CHAWNSHANG CHANG; (U.S.A. Citizen)
Office
Address: 601 Elmwood Ave. Box 626, University of Rochester,
Rochester, NY 14642
(Tel:585-2759994;
Fax:585-7564133; E-Mail: chang@urmc.rochester.edu)
Education:
1974-1978 National Taiwan
University (B.S.) Agriculture
Chemistry
1978-1980 Army Chemical
School (R.O.T.C.) Nuclear Chemistry
& Biology
1980-1985 University of
Chicago (Ph.D.) Biochemistry
& Molecular Biology
1985-1988 University of
Chicago (Post Dr.) Molecular
Endocrinology
Academic
Experience:
1988-90 Assistant Professor and Director, Urology Research Labs, Dept.
of Surgery/Urology and Ben May Institute for Cancer Research, University of
Chicago, Chicago, IL
1990-00 Assistant Professor (90-93), Associate
Professor (93-96), Professor (96-97). Visiting Professor (97-00), Director,
Tissue & Blood Bank (90-97). Departments of Human Oncology and Medicine and
UW Comprehensive Cancer Center, UW-Madison, WI
1998- Visiting
Professor, Osaka University, Yokohama University, Japan; Peking University and
Xiamen Univ. ,Wuhan Univ., Tianjin Medical Univ, China
1999- Visiting
Prof., Chang Gung Univ./National Taiwan Univ./Taipei Medical Univ.
1997-02 Director,
Molecular Oncology Graduate Program. Univ. of Rochester, Rochester, NY
1997- Director,
George Whipple Laboratory for Cancer Research, Univ. of Rochester,
1997- Director,
Urology Research Center, University of Rochester, Rochester, NY
George Whipple Distinguished Professor,
Departments of Pathology, Urology and Radiation Oncology, and The Cancer
Center, University of Rochester, Rochester, NY
2000-
Founder, AndroScience Corporation. San Diego, CA.
Honors:
1988 The
Ayerst Award for Outstanding Young Endocrinologist from the Endocrine Society
1989 Andrew
Melon Award for Outstanding Young Faculty in USA from Andrew Melon Foundation
1990 Outstanding
Young Investigator Award from Cancer Research Foundation
2003
The Milheim Award for Excellence in Cancer Research
from Milheim Foundation
1992 Tokyo
Society of Medical Science and University of Tokyo Lecturer
1991-94 American
Cancer Society Junior Professorship in Cancer Research
1995-97 Blowity-Ridgeway
Award in Andrology from Blowity-Ridgeway Foundation
1991-97 CapCure Award (6 times) for Excellence
in Prostate Cancer Research
1996 Award
with Honorary Fellow from The Japan Society of Andrology (The 2nd Non-Japanese
ever awarded such honor)
1998 Scholar of the Year, The highest honor
from The Taiwanese Osteoporosis Association for Outstanding Contribution in Sex
hormones and Osteoporosis.
1998 George
Hoyt Whipple Lecture, University of Rochester, Rochester, NY
1998 Jiepimg Wu Award, for Outstanding
Achievement in Urology (The highest honor for Chinese-Urology Researcher).
Beijing, China.
1999 President
Award for Outstanding Urology Research, The highest honor from The Urology
Association of Taiwan for the Contribution in Androgen Receptor and Prostate
Cancer.
1999 Davey Memorial
Award for Outstanding Cancer Research, University of Rochester.
2000 President
Award for Outstanding Andrology Research, The highest honor from The Taiwanese
Andrology Association for the studies of Androgens and Androgen Receptor.
2001 Who’s Who
in America
2001 Dr.
S.T.Huang-Chan memorial Lecture/Award, University of Hong Kong.
2001- President Award for
Outstanding Andrology Research, The highest honor from The
Chinese Andrology Association for the studies of Androgens and Androgen
Receptor.
2002 Dr.
Chien-Tien Hsu Memorial Lecture/Award at 2002 Annual Meeting of OBGYN
Grant and Publication Review:
1.Member
of Editorial Board, Endocrine (2000-)
2.Member
of Editorial Board, The Prostate
Journal(2002)
3.Member
of Editorial Board, The Prostate(2003-)
4.Member
of Editorial Board, Neuroimmune biology
(2002)
5.Reviewer in PNAS/JBC/Mol
Endo/Cancer Research and 16
other peer-reviewed journals
6.NIH
Study Section: Ad Hoc & Regular Member at Biochemical Endocrinology &
Other Study Section (1995-2001)
7.NIH
Study Section: Ad Hoc & Regular Member at Reproductive Endocrinology (2003)
8.VA Merit Grant Oncology Study Section (1996-2002)
9.NIH
Prostate SPORE P50 Center Grant; and NIH PO1 Core Grant, NIH Research Centers
in Minority Institutes Core Grant, NIH P19 Orphan Receptor Center Grant.
10.ARMY
Breast and Prostate Cancer Grant Study Section (1999-)
11.Air
Force TCDD Grant (reviewer) (2001)
12.Medical Research Council of Canada and Dutch
Cancer Society Grant;
13.Taiwan CRC Biomedical Sciences Project and Taiwan
National Science Council Grant
14.Hong Kong Earmarked Research Grant; Italian
Association for Cancer Research
Teaching:
(all in University of Rochester)
1.Cancer
Biology (3 credit, course director)
2.Biochemistry
of Steroid Hormones
3.Current
Topic in Pathology and Oncology
4.Signal
Transduction (2 hours lecture)
5.Toxicology
(2 hours lecture)
6.Epidemiology
(2 hours lecture)
7.
Hormones and Cancer
7.Graduate
Independent Study (current 15 Ph.D. students)
Current
Research Grants: direct cost only (59% extra indirect cost for U of R)
2003-2006DOD-ARMY
Grant, Years 1-3 ($375,000), P.I.
Knockout
AR in Prostate
2003-2007NIH
RO1 Grant DK61222, Years 1-4 ($900,000), P.I.
TR2
& TR4 knock-out mice
2002-2007NIH
RO1 Grant DK60948, Years 1-5 ($875,000), P.I.
PTEN
in prostate cancer
1993-2000NIH
RO1 Grant CA103006, Years 1-3 ($600,000), P.I.
AR
in prostate -bone
2002-2006NIH
RO1 Grant DK60905, Years 1-4 ($700,000), P.I.
Induction
of AR transactivation by DHT vs E2.
2001-2005NIH
RO1 Grant DK56984, Years 1-4 ($700,000), P.I.
TR4
orphan receptor in testis & prostate
2001-2004 ARMY Prostate Research Grant
($375,000), P.I.
suppression
of AKT signal in prostate cancer.
2002-2004ARMY
Research Grant ($300,000), P.I.
PTEN
in breast cancer.
1997-2022 George Whipple Professorship
Endowment for 25 years
Previous
Research Grants: direct cost only (59% extra indirect cost for U of R)
1995-2003NIH
RO1 Grant DK47258, Year 1-8 ($1,517,400), P.I.
TR2
& TR3 orphan receptors in prostate cancer.
1997-2002NIH
RO1 Grant CA71570, Years 1-5 ($806,592), P.I.
Title:
AR coregulators in prostate carcinogenesis.
1993-2001NIH
RO1 Grant CA55639, Years 1-9 ($569,349), P.I
Title:
T vs DHT effects in prostate cancer.
1995-97Hollis-Eden
Research Award ($60,000).
Title:
DHEA-derivatives receptor.
1998-2000NIH-NCI
Research Grant Contract ($180,000), P.I.
Title:
ARA-A1B1 CAG repeat polymorphism
1998-2001ARMY
Prostate Research Grant ($486,000), Co-P.I. (PI:Harrison.
Title:
Androgen effects on LNCaP prostate cancer cell growth
1997-2001Rhone-Poulenc
Rorer Research Award ($50,000)
Title: AR Coregulators
1995-2000NIH
RO1 Grant DK51346, Years 1-5($950,815), P.I.
AR CAG polymorphism
1998-2000 NIH Training Grant ($60,000
for Drs. Young & Yeh to study in P.I.’ lab)
1999-2002CaP
CURE Research Award ($600,000), P.I.
The roles of AR in prostate
1995-1998 NIH Research Grant CA 23563 ($465,433) Co P.I.(P.I.:Verma)
1993-1997 NIH Research Grant P30 CA
14520 ($210,000), P.I.(Tissue Bank Project)
1992-1997 NIH Research Grant CA 10536 ($607,331) Co
P.I.(P.I.:Weindruch)
1996-1997 The Blowity-Ridgeway
Foundation Award ($120,000), P.I.
1996-1997 Glaxo Research Fund
($35,000), P.I.
1992-1997 Taiwan National Science
Council ($100,000 for 2 scientists studying in lab )
1990-1997 NIH Research P30 CA 14520. Co
Investigator, 30% salary support
1995-1996 UW Comprehensive Cancer
Center Award ($14,000), P.I.
1995-1996 UW Graduate School Research
Award ($10,000), P.I.
1994-1996 Triton Research Fund
($21,400), P.I.
1994-1996 UW Medical School Merit Award
($65,000), P.I.
1994-1996 Anderson Research
Fund($23,000), P.I.
1994-1995 CaP CURE Research Award
($100,000), Co P.I. (P.I.:Messing)
1994-1995 Adria Research Fund
($20,000), P.I.
1993-1994 NIH Training Grant ($40,000
for Dr. Lin to study in my lab)
1992-1994 Uehara Foundation ($20,000
for Dr. Kurada to study in my lab)
1992-1994 Shiseido Research Foundation
($35,000), P.I.
1991-1994 ACS Research Grant BE-78 and BE-78a ($314,968), P.I.
1991-1994 University of
Wisconsin Grants (4 grants for total $106,000), P.I.
1990-1993 American Cancer
Society Junior Faculty Award ($90,500)
1989-1991 Cancer Research Foundation
Young Investigator Award ($40,000)
1989-1991 Milheim Foundation Young
Investigator Award ($20,000)
1988-1991 American Cancer
Society (ACS) Research Grants ($81,415), P.I.
1988-1989
Louis Block and Coleman
Foundations ($45,000), P.I.
Patents:
1.
Androgen receptor and TR2 orphan receptor.
2.
Androgen receptor coregulators ARA70, ARA55, ARA54, ARA24, BRCA1, Rb
3. Using differential length of
androgen receptor’ and ARAs’ CAG repeat to predict prostate cancer risk in
Chinese population.
4.Cross-talk between androgen
receptor and other signal pathways (TGFb, Her2/Neu,MAPK, IL6/PI3K/AKT, PTEN,
BRCA1, RB).
5.Using Aortic endothelial cells
to screen SERMs.
6.Vitamin E as anti-prostate
cancer agent
7.Androgen receptor knock out mice
8.TR2 and TR4 knock out mice
9, Antiandrogen HF avtivates MAPK
pathway in prostate cancer.
10.Cucurmin
analogs function as antiandrogen
Membership:
1.
The Endocrine Society
2.
American Society for Biochemistry and Molecular Biology
3.
American Association for Cancer Research
3.
American Urology Association
Invited
Speaker:
I. International and National
Meetings: (Total 67 since 1988)
1.Second International Symposium on
"The Steroid/Thyroid Hormone Receptor Family
and
Gene Regulation".Stockholm, Sweden. (1988)
2.Satellite
Symposium of the 8th International Congress of Endocrinology on "Steroid
Antagonists",
Kyoto, Japan. (1988)
3.Prostate
Cancer National Symposia on "Molecular and Cellular Biology of Prostate
Cancer",
Prouts Neck, Maine. (1989)
4.Terra
Symposia on "Androgens & Antiandrogens" New Paltz, New York. (1991)
5.The
First International Symposium on "Steroid Receptor Superfamily"
UW-Madison. WI
(1992)
Symposium director.
6.First
Asian & Oceanic Congress of Andrology. Nanjing, China (1992).
7.International
Symposium on Tumor Biology. Taipei, Taiwan (1994)
8.International
Symposium on Sex Hormones and Antihormones. Milano, Italy (1994)
Chairman of the Androgen
Section.
9.American
Urological Association Summer Research Conference. Houston, Texas (1994)
10.The
American Association for Cancer Research/Taiwan Conference. Taipei, Taiwan (1994)
11.The
Second International Symposium on "Steroid Receptor Superfamily"
UW-Madison. WI
(1994)
Symposium director.
