, Wu SM, Baxendale V, Yali Chen, Li X, Pang ALY, Leung MYK, Ravindranath N, Dym

M, Rennert OM. A global view on male fertility: gene expression profile in spermatogenesis. Society of Chinese Bioscientists in America Annual Meeting, Beijing, China, July 18-23, 2004. (podium).

141.  Chan WY, Biological implications of functional genomic studies of germ cell development. Wuhan               SCBA Satellite Workshop Abstract book, p. 13, 2004 (podium).

142.  WY Chan, SM Wu, L Ruszczyk,V Baxendale, E Law, M Dym, and OM Rennert. Anti-Sense

         Transcription Plays An Important Role in Gene Regulation During Spermatogenesis. Amer J Human

          Genet. 54th Annual Meeting Abstract Book, p. 209, 2004.

143.  ALY Pang, MM Martin, D Bellan, ALA Martin, OM  Rennert and WY Chan. Alterations of Gene

Expression Pattern in Testicular Biopsy from A Patient with DAX-1 Mutation. Amer J Human Genet 54th Annual Meeting Abst Bk, p. 298, 2004.