Dolores J. Lamb, Ph.D.

Professor of Urology and Molecular and Cellular Biology
Scott Department of Urology
Baylor College of Medicine
One Baylor Plaza Rm N730
Houston, Texas  77030

Phone:  713-798-6266
Fax:  713-798-5577
email: dlamb@bcm.tmc.edu

I. GENERAL BIOGRAPHICAL INFORMATION

Education:

1. Undergraduate:

Molloy College 1970-1974

1000 Hempstead Avenue

Rockville Centre, NY 11530

Bachelor of Science, 1974 (Highest Honors in Biology)

Supervisor: S. Justine Jones, O.P., Ph.D.

2. Graduate Education:

1. Graduate:

Adelphi University, Garden City, NY 11570

Research Assistantship in Biology 1974-1976

Master of Science 1976

Thesis Title: “Maternal Responses to the Fetal Allograft”

Supervisor: John K. Hampton, Jr., Ph.D.

2. Doctoral:

The University of Texas Health Science Center at Houston 1976-1980

Program in Reproductive Biology

Houston, TX 77025

Graduate Assistantship in Reproductive Biology, Department of Reproductive 1976-1978

Medicine and Biology, The University of Texas Health Science Center, Houston,

TX

NIH Predoctoral Trainee in Reproductive Biology, Department of Reproductive 1978-1980

Medicine and Biology, The University of Texas Health Science Center, Houston,

TX

Doctor of Philosophy: 06/1980

Dissertation Title: “An Investigation into the Molecular Mechanisms of

Androgen Action in the Sertoli Cell”

Supervisor: Barbara M. Sanborn, Ph.D.

3. Postgraduate Training:

NIH Postdoctoral Fellow in Reproductive Biology, Department of Reproductive

Medicine and Biology, The University of Texas Medical School, Houston, TX 1980-1981

NIH-NRSA Postdoctoral Fellow, Department of Cell Biology, Baylor College of

Medicine, Houston, TX 1981-1983

Academic Appointments:

1. Current Faculty Positions at BCM:

Director, Laboratory for Male Reproductive Research and Testing, Scott 1987-Present

Department of Urology, Baylor College of Medicine, Houston, TX

Professor of Urology (Tenured), Scott Department of Urology, 2003-Present

Baylor College of Medicine, Houston, TX

Professor of Molecular and Cellular Biology (Tenured),Department of Molecular 2003-Present

and Cellular Biology, Baylor College of Medicine, Houston, TX

Director, Special Procedures Laboratory, Scott Department of Urology,

Baylor College of Medicine, Houston, TX 2002-Present

Associate Professor of Urology (Tenured), Scott Department of Urology, 1995-2003

Baylor College of Medicine, Houston, TX

Associate Professor of Molecular and Cellular Biology (Tenured), 1996-2003

Department of Molecular and Cellular Biology, Baylor College of

Medicine, Houston, TX

2. Previous Faculty Position(s) at Other Institutions: Not Applicable

3. Courtesy Faculty Appointment(s) at Other Institutions While at BCM: Not Applicable

Other Advanced Training/Experience:

1. Formal Sabbatic Leave: Not Applicable

2. Other Specialized Training Following Academic Appointment:

“Review of Clinical Chemistry for Practicing Pathologists and Clinical Chemists.” 1988

Sponsored by The National Registry in Clinical Chemistry, Greenville, NC

“Course on Micromanipulation.” Eastern Virginia Medical School, Norfolk, VA 1994

“Media Training.” Ketchum Public Relations, New York City, NY 1996

Other Information:

1. Honors or Awards:

American Society for Reproductive Medicine, First Prize Paper, Society for Male 1974

Reproduction/Urology (Niederberger et al)

Tissue Culture Association, Texas Branch, Student award for best paper presented 1980

Gordon Research Conference Travel Award 1980

Gordon Research Conference Travel Award 1982

American Fertility Society First Prize Paper in Urology 1987

Outstanding Young Women of America 1987

American Fertility Society, First Prize Video 1991

American Fertility Society, First Prize Paper in Urology 1992

American Urological Association, South Central Section, Essay Prize (O’Halloren) 1993

American Society of Andrology, Journal of Andrology Prize Paper, Second 1994

Runner-Up (Shubhada et al)

CaP Cure Award for Prostate Cancer Research 1994

CaP Cure Award for Prostate Cancer Research 1995

American Urological Association Bruce Stewart Memorial Lecturer at the 2003

59^th Annual Meeting of the American Society for Reproductive Medicine

2. Board Eligibility/Certification:

Certified as a Clinical Chemist by The National Registry in Clinical Chemistry (License #2089)

Certified as a High Complexity Clinical Laboratory Director by the American Board of Bioanalysts (License #6502)

3. Other Non-Academic Positions: Not Applicable

II. RESEARCH INFORMATION

A. Research Support:

1. Genetic Basis of Male Infertility

2. National Institutes of Health, National Institute of Child Health and Human Development

3. Program Project Director

4. 2000-2005

5. $747,867; $3,763,625

6. P01HD36289-03

1. Androgen Receptor Mutations in Advanced Prostate Cancer

2. National Institutes of Health, National Cancer Institute

3. Principal Investigator

4. 1996-2001 (Competitive Renewal Pending [2004-2008])

5. $243,695; $1,361,838

6. Public Health Service Grant 1-R01-CA68615

1. Urological Research Career Development Program

2. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

3. Co-Director

4. 1999-2004

5. $72,694; $654,246

6. K12DK02632-01

1. Urological Research Career Development Program

2. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

3. Director

4. 1999-2004

5. $26,905; $274,745

6. T32DK07763-01 (Competitive Renewal Pending Review)

1. Regenerative Stem Cells and Male Infertility

2. National Institutes of Health, National Institute of Child Health and Human Development

3. Principal Investigator

4. 2003-2008 Pending

5. $250,000, $1,671,800

6. R01 HD42664-01, Pending

1. Transgenic Mutations Affecting Sex Determination and Fertility

2. National Institutes of Health, National Institute of Child Health and Human Development

3. Investigator (Colin Bishop, Ph.D., PI)

4. 2002-2007

5. $ 676,536, $3,591,819

6. 1 U01 HD43421-01

1. Baylor Center for Reproductive Research

2. National Institutes of Health, National Institute of Child Health and Human Development

3. Investigator/Co-Project Leader (Bert W. O’Malley, M.D., Director)

4. 2004-2009

5.

6. 2 U54 HD007495-31

B. National Scientific Participation:

1. Journal Editorial Boards:

Journal of Andrology 1992-1995, 2000-2003

Fertility and Sterility 1993-1996

Urology 1996-2004

Biology of Reproduction 1997-2002

Journal of Urology, Investigative Urology Section 2001-2004

Human Reproduction, Associate Editor 2003-Present

Steroids 2003-Present

Journal Editorial Boards – Ad Hoc Reviewer:

Journal of Steroid Biochemistry 1984-Present

Endocrinology 1984-Present

Fertility and Sterility 1986-Present

Molecular Endocrinology 1988-Present

Journal of Clinical Endocrinology and Metabolism 1998-Present

Journal of Andrology 1989-Present

Clinical Chemistry 1989-Present

Investigative Urology 1990-Present

Journal of Urology 1990-Present

Molecular and Cellular Neurosciences 1990-Present

Journal of Andrology 1992-Present

Endocrine 1995-Present

Steroids 1997

The Society for the Study of Basic Urological Research Essay Contest 1997-2001

Urology 2000-Present

2. Review Panels – Ad Hoc Reviewer:

National Science Foundation – Grants 1990

National Institutes of Health, Reproductive Biology Study Section 1993

Ontario Ministry of Health – Grants 1995

Visions of Tomorrow – Grants 1995

Stanford University School of Medicine – Grants 1997

Canadian Cystic Fibrosis Foundation – Grants 1998, 2000

Canadian Physician Services 2001-2003

National Institutes of Health, Biochemical Endocrinology Study Section 2003

Full Review Panels – Reviewer:

National Institutes of Health, Interstitial Cystitis Study Section 1994

American Foundation of Urologic Disease 1995-2001

National Institutes of Health, P50 Population Center Grant Site Visit Team, 1996

Chapel Hill, NC

National Institutes of Health Endocrinology Fellowship Study Section 1996-1997

National Institutes of Health, Reproductive Endocrinology Study Section 1997-2001

Special Review Panel 2003

Medical Research Council of Canada – Grants 1999, 2001

American Cancer Society, Baylor College of Medicine Junior Investigators 1999-2001

American Society for Reproductive Medicine – Research Grant Awards 2000-2001

American Institute for Cancer Research – Molecular Biology Panel II 2000-2002

National Institutes of Health Center Council, Environmental Health Sciences

Review Committee, National Institute of Environmental Health Sciences 2000-2004

(NIEHS)

National Institutes of Health, Child Health and Human Development, Program

Project Grant 2000

National Institutes of Health, National Institute of Environmental Health Sciences,

Program Grant (Chair) 2000

National Institutes of Health, National Institute of Kidney and Digestive Disease,

Mentored Scientist Grant (Chair) 2000

National Institute of Environmental Health Sciences (NIEHS), Special Emphasis 2001

Panel

National Institute of Environmental Health Sciences (NIEHS), P50 Site Visit Review 2001

United States Department of Defense

Prostate Cancer Grant Review Committee (Molecular Genetics) 1998-1999, 2001-2002

Prostate Cancer Consortium Grant Review Committee 2002

Breast Cancer Grant Review Committee (Molecular Genetics) 2001

Ovarian Cancer Center Grant Review Committee 2001-2002

Breast Cancer Concept Grant Review Committee 2003

National Institute of Environmental Health Sciences (NIEHS), Training Grants Panels 2001

California Cancer Research Program, Prostate and Ovarian Cancer Review 2002

National Institute of Environmental Health Sciences (NIEHS), P50 Site Visit Panels (42) 2002-2003

National Institutes of Health, Male-Site: Contraceptive Clinical Trials (NICHD) 2003

National Institutes of Health, P40 Animal Model and Animal and Biological Materials 2003

Resources Grants (NCRR)

National Institutes of Health, P30 Site Visits (NIEHS)

Mount Desert Island Marine Biological Laboratory, Bar Harbor Maine

Wayne State University School of Medicine, Institute of Environmental Sciences 2003

Veterans Administration REAP (Research Excellence in Prostate Cancer), University 2002-2003

of Iowa School of Medicine

National Institutes Health, ZRG1 Endocrinology (02) 2002-2003

Consultant:

National Institutes of Health, HIV in Semen Consensus Conference, Co-Chair 1996

Centers for Disease Control, Workshop on Medical Monitoring at 09/23-24/1997

Bunker Hill Presentation on Lead Effects on Male Reproduction

National Institutes of Health, Prostate Cancer Workshop in Molecular 09/17-18/1998