12.The
Second International Conference on Androgens. Long Beach, CA (1995)
13.Mary
Lasker Symposium on Frontiers of Cancer Research. San Diego, CA (1995)
14.The
Second Annual CaP CURE Scientific Meeting. Santa Barbara, CA (1995)
15.The
Second Symposium of Severtance Institute of Andrology, Seoul, Korea (1996)
16.The
Third Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1996)
17.The
10th International Congress of Endocrinology. SF, CA (1996)
18.National
Prostate Cancer Coalition. Houston, TX (1996)
19.The
Third International Symposium on "Steroid Receptor Superfamily"
UW-Madison. WI
(1996), Symposium director.
20.The
Fourth Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1997)
21.Golden
Conference. New England (1997)
22.The
VIth International Congress of Andrology. Salzburg, Austria (1997), Plenary
Lecture
23.Cambridge
Symposium on ”Gene Transcription and Therapeutic Interaction”. Washington
D.C.
(1997)
24.The
7th SCBA International Symposium on Hormone Action, Toronto, Canada (1997)
25.International
Symposium of “Molecular Basis of Sex Hormone Receptor Function-New
Targets
for Intervention” Berlin, Germany (1997)
26.The
International Symposium for 50th Year Urology in Yokohama City University,
Japan.
(1997), Keynote speaker.
27.The
Japan Annual Andrology Meeting. Yokohama, Japan. (1997), Keynote speaker
28.The
China Andrology Meeting, Yichong, China (1997), Keynote speaker.
29.The
Annual Endocrine Society Meeting, Minneapolis, (1997)
30.The
Fifth Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1998)
31.The
China-Japan International Urology Symposium, Shanghai, China, Keynote speaker
(1998)
32.The
Annual China Urology Meeting, Shanghai, China, Keynote speaker (1998)
33.Keystone
Symposium on “Nuclear Receptor Gene Family” (1998)
34.The
First International Chinese Urology Symposium, Shanghai, China, Keynote speaker
(1998)
35.The
Annual Taiwan Urology Meeting, Hualein, Taiwan, Keynote speaker (1999)
36.AACR
Conference on “The Steroid Receptor Superfamily” Palm Springs, CA (1999)
37.The
8th SCBA International Symposium on Hormone Action, Hong Hong (1999)
38.The
Annual Taiwanese Osteoporosis Association Meeting, Kaohsiung, Taiwan,
Keynote
speaker (1999)
39.
International Conferences on Gene Therapy and Mol. Biology & Medicine,
Grete, Greece (1999)
40.The
Sixth Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1999)
41.The
Annual Endocrine Society Meeting, San Diego, (1999)
42.The
92nd Annual Meeting of Formosan Medical Association, Taipei, (1999)
43.Golden
Conference. New England (1999)
44.North
American Taiwanese Professor Association-Southern California Chapter, Irvine,
CA (1999)
45.The
Asia-Pacific International Urology Meeting, Beijing, China, Keynote speaker
(2000)
46.17th
Meeting of the International Academy of Tumor Marker Oncology, Hong Kong (2000)
47.The
Second International Chinese Urology Symposium, Beijing, China, Keynote speaker
(2000)
48.The
Annual China Urology Meeting, Beijing, China, Keynote speaker (2000)
49.The
4th International Spinal and Muscular Atrophy Research &
Clinical Meeting. St Louis (2000)
50.The
Steroid Receptors and Cell Signal Pathways Symposium. Cincinnati, Ohio (2000)
51.The
International Scientific Summit Conference On Current Gynecology, Taipei,
Taiwan (2000)
52.
The Annual Chinese Andrology Meeting, Han-Chou, China, Keynote speaker (2001)
53.
The Annual Taiwanese Andrology Meeting, Taichung, Taiwan. Keynote speaker
(2001)
54.US-Taiwan
Global Bio/Pharm Conference. Newark, NJ (2001)
55.Annual
Meeting of Taiwanese Association of OBGYN, Taipei, Taiwan (2002)
56.The
2002 Annual Meeting of Chinese Medical Association, Taipei, Taiwan (2002)
57.The
2002 Annual Meeting of Taiwanese Urology Association, Taipei, Taiwan (2002)
58.the
3rd Conference of the Pacific Rim Society for Fertility and
Sterility, Taipei, Taiwan (2002)
59.The
2002 Annual Meeting of Chinese Urology Association, Changsha, China (2002)
60.The
12th Asia-Oceania Congress of Endocrinology, Taipei, Taiwan (2002)
61.Midwest
Taiwanese Summer Conference, Bowling Green, Ohio (2003)
62.Asia-Pacific
Conference of Aging Male Study, Taipei, Taiwan (2003)
63.Jensen
Symposium on Nuclear receptors and Endocrine Disorders, Cincinnati, Ohio (2003)
64.Taiwan
Biotechnology Symposium, Chan-Wha, taiwan (2003)
65.10th
SCBA International Synposium, Beijing, China.(2004)
66.Symposium on Anti-tumor Drug Discovery-from basic
to clinical” Taipei, Taiwan (2003)
67.The 6th US-Taiwan neuroscience
Symposium, New Orleans (2003)
II. University and Institute:
(Total 245 since 1988)
1.
McGill University, Department of Pediatrics, Montreal, Canada. (1988)
2.
Institute of Biological Chemistry Academia Sinica, Taiwan. (1988)
3.
Baylor College of Medicine, Department of Cell Biology, Houston, Texas.
(1988)
4.
Georgetown University, Department of Anatomy and Cell Biology, Washington DC.
(1988)
5.
M.D. Anderson Hospital and Tumor Institute, Section of Urology, Houston, Texas.
(1988)
6.
National Taiwan University, Department of Biological Chemistry, Taiwan. (1988)
7.
University of Chicago, Department of Madicine, Chicago, Illinois. (1988)
8.
Columbia University, Department of Urology, New York, New York. (1988)
9.
Mt. Sinai Medical School, Department of Urology, New York, New York. (1988)
10.Karolinska
Institutet, Department of Medical Nutrition, Stockholm, Sweden. (1988)
11.Case
Western Reserve University, Department of Biochemistry, Cleveland, Ohio. (1989)
12.University
of Tokyo, Department of Zoology, Tokyo, Japan. (1989)
13.Chiba
University, Department of Pharmacology, Chiba, Japan. (1989)
14.Osaka
University, Department of Madicine, Osaka, Japan. (1989)
15.University
of Chicago, Department of Surgery, Chicago, Illinois. (1989)
16.Kyushu
University, Department of Madicine, Fukuoka, Japan. (1989)
17.Institute
of Biomedical Sciences, Academia Sinica, Taiwan., (1989)
18.Northwestern
University, Department of Pharmacology, Chicago, Illinois. (1990)
19.U.
of British Columbia, Dept. of Cancer Endocrinology, Vancouver, Canada. (1990)
20.Medical
College of Wisconsin, Department of Urology, Milwalkee. Wisconsin (1990)
21.National
Cheng Kung University, Department of Urology, Tainan, Taiwan. (1990)
22.National
Chung Heing University, Institute of Genetics, Taichung, Taiwan. (1990)
23.Veterans
Hospital, Department of Urology, Taichung, Taiwan. (1990)
24.National
Taiwan University, Institute of Biochemistry, Taipei, Taiwan. (1990)
25.Eli
Lilly and Company, Indianapolis, Indiana. (1991)
26.Hybritech
Incorporated, La Jolla, California (1991)
27.W.
Alton Jones Cell Science Center, Lake Placid, New York (1991)
28.University
of Wisconsin Comprehensive Cancer Center, Madison. Wisconsin (1991)
29.Merck,
Sharpe & Dohme Research Laboratories, Rahway. New Jersey (1991)
30.Glaxo
Inc. Research Institute, Research Triangle Park, NC. (1991)
31.Tufts
University, Department of Anatomy and Cell Biology, Boston. Massachusetts
(1992)
32.Ohita
University, Department of Dermatology, Ohita. Japan (1992)
33.Shiseido
Research Center, Yokohama. Japan (1992)
34.University
of Tokyo, Depart of Dermatology, Tokyo. Japan (1992)
35.Taisho
Phamaceutical Company, Ohmia. Japan (1992)
36.Chiba
University, Department of Urology, Chiba. Japan (1992)
37.Tokyo
Medical Society, Tokyo. Japan (1992)
38.Yokohama
University, Department of Dermatology, Yokohama, Japan (1992)
39.Iwate
Medical University, Department of Biochemistry, Morioka, Japan (1992)
40.Krume
University, Department of Dermatology, Kurume. Japan (1992)
41.University
of Wisconsin, Endocrinology Program. Madison, Wisconsin (1993)
42.Pacific
Chemical Company, Seoul. Korea (1992)
43.Korea
Institute of Science and Technology, Taejon. Korea (1992)
44.National
Chi-Hua University, Institute of Life Science, Hsinchu. Taiwan (1992)
45.Veterans
General Hospital, Taipei. Taiwan (1992)
46.Institute
of Biological Chemistry, Academia Sinica, Taipei. Taiwan (1992)
47.Merck,
Sharpe & Dohme Research Laboratories, West Point, PA. (1993)
48.Marion
Merrell Dow Research Institute, Cincinnati, Ohio (1993)
49.University
of Southern Illinois, Department of Pharmacology, Springfield, Illinois (1993)
50.University
of Wisconsin, Department of Madicine. Madison, Wisconsin (1993)
51.Glaxo
Inc. Research Institute, Research Triangle Park, NC. (1993)
52.La
Jolla Cancer Research Foundation, San Diego, CA. (1993)
53.PharMingen,
San Diego, CA. (1993)
54.University
of Wisconsin, Institute on Aging. Madison, Wisconsin (1993)
55.Acracetus
Inc. Middleton, Wisconsin (1994)
56.Ohio
State University, Department of Biochemistry, Columbus, Ohio (1994)
57.University
of Southern California, Department of Biochemistry, Los Angeles, CA (1994)
58.Harvard
University, Institute on Aging, Boston, MA (1994)
59.Institute
of Zoology, Chinese Academy of Sciences, China (1994)
60.State
Key Lab of Reproductive Biology, Academia Sinica, China (1994)
61.Shanghai
Institute of Biochemistry, Academia Sinica, China (1994)
62.Fudan
University, Department of Biology, Shanghai, China (1994)
63.Shanghai
Cancer Research Center, China (1994)
64.Ther-Chiang
Madical University, Department of Biochemistry, China (1994)
65.Harbor
UCLA Medical Center, Department of Pathology, Torrance, CA (1994)
66.Panvera
Biotech. Madison, WI (1994)
67.Memorial
Sloan-Kettering Cancer Center, New York, NY (1994)
68.Yamanouchi
Pharmaceutical Company, Tsukuba, Japan (1994)
69.Tokyo
University of Agriculture, Department of Biochemistry, Tokyo, Japan (1994)
70.University
of Wisconsin, Department of Human Oncology. Madison, WI (1994)
71.Sumitimo
Chemical Company, Osaka, Japan (1994)
72.Shiseido
Research Center, Yokohama. Japan (1994)
73.University
of California-Los Angeles, Department of Obstetrics & Gynecology, CA (1994)
74.Institute
of Biomedical Sciences, Academia Sinica, Taipei (1994)
75.National
Yang-Ming Medical College, Department of Genetics, Taipei (1994)
76.U.
of Texas Medical Branch at Galveston. Dept. of Pathology, Galveston, Texas
(1994)
77.Case
Western Reserve University, Cancer Center, Cleveland, Ohio. (1994)
78.University
of Maryland, Department of Biochemistry, Baltimore, Maryland (1995)
79.Harvard
University, Dana Farber Cancer Institute, Boston, MA (1995)
80.Johns
Hopkins University, Department of Urology, Baltimore, Maryland (1995)
81.Uniformed
Services University, Department of Surgery/Urology, Baltimore, MD (1995)
82.National
Chung-Hsing University, Department of Animal Science, Taichung, Taiwan (1995)
83.National
Cheng-Kung University, Department of Biochemistry, Tainan, Taiwan (1995)
84.Chung-Shan
Madical College, Department of Nutritional Science, Taichung, Taiwan (1995)
85.Veterans
General Hospital, Department of Surgery/Urology, Taichung. Taiwan (1995)
86.National
Taiwan University, Department of Biochemistry, Taipei, Taiwan (1995)
87.Veterans
General Hospital, Institute of Madical Research, Taipei. Taiwan (1995)
88.Development
Center for Biotechnology, Taipei, Taiwan (1995)
89.University
of California-San Francisco, Department of Phamacology, SF, CA (1995)
90.New
Jersey Medical School. Department of Biochemistry, Newark, New Jewsey. (1995)
91.Tufts
University, Department of Biology, Boston. Massachusetts (1995)
92.National
Cancer Institute. Baltimore, Maryland (1995)
93.Albert
Einstein College of Medicine, Department of Molecular Pharmacology, NY (!995)
94.New
Jersey Medical School. Department of Urology, Newark, New Jewsey. (1995)
95.Mayo
Clinic, Department of Biochemistry, Rochester, MN (1995)
96.University
of Wisconsin, Department of Surgery/Urology. Madison, WI (1995)
97.Merck,
Sharpe & Dohme Research Laboratories, Rahway. New Jersey. (1995)
98.University
of Maryland, Department of Urology, Baltimore, Maryland (1995)
99.R.W.