National Institute of Child Health and Human Development

“Genetic Basis of Male Infertility”

“Microassisted Fertilization and Genetic Defects”

Special Symposium to the Internal Advisory Committee, NICHD, 04/25/2001

American Urological Association, Search Committee for Director, 2001

Office of Research

VA Research Enhancement Program in Prostate Cancer, Iowa City, Iowa 2002-2003

c. Professional Societies:

The Society for the Study of Basic Urological Research Executive Committee 1986-Present

Member-at-Large 1990-1994

President Elect 1997-1998

President 1998-1999

Past President 2000

Program Committee

New Orleans, LA 1990

Rochester, MN 1991

San Antonio, TX 1993

San Francisco, CA 1994

San Diego, CA 1998

Program Chair for Annual Meeting 1993, 1998

Nominating Committee 1993-1995

Chair of Nominating Committee 1999

Finance Committee 1994-1999

Industrial Relations Committee 1996-1999

Advocacy Committee 1998-1999

Executive Planning Committee

Washington, DC 1990

Houston, TX 1993

New Orleans, LA 1997

Monterey, CA 1997

The American Society for Reproductive Medicine (American Fertility Society) 1992-2000

Urology/Male Reproduction Executive Committee

President-Elect, Affiliated Society for Male Reproduction/Urology (SMRU) 1992-1999

President, Affiliated Society for Male Reproduction/Urology (SMRU) 1997

SMRU Appointee to the CDC Board for Development of Guidelines

for Assisted Reproductive Techniques and Andrology.

ASRM Board of Directors (SMRU Representative) 1997

SMRU Past President 1998

Postgraduate Course Chair (SMRU) 1999

Postgraduate Course Co-Chair (SMRU) 2002

ASRM Research Career Development Committee 1999-2001

Abstract Review Committee 2003

American Society of Andrology 1978-Present

Executive Council 1993-2001

Secretary 1998-2001

Chairman, Program Committee 1997

Program Committee 2002-2003

Postgraduate Course Committee 1995

Women in Andrology, President, Past President 1997-2000

Society for the Study of Reproduction 1981-Present

Program Committee 1998-2001

The Endocrine Society 1977-Present

Chairman, Endocrine Disruptor Task Force 1998

Media Relations Committee 2000-2003

Abstract Review Committee 2001-2002

Women in Endocrinology 1979-Present

Executive Council, Nominating Committee 2001-2002

Chair, Communications Committee 2002-2004

The American Society for the Advancement of Science 2000

Tissue Culture Association, Texas Branch 1976-1982

The American Chemical Society 1988-Present

The American Association for Clinical Chemistry 1988-Present

American Association of Tissue Banks 1996-2002

Reproductive Council 1996-Present

Program Committee 1999-2001

The American Society for Cell Biology 1984-Present

Congressional Liaison Committee Member, 2001-Present

Joint Steering Committee for Public Policy

New York Academy of Sciences

American Urological Association 1994-Present

Chairman, Office of Continuing Education, Summer Basic Research

Conference of Male Reproductive Biology 1997

American Urological Association Research Committee

Search Committee for Director, Office of Research 2001

Ad Hoc Member for NIH Institute Directors Meeting 1997

Research Funding Initiatives 1998-2001

Member, Research Priorities Group 2003-2004

Office of Continuing Education, Summer Basic Research Conference on Prostate 2003

Growth in Benign and Malignant Disease (Program Committee)

Society for the Study of Male Reproduction, Treasurer 2002-2004

American Foundation of Urologic Disease

NIH Research Priorities 1997-2001

Research Scholar Review Panel 1997-Present

The American Association of Bioanalysts 1991-Present

Test Writer’s Committee (Director Certification), Andrology 1999, 2001

Licensing Examination Test Writer Committee, Molecular Diagnosis 2001-2002

Frontiers in Reproductive Biology: Reproductive Genetics, Genomics, and Proteomics 2001

Chairman (Scott Conrad, Co-Chair)

4. Invited Lectures, Presentations, Research Seminars: (National, International)

1. “RNA Synthetic Activities in the Cellular Elements of the Testis.” The University of Texas Medical School, Department of Reproductive Medicine and Biology, Houston, TX, 1979.

2. “Androgen Action in the Sertoli Cell.” Dartmouth Medical School, Department of Physiology, Hanover, NH, 1980.

3. “Specificity and Dose-Dependence of Testosterone Stimulation of Sertoli Cell RNA Polymerase II Activity In Vitro.” The Tissue Culture Association, Texas Branch, Houston, TX, 1980.

4. “An Investigation Into the Molecular Mechanisms of Androgen Action in the Sertoli Cell.” University of Texas Graduate School of Biomedical Sciences, Houston, TX, 1980.

5. “Temporal and Quantitative Correlations Between Nuclear Androgen Binding and Stimulation of RNA Polymerase II Activity in Sertoli Cells.” Reproductive Biology Seminar, Baylor College of Medicine, Department of Cell Biology, Houston, TX, 1981.

6. “Purification of Rabbit Uterine Progesterone Receptor by Hydrophobic and Affinity Chromatography.” The National Institute of Environmental Health Sciences, Research Triangle Park, NC, 1982.

7. “Purification of a Progesterone Receptor from Rabbit Uterus.” Gordon Research Conference on the Mammalian Genital Tract, Wolfeboro, NH, 1982.

8. “Heterogeneous DNA-binding Forms of the Rabbit Progesterone Receptor.” University of Florida Medical School, Department of Physiology, Gainesville, FL, 1984.

9. “Subunit Structure of the Rabbit Progesterone Receptor.” University of Indiana Medical School, Department of Physiology, Indianapolis, IN, 1984.

10. “Evidence for a Single Steroid-Binding Subunit of the Rabbit Uterine Progesterone Receptor.” University of Pennsylvania Medical School, Department of Obstetrics and Gynecology, Philadelphia, PA, 1984.

11. “The Rabbit Uterine Progesterone Receptor is Composed of a Single Subunit.” The Population Council, Center for Biomedical Research, New York City, NY, 1985.

12. “Growth Regulatory Factors Secreted by Rat Sertoli Cells In Vitro.” University of Texas School of Medicine, Department of Obstetrics and Gynecology and Reproductive Biology, Houston, TX, 1989.

13. “Mechanisms of Androgen Regulated Growth in Tumors of the Male Reproductive Tract.” Baylor College of Medicine, Molecular Carcinogenesis Workshop, Houston, TX, 1989.

14. “Growth Factors and Oncogenes in Genitourinary Tumors.” University of Texas, M.D. Anderson Tumor Center, Department of Urology, Houston, TX, 1990.

15. “Steroid Regulated Growth of Male Reproductive Tumors.” University of Texas, M.D. Anderson Tumor Center, Department of Urology, Houston, TX, 1990.

16. “Regulatory Factors Secreted by Cultured Rat Sertoli Cells.” The Population Council, New York, NY, November, 1990.

17. “Micromanipulation of Oligoteratospermia.” American Fertility Society, Round Table, New Orleans, LA, 1992.

18. “Andrology Laboratory Certification Requirements for the Practicing Urologist.” Society for the Study of Male Reproduction/Urology, Montreal, Quebec, Canada, 1993.

19. “Growth Factors, Oncogenes, and Testicular Development and Function.” Department of Urology, Mount Sinai School of Medicine, New York, NY, 1994.

20. “Growth Related Genes and the Regulation of Spermatogenesis.” Department of Molecular Biology and Biochemistry, The Mayo Clinic, Rochester, MN, 1994.

21. “Androgen Receptor Mutations in Advanced Prostate Cancer.” Ligand Pharmaceutical, San Diego, CA, 1995.

22. “Paracrine Regulation of Spermatogenesis.” Colorado State University Veterinary School, Fort Collins, CO, 1995.

23. “Androgen Receptor Mutations in Advanced Prostate Cancer.” Wayne State University School of Medicine, Detroit, MI, 1995.

24. “Androgen Receptor Mutations in Advanced Prostate Cancer.” CaP Cure Research Retreat, Santa Barbara, CA, 1995.

25. “Reproductive Rescue of Human Male Infertility Using Gamete Micromanipulation.” Visiting Professor, University of Iowa School of Medicine, Department of Urology, Iowa City, IA, 1996.

26. “Androgen Receptor Mutations in Advanced Prostate Cancer.” Visiting Professor, University of Iowa School of Medicine, Department of Urology, Iowa City, IA, 1996.

27. “Androgen Receptor Mutations in Advanced Prostate Cancer.” CaP Cure Scientific Retreat, Lake Tahoe, NV, 1996.

28. “Androgen Receptor Mutations in Advanced Prostate Cancer.” Genitourinary/Head and Neck Oncology Service Research Conference, Sloan-Kettering Cancer Center, New York, NY, 1996.

29. “Androgen Receptor Mutations in Prostate Cancer.” Sloan-Kettering Cancer Center, Department of Urology, New York, NY, 1996.

30. “Androgen Receptor Mutation and Progression of Prostate Cancer.” Merck Research Labs, Rahway, NJ, 1997.

31. “Research Tools for the Molecular Endocrinologist.” Duchesne Academy, Houston, TX, March 1998.

32. “Genetic Control of Sexual Development.” Andrology Postgraduate Course, San Diego, CA, , March 1998.

33. “Endocrine Disruptors and Male Infertility: Are Men at Serious Risk?” Wichita State University Life Sciences Forum, Wichita, Kansas, March 1998.

34. “Genetic Control of Sexual Development.” Andrology Postgraduate Course, San Diego, CA, March 1998.

35. “Androgen Receptor Mutations in Advanced Prostate Cancer.” Visiting Professor, University of South Florida, Department of Pathology, Tampa, FL, November 1999.

36. “Microassisted Fertilization and Genetic Defects.” University of Hawaii School of Medicine, Honolulu, HI, August 7, 2001.

37. “Round Spermatid Nucleus Injection (ROSNI) Should not be Offered to Male Infertility Patients at this Time.” 34^th Annual Postgraduate Program, American Society for Reproductive Medicine, Orlando, FL, October 20-21, 2001.

38. “Male Infertility and the New Genetics.” 34^th Annual Postgraduate Program, American Society for Reproductive Medicine, Orlando, FL, October 20-21, 2001.

39. “Libido.” 34^th Annual Postgraduate Program, American Society for Reproductive Medicine, Orlando, FL, October 20-21, 2001.

40. “Male Infertility and the New Genetics.” American Society for Reproductive Medicine, Orlando, FL, October 20-21, 2001.

41. “Microassisted Fertilization and Genetic Defects.” The Population Council, Rockefeller University, New York, NY, January 10, 2002.