Johnson Pharmaceutical Research Institute, Ratitan, New Jersey. (1995)
100.University
of Hamburg, Institute for Hormone Research, Hamburg, Germany. (1995)
101.University
of Wisconsin, Department of Biomolecular Chemistry. Madison, WI (1995)
102.University
of Rochester, Department of Pathology. Rochester, NY (1995)
103.Amgen
Inc. Thousand Oaks, CA (1995)
104.Yokohama
University, Department of Urology, Yokohama, Japan (1995)
105.Sumitimo
Chemical Company, Osaka, Japan (1995)
106.Ono
Pharmaceutical Co. Osaka, Japan (1995)
107.Kyushu
University, Department of Third Madicine, Fukuoka, Japan. (1995)
108.University
of Occupational and Environmental Health, Kokura, Japan. (1995)
109.University
of Hiroshima, Department of Urology, Hiroshima, Japan. (1995)
110.National
Chi-Hua University, Department of Life Science, Hsinchu. Taiwan (1995)
111.University
of Minnesota, Department of Pharmacology. Minneapolis, MN (1995)
112.National
Taiwan University, Institute of Microbiology, Taipei, Taiwan (1995)
113.Institute
of Molecular Biology, Academia Sinica, Taipei (1995)
114.Chiba
University, Department of Urology, Chiba, Japan. (1996)
115.Oregon
Health Sciences University, Endocrinology, Porland, OR. (1996)
116.Osaka
University, Department of Dermatology, Osaka, Japan. (1996)
117.Harvard
Medical School, MGH Cancer Center, Boston, MA (1996)
118.Kochi
Medical School, Department of Urology, Kochi, Japan. (1996)
119.Women's
Health Research Institute, Radnor, PA. (1996)
120.Rhone-Poulenc
Rorer Research Center, Collegeville, PA. (1996)
121.University
of Wisconsin, Department of Medicine. Madison, WI (1996)
122.U.
of British Columbia, Dept. of Cancer Endocrinology, Vancouver, Canada. (1996)
123.Harvard
Medical School, Department of Dermatology, Boston, MA (1996)
124.University
of Tokyo, Institute of Molecular & Cellular Biosciences, Tokyo, Japan
(1996)
125.University
of Washington, Department of Urology, Seattle, WA (1996)
126.Sumitomo
Cnemical Company, Environmental Health Science Lab. Osaka, Japan (1996)
127.Oregon
Region Primate Research Center, Beaverton, OR. (1996)
128.Saitama
Medical School, Department of Biochemistry, Saitama, Japan (1996)
129.Parmingen
Inc. San Diego, CA (1996)
130.National
Yang-Ming University, Department of Biochemistry, Taiwan (1996)
131.University
of Nebraska, Department of Biochemistry, Omaha, NB (1996)
132.University
of Rochester, Department of Biochemistry, Rochester, NY (1996)
133.Institute
of Biological Chemistry, Academia Sinica, Taipei (1996)
134.NYU-Mt.
Sinai Medical School, Cancer Center, New York, New York. (1996)
135.University
of Tokyo, Department of Urology, Tokyo, Japan (1996)
136.University
of Laval, Department of Physiology-Endocrinology, Quebec, Canada (1996)
137.Ligand
Pharmaceutical Co. San Diego, CA (1996)
138.Kyoto
University, Department of Urology, Kyoto, Japan (1996)
139.National
Taiwan University, Department of Urology, Taiwan (1996)
140.Northwestern
University, Department of Medicine/Endocrinology, Chicago, Illinois. (1996)
141.UCLA,
Department of Urology, LA, CA (1997)
142.Loyola
University of Chicago, Department of Molecular Biology, Chicago, Illinois
(1997)
143.University
of Wisconsin, Department of Medicine/Endocrinology, Madison, WI (1997)
144.The
Burnham Institute, San Diego, CA (1997)
145.Pfizer
Central Research, Section of Molecular Sciences, Croton, CT (1997)
146.University
of Rochester, Department of Pathology, Rochester, NY (1997)
147.Harbor-UCLA,
Department of Medicine/Endocrinology, Torrance, CA (1997)
148.Institute
of Biological Chemistry, Academia Sinica, Taipei (1997)
149.University
of Wisconsin Comprehensive Cancer Center, Madison, WI (1997)
150.Yale
University, Department of Pharmacology, New Haven, CT (1997)
151.Veterns
General Hospital, Department of Surgery/Urology, Taipei. Taiwan (1997)
152.Harvard
Medical School, Dana Faber Cancer Institute, Boston, MA (1997)
153.Sumitomo
Cnemical Company, Environmental Health Science Lab. Osaka, Japan (1998)
154.Osaka
University, Department of Urology, Osaka, Japan. (1998)
155.Univ.
of Occupational and Environmental Health, Dept of Urology Kokura, Japan.(1998)
156.University
of Hiroshima, Department of Urology, Hiroshima, Japan. (1998)
157.Kobe
University, Department of Animal Science, Kobe, Japan. (1998)
158.Bristol
Myles-Squibbe Pharmaceutical Co. Princeton NJ (1998)
159.National
Yang-Ming University, Department of Urology, Taiwan (1998)
160.Beijing
University, Institute of Urology, China (1998)
161.Rhone-Poulenc
Rorer Research Center, Collegeville, PA. (1998)
162.University
of Southern California, Department of Biochemistry, Los Angeles, CA (1998)
163.Merck,
Sharpe & Dohme Research Laboratories, Rahway. New Jersey. (1998)
164.University
of Pennsylvania, Department of Medicine/Endocrinology, PA (1998)
165.Annual
Meeting of Beijing Urology Association, Beijing, China (1998)
166.Laboratoire
de Biochimie B, Hopital Necker, The Fifth University of Paris. France (1998)
167.Burnhan
Institute/La Jolla Cancer Center, La Jolla, CA (1998)
168.Institut
des Neurosciences, The Sixth University of Paris. France (1998)
169.Schering-Plough
Research Institute, Kenilworth, NJ (1998)
170.Xiamen
University, Department of Biology, Xiamen, China (1998)
171.Iinst
Natl Sante Res Med, The University of Paris at South. France (1998)
172.Keio
University, Department of Urology, Tokyo, Japan (1999)
173.University
of Rochester, Department of Medicine/Medical Oncology, Rochester, NY (1999)
174.Yokohama
City University, Department of Urology, Yokohama, Japan (1999)
175.Snow
Brand Milk Products Co. Res. Institute of Life Sci. Tochigi Japan (1999)
176.State
University of New York at Buffalo, Department of Nutrition, Buffalo, NY (1999)
177.Shiseido
Co. Research Institute, Yokohama, Japan (1999)
178.Chang
Gung University, Department of Oncology/Medicine, Taipei, Taiwan (1999)
179.Indiana
University Cancer Center, Indianapolis, IN (1999)
180.Kaosiuang
Medical School, Department of Urology, Kaosiuang, Taiwan (1999)
181.Eli
Lilly and Company, Indianapolis, Indiana. (1999)
182.Chang
Gung University, Department of OB-GYN, Kaosiuang, Taiwan (1999)
183.Stanford
University, Department of Medicine/Endocrinology, CA (1999)
184.National
Taiwan University, Department of Urology, Taipei, Taiwan (1999)
185.UCSF,
Department of Urology, SF, CA (1999)
186.National
Cheng-Kung University, Department of Biochemistry, Tainan, Taiwan (1999)
187.Rhone-Poulenc
Rorer Research Center, Collegeville, PA. (1999)
188.National
Taiwan University, Institute of Biological Chemistry, Taipei, Taiwan (1999)
189.UC
Davis Cancer Center, Sacramento, CA (1999)
190.Kyowa
Hakko Kogyo Co-Pharmaceutical Research and Planning Dept., Tokyo, Japan (1999)
191.M.D.
Anderson Hospital and Tumor Institute, Dept. Medical Oncology, Houston, Texas.
(1999)
192.University
of Mississippi, Department of Phamacology and Toxicology, Jackson, MS. (2000)
193.University
of Southern California, Department of Pathology, Los Angeles, CA (2000)
194.Parmingen
Inc. San Diego, CA (2000)
195.National
Cancer Institute, NIH, Bethesda, MD (2000)
196.University
of North Carolina, Department of Medicinal Chemistry, Chapel Hill, NC (2000)
197.Johns
Hopkins University, Department of Biology, Baltimore, Maryland (2000)
198.Wayne
State University, Department of Pathology. Detroit, MI (2000)
199.New
York University, Department of Pathology, New York, NY (2000)
200.Beckman
Research Institute, City of Hope, Duarte, CA (2000)
201.Chang
Gung University, Department of OB-GYN, Kaosiuang, Taiwan (2000)
202.Connell
University, Department of Medicine/Endocrinology, New York, NY (2000)
203.National
Taiwan University, Department of OB-GYN, Taipei, Taiwan (2000)
204.Oregon
Regional Primate Research Center, Beaverton, OR (2001)
205.UC
Davis Cancer Center, Sacramento, CA (2001)
206.National
Taiwan University, Department of Pathology, Taipei, Taiwan (2001)
207.Univ,
of Pittsburgh, Cancer Institute. Pittsburgh. PA (2001)
208.National
Taipei Medical University, Department of Medicine, Taipei, Taiwan (2001)
209.Shanghai
Institute of Biochemistry and Cell Biology, Shanghai, China (2001)
210.National
Taiwan University, Biotechnology Seminar, Taipei, Taiwan (2001)
211.University
of Washington, Department of Pathology, Seattle (2002)
212.National
Yang Ming Medical University, Institute of Biochemistry, Taipei, Taiwan (2002)
213.Veterans
General Hospital, Department of OBGYN, Taipei. Taiwan (2002)
214.UT
Southwestern Medical School. Department of Urology. Dallas (2002)
215.National
Taiwan University, Department of Agriculture Chemistry, Taipei, Taiwan (2002)
216.University
of North Texas, Department of Biochemistry. Dallas (2002)
217.Ma-Kai
Memorial Hospital, Department of OBGYN, Taipei. Taiwan (2002)
218.UT
Health Center. Institute of Biotechnology. San Antonio (2002)
219.Baylor
College of Medicine, Department of Molecular and Cellular Biology. Houston
(2002)
220.University
of California-San Diego, Dept of Reproductive Medicine. San Diego (2003)
221.Roswell
Park Cancer Institute, Buffalo, NY (2003)
222.University
of Chicago, Dept of Medicine/Endocrinology, Chicago (2003)
223.Taipei
Medical Univ. Dept of OBGYN. Taiwan (2003)
224.University
of Wisconsin Comprehensive Cancer Center, Madison (2003)
225.University
of Southern California, Dept of Microbiology, Los Angeles, CA (2003)
226.Taipei
Veterans General Hospital, Dept. of OBGYN, Taiwan (2003)
227.Case
Western Reserve Univ. Dept of Biochemistry, Cleveland (2003)
228.Ohio
State University, Dept of Medicine Chemistry, Columbus, Ohio (2003)
229.University
of California-Los Angeles, Dept of OBGYN, Los Angeles, CA (2003)
230.Cleveland
Clinic Foundation, Dept of Tumor Biology, Cleveland, (2003)
231.TAA
at Columbus, Columbus, Ohio (2003)
232.John
Hopkins University, Dept of Biochemistry and Molecular Biology, Baltimore
(2003)
233.Cornell
University, Dept of Urology, New York, (2003)
234.TAA
at Cleveland, Cleveland, Ohio (2003)
235.NATPA
at Southern California, LA (2003)
236.TAA
at Cincinnati, Ohio (2003)
237.MD
Anderson Cancer Center, Dept of Cancer Biology, Houston, (2004)
238.TAA
at Houston, TX (2004)
239.TAA
at Chicago, Ill (2004)
240.University
North Carolina, Dept of Biochemistry, Chapel Hill, (2004)
241.TAA
at North Carolina, Raleigh, NC (2004)
PUBLICATIONS
1.