42. “Microassisted Fertilization and Genetic Defects.” North Shore University Hospital, Manhasset, NY, March 5, 2002.

43. “Genetic Screening and ICSI.” 58^th Annual Meeting of the American Society for Reproductive Medicine, Orlando, FL, October 15, 2002.

44. “Semen Analysis in the 21^st Century.” 59^th Annual Meeting of the American Society for Reproductive Medicine, Seattle, WA, October, 15, 2002.

45. “Tests of Sperm Function.” American Association of Bioanalysts Board Review, Chicago, IL, April 4-5, 2003.

46. “Types of Abnormalities in ART: Consent/Follow-up Issues. Evidenced Based Assisted Reproductive Technologies.” Sponsored by the National Institute of Child Health and Human Development, National Institutes of Health. The Food and Drug Administration and the Centers for Disease Control, September 18-19, 2002.

47. “Male Infertility.” Endocrine Grand Rounds, Baylor College of Medicine, Houston, TX, October 3, 2002.

48. “Animal Models of Male Reproductive Defects.” American Society of Reproductive Medicine, Male Reproductive Genetics and Toxicology – Nature and Nurture Postgraduate Course, Seattle, WA, October 12-13, 2002.

49. “New Research Advances in Genetic Male Infertility – What Does the Future Hold?” American Society for Reproductive Medicine, Male Reproductive Genetics and Toxicology- Nature and Nurture Postgraduate Course, Seattle, WA, October 12-13, 2002.

50. “ICSI and the Oligospermic or Azoospermic Male: Genetic Consequences.” American Society for Reproductive Medicine, Male Reproductive Genetics and Toxicology – Nature and Nurture Postgraduate Course, Seattle, WA, October 12-13, 2002.

51. “Primer on Molecular Biology Techniques in the Evaluation of Genetic Aberrations.” American Society for Reproductive Medicine, Male Reproductive Genetics and Toxicology – Nature and Nurture Postgraduate Course, Seattle, WA, October 12-13, 2002

52. Postgraduate Course Co-Chair, Male Reproductive Genetics and Toxicology – Nature and Nurture, American Society for Reproductive Medicine, Developed in Cooperation with the Society for Male Reproduction and Urology, Seattle, WA, October 12, 2002.

53. “Semen Analysis in the 21^st Century: What Does the Future Hold?” Symposium Speaker, American Society for Reproductive Medicine, Society for Male Reproduction and Urology, Seattle, WA, October 15, 2002.

54. “Genetic Screening and ICSI.” Roundtable Luncheon, 58^th Annual Meeting of the American Society for Reproductive Medicine, Seattle, WA, October 15, 2002.

55. “Genetic Causes of Male and Female Infertility.” American Association of Bioanalysts Board Review, Chicago, IL, April 4-5, 2003.

56. “Male Fertility: A View from the Clinical Andrology Laboratory.” Society for the Study of Reproduction, Cincinnatti, OH, July 19-22, 2003.

57. “Androgen and Prostate Gland Growth.” American Urological Association, Office of Continuing Education, Prostate Grwoth in Benign and Malignant Diseaes, Houston, TX, August 1-3, 2003.

58. “The New Genetics of Male Infertility in the Era of ICSI.” American Urological Association Bruce Stewart Memorial Lecture, Presented at the 59^th Annual Meeting of the American Society for Reproductive Medicine, San Antonio, TX, October 13, 2003.

C. Publications:

1. Full Papers:

a. Published in Referred Journals:

1. Lamb DJ, Tsai YH, Steinberger A, Sanborn BM: Sertoli cell nuclear transcriptional activity: Stimulation by FSH and testosterone. Endocrinology 108:1020-1026, 1981.

2. Lamb DJ, Steinberger A, Sanborn BM: Temporal and quantitative correlations between nuclear androgen binding and stimulation of RNA polymerase II activity in Sertoli cells. Endocrin Res Comm 8:263-272, 1981.

3. Lamb DJ, Kessler MJ, Shewach DS, Steinberger A, Sanborn BM: Characterization of Sertoli cell RNA synthetic activities in vitro at selected times during sexual maturation. Biol Reprod 27:374-382, 1982.

4. Lamb DJ, Wagle JR, Tsai YH, Lee AL, Steinberger A, Sanborn BM: Specificity and nature of the rapid steroid-stimulated increase in Sertoli cell nuclear RNA polymerase activity. J Steroid Biochem 16:653-659, 1982.

5. Lamb DJ, Holmes SD, Smith RG, Bullock DW: Purification of a progesterone receptor from rabbit uterus. Biochem Biophys Res Comm 108:1131-1135, 1982.

6. Lamb DJ, Bullock DW: Hydrophobic interaction chromatography of the rabbit uterine progesterone receptor. J Steroid Biochem 19:1039-1045, 1983.

7. Lamb DJ, Bullock DW: Heterogeneous DNA-binding forms of the rabbit uterine progesterone receptor. Endocrinology 114:1833-1840, 1984.

8. Lamb DJ, Kima P, Bullock DW: Evidence for a single steroid-binding protein in the rabbit progesterone receptor. Biochemistry pp 6319-6324, 1986.

9. Lamb DJ, Kima PE, Bullock DW: Occurrence of a 6S intermediate form of the progesterone receptor that is sensitive to ribonuclease. Molec Cell Biochem pp 77-84, 1987.

10. Bullock DW, Lamb DJ, Rider VC, Kima PE: The rabbit progesterone receptor and uteroglobin gene expression. Adv Exp Med Biol 230:79-97, 1987.

11. Lamb DJ, Bullock DW, Hoyte RM, Hochberg RB: Delta⁹-[16-alpha]-¹²⁵-iodo-19-nortestosterone: A gamma-emitting photoaffinity label for the progesterone receptor. Endocrinology 122:1923-1932, 1988.

12. Buch JP, Smith RG, Lipshultz LI, Lamb DJ: Human Sertoli cells secrete a potent growth factor. Fertil Steril 49:658-665, 1988.

13. Liu B, Harrell R, Lamb DJ, Dresden M, Spira M: The growth of human fibroblasts and A431 epidermoid carcinoma cells on gamma irradiated human amnion collagen substrata. Experentia 45:1002-1006, 1989.

14. Nowak RA, Wang MW, Hannon MF, Lamb DJ, Bullock DW, Heap RB: The effect of passive immunization against progesterone on the distribution of bound and unbound progesterone in circulation and tissues. J Reprod Fertil 89:671-679, 1990.

15. Bern EMJJ, Schuurmans ALG, Bolt J, Lamb DJ, Foekens JA, Mulder E: Antiproliferative effects of Suramin on androgen responsive tumour cells. Eur J Cancer 26:470-474, 1990.

16. Johnson AR, Smith RG, Bassham B, Lipshultz LI, Lamb DJ: The micro-SPA: Development of a miniaturized sperm penetration assay for oligospermic males. Fertil Steril 56:528-534, 1991.

17. Lamb DJ, Spotts GS, Shubhada S, Baker KR: Partial characterization of a unique mitogenic activity secreted by rat Sertoli cells. Molec Cell Endocrinol 79:1-12, 1991.

18. Lamb DJ: Growth factors and testicular development. Invited review. J Urol 150:583-592, 1993.

19. Lamb DJ, Shubhada S: Tyrphostins inhibit Sertoli cell secreted growth factor (SCSGF) stimulation of A431 cell growth. Rec Prog Horm Res 48:511-519, 1993.

20. Sankararaman S, Baker KR, Baker S, Lamb DJ: Sertoli cell secreted growth factor: Cellular origin, paracrine and endocrine regulation of secretion. J Androl 14:99-109, 1993.

21. Lipshultz LI, Lamb DJ, Glinz M, Scully NF: Tests of sperm function for evaluation of the male: Penetrak and Tru-Trax. Fertil Steril 60:319-323, 1993.

22. Lipshultz LI, Lipshultz LI, Lamb DJ: A neural network to predict fertility potential. Fertil Steril 60:324-330, 1993.

23. Lamb DJ, Sankararaman S, Lee SK: Sertoli cell secretion of a factor which inhibits the incorporation of ³H-thymidine into cells in vitro. J Androl 15:110-116, 1994.

24. Lamb DJ, Sankararaman S, Baker K, Lee SK: Sertoli cell conditioned medium effects nucleoside utilization in vitro. J Androl 15:117-124, 1994.

25. Ross LS, Cho Y, Pursell S, Rizvi S, Glinz M, Maislos S, Kim S, Lipshultz LI, Lamb DJ: Genetic regulation of spermatogenesis. Mol Androl 6:270-280, 1995.

26. Lipshultz LI, Ross LS, Lipshultz LI, Lamb DJ, Golden R: Artificial intelligence: The new frontier of fertility data analysis. Int J Androl 7:57-68, 1995.

27. Lipshultz LI, Ross LS, Cho Y, Pursell S, Rizvi S, Lipshultz LI, Glinz M, Maislos S, Kim S, Lamb DJ: In situ hybridization analysis of the expression of the immediate early gene, nur-77, in mouse and human spermatogenesis. Int J Androl 7:57-68, 1995.

28. Johnson AJ, Bassham B, Lipshultz LI, Lamb DJ: A quality control system for the optimized SPA. Fertil Steril 64:832-837, 1995.

29. Shubhada S, Soli P, Lamb DJ: Mechanism of growth inhibition of the androgen responsive DDT₁MF-2 cell line by glucocorticoids: The role of ornithine decarboxylase. Endocrin J 3:493-495, 1995.

30. Lamb DJ, Ray M: Steroid-regulated growth of DDT₁-MF-2 cells is profoundly influenced by culture conditions. In Vitro Cell Dev Biol, 1995.

31. Lamb DJ, Lipshultz LI: New statistical techniques that predict medical outcomes. Adv Urol 9:407-425, 1996.

32. Sutherland RW, Wiener JS, Hicks JP, Marcelli M, Gonzales ET Jr, Roth DR, Lamb DJ: Androgen receptor gene mutations are rarely associated with isolated penile hypospadias. J Urol 156:828-831, 1996.

33. Qin Y, Lamb DJ, Golden RM, Lipshultz LI: A neural network predicts mortality and new metastases in patients with renal cancer. Comp Med, 1996.

34. Vereb M, Agulnik AI, Houston JT, Lipshultz LI, Lamb DJ, Bishop CE: Absence of DAZ gene mutations in cases of non-obstructed azoospermia. Molec Human Reprod 3:55-59, 1997.

35. Wiener JS, Teague RL, Roth DR, Gonzales ET Jr, Lamb DJ: Molecular biology and function of the androgen receptor in genital development. J Urol 157:1377-1386, 1997.