Liao S, Hiipakka RA, Schilling K, Oberhauser AK, Chang C, and Judge SM (1981) in
“Cellular dynamics of androgen receptor and protein induction in rat ventral
prostate.” Prog. Clin. Biol. Res., 75A, 381-389.
2.
Liao S, Chang
C, and Saltman AG (1983) “Androgen-receptor interaction: An overview.”
Nobel symposium, Sweden, No.57, (Eriksson H, and Gustafsson JA eds.) pp.
407-418, Elsevier Science Publishing, New York.
3.
Liao S, Witte D, Schilling K, and Chang C (1984) “The use of a
hydroxylapatite-filter steroid receptor assay method in the study of the
modulation of androgen receptor interaction.” JSBMB, 20, 11-17.
4.
Liao S, Chang
C, Witte D, Saltzman AG, and Hiipakka RA (1985) “Modulation of androgen
receptor and androgen-dependent enhancement and repression of protein
synthesis.” in Regulation of Androgen Action, (Bruchovsky N, Chapdelaine
A, and Neumann F, eds.) pp.149-154, Congressdruck R. Bruckner, Berlin.
5.
Liao S, and Chang
C (1985) “Cellular dynamics and control of androgen receptor activity.” in Interaction
of Steroid Hormone Receptors with DNA (Sluyser M, ed.) pp.190-201, Ellis
Horwood Ltd. Publishers, Chichester, England.
6.
Chang
C, Hiipakka RA, and Liao S (1986) “Spermine-binding protein
of rat ventral prostate: phosphorylation, cDNA structure, and gene expression.”
Proc. Intl. Conf. Polyam. Life Sci. 99-100.
7.
Chang
C, and Liao S (1987) “Topographic recognition of cyclic
hydrocarbons and related compounds by receptors for androgens, estrogens, and
glucocorticoids.” JSBMB., 27, 123-131.
8.
Chang
C, Saltzman AG, Hiipakka RA, Huang I-Y, and Liao S (1987)
“Prostatic spermine-binding protein: cloning and nucleotide sequence of cDNA, amino
acid sequence, and androgenic control of mRNA level.” J. Biol. Chem., 262, 2826-2831.
9.
Saltzman AG, Hiipakka RA, Chang C, and Liao S (1987) “Androgen repression of the production
of a 29 kilodalton protein and its mRNA in the rat ventral prostate.” J. Biol. Chem., 262, 1,432-437.
10.
Chang
C, Saltzman AG, Sorensen NS, Hiipakka RA, and Liao S (1987)
“Identification of glutathione S-transferase Yb1 mRNA as the
androgen-repressed mRNA by cDNA cloning and sequence analysis.” J. Biol. Chem., 262, 11901-11903.
11.
Chang
C, Kokontis J, Chang C-T, and Liao S (1987) “Cloning and
sequence analysis of the rat ventral prostate glucocorticoid receptor cDNA.” Nucleic
Acids Res., 22, 9603.
12.
Liao S, Chang
C, Sorensen NS, Chang C-T, and Hiipakka RA (1987) “Modulation of androgen
receptor activity and the effect of androgens on gene expression for specific
proteins.” in Hormonal Therapy of Prostatic Disease: Basic and Clinical
Aspects (Motta, M., and Serio, M. eds) pp. 48-62, Medicom Europe, The
Netherlands.
13.
Anderegg RJ, Carr SA, Huang I-Y, Hiipakka RA, Chang C, and Liao S (1988) “Correction
of the cDNA-derived protein sequence of prostatic spermine binding protein:
Pivotal role of tandem mass spectrometry in sequence analysis.” Biochemistry,
27, 4214-4221.
14.
Chang
C, and Liao S (1988) “Gene expression and structure analysis
of cDNA's for androgen-sensitive proteins and different forms of
steroid-receptors.” Progress in Cancer Research and Therapy. 35, 43-48.
15.
Chang
C, Kokontis J, and Liao S (1988) “Molecular cloning of human
and rat complementary DNA encoding androgen receptors.” Science, 240, 324-326.
16.
Chang
C, Kokontis J, and Liao S (1988) “Structural analysis of
complementary DNA and amino acid sequences of human and rat androgen
receptors.” Proc. Natl. Acad. Sci., 85, 7211-7215.
17.
Chang
C, and Kokontis J (1988) “Identification of a new member of
steroid receptor superfamily by cloning and sequence analysis.” BBRC,
155, 971-977.
18.
Liao S, Chang
C, Kokontis J, Popovich T, and Hiipakka RA (1989) “Structure and
intranuclear dynamics of androgen receptors.” in The Steroid/Thyroid Hormone
Receptor Family and Gene Regulation. (Gustafsson, JA., Eriksson, H. and
Carlstedt-Duke, J. eds). 83-92, Congressdruck R. Bruckner, Berlin, Burkhauser
Verlag Basel.
19.
Buttyan R, Olsson CA, Pintar J, Chang C, Bandyk M, Ng P-Y, and Sawczuk SI (1989) “Induction of the
TRPM-2 gene in cells undergoing programmed death.” MCB. 9, 3473-3481.
20.
Chang
C, Whelan CT, Popovich TC, Kokontis J, and Liao S (1989)
“Fusion proteins containing androgen receptor sequences and their use in the
production of poly- and monoclonal anti-androgen receptor antibodies.” Endocrinology,
125, 1097-1099.
21.
Chang
C, Chodak G, Sarsac E, Takeda H, and Liao S (1989) “Prostate
androgen receptor: immunohistological localization and mRNA characterization.” JSBMB.
34, 311-313.
22.
Chang
C, Lau L, Liao S, and Kokontis J (1989) “Characterization
of new members of steroid receptor
superfamily.” in The Steroid/Thyroid Hormone Receptor Family and Gene
Regulation. (Gustafsson JA, Eriksson H, and Carlstedt-Duke J eds.) 183-195,
Congressdruck R. Bruckner, Berlin, Burkhauser Verlag Basel.
23.
Chang
C Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, and Chang Y
(1989) “Molecular cloning of new human TR2 receptors: A class of steroid
receptor with multiple ligand-binding domains.” BBRC.165, 735-741.
24.
Chang
C, Kokontis J, Liao S, and Chang Y (1989) “Isolation and
characterization of human TR3 receptor: A member of steroid receptor
superfamily.” JSBMB. 34, 391-395.
25.
Chang
C, Kokontis J, Swift S, and Liao S (1990) “Molecular cloning
and structural analysis of complementary DNA of human and rat androgen
receptors.” Molecular Endocrinology and Steroid Hormone Action, 53-63.
26.
Simerly RB, Chang
C, Muramatsu M, and Swanson LW (1990) “The distribution of androgen and estrogen
receptor mRNA-containing cells in the rat brain: An in situ hybridization study.” Journal of Comparative Neurology,
294, 76-95.
27.
Sai T, Seino S, Chang
C, Trifiro M, Pinsky L, Mhatre A, Kaufman, M, Lambert B, Trapman J,
Brinkmann AO, Rosenfield RL, and Liao S (1990) “An exonic point mutation of the
androgen receptor gene in a family with complete androgen insensitivity.” American
Journal of Human Genetics, 46, 1095-1100.
28.
West NB, Chang
C, Liao S, and Brenner RM (1990) “Localization and regulation of estrogen,
progestin and androgen receptors in the seminal vesicle of the rhesus monkey.” JSBMB,
37. 11-21.
29.
Imperato-McGinley J, Ip NY, Gautier T, Neuweiler J,
Gruenspan H, Liao S, Chang C, and
Balazs I (1990) “DNA linkage analysis and studies of the androgen receptor gene
in a large kindred with complete androgen insensitivity.” American Journal
of Medical Genetics, 36, 104-108.
30.
Masai M, Sumiya H, Akimoto S, Yatani R, Chang C, Liao S, and Shimazaki J (1990) “Immunohistochemical study of
androgen receptor in benign hyperplastic and cancerous human prostates.” The
Prostate, 17, 293-300.
31.
Kranc DM, Chodak GW, and Chang C (1990) “Androgen receptor staining in heterogeneous samples
of normal, hyperplastic, and neoplastic human prostate.” Surgical Forum,41,
687-689.
32.
Takeda H, Chodak GW, Mutchnik SE, Nakamoto T, and Chang C (1990) “Immunohistochemical
localization of androgen receptors with mono-and polyclonal antibodies to
androgen receptor.” Journal of Endocrinology, 126, 17-27.
33.
Matusik RJ, Cattini PA, Leco KJ, Sheppard PC, Nickel
BE, Neubauer BL, Davie JR, Chang C,
Liao S, Matuo Y, and McKeehan WL (1991) “Regulation of gene expression in the
prostate.” in Molecular and Cellular Biology of Prostate Cancer,
299-314, Plenum, New York.
34.
Takeda H, Nakamoto T, Kokontis J, Chodak GW, and Chang C.(1991) “Autoregulation of
androgen receptor expression in rodent prostate: Immunohistochemical and in situ hybridization analysis.” BBRC,
177, 488-496.
35.
Kokontis J, Nakamoto T, and Chang C (1991) “Structural analysis and gene expression of TR2
receptor and TR3 receptor.” Molecular and Cellular Biology of Prostate
Cancer, 229-234. Plenum, New York.
36.
Takeda H, and Chang
C (1991) “Immunohistochemical and in
situ hybridization analysis of androgen receptor expression during the development
of mouse prostate gland.” Journal of Endocrinology, 129, 83-91.
37.
Trifiro M, Gottlieb B, Pinsky L, Kaufman M, Prior L,
Belsham DD, Wrogemann K, Brown CJ, Willard HF, Trapman J, Brinkmann AO, Chang C, Liao S, Sergovich F, and Jung
J (1991) “The 56/58 kDa androgen-binding protein in male genital skin
fibroblasts with a deleted androgen receptor gene.” Molecular and Cellular
Endocrinology,75, 37-47.
38.
Chang
C, Takeda H, and Kokontis J (1991) “cDNA cloning, antibody
production and immunohistochemical localization of the androgen receptor.” Molecular
and Cellular Biology of Prostate Cancer, 235-241, Plenum, New York.
39.
Mestayer C, Gabou L, Portois MC, Boucekkine C, Chang C, and Mowszowicz I.(1991)
“Expression du gene durpecepteur des androgenes chez des sujets normaux et des
patients presentant une insensibilite complete aux androgenes.” Annales
d'Endocrinologie 52, 431-434.
40.
Sanborn BM, Caston LA, Chang C, Liao S, Speller R, Porter LD, and Ku CY (1991) “Regulation
of androgen receptor mRNA in rat sertoli and peritubular cells.” Biology
Reproduction, 45, 634-641.
41.
Kokontis J, Liao S, and Chang C.(1991) “Transcriptional activation by TR3 receptor, a
member of steroid receptor superfamily.”
Receptor, 1, 261-270.
42.
Chodak GW, Kranc DM, Puy LA, Takeda H, Johnson K, and
Chang C (1992) “Nuclear localization
of androgen receptor in heterogeneous samples of normal, hyperplastic, and
neoplastic human prostate.” Journal
of Urology, 147, 798-803.
43.
Nakamoto T, Chang
C, Li A, and Chodak GW (1992) “Basic fibroblast growth factors in human
prostate cancer cells.” Cancer
Research, 52, 571-577.
44.
Prior L, Bordet S,Trifiro MA, Mhatre A, Kaufman M,
Pinsky L, Wrogeman K, Belsham DD, Pereira F, Greenberg C, Trapman J, Brinkmann
AO, Chang C, and Liao S (1992)
“Replacement of arginine 773 by cysteine or histidine in the human androgen
receptor causes complete androgen insensitivity with different receptor
phenotypes.” American Journal of Human Genetics, 51, 143-155.
45.
Gipp JJ, Chang
C, and Mulcahy RT. (1992) “Cloning and nucleotide sequence of a full-length
cDNA for human liver g glutamylcysteine synthetase.” BBRC, 185,
29-35.
46.
Leav I, Kwan PW-L, Merk FB, Chang C, and Ho S-M. (1992) “Immunohistochemical and in situ hybridization studies of
androgen receptor expression in a transplantable androgen-independent prostate
carcinoma cell line of AIT noble rats.” Laboratory Investigation, 67,
788-795.
47.
Jiang S-Y, Wolf DM, Yingling JM, Chang C, and Jordan VC. (1992) “An estrogen receptor positive MCF-7
clone that is resistant to antiestrogens and estradiol.” Molecular and
Cellular Endocrinology, 90, 77-86.
48.
Chang
C, Wang C, Deluca HF, Ross TK, and Shih CC-Y (1992)
“Characterization of an human
androgen receptor overexpressed in the baculovirus system.” Proc. Natl.
Acad. Sci., 89, 5946-5950.
49.
Kaku A, Chang
C, Tamura T, Okamoto T, and Yoshimura Y. (1993) “Immunolocalization of
androgen receptor in the cloacal gland of male Japanese quail (Coturnis
coturnix japonica).” Japanese Poultry Science, 30, 413-418.
50.
Rennie PB, Bruchovsky N, Leco KJ, Sheppard PC,
McQueen SA, Cheng H, Snoeck R, Hamel A, Bock ME, MacDonald BS, Nickel BE, Chang C, Liao S, Cattini PA, and
Matusik RJ (1993) “Characterization of two cis-acting DNA elements involved in
the androgen regulation of the probasin gene.” Mol. Endocrinology, 7,
23-36.
51.
Mowszowicz I, Lee H-J, Chen H-T, Mestayer C, Portois
M-C, Carbrol S, Mauvais-Jarvis P, and Chang
C (1993) “A point mutation in the second zinc-finger of the DNA-binding
domain of the androgen receptor gene causes complete androgen insensitivity in
two siblings with receptor-positive androgen resistance.” Mol.
Endocrinology. 7, 861-869.
52.
Lee H-J, Kokontis J, Wang K-C, and Chang C (1993) “The use of a
DNA-binding domain replacement method for the detection of a potential TR3
orphan receptor response element in the mouse mammary tumor virus long terminal
repeat.” BBRC. 194, 97-103.
53.
Yoshimura Y, Chang
C, Okamoto T, and Tamura T (1993) “Immunolocalization of androgen receptor
in the small, preovulatory and postovulatory follicles of laying hens.” General
and Comparative Endocrinology, 91, 81-89.
54.
Mowszowicz I, Lee H-J, Portois M-C, Kuttenn F, and Chang C (1993) “Complete androgen
insensitivity due to a single base substitution in exon 8 of the
steroid-binding domain of the androgen receptor.” Endocrine, 1, 203-209.
55.
Zhang Y-L, Wang C, Wilding G, and Chang C (1993) “Identification of an
androgen-induced C3-P4 DNA binding protein in the cytosol of rat ventral
prostate.” BBRC. 195, 710-716.
56.
Chang
C, Saltzman AG, Lee H, Uemura H, Su C, Chodak GW, Nakamoto T,
LeBeau M, Espinosa R, Davis E, Lemons R, Sivak L, and Shih C (1993) “Genomic
structure, chromosomal localization and expression of an inducible TR3 orphan
receptor: A member of the steroid receptor superfamily.” Endocrine, 1,
541-549.
57.
Mizuno Y, Hosoi T, Inoue S, Ikegami A, Kaneki M,
Akedo Y, Nakamura T, Ouchi Y, Chang C, and
Orimo H (1994) “Immunocytochemical
identification of androgen receptors in mouse osteoclast-like multinucleated
cells.” Calcified Tissue
International 54, 325-326.
58.
Mizokami A, Yeh S, and Chang C (1994) “Identification of 3', 5' cyclic adenosine
monophosphate response element and other
cis-acting elements in human androgen receptor gene promoter.” Mol.
Endocrinology 8, 77-88.
59.
Young W-J, Roecker EB, Weindruch R, and Chang C (1994) “Quantitation of
androgen receptor mRNA by competitive reverse transcription-polymerase chain
reaction.” Endocrine 2, 321-329.
60.
Mizokami A, and Chang
C (1994) “Induction of translation by 5'-untranslated region of human
androgen receptor mRNA.” J. Biol. Chem. 269, 25655-25659.
61.
Lustig RH, Hua P, Smith LS, Wang C, and Chang C (1994) “An in vitro model for the effects of androgen on neurons employing
androgen receptor-transfected PC12 cells.” Mol. Cel. Neuro Sciences. 5,
587-596.
62.
Chang
C, Da Silva SL, Ideta R, Lee Y-F, Yeh S, and Burbach JPH
(1994) “Human and rat TR4 orphan receptors specify a subclass of the steroid
receptor superfamily.” PNAS 91, 6040-6044.
63.
Pugh TD, Chang
C, Uemura H and Weindruch R (1994) “Prostatic localization of spontaneous
early invasive carcinoma in Lobund-Wistar rats.” Cancer Research 54,
5766-5770.
64.
Joubert Y, Tobin C, Lebart MC and Chang C (1994) “Ultrastructural
localization of androgen receptors in levator ani muscle in the rat.” Proc.
Intl. Conf. Elec. Microscopy 13, 325-326.
65.
Ideta R, Yeh S, Lee YF, Adachi K, Takeda H, Su C,
Saltzman A and Chang C (1995) “Gene
expression of the androgen repressed rat TR2 orphan receptor: a member of
steroid receptor superfamily.” Endocrine, 3, 277-283.
66.
Da Silva SL, Van Horssen AM, Chang C, and Burbach JPH (1995) “Expression of nuclear hormone
receptors in the rat supraoptic nucleus.” Endocrinology, 136, 2276-2283.
67.
Garcias-Arenas R, Lin F-F, Lin D-L, Jin L-P, Shih
C-Y, Chang C, and LinM-F “The
expression of prostatic acid phosphatase is transcriptionally regulated in
human prostate carcinoma cells.” Mol. and Cel. Endo. 111, 29-37.
68.
Chang
C, Saltzman A, Yeh S, Young W-J, Keller E, Lee H-J, Wang C,
and Mizokami A (1995) “Androgen receptors: an overview.” Critical Reviews in
Eukaryotic Gene Expression, 5(2), 97-125.
69.
Uemura H, Mizokami A, and Chang C (1995) “Identification of a new enhancer in the promoter
region of human TR3 orphan receptor gene: a member of steroid receptor
superfamily.” J. Biol. Chem. 270, 5427-5433.
70.
Lee H-J, and Chang
C (1995) “Identification of human TR2 orphan receptor response element in
the transcriptional initiation site of the Simian Virus 40 major late
promoter.” J. Biol. Chem. 270, 5434-5440.
71.
Lin T-M, Young W-J, and Chang C (1995) “Multiple functions of the TR2-11 orphan receptor in
modulating activation of two key cis-acting
elements involved in the retinoic acid signal transduction system.” J. Biol.
Chem. 270, 30121-30128.
72.
Lee H, Lee Y, Burbach P, and Chang C (1995) “Suppression of gene expression on the Simian Virus
40 major late promoter by human TR4 orphan receptor: a member of steroid
receptor superfamily.” J. Biol. Chem. 270, 30129-30133.
73.
Yuan Z, Zhang Y,
Chang C and Zhang YL (1995) “Differential regulation of glutathione
S-transferase -Yb1 mRNA levels in rat prostate, liver, and brain by androgen.” Cell
Research, 55, 235-242.
74.
Chang
C, Lin T-M, Hsiao P, Su C, Riebe J, and Lin D-L (1996)
“Androgen-responsive genes.” In: Pharmacology, Biology and Clinical
Application of Androgens. (Basin C, and Swarlorf G eds). pp. 65-71,
Wiley-Liss, Inc.
75.
Su C-Y, Chang C, and Lai C-C (1996) “Induction
of heat shock proteins by exercise.” in Pharmacology in Exercise and Sports.
(Somani SM ed), pp. 147-167, CRC Press, London.
76.
Lin T,
Lustig RH, and Chang C (1996) “The
role of androgens-androgen receptor in immune system activity.” in: The
Physiology of Immunity (Marsh JA and Kendall MD eds) pp. 263-276, CRC
Press, Boca Raton FL.
77.
Keller ET, Ershler WB, and Chang C (1996) “The androgen receptor: a mediator of diverse
responses.” Frontiers in Bioscience 1: d59-71.
78.
Yeh S, and Chang
C (1996) “Cloning and characterization of a specific coactivator, ARA70,
for the androgen receptor in human prostate cells.” Proc. Natl. Acad. Sci. 93: 5517-5521.
79.
Lee H-J, Young W-J, Shih CC-Y and Chang C (1996) “Suppression of the
human erythropoietin expression gene by the TR2 orphan receptor: a member of
steroid receptor superfamily.” J. Biol. Chem. 271, 10405-10412.
80.
Lin D-L, and Chang
C (1996) “P53 is a mediator for radiation-repressed human TR2 orphan
receptor expression in MCF-7 cells, a new pathway from tumor suppressor to
member of steroid receptor superfamily.” J. Biol. Chem. 271,
14649-14652.
81.
Lee H-J,
Mowszowicz I, and Chang C (1996)
“The first detection of complete androgen insensitivity with no mutation in the
coding sequence of the androgen receptor gene.” Frontiers in Bioscience
1: a34-38.
82.
Keller ET, Chang
C, and Ershler WB (1996) “Inhibition of NFkB activity through maintenance
of IkBa levels contributes to
dihydrotestosterone-mediated repression of the interleukin-6 promoter.” J.
Biol. Chem. 271, No.9055, 26267-26275.
83.
Yeh S, Miyamoto H, and Chang C (1997) “Hydroxyflutamide may not always be a pure
antiandrogen.” The Lancet 349, 852.
84.
Obana N, Chang
C, and Uno H (1997) “Inhibition of hair growth by testosterone in the
presence of dermal papilla cells from the frontal bald scalp of the
postpubertal stumptailed macaque.” Endocrinology, 138, 356-361.
85.
Miyamoto H, Yeh S, Kinoshita H, Fujimoto N, Nishimura
K, Inui S, Mizokami A, Uemura H, and Chang
C (1997) “Androgen receptor and androgen receptor cofactors in prostate.” Proc.
Jap. Nat. Conf. Andrology, 1-4.
86.
Yeh S, and Chang
C (1997) “The effect of androgens and 17b-estradiol
on the androgen receptor transcriptional activity in the presence of the
androgen receptor coactivator ARA70 in human prostate DU145 cells.” from: Current
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87.
Young W-J, Smith SM, and Chang C (1997) “Induction of the intronic enhancer of the human
ciliary neurotrophic factor receptor (CNTFR) a
gene by the TR4 orphan receptor.” J. Biol. Chem. 272, 3109-3116.
88.
Lee YF, Pan H-J, Burbach JPH, Morkin E, and Chang C (1997) “Identification of
direct-repeat 4 as a positive regulatory element for the human TR4 orphan
receptor: a modulator for the thyroid hormone target genes.” J. Biol. Chem.
272, 12215-12220.
89.
Yeh S, and Chang
C (1997) “ARA70, Cloning and characterization of a specific coactivator,
ARA70, for the androgen receptor in human prostate cells.” Worldwide
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90.
Lin T-M, and Chang
C (1997) “Cloning and Characterization of TDD5, an androgen target gene
that is differentially repressed by testosterone and dihydrotestosterone.” Proc.
Natl. Acad. Sci. 94, 4988-4993.
91.
Wiren KM, Zhang X, Chang C, Keenan E, and Orwoll ES (1997) “Transcriptional up-regulation of the human androgen
receptor by androgen in bone cells.” Endocrinology 138, 2291-2300.
92.
Magi-Galluzzi C, Xu X, Hlarty L, Hahnfeldt P, Kaplan
I, Hsiao P, Chang C, and Loda M
(1997) “Heterogeneity of androgen receptor content in advanced prostate
cancer.” Modern Pathology, 10, 839-845.
93.
Chang
C, and Lee H (1997)
“Identification of the human aldolase A gene as the first induced target for
the human TR2 orphan receptor: a member of the steroid hormone receptor
superfamily.” Biomed. Biophysic. Res. Commun. 235, 205-211.
94.
Schirar A, Chang
C, and Rousseau JP (1997) “Localization of androgen receptor in nitric
oxide synthase- and vasoactive intestinal peptide-containing neurons of the
major pelvic ganglion innervating the rat penis.” Journal of
Neuroendocrinology 9, 141-150.
95.
Lin M-F, Meng T-C, Roa PS, Chang C, Schonthal AH, and Lin F-F (1998) “Expression of human
prostatic acid phosphatase correlates with androgen-stimulated cell
proliferation in prostate cancer cell lines.” J. Biol. Chem. 273,
5939-5947.
96.
Uemura H, and Chang
C (1998) “Antisense TR3 orphan receptor can increase prostate cancer cell
viability with Etoposide treatment.” Endocrinology 139, 2329-2334.
97.
Lin D-L Wu S-Q, and Chang C (1998) “The genomic structure and chromosomal location of
the human TR2 orphan receptor: a member of steroid receptor superfamily.” Endocrine
8, 123-134.
98.