36. Wiener JS, Lamb DJ: New concepts in sexual differentiation. Contemp Urol 9:43-62, 1997.

37. Niederberger C, Agulnik AI, Cho Y, Lamb DJ, Bishop CE: In situ hybridization shows that Dazla expression in mouse testis is restricted to premeiotic stages IV-VI of spermatogenesis. Mammalian Gen 8:277-278, 1997.

38. Lin WW, Lamb DJ, Wheeler TM, Abrams J, Lipshultz LI, Kim ED: Apoptotic frequency is increased with spermatogenic maturation arrest and hypospermatogenesis states. J Urol 158(5):1791-1793, 1997.

39. Hood L, Belldegrun A, Lange P, Witte O, Lamb DJ: Symposium – Urology in the 21^st Century: The challenge of molecular biology, the coming revolution in Urology. Contemp Urol 9:33-50, 1997.

40. Hood L, Belldegrun A, Lange P, Witte O, Lamb DJ: Symposium – Urology in the 21^st Century: Preparing for the urologic revolution. Contemp Urol 9:39-58 (July) 1997.

41. Lamb DJ: Hormonal disruptors and male infertility: Are men at serious risk? Regulatory Toxicology and Pharmacology 26:30-33, 1997.

42. Klein KA, Reiter RE, Redula J, Moradi H, Zhu XL, Brothman AR, Lamb DJ, Marcelli M, Belldegrun A, Witte ON, Sawyers CL: Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nature Med 3:402-408, 1997.

43. Tripp BM, Kolon TF, Bishop C, Lipshultz LI, Lamb DJ: Intracytoplasmic sperm injection and the potential transmission of genetic disease. JAMA 277:963-964, 1997.

44. Lin WW, Lamb DJ, Wheeler TM, Lipshultz LI, Kim ED: In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis. Fertil Steril 68(6):1065-1069, 1997.

45. Orejuela F, Lipshultz LI, Lamb DJ: Debate about sperm count deadline: The reanalysis of global trends in reported human sperm counts by Swan et al. Environ Health Perspect 105:1228-1232, 1997.

46. Kolon TF, Lamb DJ: Gene transcription and expression. Contemp Urol 10:42-67, 1998.

47. Wiener JS, Marcelli M, Gonzales ET Jr, Roth DR, Lamb DJ: Androgen receptor gene alterations are not associated with isolated cryptorchidism. J Urol 160:863-865, 1998.

48. Kim ED, Bischoff FZ, Lipshultz LI, Lamb DJ: Genetic concerns for the subfertile male in the era of ICSI. Prenat Diagn 18:1349-1365, 1998.

49. Orejuela F, Lamb DJ: Debate about sperm count decline. Environ Health Perspect 106(8):A370-A371-1, 1998.

50. Lin WW, Lamb DJ, Wheeler TM, Lipshultz LI, Kim ED: Absence of cyclic AMP-responsive element modulator expression at the spermatocyte arrest stage. Fertil Steril 69:533-538, 1998.

51. Ben-Jonathan N, Cooper RL, Foster P, Hughes CL, Hoyer PB, Klotz D, Kohn M, Lamb DJ, Stancel GM: An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults. Environ Health Perspect 107(4):605-611, 1999.

52. Ropiquet F, Giri D, Lamb DJ, Ittmann M: FGF7 and FGF2 are increased in benign prostatic hyperplasia and are associated with increased proliferation. J Urol 162:595-599, 1999.

53. Huang WJ, Lamb DJ, Kim ED, de Lara J, Lin WW, Lipshultz LI, Bischoff FZ: Germ-cell nondisjunction in testes biopsies of men with idiopathic infertility. Am J Hum Genet 64:1638-1645, 1999.

54. Pisarska MD, Casson PR, Cisneros PL, Lamb DJ, Lipshultz LI, Buster JE, Carson SA: Fertilization after standard in vitro fertilization versus intracytoplasmic sperm injection in subfertile males using sibling oocytes. Fertil Steril 71(4):627-632, 1999.

55. Lamb DJ: Debate: Is ICSI a genetic time bomb? Yes. J Androl 20(1):23-33, 1999.

56. Kolon TF, Wiener JS, Lewitton M, Roth DR, Gonzales ET Jr, Lamb DJ: Analysis of homeobox gene H0XA10 mutations in cryptorchidism. J Urol 161(1):275-280, 1999.

57. Chan DW, Kelley CA, Ratliff TL, D’Agostino D, Ritchey J, Lamb DJ, Beck J, Lott N, Wener MH, Daum P, Henkin RE, Kaske DN, Golightly DW, McBride J, Layco G, et al: Analytical and clinical performance characteristics of Hybritech’s Tandem-R free PSA assay during a large multicenter clinical trial to determine the clinical utility of percentage of free prostate-specific antigen. Clin Chem 45:1863-1865, 1999.

58. Lin WW, Lamb DJ, Lipshultz LI, Kim ED: The role of autosomal cell apoptosis regulator genes in human spermatogenesis. Int J Urol Nephrol 31:237-246, 1999.

59. Lin WW, Lamb DJ, Lipshultz LI, Kim ED: Demonstration of testicular apoptosis in human male infertility states using a DNA laddering technique. Int J Urol Nephrol 31(3):361-370, 1999.

60. Lamb DJ, Schlegel PN: Bioethics and law forum. J Androl 20(4):454-455, 1999.

61. Nazareth LV, Stenoien DL, Bingman III, WE, James AJ, Wu C, Zhang Y, Edwards DP, Marcelli M, Lamb DJ, Weigel NJ: A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1. Mol Endocrinol 13(12):2065-2075, 1999.

62. Elliott SP, Orejuela F, Hirsch IH, Lipshultz LI, Lamb DJ, Kim ED: Testis biopsy findings in the spinal cord injured patient. J Urol 163(3):792-795, 2000.

63. Marcelli M, Ittmann M, Mariani S, Sutherland R, Nigam R, Zhao Y, DeConcini D, Puxeddu, E, Esen A, Eastham, J, Weigel NL, Lamb DJ: Androgen receptor mutations in prostate cancer. Cancer Res 60(4):944-949, 2000.

64. Gvakharia M, Lipshultz LI, Lamb DJ: Human sperm microinjection into hamster oocytes: A new tool for training and evaluation of technical proficiency of intracytoplasmic sperm injection. Fertil Steril 73(2):395-401, 2000.

65. Lamb DJ, Lipshultz LI: Male infertility: Recent advances and a look towards the future. Curr Opin Urol (Anniversary Issue) 10:359-362, 2000.

66. Cozzolino DJ, Lamb DJ: Germ cell transplantation: The potential treatment of severe testicular failure. Current Science: Current Urology Reports 1(4):262-265, 2000.

67. Schatte EC, Orejuela FJ, Lipshultz LI, Kim ED, Lamb DJ: Treatment of infertility due to anejaculation in the male with intracytoplasmic sperm injection and electroejaculation. J Urol 163(6):1717-1720, 2000.

68. Lamb DJ: The crucial need for dependable PSA assays in the laboratory. Am Clin Lab 19:6, 2000.

69. Cozzolino DJ, Lamb DJ: Are endocrine disruptors a cause of male reproductive defects? Contemp Urol 12(11):69-78, 2000.

70. Burger M, Sikka SC, Bivalacqua TJ, Lamb DJ, Hellstrom WJ: The effect of sildenafil on human sperm motion and function from normal and infertile men. Int J Impot Res 12(4):229-34, 2000.

71. Lamb DJ: The clinical and economic benefits of PSA and fPSA testing. Medical Laboratory Observer 33:32-38, March 2001.

72. Simpson JL, Lamb DJ: Genetic effects of intracytoplasmic sperm injection. Semin Reprod Med 19(3):239, 2001.

73. Casella R, Maduro RM, Lamb DJ: Significance of androgen receptor polymorphisms in urology. Urology 58:51-6, 2001.

74. Ryu HM, Lin WW, Lamb DJ, Chuang W, Lipshultz LI, Bischoff FZ: Increased chromosome X, Y, and 18 nondisjunction in sperm from infertile patients that were identified as normal by strict morphology: implication for intracytoplasmic sperm injection. Fertil Steril 76(5):879-83, 2001.

75. Mifsud A, Sim CKS, Boettger-Tong H, Moreira S, Lamb DJ, Lipshultz LI, Yong EL: Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: Molecular markers of male infertility risk. Fertil Steril 75:275-81, 2001.

76. Smith CL, DeVera DG, Lamb DJ, Jiang Y-H, Beaudet AL, O’Malley BW: Genetic ablation of the steroid receptor coactivator/ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. Molecular Cellular Biol 22:525-535, 2002.

77. Maduro MR, Davis E, Davis A, Lamb DJ: Osteotesticular protein tyrosine phosphatase (OST-PTP) expression in testis. J Urol 167:2282-2283, 2002.

78. Shariat SF, Lamb DJ, Kattan MW, Nguyen C, Kim JH, Beck J, Wheeler TM, Slawin KM: Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding protein-2 and -3 with prostate cancer invasion, progression, and metastasis. J Clin Oncol 20:833-841, 2002.

79. Matzuk MM, Lamb DJ: Genetic dissection of mammalian fertility pathways. (Invited Review.) Nature Cell Biology and Nature Medicine 8 (S1), S41-S49, 2002.

80. James AJ, Agoulnik IU, Harris JM, Buchanan G, Tilley WD, Marcelli M, Lamb DJ, Weigel NL: A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity. Mol Endocrinol 16:2692-2705, 2002.

81. Pagani R, Brugh VM, Lamb DJ: Y chromosome genes and male infertility. Urol Clin North Am 29:745-753, 2002.

82. King SR, Manna PR, Ishii T, Syapin PJ, Ginsberg SD, Wilson K, Walsh LP, Parker KL, Stocco DM, Smith RG, Syapin PJ, Lamb DJ: An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci 22(24):10613-10620, 2002.

83. Gorlov IP, Kamat A, Bogatchova N, Jones E, Lamb DJ, Truong A, Bishop CE, McElreavey KE, Agoulnik AI: Mutations of the GREAT gene cause cryptorchidism. Hum Mol Genet 11(19):2309-2318, 2002.

84. Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal HB, Lamb DJ: Azoospermia in patients heterozygous for a mutation in SYCP3. Lancet 362:1714-1719, 2003.

85. Castro P, Giri D, Lamb DJ, Ittmann M: Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate 55:30-38, 2003.

86. Lamb DJ, Puxeddu E, Malik N, Stenoien DL, Nigam R, Saleh GY, Mancini M, Weigel NL, Marcelli M: Molecular analysis of the androgen receptor in ten prostate cancer specimens obtained before and after androgen ablation. J Androl 24(2):214-225, 2003.