Lee Y-F, Young W-J, Burbach JPH, and Chang C (1998) “Negative feedback
control of the retinoid-retinoic acid/retinoid X receptor pathway by the human
TR4 orphan receptor: a member of steroid receptor superfamily.” J. Biol.
Chem. 273, 13437-13443.
99.
Yeh S, Miyamoto H, Shima H, and Chang C (1998) “From estrogen to androgen receptor: a new pathway
for sex hormone in prostate.” Proc.
Natl. Acad. Sci. 95, 5527-5532.
100. Miyamoto
H, Yeh S, Wilding G, and Chang C (1998)
“Promotion of agonist activity of antiandrogens by the androgen receptor
coactivator, ARA70, in human prostate cancer DU145 cells.” Proc. Natl. Acad.
Sci. 95, 7379-7384.
101. Huang
S-B, Burbach JPH, and Chang C,
(1998) "TR4 orphan receptor crosstalks to chicken ovalbumin upstream
protein-transcription factor and thyroid hormone receptor to induce the
transcriptional activity of the human immunodeficiency virus type-1 long
terminal repeat." Endocrine, 8, 169-175.
102. Su
C, Chong K, Dillmann W, Chang C, Owen
O, and Lai C (1998) “Constitutive
and inducible hsps70s are involved in oxidative resistance evoked by heat shock
or ethanol.” J. Mol. Cell Cardiology 30, 587-598.
103. Chong
K-Y, Lai C-C, Lilly S, Chang C, and
Su C-Y (1998) “Stable overexpression of the constitutive form of heat shock
protein 70 confers oxidative protection.” J. Mol. Cell Cardiol. 30,
599-608.
104. Miyamoto
H, Yeh S, Huang S-B, Fugimoto N, Hsiao P, Ting H, Inui S, Nishimura K, Wang C,
Uemura H, Kang H, and Chang C (1998)
“The Androgen Receptor Coregulator ARA70.” in Molecular Basis of Sex Hormone
Receptor Function (Gronemeyer H, Fugymann U and Parczyk ed) pp. 43-51,
Springer, Berlin.
105. Young
W-J, Lee Y-F, Smith SM, and Chang C (1998)
“A bi-directional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and
the ciliary neurotrophic factor (CNFT) signaling pathway.” J. Biol. Chem.
273, 20877-20885.
106. Chen
X, Zachar V, Chang C, Ebbesen P, and
Liu X (1998) “Differential
expression of Nur77 family members in human T-lymphotropic virus type
1-infected cells: transactivation of the TR3/Nur77 gene by Tax protein.” J. of Virology 72, 6902-6906.
107. Young
W-J, and Chang C (1998) “Ontogeny
and autoregulation of androgen receptor mRNA expression in the nervous system.”
Endocrine 9, 79-88.
108. Chang C, and Pan, H-J (1998) “Thyroid hormone
direct repeat 4 response element is a positive regulatory element for the human
TR2 orphan receptor, a member of the steroid receptor superfamily.” MCB.
189, 195-200.
109. Mu
X. Young W-J, Liu Y-X, Uemura H, and Chang
C (1998) “Induction of an intronic enhancer of the human ciliary
neurotrophic factor receptor (CNTFRa) gene by the TR3 orphan receptor.” Endocrine
9, 27-32.
110. Pan H-J, Wilding G, Uno H, Inui S,
Goldsmith L, Messing E, and Chang C (1998)
“Evaluation of RU58841 as an antiandrogen in prostate PC3 cells and a topical
anti-alopecia agent in the bald scalp of Stumptailed Macaques.” Endocrine
9, 39-43.
111. Yeh
S, Miyamoto H, Nishimura K, Kang H, Ludlow J, Hsiao P, Wang C, Su C, and Chang C (1998) “Retinoblastoma, a tumor
suppressor, is a coactivator for the androgen receptor in human prostate cancer
DU145 cells.” BBRC. 248, 361-367.
112. Jarrard
DF, Kinoshita H, Shi Y, Sandefur C, Hoff D, Meisner LF, Chang C, Herman JG, Isaacs WB, and Nassif N (1998) “Methylation of
the androgen receptor promoter CpG island is associated with loss of androgen
receptor expression in prostate cancer cells.” Cancer Research 58,
5310-5314.
113. Cardillo
MR, Petrangeli E, Aliotta N, Salvatori L, Ravenna L, Chang C, and Castagna G (1998) “Androgen receptors in ovarian
tumors: correlation with Oestrogen and progesterone receptors in an
immunohistochemical and semiquantitative image analysis study.” J. Exp.
Clin. Cancer Res. 17.2, 231-237.
114. Miyamoto
H, Yeh S, Lardy H, Messing E, and Chang
C (1998) “Delta5-Androstenediol is a natural hormone with androgenic
activity in human prostate cancer cells.” Proc. Natl. Acad. Sci.19,
11083-11088.
115. Cardillo
MR, Petrangeli E, Ravenna L, Salvatori L, Chang
C, DiSilverio F (1998)
“Immunohistochemical quantification and determination of Cathepsin D in
prostatic neoplasia: correlation with steroid.” Applied Immunohistochemistry
6(3), 133-139.
116. Mu
XM, Liu YX and Chang C (1998)
“Mechanism of the interaction between orphan receptor TR3 and cis-acting
element in CNTFRa gene.” Chinese J. Biochemistry and Molecular Biology
14, 484-492.
117. Kang
H-Y, Yeh S, Fujimoto N, and Chang C (1999)
“Cloning and characterization of human prostate coactivator, ARA54, a novel
protein that associates with the androgen receptor.” J. Biol. Chem. 274,
8570-8576.
118. Yeh
S, Chang H, Miyamoto H, Takatera H, Rahman M, Kang H, Thin T, Lin D, and Chang C (1999) “Differential induction
of androgen receptor transcriptional activity by selective androgen receptor
coactivators.” Keio J. of Medicine 48, 87-92.
119. Wang
C, Young W-J, and Chang C (1999)
“Androgen effects on the solubility and conformational change of androgen
receptor in baculovirus expression system.” MCB. 195, 19-23.
120. Inui,
S, Lee Y-F, Haake AR, Goldsmith LA, and Chang
C (1999) “Induction of TR4
orphan receptor by retinoic acid in human HaCaT keratinocytes.” Journal of
Investigative Dermatology 112, 426-431.
121. Heinlein
CA, Ting H-J, Yeh S, and Chang C (1999)
“Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome
proliferator-activated receptor gamma.” J. Biol. Chem. 274, 16147-16152.
122. Yeh
S, Lin H-K, Kang H-Y, Thin TH, Lin M-F, and Chang C (1999) “From HER2/Neu signal cascade to androgen receptor
and its coactivators: a novel pathway by induction of androgen target genes
through MAP kinase in prostate cancer cells.” Proc. Natl. Acad. Sci. 96,
5458-5463.
123. Lee
H-J, Lee Y-F, and Chang C (1999)
“Identification of the histamine H1 receptor gene as a differentially repressed
target of the human TR2 orphan receptor.”
MCB. 194, 199-207.
124. Lee
Y-F. Young W-J, Lin W-J, Shyr C-R, and Chang
C (1999) “Differential regulation of direct repeat 3 Vitamin D3
and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan
receptor.” J. Biol. Chem.
274, 16198-16205.
125. Hsiao
P and Chang C (1999) “Isolation and
characterization of ARA160 as an androgen receptor N-terminal associated
coactivator in human prostate cells.” J. Biol. Chem. 274, 22373-22379.
126. Hsiao
P, Lin D, Nakao K, and Chang C
(1999) “The linkage of the Kennedy’s neuron disease to ARA24, the first
identified androgen receptor poly-glutamine region-associated coactivator.” J.
Biol. Chem. 274, 20229-20234.
127. Yang
C, Yeh S, Leskov K, Odegaard E, Hsu H, Chang
C Kinsella T, Cheb D, and Boothman D (1999) “Isolation of Ku70-binding
proteins (KUBs).” Nucleic Acid Res. 27, 2165-2174.
128. Fujimoto
N, Yeh S, Kang H-Y, Inui S, Chang H-C, Mizokami A, and Chang C (1999) “Cloning and
characterization of androgen receptor coactivator, ARA55, in human prostate.” J.
Biol. Chem. 274, 8316-8321.
129. Lee
Y, Shyr C, Thin T, and Chang C
(1999) “Convergence of two repressors through heterodimer formation of androgen
receptor and TR4 orphan nuclear receptor: a new signaling pathway in the
steroid receptor superfamily.” Proc. Natl. Acad. Sci. 96, 14724-14729.
130. Shih
C, Young W, Wang C, Jin L, Ji X, Guan Q, Wang M, and Chang C (1999) “Monoclonal anti-androgen receptor antibodies:
production, characterization, and potential diagnostic applications.” MCB.
201, 131-140.
131. Kameoka
Sei, Leavitt P, Chang C, and Kuo SM (1999) “Expression of antioxidant
proteins in human intestinal Caco-2 cells treated with dietary flavonoids.” Cancer
Letters 146, 161-167.
132. Yeh
S, Kang H, Miyamoto H, Nishimura K, Chang H, Fujimoto N, Ting H, Mizokami A,
Huang K, and Chang C (1999)
“Differential induction of androgen receptor transactivation by different
androgen receptor coactivators in human prostate DU145 cells.” Endocrine
11, 195-202.
133. Chang
HC, Miyamoto H, Yeh S, Lardy H, and Chang
C (1999) “Suppression of Delta5-Androstenediol-induced AR transactivation
by selective steroids in human prostate cancer cells.” Proc. Natl. Acad.
Sci. 96, 11173-11177.
134. Pan
H, Uno H, Obana N, and Chang C (1999)
“The roles of testosterone in the growth of keratinocytes through bald frontal
dermal papilla cells.” Endocrine 11, 321-327.
135. Liu
X, Chen X, Zachar V, Chang C, and
Ebbesen P (1999) “Transcriptional activation of human TR3/nur77 gene expression
by human T-lymphotropic Virus type I Tax protein through two AP-1-like
elements.” J. of General Virology 80, 3073-3081.
136. Miyamoto
H, and Chang C (2000) “Antiandrogens
fail to block completely the androstenedione-induced mutated androgen receptor
transactivation in human prostate cancer cells.” International J. Urology
7, 32-34.
137. Inui
S, Itami S, Pan H, and Chang C (2000)
“Lack of androgen receptor transcriptional activity in human keratinocytes.” J.
Dermatological Science 23, 87-92.
138. Nishimura
K, Sampson E, Yan S, Kim E, Wang X, Uemura H, Wang C, Fujimoto N, Kang H, Yeh
S, and Chang C (2000) “Yeast two-hybrid screening of
associated proteins and characterization of mutant androgen receptors.” 329-343
in Yeast Hybrid Technologies (Zhu L and Hannon G ed). Eaton Publishing.
139. Lin D, and Chang C (2000) “Identification and characterization of an essential
cis-acting element (TR2-PACE) in the
5' promoter of human TR2 orphan nuclear receptor gene.” Endocrine 12,
89-97.
140. Hsiao
P, Thin T, Lin D, and Chang C (2000)
“Differential regulation of testosterone vs 5a-dihydrotestosterone by selective
androgen response elements.” MCB. 206, 169-175.
141. Wang
C, Young W, and Chang C (2000)
“Isolation and characterization of androgen receptor mutants with divergent
transcriptional activity in response to hydroxyflutamide.” Endocrine 12,
69-76.
142. Lee
K, Duo J, Hsiao P, and Chang C (2000)
“From androgen receptor to general transcription factor TFIIH: Identification
of cdk Activating Kinase as an AR N-terminal associated coactivator.” J.
Biol. Chem. 275, 9308-9313.
143. Hsing A, Gao Y, Wu G, Chen Y, Deng j,
Sesterhenn I, Mostofi F, and Chang C
(2000) “Polymorphic CAG/CAA repeat length in the androgen receptor gene and
prostate cancer risk: a population-based case-control study in China.” Cancer
Research 60, 5111-5116.
144. Yeh
S, Hu Y, Rahman M, Lin H, Ting H, Kang H, and Chang C (2000) “Increase of androgen-induced cell death and
androgen receptor transactivation by BRCA1 in prostate cancer cells.” Proc.
Natl. Acad. Sci. 97, 11256-11261.
145. Yeh
S, Sampson E, Lee DK, Kim E, Hsu C, Chen Y, Chang HC, Altuwaijri S, Huang K,
and Chang C (2000) “Functional
analysis of N-terminal and Ligand-binding domain of androgen receptor
coactivators in prostate cancer.” J. Formosan Medical Association 99,
885-894.