87. Maduro MR, Lo KC, Chuang WW, Lamb DJ: Genes and male infertility: What can go wrong? Andrology Lab Corner. J Androl 24(4):485, 2003.

88. Lo, KC, Chuang WW, Lamb DJ: Review Article: Stem cell research: The facts, the myths and the promises. J Urol 170:2453-2458, 2003.

89. Maduro MR, Casella R, Kim E, Levy N, Niederberger C, Lipshultz LI, Lamb DJ: Microsatellite instability and defects in mismatch repair proteins: A new aetiology for Sertoli-cell-only syndrome. Mol Hum Reprod 9(2):61-68, 2003.

90. Casella R, Maduro MR, Misfud A, Lipshultz LI, Yong EL, Lamb DJ: Androgen receptor gene polyglutamine length is associated with testicular histology in infertile patients. J Urol 169:224-227, 2003.

91. Lamb DJ, Puxeddu E, Malik N, Stenoien DL, Nigam R, Saleh GY, Mancini M, Weigel NL, Marcelli M: Molecular analysis of the androgen receptor in ten prostate cancer specimens obtained before and after androgen ablation. J Androl 24(2)215-225, 2003.

92. Lamb DJ, Buttyan R: Editorial: Hormone therapies for prostate cancer – Acute disease control, chronic disease progression. J Urol 169(4):1558, Apr 2003.

93. Practice Committee, Society for Assisted Reproductive Technology; Practice Committee, American Society for Reproductive Medicine (Lamb DJ): Round spermatid nucleus injection (ROSNI). Fertil Steril 80(3):687-689, Sep 2003.

94. Canto EI, Singh H, Shariat SF, Nguyen C, Lamb DJ, Beck J, Mikolajczyk SD, Linton HJ, Rittenhouse HG, Wheeler TM, Kadmon D, Miles BJ, Slawin KM: Serum BPSA outperforms both total PSA and free PSA as a predictor of prostate enlargement in men without prostate cancer. Urology 63(5):905-910, May 2004.

Shariat SF, Anwuri VA, Lamb DJ, Shah NV, Wheeler TM, Slawin KM: Association of preoperative plasma levels of vascular endothelial growth factor and soluble vascular cell adhesion molecule-1 with lymph node status and biochemical progression after radical prostatectomy. J Clin Oncol 22(9):1655-1663, May 2004.

95. Lo KC, Lei Z, Rao CV, Beck J, Lamb DJ: De novo testosterone production in luteinizing hormone receptor knockout mice after transplantation of Leydig stem cells. Endocrinology 145(9):4011–4015, 2004.

96. King, SR, Ginsberg SD, Ishii T, Smith RG, Parker KL, Lamb DJ: Steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain. Endocrinology 145(10):4775-4780, October 2004.

b. Accepted or In Press:

1. Lipshultz LI, Lamb DJ: Editorial perspective: Stem cells. Urology Times 2004 (In press – July 2004).

2. Shin D, Chuang WW, Lipshultz LI, Lamb DJ: Treatment options for the infertile male with cancer. J Natl Cancer Inst 2004 (Accepted for publication – August 2004).

c. Submitted:

1. Marcelli M, Weigel N, Mancini M, Polletti A, Lamb DJ: The androgen receptor in health and disease. (Under revision).

2. Wiener JS, Sutherland RW, Marcelli M, Nazareth LV, Weigel NL, Roth DR, Gonzales ET Jr, Lamb DJ: An androgen receptor gene mutation is associated both with isolated penile hypospadias and with a normal phenotype in males in a single family: A genetic and functional analysis. J Clin Endocrinol Metab (Under revision).

3. Nazareth LV, Lamb DJ, Marcelli M, Weigel NL: Mutation of Gln919 in the human androgen receptor prevents forskolin-induced ligand-independent nuclear localization and transcriptional activation. Mol Endocrinol (Under revision).

4. Lamb DJ, Ittmann M, Weigel NL, Marcelli M: Influence of DNA extraction from paraffin-embedded prostate cancer tissue on the analysis of androgen receptor mutations. J Androl (Under revision).

5. Maduro MR, Smith GA, Richardson BE, Lipshultz LI, Lamb DJ: Genomic instability at the myotonic dystrophy locus is associated with severe male factor infertility: A concern for ICSI? Am J Hum Genet 2003 (Submitted).

6. Shai S, Roadbush W, Power D, Dirnfeld M, Lamb DJ: Multicenter study: Evaluation of flowcytometric based semen analysis kit. Fertil Steril 2003 (Submitted).

7. McKenzie LJ, Kovanci E, Amato P, Cisneros P, Lamb DJ, Carson SA: Pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratozoospermia. Fertil Steril 2004 (Submitted).

8. Lo Kirk, Whirledge S, Lamb DJ: Stem Cells: Implications for Urology. Current Urology 9/2004 (Submitted)

2. Other Full Papers:

a. Published Without Review by Peer Group:

1. Smith RG, Johnson A, Lamb DJ: Functional tests of spermatozoa: Sperm penetration assay. Urol Clin North Am 14:451-469, 1987.

2. Lamb DJ, Johnson AR, Lipshultz LI: The sperm capacitation index. Contemp OB/GYN 33:108-114, 1989.

3. Lamb DJ, Stockton JD, Lipshultz LI: New roads to fertility. Contemp Urol 3:32-41, 1991.

4. Lamb DJ, Johnson A, Lipshultz LI: Humster testing and egg yolk. Letter to the Editor. Fertil Steril 5:1021-1022, 1991.

5. Lamb DJ: Oncogenes and growth factors in the development of prostate cancer. Oncology Update [Summer] pp 9-10, 1992.

6. Lipshultz LI, Shubhada S, Kim SJ, Lamb DJ: Paracrine regulation of spermatogenesis. World J Urol 11:120-128, 1993.

7. Lamb DJ, Lipshultz LI: Application of artificial intelligence to urology. World J Urol 11:129-136, 1993.

8. Bar-Chama N, Lamb DJ: Evaluation of sperm function: What is available in the modern andrology laboratory? Urol Clin North Am 21:433-446, 1994.

9. Lamb DJ, Lipshultz LI: Animal models that mimic human male reproductive defects. Urol Clin North Am 21:377-387, 1994.

10. Teague JL, Lamb DJ: Androgen receptor regulation of growth and development. Prob Urol 8:495-506, 1994.

11. Lamb DJ: Genes involved in testicular development and function. World J Urol 13:277-284, 1995.

12. Gvakharia M, Greer JA, Lipshultz LI, Lamb DJ: Treating male factor infertility with ICSI. Contemp Urol 7:58-67, 1995.

13. Wiener JS, Lamb DJ: Molecular determinants of sexual differentiation. World J Urol 14:278-294, 1996.

14. Lamb DJ: Symposium: Is semen quality declining? Contemp Urol 8:50-62, 1996.

15. Tripp B, Bishop CE, Lipshultz LI, Lamb DJ: The disappearing Y chromosome: “I told you so!” Letter to the editor. Fertil Steril 67:408, 1997.

16. Bischoff F, Lamb DJ: Chromosome analysis of spermatozoa extracted from testes of men with non-obstructive azoospermia. Letter to the Editor. Hum Reprod 15(12):2685-2686, 2000.

17. Lamb DJ: Tips on PSA testing: #3 Free and bound PSA. Med Laboratory Observer 2000.

18. Cozzolino DJ, Lamb DJ: Germ cell transplantation: The potential treatment of severe testicular failure. Curr Urol Reports 2000.

19. Jones EA, Lamb DJ: The androgen receptor in anomalies of the external genitalia. Dial Pediatr Urol 24(6):5, 2001.

20. Moreira Jr SG, Lamb DJ: Contribution of animal models to treatment of male infertility. Contemp Urol, pp 79-84, 2001.

21. Lamb DJ, Weigel NL, Marcelli M: Androgen receptors and their biology. Vitam Horm 62:199-230, 2001.

22. Maduro MR, Lamb DJ: Understanding the new genetics of male infertility. Invited review article. J Urol 168:2197-2205, 2002.

23. Pagani R, Brugh VM, Lamb DJ: Understanding the Y chromosome and its impact on male infertility. Review. In: Urologic Manifestations of Non-Urologic Disease. Urol Clin North Am 29(4):745-753, Nov 2002.

24. Brugh VM, Maduro MR, Lamb DJ: Genetic disorders and infertility. Review. In: Urologic Manifestations of Non-Urologic Disease. Urol Clin North Am 30:143-152, Feb 2003.

b. In Preparation:

1. Lamb DJ, Lipshultz LI: Testicular function. In: Reproductive Endocrinology. Yen, Jaffe (eds). Academic Press 2002.

2. Lamb DJ, Lipshultz LI: Male infertility. In: Reproductive Endocrinology. Yen, Jaffe (eds). Academic Press 2002.

3. Anwuri VA, Shariat SF, Lamb DJ, Smith RG, Beck J, Wheeler TM, Slawin KM: Association of pre-operative plasma levels of vascular endothelial growth factor and soluble vascular cell adhesion marker-1 with prostate cancer progression and metastasis.

3. Abstracts Given During Last Three Years:

1.De Lara, J, Lamb DJ, Lipshultz LI, Kim ED, Bischoff F: Increased aneuploidy in morphologically normal testes spermatocytes adjacent to germ cell neoplasms. American Society of Human Genetics, 1999 (Podium).

2.Lamb DJ, Kim ED, Huang W, Lipshultz LI, Bischoff F: Genomic instability may contribute to spermatogenic failure in non-obstructive azoospermia. Serono Symposia USA, Norwell, MA, February 1, 1999 (Poster).

3.Sutherland RW, Hicks MJ, Gonzales ET Jr, Roth DR, Lamb DJ: Increased apoptosis at the ureterovesical junction in children with congenital vesicoureteral reflux.” 94^th Annual Meeting, American Urological Association , Dallas, TX, May 2-6, 1999 (Poster).

4.Sutherland RW, Lin WW, Hicks MJ, Roth DR, Gonzales ET Jr, Lamb DJ: Apoptosis at the Ureterovesical Junction in Children with Congenital Ureterovesical Junction Obstruction. 94^th Annual Meeting, American Urological Association, Dallas, TX, May 2-6, 1999 (Poster).

5.Kim ED, Levy N, de Lara J, Lipshultz LI, Lamb DJ: Genomic instability is increased in states of abnormal spermatogenesis in male infertility. (Abstract 0419) 94^th Annual Meeting of the American Urological Association, Dallas, TX, May 2-6, 1999 (Podium).

6.Lucena RG, Brannigan RE, Lipshultz LI, Lamb DJ: Does Kruger’s method of strict criteria for sperm morphology classification correlate to the optimized sperm penetration assay? 94^th Annual Meeting of the American Urological Association, Dallas, TX, May 2-6, 1999 (Poster).

7.Orejuela FJ, Brannigan RE, Spitz A, Marin R, Crone MR, Lowentritt BH, Kim ED, Lamb DJ, Lipshultz LI: Predictors of the presence of reactive oxygen species (ROS) in the semen. 94^th Annual Meeting of the American Urological Association, Dallas, TX, May 2-6, 1999 (Poster).

8.Huang WJ, Lamb DJ, Lin EW, Lipshultz LI, Abrams J, Farideh Z: The effect of age on sex chromosome aneuploidy in primary and secondary spermatocytes of normospermatogenic men. 94^th Annual Meeting of the American Urological Association, Dallas, TX, May 2-6, 1999 (Podium).

9.Lamb DJ, Schatte EC, Orejuela FJ, Cisneros P, Carson S, Kim ED, Lipshultz LI: Infertility due to anejaculation: treatment with intracytoplasmic sperm injection (ICSI) and electroejaculation (EEJ). 94^th Annual Meeting of the American Urological Association, Dallas, TX, May 2-6, 1999 (Poster).

10.Schatte ED, Decker WK, Lipshultz LI, Kim ED, Lamb DJ, Craigen WJ: Semen characteristics of the voltage dependent anion channel-3 knockout mouse. (Abstract 0393) 94^th Annual Meeting of the American Urological Association, Dallas, TX, May 2-6, 1999 (Podium).

11.Stenoien DL, Patel K, Adams HP, Mancini MD, Marcelli M, Lamb DJ, Weigel NL, Mancini MA: Subcellular trafficking of wild-type and mutant androgen receptors. The Endocrine Society, 1999 (Poster).

12.Sheiko T, Ray M, Hyder SM, Lamb DJ: Orphan receptor NUR77 regulation in male reproductive tumor cells. 8^th Annual Society for Basic Urologic Research, 1999 (Podium).

13.Sutherland RW, Hicks MJ, Roth DR, Gonzales ET Jr, Lamb DJ: Congenital obstructed megaureter: possible role for apoptosis. 95^th Annual Meeting, American Urological Association, Atlanta, GA, April 29 - May 4, 2000 (Poster).

14.Kaufman, L, Hussein A, Onel E, Sobel D, Chulamorkodt N, Hong Y, Ross L, Orejuela F, Lipshultz L, Lamb DJ, Niederberger C: Neural computational modeling of electroejaculation outcomes. 95^th Annual Meeting, American Urological Association, Atlanta, GA, April 29–May 4, 2000 (Poster).

15.Lin WW, Lamb DJ, Lipshultz LI, Bischoff FZ: Association of spermatozoa aneuploidy in recurrent intrauterine insemination failures. 95^th Annual Meeting, American Urological Association, Atlanta, GA, April 29 – May 4, 2000 (Podium).

16.Hendin BN, Domozhirov A, Lin WW, Moreira S, Carson S, Cisneros P, Lipshultz LI, Lamb DJ: Incubation of testicular sperm enhances oocyte fertilization with ICSI procedures. 95^th Annual Meeting, American Urological Association, Atlanta, GA, April 29 – May 4, 2000 (Poster).

17.Lamb DJ, Murthy L, Zhao Y, Weigel NL, Marcelli M: Detection of an androgen receptor (AR) mutation in advanced prostate cancer at multiple metastatic sites. 82^nd Annual Meeting, The Endocrine Society, Toronto, Ontario, Canada, June 21-24, 2000 (Podium).

18.Malik N, James A, Marcelli M, Lamb DJ, Weigel NL: Androgen receptor mutants identified in prostate cancer metastases that exhibit reduced activity. 82^nd Annual Meeting, The Endocrine Society, Toronto, Ontario, Canada, June 21-24, 2000 (Poster).

19.Heard MJ, Cisneros PL, Buster JE, Lamb D, Lipshultz LI, Carson SA: A comparison of clinical pregnancy rates between cryopreserved embryos derived from intracytoplasmic sperm injection ICSI) versus conventional IVF. 56^th Annual Meeting, American Society of Reproductive Medicine, San Diego, CA, October 21-25, 2000 (Poster).

1. Lamb DJ: “Microsatellite Instability in Infertile Men. Testis Workshop, Newport Beach, California, February 22-25, 2001 (Poster).

2. James AJ, Marcelli M, Lamb DJ, Weigel NL: A novel androgen receptor mutation, identified in a metastatic prostate tumor, increases receptor stability both in the absence and presence of hormone without altering hormone binding affinity. The Endocrine Society, Denver, CO, June 2001 (Podium).

3. King SR, Ishii T, Ginsberg SD, Parker KL, Smith, RG, Lamb DJ: Immunohistochemical localization of the steroidogenic acute regulatory (StAR) protein in the mouse brain. The Endocrine Society, Denver, CO, June 2001 (Podium).

4. Casella RG, Maduro MR, Zhao Y, Murthy L, Lamb DJ, Kolon T: CAG repeat length in exon 1 of the androgen receptor gene of patients with cryptorchidism and/or hypospadias. 96^th Annual Meeting of the American Urological Association, Anaheim, CA, June 2-7, 2001 (Poster).

5. Shariat S, Lamb DJ, Nguyen C, Beck J, Kim J, Jang Y-H, Wheeler TM, Slawin KM: Preoperative plasma level of insulin-like growth factor binding protein-2 predicts progression in patients undergoing radical prostatectomy. 96^th Annual Meeting of the American Urological Association, Anaheim, CA, June 2-7, 2001 (Poster).

6. Mootha RK, Rohozinski J, Lipshultz LI, Lamb DJ, Bishop CE: Identification of the human CAN1 gene: A potential site for mutation in infertile men. 96^th Annual Meeting of the American Urological Association, Anaheim, CA, June 2-7, 2001 (Poster).

7. Casella RG, Maduro MR, Lipshultz LI, Lamb DJ: Expansion of the CAG repeat in exon 1 of the androgen receptor gene isolated from the testicular tissue of infertile males. 96^th Annual Meeting of the American Urological Association, Anaheim, CA, June 2-7, 2001 (Poster).

8. Nudell DM, Alphonse PJ, Cozzolino DJ, Murthy L, Lamb DJ, Lipshultz LI: The effects of seminal fluid review of systems (ROS) on the sperm penetration assay (SPA). 96^th Annual Meeting of the American Urological Association, Anaheim, CA, June 2-7, 2001 (Poster).

9. Pagani RL, Cozzolino DJ, Nudell DM, Lipshultz LI, Lamb DJ: Sperm penetration assay identifies functional sperm abnormalities in anejaculatory patients. 96^th Annual Meeting of the American Urological Association, Anaheim, CA, June 2-7, 2001 (Poster).

10. Rao MK, Sutton K, Pagani RL, Lamb DJ, Wilkinson MF: Identification of Pem homeobox promoter sequences sufficient to drive high transcription levels in Sertoli cells and principal cells of caput epididymis in vivo. 34^th Annual Meeting of the Society for the Study of Reproduction, University of Ottawa, Ottawa, Ontario, Canada, July 28 – August 1, 2001.

11. Lamb DJ: Comparison of single versus multiple dose regimens for human chorionic gonadotrophin stimulatory test. American Society of Pediatrics, 2001.

12. Kolon RF, Murthy L, Gonzales ET Jr, Zhao Y, Lamb DJ: Prevalence of intersex in hypospadias and cryptorchidism. American Society of Pediatrics, 2001 (Oral).

13. Lipshultz LI and Lamb DJ: Spermatogonial stem cell transplantation in male infertility. 2002 Meeting of the AAGUS, Kiawah, SC (Podium), April 17-20, 2002 (Oral).

14. Lamb DJ: Polyglutamine polymorphisms in the androgen receptor gene of infertile males: risk facto for testicular seminoma onset? 97^th Annual Meeting, American Urological Association, May 25-30, 2002 (Podium).

15. King SR, Ginsberg SD, Smith RG, and Lamb DJ: Co-localization of the steroidogenic acute regulatory (StAR) protein, P450scc, and MLN64 in the brain. The Endocrine Society Annual Meeting, San Francisco, CA, 2002 (Poster).

16. Maduro MR, Smith AG, Lamb D: Increased incidence of expanded alleles of the DMPK gene (myotonic dystrophy) associated with non-obstructive azoospermia (NOA): A new concern for ICSI? The Endocrine Society Annual Meeting, San Francisco, CA, 2002 (Podium).

17. King SR, Ginsberg S, Ishii T; Parker KL, Smith RG, Lamb DJ: Colocalization of the steroidogenic acute regulatory (STaR) protein with cytochrome P450SCC in mouse and human brain. Neuroscience Annual Meeting, San Francisco, CA, 2002 (Poster).

18. Land S, Murthy L, Lamb DJ, Lipshultz LI, Ross L, Niederberger CS: A neural computational model of ICSI outcomes from sperm source and other features. American Society for Reproductive Medicine Annual Meeting, Seattle, WA, 2002 (Poster).

19. Maduro MR, Casella R, Smith AG, Lamb DJ: Increased incidence of triplet repeat diseases expanded alleles in azoospermic men: A new concern for ICSI? American Society for Reproductive Medicine Annual Meeting, Seattle, WA, 2002 (Podium).

20. Brugh VM III, Parker MA, Murphy L, Lipshultz LI, Lamb DJ: A novel technique of spermatogonial stem cell isolation. American Society for Reproductive Medicine Annual Meeting, Seattle, WA, 2002 (Podium).

21. Lamb DJ: The potential of regenerative stem cells for the treatment of male infertility. NICHD sponsored meeting: Apoptosis in the Male Reproductive Tract, May 2002 (Podium).

22. Lamb DJ: Understanding the new genetics of male reproductive failure. Annual Clinical Genetics Meeting, San Diego, CA, March 16, 2003.

23. Anwuri VA, Shariat SF, Lamb DJ, Kattan MW, Wheeler TM, Slawin KM: Associatino of preoperative plasma levels of vascular endothelial growth factor and soluble vascular cell adhesion marker-1 with biochemical progression after radical prostatectomy. Abstract #1444. 98^th Annual Meeting of the American Urological Association, Chicago, IL, April 26 – May 1, 2003. J Urol (suppl) 169(4):386, 2003.

24. Lo KC, Brugh VM III, Lamb DJ: Colonization of enriched testicular stem cells in the interstitial and peritubular space following transplantation into a testis. Abstract #1544. 98^th Annual Meeting of the American Urological Association, Chicago, IL, April 26 – May 1, 2003. J Urol (suppl) 169(4):413, 2003.