146. Schaick
H, Rosmalen J, Silva S, Chang C, and
Burbach P (2000) “Expression of the orphan receptor TR4 during brain
development of the rat.” Mol. Brain Res. 77, 104-110.
147. Mu
X, Liu Y, Collins L, Kim E, and Chang C (2000)
“The p53/Rb-mediated repression of testicular orphan receptor-2 in the rhesus
monkey with crytorchidism.” J. Biol. Chem. 275, 23877-23883.
148. Kinoshita
H, Shi Y, Sandefur C, Meisner L, Chang C,
Choon A, Reznikoff C, Bova S, Friedel A, and Jarrard D (2000) “Methylation of
the androgen receptor minimal promoter silences transcription in human prostate
cancer.” Cancer Research 60, 3623-3630.
149. Kang
HY, Lin HK, Hu YC, Yeh S, Huang
KE, and Chang C (2001) “From TGF-b signaling to androgen
action: Identification of Smad3 as an androgen receptor coregulator in prostate
cancer cells.” Proc. Natl. Acad. Sci. 98, 3018-3023.
150. Lee
DK, Duan HO, and Chang C (2001)
“Androgen receptor interacts with the positive elongation factor P-TEFb and
enhances the efficiency of transcriptional elongation.” J. Biol. Chem
276, 9978-9984.
151. Lin
H, Yeh S, Kang H, and Chang C (2001)
“Akt suppresses androgen-induced apoptosis by phosphorylatiing and inhibiting
androgen receptor.” Proc. Natl. Acad. Sci. 98, 7200-7205.
152. Heinlein
CA, and Chang C (2001) “The role of
chaperones in the nuclear translocation and transactivation of steroid
receptors.” Endocrine 14, 143-149.
153. Mantalaris
A, Panoskaltsis N, Sakai Y, Bourne P, Messing E, Chang C, and Wu D (2001) “Localization of androgen receptor
expression in human bone marrow.” J. Pathology 193, 361-366.
154. Si
M, AI-Sharafi B, Lai C, Khardori R, Chang
C, and Su C. (2001) “Gender difference in cytoprotection induced by
estrogen on female and male bovine aortic endothelial cells.” Endocrine
15, 255-262.
155. Sampson
E, Yeh S, Chang H, Tsai M, Wang X, Ting H-J, and Chang C (2001) “Identification and characterization of androgen
receptor associated coregulators in prostate cancer cells.” J. Biological
Regulation & Homeostatic Agents 15, 123-129.
156. Collins
L, Lin D, Mu X, and Chang C (2001)
“Feedback regulation between orphan nuclear receptor TR2 and human papilloma
virus type 16.” J. Biol. Chem.
276, 27316-27321.
157. Lee
HJ, Lee YF, and Chang C (2001) “TR4
orphan receptor represses the human steroid 21-hydroxylase gene expression
through the monomeric AGGTCA motif.” Biochem. Biophys. Res. Commun. 285,
1361-1368.
158. Wang
X, Yeh S, Wu G, Hsu C, Wang L, and Chang
C (2001) “Cloning and characterization of androgen receptor coregulator,
ARA267-a in prostate cancer cells.” J. Biol. Chem. 276, 40417-40423.
159. Kuo
SM, Huang CT, Blum PB, and Chang C (2001)
“Quercetin cumulatively enhances copper induction of metallothionein in
intestinal cells.” Bio.Trace
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160. Heinlein
C and Chang C (2002) “Structural and
Functional Analysis of the Androgen Receptor.” pp17-56 in Androgens and
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161.
Li M, Richter F, Chang C, Irwin RJ and Huang H.(2002)“Androgen and retinoic acid interaction in LNCaP
cells, effects on cell proliferation and expression of retinoic acid receptors
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162. Miyamoto
H, Rahman M, Takatera H, Kang H, Yeh S, Chang H, Nishimura K, Fujimoto N, and Chang C (2002) “A dominant-negative
mutant of androgen receptor coregulator, ARA54 inhibits androgen
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163. Heinlein
C and Chang C (2002) “Signal
Transduction Pathways Modulate Androgen Receptor Transcriptional Activity.” pp
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164. Schinner
S, Dellas C, Schroder M, Heinlein C, Chang
C, Fischer J and Knepel W (2002) “Repression of glucagon gene transcription
by PPARg
through inhibition of Pax6 transcriptional activity.” J. Biol. Chem.
277, 1941-1948.
165. Shyr
C, Hu YC, Kim ES, and Chang C (2002)
“Modulation of estrogen receptor-mediated transactivation by orphan receptor
TR4 in breast cancer MCF-7 cells.”
J. Biol. Chem. 277, 14622-14628.
166. Heinlein
C, Sampson E and Chang C (2002)
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167. Ting
H, Yeh S, Nishimura K, and Chang C (2002)
“Supervillin associated with androgen receptor and modulates its
transcriptional activity.” Proc Natl. Acad. Sci .99, 661-666.
168. Hsing
A, Chokkalingam A, Gao Y, Wu G, Wang X, Deng j, Cheng J, Sesterhenn I, Mostofi
F, Chiang T, Chen Y, Stanczyk F, and Chang
C (2002) “Polymorphic CAG/CAA repeat length in the A1B1/SRC-3 gene and
prostate cancer risk: a population-based case-control study.” Cancer
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169. Shyr
C, Collins L, Mu XM, Platt KA and Chang
C (2002) “Spermatogenesis and testes development are normal in mice lacking
the testicular orphan nuclear receptor-2 (TR2).” MCB. 22, 4661-4666.
170. Heinlein
C and Chang C (2002) “Nongenomic
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171. Wang
X, Yang Y, Guo X, Sampson E, Hsu CL, Tsai MY, Wu G, Guo Y and Chang C (2002) “Suppression of androgen
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ARA55 coregulator.” J. Biol.
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172. Heinlein
CA, and Chang C (2002) “Androgen
receptor coregulator: an overview.” Endocrine Review. 23, 175-200.
173. Lin
HK, Wang L, Hu YC, Altuwaijri S and Chang
C (2002) “Phosphorylation-dependent ubiquitination and degradation of AR by
Akt requires Mdm2 E3 ligase.” EMBO 21, 1-12.
174. Fu
M, Wang C, Wang J, Zhang X, sakamaki T, Yeung YG, Chang C, Hopp T, Fuqua S, Jaffray E, Hay RT, palvino JJ, Janne OA
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MEKK1-induced apoptosis without affecting in vitro sumoylation and
transrepression function.” MCB 15, 3373-3388.
175. Thin
TH, Kim E, Yeh S, Sampson ER, Chen YT, Collin L, Basavappa R, and Chang C (2002) “Mutations in the helix
3 region of the androgen receptor abrogate ARA70 promotion of 17b-estradiol-induced
androgen receptor transactivation.” J. Biol. Chem. 277, 36499-36508.
176. Hsing
A, Culig Z, Wang X, Uemura H and Chang C
(2002) “The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their
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Mechanisms, Functions and Clinical Application. (Chang C ed). Kluwer, USA.
177. Hu
YC, Shyr CR, Che S, Mu XM, Kim E and Chang
C (2002) “Suppression of estrogen receptor-mediated transcription and cell
growth by interaction with TR2 orphan receptor.” J. Biol. Chem. 277,
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178. Collins
L and Chang C (2002) “Androgens in Spermatogenesis and
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179. Lee
Y, Lee H and Chang C (2002) “Recent
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180. Sampson
E, Yeh S. Miyamoto H, Lee DK, Tsi, MY, Wang X, Hsu CL, and Chang C (2002) “Interaction
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181. Lin
HK, Hu YC, Altuwaijri S and Chang C
(2002) “Proteasome activity is required for
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nuclear translocation and interaction with coregulators in prostate cancer
cells.” J. Biol. Chem. 277, 36570-36576.
182. Lee
Y, Lin W, Huang J, Messing E, C Kuo, Wilding G, and Chang C (2002) “Activation of MAP kinase pathway by the
antiandrogen hydroxyflutamide in androgen receptor negative prostate cancer
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183. Itami
S. Inui S, Uno H, Pan H, Chang E, Takayasu S, Ye F, Imamura K, Seki T, Ideta R,
Aoki H, Adachi K, Price V, Kurata S, Collins L, Heinlein C and Chang C (2002) “Androgens in Dermatology: Hair Loss, Acne, and Other Diseases.”
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184. Heinlein
CA, and Chang C (2002) “The roles of
AR and androgen binding proteins in nongenomic androgen actions.” Mol. Endo.
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185. Yeh
S, Tsai MY, Xu Q, Mu X, lardy H, Huang KE, Lin H, Yeh SD, Altuwaijrl S, Zhou X,
Xing L, Boyce B, Hung MC, Zhang S, Gan L and Chang C (2002) “Generation and characterization of androgen
receptor knockout (ARKO) mice: an in vivo
model for the study of androgen functions in selective tissues.” Proc Natl.
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186. Ohtsu
H, Ishida J, Nagai M, Wang H, Itokawa H, Su C, Shih C, Chiang T, Chang E, Lee
Y, Tsai M, Chang C and Lee K (2002)
“Antitumor agents 217. Curcumin analogues as novel androgen receptor
antagonists with potential as anti-prostate cancer agents.” J. of Medicinal
Chemistry 45, 5037-5042.
187. Shih
C, Chang E, Zhang Y, Lai C, Su C, Chen Y, Chang H, Chiang T and Chang C (2002) “The use of a flow
cytometry analysis in the study of different expression of androgen receptor in
human prostate cancer LNCaP and PC-3 cells.” New Taipei Journal of Medicine
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H, Huang KE, Chang S, Ma WL, Lin
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receptor-mediated transactivation by Smad3 and tumor suppressor Smad4." J. Biol. Chem. 277, 43749-43756.
189. Lin
J, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH and Chang C (2003) “Suppression of hepatitis B virus core promoter by
the nuclear orphan receptor TR4.” J. Biol. Chem. 278, 9353-9360.
190. Yang
Y, Wang X, Dong T, Kim E, Lin WJ and Chang
C (2003) “Identification of a novel TR4 orphan receptor associated protein
(TRA16) as repressor for the selective suppression of TR4-mediated
transactivation.” J. Biol. Chem. 278, 7709-7717.
191. Lee
DK and Chang C (2003) “Molecular
communication between androgen receptor and general transcription machinery.” JSBMB 84, 41-49.
192. Thin
TH, Kim E, Basavappa R, and Chang C
(2003) “Isolation and characterization of androgen receptor mutant, AR(M749L),
with hypersensitivity to the 17-beta estradiol treatment.” J. Biol. Chem.
278, 7699-7708.
193. Rahman
MM, Miyamoto H, Takatera H, Yeh S, Altuwaijri S and Chang C (2003) “Reducing the agonist activity of antiandrogens by a
dominant-negative androgen receptor coregulator ARA70 mutant in prostate cancer
cells.” J. Biol. Chem. 278, 19619-19626.
194. Rahman
MM, Miyamoto H, Kan PY, Lardy H and Chang
C (2003) “Inactivation of androgen receptor (AR) coregulator ARA55 leads to
an inhibition of AR transactivation and a reduction of the agonist activity of
antiandrogens in prostate cancer cells." Proc Natl. Acad. Sci. 100, 5124-5129
195. Lee
DK, Li M and Chang C (2003) “The
second largest subunit of RNA polymerase II interacts with and enhances
transactivation of androgen receptor.” BBRC 302, 162-169.
196. Miyamoto H, Marwah P, Lardy H and Chang C (2003) "3b-Acetoxyandrost-1,5-diene-17-ethylene
ketal functions as a potent antiandrogen with marginal agonist activity." Proc
Natl. Acad. Sci. 100, 4440-4444.
197. Yang
L, Lin HK, Altuwaijri S, Xie S and Chang
C (2003) “APPL suppresses androgen receptor transactivation via
potentiating Akt activity.” J. Biol. Chem. 278, 16820-16827.
198. Hsu
CL, Yeh S, Chen YL, Ting HJ, Hu YC, Hank L, Wang X and Chang C (2003) “The use of phase display technique for the
isolation of androgen receptor interacting peptides with F/WXXLF/W and FXXLY
new signature motifs.” J. Biol. Chem. 278, 23691-23698.
199. Mu
X, and Chang C. (2003) “TR3 orphan
nuclear receptor mediates apoptosis through up-regulating E2F1 in human
prostate cancer LNCaP cells” J. Biol. Chem. 278, 42840-42845.
200. Kim
E, Xie S, Lee YF, Collins L, Hu YC, Shyr CR, Mu XM, Liu NC, Chen YT, Wang PH,
and Chang C (2003) “ApoE-TR4 orphan
nuclear receptor induces the expression of liver apolipoprotein E/C-I/C-II gene
cluster via hepatic control region.” J. Biol. Chem. 278, 46919-46926
201. Lee
HJ, Sampson ER, Hsu CL, Chen YT and Chang
C (2003) “Androgen receptor.” pp 87-101 in Molecular mechanisms of
action of steroid receptors (Marija and Costas Demonacos ed). Research
Signpost, India.
202. Chey
WY, Chang CH, Pan H, Chang C, Kim
BK, Park IS and Chang TM (2003) “Evidence on the presence of secretin cells in
the gastric antral and oxyntic mucosa.” Regulatory Peptides 111,
183-190.
203. Yang
L, Wang L, Lin HK, Kan P, Xie S, Tsai MY, Wang PH, Chen YT and Chang C (2003) “Interleukin-6
differentially regulates androgen receptor transavtivation via PI3K-Akt, STAT3
and MAPK three distinct signal pathways in prostate cancer cells.” BBRC.
305, 462-469.
204. Lee
H, and Chang C (2003) “Recent
advances in the androgen receptor action.” Cellular and Molecular Life
Sciences. 60, 1613-1622.
205. Inui,
S, Lee Y, Chang E, Shyr CR and Chang C (2003) “Differential and bidirectional
regulation between TR2/TR4 orphan nuclear receptors and a specific ligand
mediated-peroxisome proliferator-activated receptor a
(PPARa)
in human HaCaT keratinocytes.” J. of Dermatology Science 31:65-71.
206. Mu
X and Chang C (2003) “TR2 orphan
receptor functions as negative modulator for androgen receptor in prostate
cancer cells PC-3.” The Prostate. 57, 129-133.
207. Heinlein
CA, and Chang C (2003) “Induction and Repression of Peroxisome
Proliferator-Activated Receptor alpha (PPARa)
Transcription by the Coregulator
ARA70.” Endocrine 21, 139-146.
208. Cai
Y, Dai T, Ao Y, Konishi T, chuang KH, Lue Y, Chang C and Wan Y (2003) “Cytochrome P450 gene are differentially
expressed in female and male hepatocyte retinoid X receptor a-deficient mice.” Endocrinology
144, 2311-2318.
209. Kang
HY, Tsai MY, Chang C and Huang KE
(2003) “Mechanisms and clinical relevance of androgens and androgen receptor
action.” Chang Gung Medical J. 26, 388-402.
210. Lee
DK and Chang C. (2003) “Expression
and Degradation of Androgen Receptor: Mechanism and Clinical Implication.” Journal
of Clinical and Metabolism of Endocrinology. 88, 4043-4954
211. Nishimura
K, Ting HJ, Harada Y, Tokizane T, Nonomura N, Kang HY, Chang HC, Yeh S, Shin M,
AozasaK, Okuyama A and Chang C (2003)
“Modulation of androgen receptor transactivation by gelsolin: A new identified
AR coregulator” Cancer Research. 63, 4888-4894.
212. Altuwaijri
S, Lin HK, Chuang KH, Yeh S, Hanchett L, Zhang Y, Tsai MT, Yang L, and Chang C (2003) “Interruption of NFkB
Signaling by Androgen Receptor Facilitates TPA-induce apoptosis in an Androgen
Sensitive Prostate Cancer Cell Line.” Cancer Research. 63, 7106-7112.
213. Fu
M, rao M, Wang C, sakamaki T, Wang J, Vizio DD, Zhang X, Albanese C, Balk S, Chang C. Fan S, Rosen E, Palvimo J,
Janne O, Muratoglu S, Avantaggiati ML and Pestell RG (2003) “Acetylation of
androgen receptor enhances coactivator binding and promotes prostate cancer
cell growth.” MCB. 23, 8563-8573.
214. Yeh
S, Hu YC, Wang PH, Xie C. Xu Q, Zhou X, Tsai MY, Dong Z, and Chang C. (2003) “Abnormal mammary gland
development and growth retardation in breast cancer MCF7 cells and female mice
lacking androgen receptor.” J.
Experimental Medicine 198, 1899-1908.
215. Ohtsu
H, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee YF, Chen YT, Chang C, and Lee, KH. (2003) “Antitumor
Agents 222. Synthesis and Anti-androgen Activity of New Diarylheptanoids.” Bioorg
Med Chem. 17, 5083-5090.
216. Lin
H, Hu W, Yang L, Altuwaijri S, Chen YT Kang HY and Chang C (2003) “Suppression vs induction of androgen receptor by
the PI3K/Akt pathway in prostate cancer LNCaP cells with different passage
numbers.” J. Biol. Chem 19, 50902-50907.
217. Miyamoto
H, Rahman MM and Chang C (2004)
“Molecular basis for the antiandrogen withdrawal symdrome” J. Cellular
Biochemistry. 1, 3-12.
218. Collins
L, Lee H, Chen YT, Yeh S and Chang C. (2004) "Androgen receptor
in spermatogenesis” Cytogenetic and Genome Research in press
219. Zhang
Y, Yang Y, Yeh S and Chang C. (2004)
“ARA67 functions as a repressor to suppress androgen receptor transactivation.”
MCB. 24, 1044-1057.
220. Hu
YC, Wang PH, Hu YC, Yeh S, Xie C, Zhou X, Xu Q, Chao HT, Tsai MY, and Chang C. (2004) “Reduced fertility and
defective ovulation in female mice lacking androgen receptor.” Proc Natl. Acad. Sci. In press.
221. Yang
L, Yeh SD, Xie S, Altuwaijri S, Ni J, Hu YC, Chen YT, Bao BY, Su CH and Chang C (2004) “Androgen suppresses PML protein expression in
prostate cancer CWR22R cells” BBRC in press
222. Heinlein
CA, and Chang C (2004) “Androgen
receptor in prostate cancer.” Endocrine Review. In press
223. Rahman
M, Miyamoto H, and Chang C. (2004)
“Androgen Receptor Coregulators in Prostate Cancer Progression: Mechanisms and
Clinical Implications.” Clinical Cancer Research. In press.
224. Collins
L, Lee YF, Lin WJ, Heinlein CA, Liu NC, Chen YT, Chen Y, Shyr CR, Meshul CK,
Uno H, Chou S, Platt KA and Chang C (2004)
“Growth retardation and abnormal female maternity in mice lacking testicular
orphan nuclear receptor 4” Proc
Natl. Acad. Sci. In press
225. Wang
L, Hsu CL, Ni J, Wang PH, Yeh S, Ken P and Chang
C. (2004) “Human checkpoint protein hRad9 functions as a negative
coregulator to repress androgen receptor transactivation in prostate cancer
cells” MCB. In press.
226. Miyamoto
H and Chang C. (2004) “Androgen
Deprivation Therapy for Prostate Cancer: Current Status and Future Prospects.”
The Prostate. In press.
227. Chang C, Chen
YT, Yeh SD, Xu Q, Guillou F, and Yeh S. (2004) “Infertility with defective
spermatogenesis and hypotestosteronemia in mice lacking androgen receptor in
Sertoli cells.” Proc Natl. Acad. Sci. In press
228. Xie
S, Lin HK, Ni J, Wang L, Yang L, di Sant’Agnese PA, and Chang C. (2004) “Regulation of interleukin-6 mediated P13K
activation and neurendocrine diffrentiation by androgen signaling in prostate
cancer LNCaP cells.” The Prostate.
In press
229. Litvinov
I, Chang C and Isaacs J. (2004) “Molecular characterization of commonly-used
human androgen receptor expression vector, pSG5-AR” The Prostate. In press.
230. Wang
L, Lin HK, Hu YC, Mu X, Xie S, and Chang
C. (2004) “Glycogen Synthase Kinase 3b
Negatively Regulates Androgen Receptor-Dependent Transcription and Cell
Growth.” JBC. In press.
231. Lin
H, Hu W, Lee K, and Chang C (2004)
“Suppression of androgen receptor transactivation by PTEN tumor suppressor via
protein degradation and nuclear translocation.” Cancer Research
submitted.
232. Lin
H, Xu Q, Yeh S and Chang C (2004)
“Insulin resistance with obesity in aging mice lacking androgen receptor” MCB
Submitted.
233. Tsai
MY, Yeh SD, Yeh S, Xu Q, Zhou X, Lin H, Chiang HS, and Chang C. (2004) “Normal Spermatogenesis and Fertility in Germ
Cell-Specific Androgen Receptor Knockout Mice.” Endocrinology.
Submitted.
234. Collins
L, Lee YF, Lin WJ, Heinlein CA, Liu NC, Chen YT, Chen Y, Shyr CR, Meshul CK,
Uno H, Chou S, Platt KA and Chang C (2004)
“Priapism with reduced fertility in mice lacking testicular orphan nuclear
receptor 4” Proc Natl. Acad. Sci. Submitted.
235. Mu
X, Liu NC, Chen YT, Collins L, Kim E, Shyr CR, Lee YF and Chang C. (2004) “Target inactivation of TR4 orphan receptor delays
and disrupts late meiotic prophase and subsequent meiotic divisions of
spermatogenesis” MCB. Submitted
236. Lin
J, Lee YF, Li J, Ou JH, Chuang KH, Altuwaijri S and Chang C
(2004) “Androgen receptor represses hepatitis B virus core promoter via
interaction with nuclear receptors TR4 and androgen receptor.” Hematology Submitted
237. Yang
L, Xie S, Altuwaijri S, Ni J, Hu YC, Bao B, and Chang C. (2004) “Induction of androgen receptor gene expression by
PI3K/Akt downstream substracts, FKHRL1 and their roles in prostate cancer LNCaP
cell apoptosis.”JBC. Submitted.
238. Mu
X, Liu Y, Shyr CR, Kim E, Hu YC, Liu NC and Chang C. (2004) “Androgen-induced receptor TR4 is Involved in Attachment of Round Spermatids
to Sertoli Cells in Rhesus Monkey and Mice.” Development. Submitted
239. LeeDK,
Altuwaijri S, Yang Z, Xu Q, Tsai MY, Yeh S and Chang C. (2004) “Androgen receptor regulates expression of skeletal
muscle specific proteins and muscle cell types.” Endocrinology. Submitted.
240. Liu
Y, Shyr CR, Kim E, Hu YC, Liu NC and Chang
C. (2004) “Reduced viability with hypoglycemia via down regulatation of
PEPCK in the newborn and young mice lacking TR4 orphan nuclear receptor” Nature
Medicine. Submitted
241. Hu
YC, Yeh S, Yeh SD, Sampson E, Li
P, Hsu CL, Ting H, Lin H, Wang L,
Kim E and Chang C (2004) “Functional
Domain and Motif analyses of androgen receptor coregulator ARA70 and its
differential expression in prostate cancer.” JBC Submitted
242. Chuang
KH, Lee YF, Lin WJ, Wan Y and Chang C
(2004) “Mutual regulation and interaction between androgen receptor and
retinoid X receptor.” MCB
Submitted
243. Kim
ES, Inui S, Lin D, and Chang C (2004)
“Induction of Bcl-2 gene expression by the human TR4 orphan nuclear receptor; a
new pathway from nuclear hormone receptor to apoptosis modulator.” J. Biol.
Chem. Submitted.
244. Lee
Y, and Chang C (2004) “Modulation of
the retinoic acid-induced cell apoptosis and differentiation by the human TR4
orphan receptor.” J. Biol. Chem. Submitted
245. Young
W, Collins L, and Chang C (2004)
“Stage-specific expression of the TR2 orphan receptor during male germ cell
development.” Endocrine Submitted.
246. Chang C.
(2004) “Functional Analysis the MAP Kinase Target Sites on Androgen Receptor.”JBC.
Submitted.
247. Si
M, Lai C, Khardori R, Su C, and Chang C
(2004) “Differential suppression of estrogen-induced oxidative resistance by
4-hydroxy-tamoxifen and raloxifene in bovine aortic endothelial cells.” J.
Biol. Chem. submitted.
248. Su
CY, Miyamoto H, Russell B, Lai CC, Chang E, Lin WJ, Yan L, Altuwaijri S, Chen
YT, Lee, KH, Shih C, and Chang C.
(2004) “Identification of Curcumin analogue JC-15 as a powerful antiandrogen to
suppress androgen receptor-mediated prostate cancer growth.” Submitted.
249. Kim
E, and Chang C. (2004) “Regulation
of Apolipoprotein E Expression by TR4 Orphan Receptor via 5’ Proximal Promoter
Region.” Endocrinology Submitted.
(Abstracts are also available upon requested