25. Casella R, Maduro MR, Lipshultz LI, Lamb DJ: Microsatellite instability in cryptorchid patients. Abstract #1555. 98^th Annual Meeting of the American Urological Association, Chicago, IL, April 26 – May 1, 2003. J Urol (suppl) 169(4):416, 2003.

26. Matschke HM, Lo KC, Brugh VM III, Lamb DJ, Lipshultz LI: Sperm DNA damage and smoking: Evaluation of association using DNA Comet assay. Abstract #1566. 98^th Annual Meeting of the American Urological Association, Chicago, IL, April 26 – May 1, 2003. J Urol (suppl) 169(4):419, 2003.

27. Lo KC, Chuang WW, Matschke, Richardson BE, Lipshultz LI, Lamb DJ: Sperm DNA damage is associated with decreased sperm density in semen analysis. Abstract #1686. 98^th Annual Meeting of the American Urological Association, Chicago, IL, April 26 – May 1, 2003. J Urol (suppl) 169(4):450, 2003.

28. Chuang WW, Lo KC, Lipshultz LI, Lamb DJ: Does sperm selection by binding to hyaluronic acid improve selection of sperm with less DNA damage for use in ICSI? Abstract #1697. 98^th Annual Meeting of the American Urological Association, Chicago, IL, April 26 – May 1, 2003. J Urol (suppl) 169(4):452-453, 2003.

29. King SR, Lamb DJ, Smith RG, Ginsberg SD: Localization of the steroidogenic acute resultatory (StAR) protein homolog MLN64 in Alzheimer’s disease: A potential link between cholesterol transport and neurodegeneration. Abstract #OR17-5. Endo 2003: The Endocrine Society’s 85^th Annual Meeting, Focus: Cardiovascular Endocrinology, Philadelphia, PA, June 19-22, 2003 (Oral).

30. Chuang WW, Lo KC, Lamb DJ, Lipshultz LI: The determination of multiple copies of the deleted in azoospermia (DAZ) gene and its deletion patterns in azoospermic and oligospermic patients. Abstract #P-354. 59^th Annual Meeting of the American Society for Reproductive Medicine, San Antonio, TX, October 11-15, 2003 (Poster).

31. McKenzie LJ, Amato P, Kovanci E, Lamb DJ, Lipshultz LI: A significantly higher early pregnancy loss rate is seen with intracytoplasmic sperm injection (ICSI) versus in vitro fertilization (IVF). Abstract #P-248. 59^th Annual Meeting of the American Society for Reproductive Medicine, San Antonio, TX, October 11-15, 2003 (Poster).

32. Lo KC, Lei ZM, Rao CV, Lamb DJ: De novo testosterone production in a luteinizing hormone receptor knockout mouse after transplantation of Leydig stem cells. Abstract #0-9. 59^th Annual Meeting of the American Society for Reproductive Medicine, Society for Male Reproduction and Urology Traveling Scholars, San Antonio, TX, October 13, 2003 (Oral).

33. McKenzie LJ, Buster JE, Cisneros P, Lamb DJ, Lipshultz LI, Carson SA: Pregnancy outcome of IVF/ICSI with profound teratospermia (Kruger strict criteria of zero). Abstract #0-291. 59^th Annual Meeting of the American Society for Reproductive Medicine, ART: Male Factor, San Antonio, TX, October 15, 2003 (Oral).

34. Canto EI, Singh H, Shariat SF, Nguyen C, Lamb DJ, Beck J, Mikolajczyk SD, Linton HJ, Rittenhouse HG, Wheeler TM, Kadmon D, Miles BJ, Slawin KM: Serum BPSA is a better predictor of prostate enlargment than either total PSA or free PSA in men without prostate cancer. Abstract #1532. 99^th Annual Meeting of the American Urological Association, San Francisco, CA, May 8-13, 2004. J Urol (suppl) 171(4):403, 2004.

35. Canto EI, Singh H, Shariat SF, Nguyen C, Lamb DJ, Mikolajczyk SD, Linton HJ, Rittenhouse HG, Stephenson AJ, Wheeler TM, Kadmon D, Miles BJ, Slawin KM: Comparison of %FPSA, %BPSA, [-2]PPSA/FPSA, and [-2]PPSA/BPSA for prostate cancer detection in men with total serum PSA concentrations between 4 and 10 ng/mL. Abstract #1661. 99^th Annual Meeting of the American Urological Association, San Francisco, CA, May 8-13, 2004. J Urol (suppl) 171(4):439, 2004.

36. Lo KC, Brugh VM III, Parker M, Lamb DJ: Isolation and enrichment of spermatogonial stem cells using rhodamine 123 mitochondrial dye. Abstract #1372. 99^th Annual Meeting of the American Urological Association, San Francisco, CA, May 8-13, 2004. J Urol (suppl) 171(4):361, 2004.

37. King SR, Smith AGA, Lamb DJ: Identification of the phosphorylaction site of the steroidogenic acute regulatory protein in steroidogenic cells. 12^th International Congress of Endocrinology, Lisbon, Portugal, August 31 – September 4, 2004.

4. Books:

a. Complete Books Written: Not Applicable

b. Books Edited: Not Applicable

c. Book Chapters Written:

1. Sanborn BM, Lamb DJ, Tsai YH, Steinberger A: Androgen action in the Sertoli cell. In: Functional Correlates of Hormone Receptors in Reproduction. Mahesh, V (ed). New York: Elsevier-North Holland Press, 1980, pp 205-220.

2. Sanborn, BM, Wagle JR, Steinberger A, Lamb DJ: The Sertoli cell as an androgen target. In: Serono Symposium on Recent Advances in Male Reproduction: Molecular Basis and Clinical Implications. D’Agata R (ed). New York: Raven Press, 1982, pp 69-78.

3. Lamb DJ, Spotts G, Holmes SD, Smith RG: Unique characteristics of rat Sertoli cell secreted growth factor. In: The Cell Biology of the Testis and Epididymis. Obregon-Christ M-C (ed). New York: New York Academy of Science, 1987, pp 497-499.

4. Bullock DW, Lamb DJ, Rider VE, Kima PE: The rabbit progesterone receptor and uteroglobin gene expression. In: The Cell Biology of the Uterus. Leavitt W, Yoshinage J (eds). New York: Plenum Press, 1988, pp 79-95.

5. Johnson AR, Bassham B, Lipshultz LI, Lamb DJ: Methodology for the optimized sperm penetration assay. In: Laboratory Diagnosis and Treatment of Infertility. Keel B, Webster B (eds). Boca Raton: CRC Publishers, 1990, pp135-147.

6. Buch JP, Tindall DJ, Rowley DW, Lamb DJ: Sertoli cell structure and function in vivo and in vitro. In: Infertility in the Male, 2^nd Edition, Chapter 4. Lipshultz LI, Howards SS (eds). St Louis: Mosby-Year Book Publishers, 1991, pp 54-83.

7. Brody S, Lamb DJ, Gibbons E: Male factor IVF. In: Infertility in the Male, 2^nd Edition, Chapter 22. Lipshultz LI, Howards SS (eds). St. Louis: Mosby-Year Book Publishers, 1991, pp 423-443.

8. Smith RG, Harris S, Lamb DJ: Mechanism of growth regulation in androgen responsive cells. In: Molecular and Cellular Biology of the Prostate. Karr J, Tindall D, Smith RG (eds). New York: Plenum Press, 1991, pp 15-26.

9. Lamb DJ, Lipshultz LI: New statistical techniques that predict medical outcomes. In: Advances in Urology, Vol 9. McGuire EJ, Bloom D, Catalona WJ, Lipshultz LI (eds). St. Louis: Mosby-Year Book, Inc., pp 407-426.

10. Tripp B, Lamb DJ: The Sertoli cell: Morphology, function and regulation. In: Infertility in the Male, 3^rd Edition. Lipshultz LI, Howards SS (eds) St. Louis: Mosby-Year Book, Inc., 1997, pp 71-105.

11. Lipshultz LI, Lamb DJ: Spermatogenesis in the adult. In: Infertility in the Male, 3^rd Edition. Lipshultz LI, Howards SS (eds) St. Louis: Mosby-Year Book, Inc., 1997, pp 106-122.

12. Beck J, Lott N, Lamb DJ: Immunobead assay. In: Infertility in the Male, 3^rd Edition, Appendix. Lipshultz LI, Howards SS (eds) St. Louis: Mosby-Year Book, Inc., pp 506-508.

13. Gvakharia M, Lamb DJ: Sperm penetration assay. In: Infertility in the Male, 3^rd Edition, Appendix. Lipshultz LI, Howards SS (eds) St. Louis: Mosby-Year Book, Inc., pp 512-514.

14. Kim ED, Gvakharia M, Lamb DJ, Lipshultz LI: Gamete micromanipulation intracytoplasmic sperm injection. In: Atlas of Urologic Clinics of North America 4(2):67-82, 1996.

15. Vereb M, Gvakharia M, Lamb DJ: Intracytoplasmic sperm injection: The new frontier in male infertility treatment. In: Advances in Urology, Vol 10. McGuire EJ, Bloom D, Catalona WJ, Lipshultz LI (eds). St. Louis: Mosby-Year Book, Inc., 1997, pp 71-83.

16. Lamb DJ, Weigel NL, Marcelli M: Steroid receptors in prostate cancer development and progression. In: Contemporary Oncology: Endocrine Oncology. Ethier S (ed). New Jersey: Humana Press, 2000, pp 255-276.

17. Lin WW, Hendin B, Lamb DJ, Lipshultz LI: Handling and cryopreservation of testicular sperm. In: Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives. Gardner DK, Weissman A, Howles CM, Shoham Z (eds). London: Martin Dunitz Publishers, Ltd, 2001, pp 273-277.

18. Lamb DJ, Weigel NL, Marcelli M: Androgen receptors and their biology. In: Vitamins and Hormones. Litwak G (ed). 62:199-230, 2001.

19. McGinnis M, Marcelli M, Lamb DJ: Consequences of mutations in the androgen receptor genes: Molecular biology and behavior. In: Hormones, Brain, and Behavior. Pfaff, Arnold, Etgen, Fahrbach, Rubin (eds). San Diego: Academic Press, 2001, pp 347-380.

20. Marcelli M, Lamb DJ, Weigel NL, Cunningham GR: Androgen signaling in prostatic neoplasia and hyperplasia. In: Androgens in Health and Disease. Bagatell C, Bremner WJ (eds). Towata: Humana Press, Inc, 2002.

21. Lamb DJ: Androgen receptors and prostate cancer. In: Encyclopedia of Hormones. Henry H, Norman AW (eds), San Diego: Academic Press, 2003.

22. Chuang WW, Lo KC, Lamb DJ: Genetic basis of male infertility. In: Reproductive Medicine Secrets: Questions and Answers Reveal the Secrets to the Safe and Effective Practice of Reproductive Medicine, Chapter 11. Chan P, Goldstein M, Rosenwaks Z (eds), Philadelphia: Hanley & Belfus, Inc, 2004, pp 76-83.

Book Appendix (Guest Editor):

1. Lamb DJ, Ord T (Guest Editors): Laboratory methods in andrology. In: Infertility in the Male, 3^rd Edition. Lipshultz LI, Howards SS (eds) St. Louis: Mosby-Year Book, Inc, 1997.

Book Review:

1. Lamb DJ: Handbook of the Assisted Reproduction Laboratory. Brooks A, Keel, JV, DeJonge May CJ (eds).

2. Lamb DJ: WHO Laboratory Manual for the Examination of Human Semen and Human Semen Cervical Mucus Interactions. J Androl 22(2), 2001.

5. Other Works Communicating Research Results to Scientific Colleagues:

1. Lamb DJ: “Maternal Responses to the Fetal Allograft.” M.S. Dissertation , 1976.

2. Lamb DJ: “An Investigation into the Molecular Mechanisms of Androgen Action in the Sertoli Cell.” Ph.D. Dissertation, 1980.

3. Sigman M, Lamb DJ: “Molecular Biology for Urologists.” Interactive Computer Program, AUA Decision Making, Decker Publishing, Vol 3, January-February, 1989.

4. Stockton JD, Lipshultz LI, Lamb DJ: “Gamete Micromanipulation: A New Approach to the Treatment of Male Infertility.” American Fertility Society First Prize Video, 1991.

5. Lamb DJ: “Growth Factors and Testicular Development.” American Association of Pediatric Urologists (Syllabus), 1992.

6. Lipshultz LI, Lamb DJ: “Sperm Micromanipulation Techniques.” American Urological Association (Syllabus), 1992.

7. Lamb DJ, Stockton JD, Meistrich ML, Lipshultz LI: “Animal Models that Mimic Human Sperm Defects.” American Fertility Society Postgraduate Course (Syllabus), 1993.

8. Lamb DJ: “Molecular Tests for Male Infertility Diagnosis in the Future.” American Fertility Society Postgraduate Course (Syllabus), 1994.

9. Lipshultz LI and Lamb DJ: “Gene Therapy and Genetic Models of Male Infertility.” American Fertility Society Postgraduate Course (Syllabus), 1994.

10. Lamb DJ: “A Review of Molecular Technologies Leading to Advances in our Understanding of Male Reproductive Defects.” Society for the Study of Male Reproduction, American Urological Association (Syllabus), 1997.

11. Lamb DJ: “The Role of Environmental Endocrine Disruptors.” Annual Meeting, The Society for the Study of Male Reproduction, 1998.

12. Lamb DJ: “Genetic Control of Sexual Development.” Andrology Postgraduate Course, San Diego, CA, (Syllabus), March 1998.

13. Lamb DJ: “Endocrine Disruptors and Male Reproductive Defects.” American Association of Occupational Medicine Plenary Lecture, San Antonio, TX, (Syllabus), October 2, 1999.

14. Lamb DJ: “Germ Cell Transplantation.” American Association of Reproductive Medicine, Toronto, ON, Canada, (Syllabus), September 1999.

15. Lamb DJ, Cozzolino DJ: “Gene Therapy American Association of Reproductive Medicine,” Toronto, ON, Canada, (Syllabus), September 1999.

16. Lamb DJ: “Immunologic Infertility.” American Association of Reproductive Medicine, Toronto, ON, Canada, (Syllabus), September 1999.

17. Lamb DJ: “Laboratory Evaluation of the Infertile Male: Current Strategies and a Look Towards the Future.” American Association of Reproductive Medicine, Toronto, ON, Canada, (Syllabus), September 1999.

18. Lamb DJ: “Computer-Assisted and Automated Techniques for Genetic Analysis.” American Association of Reproductive Medicine, Toronto, ON, Canada, (Syllabus), September 1999.

19. Lamb DJ: “Y Chromosome Microdeletions.” American Association of Reproductive Medicine, Toronto, ON, Canada, (Syllabus), September 1999.

20. Lamb DJ, Cozzolino DJ: “Basic Overview of Molecular Techniques.” American Association of Reproductive Medicine, Toronto, ON, Canada, (Syllabus), September 1999.

21. Lamb DJ: “A Look Towards the Future: New Technologies that May Influence Sperm Banking.” American Association of Tissue Banks, Miami, FL, (Syllabus), September 2000.

22. Lamb DJ: “Diagnosing Male Infertility in the New Genetics.” 8^th Innovations in Urologic Practice, Santa Fe, NM (Syllabus), October 5-7, 2000.

23. Lamb DJ: “Male Infertility.” Serono Symposium on Reproductive Endocrinology, Washington, DC, January 2001.

24. Lamb DJ, King SR: “Libido.” American Society for Reproductive Medicine, Orlando, FL (Syllabus) October 20-24, 2001.

25. Lamb DJ: “Male Infertility and the New Genetics.” American Society for Reproductive Medicine, Orlando, FL (Syllabus) October 20-24, 2001.

26. Lamb DJ: “Round Spermatid Nucleus Injection (ROSNI) Should Not Be Offered To Male Infertility Patients at This Time” American Society for Reproductive Medicine, Orlando, FL (Syllabus), October 20-24, 2001.

27. Lamb DJ: “Primer on Molecular Biology Techniques In Evaluating Genetic Aberrations”, American Society for Reproductive Medicine (Syllabus), October 12-13, 2002.

28. Lamb DJ: “Animal Models of Male Reproductive Defects: What Can We Apply to Humans?” American Society for Reproductive Medicine (Syllabus), October 12-13, 2002.

29. Lamb DJ: “ICSI and the Oligospermic and Azoospermic Male-Genetic Consequences” American Society for Reproductive Medicine (Syllabus), October 12-13, 2002.

30. Lamb DJ: “New Research Advances in Male Infertility – What Does the Future Hold?” American Society for Reproductive Medicine (Syllabus), October 12-13, 2002.

31. Lamb DJ: “Tests of Sperm Function.” American Association of Bioanalysts (Syllabus), April 4-5, 2003.

6. Other Works Communicating Research Results to General Public:

1. “Science as a Career.” Wilson Elementary School, 1988-1990; Memorial Hall School, 1990; 1993; Langham Creek High School, 1998; Cypress Springs High School, 2000.

2. “Gamete Micromanipulation to Overcome Male Infertility.” Infertility Network, Houston, TX, 1993.

3. “Celebrity Reader in Science.” Carillo Elementary School, Houston Independent School District, 1995.

4. Sidebar for: “Environmental Assault on the Male: Fact or Fiction?” Lipshultz LI, Lamb DJ, RESOLVE Newsletter, August 1995.

5. “Hormone Imposters Spark Heated Debate.” Denver Post, Denver CO, March 1996.

6. “Study Finds Way to Produce Sperm Cells in Other Species.” (Lamb DJ quoted in article) Gina Kolata: The New York Times, May 1996.

7. “Study: Sperm From 1 Species Could Be Nurtured in Another Animal.” (Lamb DJ quoted in article) Gina Kolata: The New York Times, June 1996.

8. “The Father Factor.” American Society for Reproductive Medicine Conference: A documentary program for The Discovery Channel, Boston, MA, 1997.

9. “Study Finds Sperm Counts, Birth Rates Correlate; Dramatic Yearly Variability.” Environmental Health Letter, February 1997.

10. “Slants and Trends: Let Science Prevail.” Environmental Health Letter, February 1997.

11. “The Quest For Answers: Advancing the Health Effects Debate.” Chemical Week, February 1997.

12. “Hormone Disrupter Research Expands: Number of Health Effects Linked to Endocrine Disrupters Grows, Cause-Effect Relationships Remain Elusive.” Chemical and Engineering News, August 1997.

13. “Low Sperm Counts: The Untold Story.” Health, July/August 1997.

14. “More Deformities in Baby Boys: Hypospadias increase may be linked to fertility drugs.” Newsday (Nassau Edition), July 1997.

15. “Endocrine Disruptors.” Minnesota Public Radio Press Conference, Endocrine Society Meeting, Minneapolis, MN, 1997.

16. “Declining Male Reproductive Health.” Detroit Talk Radio, Detroit, MI, 1999.

17. “Endocrine Disruptors and Birth Defects; Male Infertility and Assisted Reproductive Techniques.” Eyewitness News: Christy Meyers, May 1998.

18. “Update of Male Reproductive Health.” Press Conference, Endocrine Society, Toronto, ON, Canada, June 2000.

19. “Male Infertility.” Korean Broadcast System Documentary, August 2000.

20. “Human Cloning.” Time Magazine, February 2001.

21. “Environmental Endocrine Disruptors.” Chair, Press Conference, Endocrine Society 83^rd Annual Meeting, Denver, CO, June 20, 2001.

22. ENDO 2001 Press Conferences: New Endocrine Therapies (Steroid Receptors). Media Advisory Committee, Endocrine Society 83^rd Annual Meeting, Denver, CO, June 20-23, 2001.

23. “Fringe Cloning Venture Raises Troubling Issues; A reproduction specialist once accused of unethical behavior is helping to spearhead a team of foreign scientists on a crash research program to clone humans.” (Lamb DJ quoted in article – Aaron Zitner, The Los Angeles Times, April 22, 2001.)

24. “Stem Cells.” TV Interview on San Diego CBS affiliate (Channel 12), August 22, 2001.

25. Rubin R: Sperm shape, swimming ability prove to be better indicator of fertility. USA Today (Lamb DJ quoted in article), November, p 10D, 2001.

26. Zamora D: Sperm count: Not the whole story in male infertility. (Lamb DJ quoted in article.) CBS Health Watch Newsletter, by Medscape. Medscape Health, November 2001.

27. “The Cloning Wars.” (Lamb DJ quoted in article.) Readers Digest p 50, December 2001.

28. “Genetic Basis of Male Infertility: Implications for Assisted Reproductive Technologies” Press Conference (Istanbul, Turkey) CNN (Asia) Television, Turkish News, April 2002.

29. “Increased Incidence of Expanded Alleles of the DMPK Gene (Myotonic Dystrophy) Associated with Non-Obstructive Azoospermia (NOA): A New Concern for ICSI? (Maduro MR, Lamb DJ.) The Endocrine Society Press Conference, June 2002.

30. What Does a Scientist Look Like?” University of Texas Graduate School of Biomedical Sciences Alumni Association Community Outreach: Sylvan Rodriguez Elementary (Lamb DJ, Chuang W), October 22, 2002.

31. “The New Genetics of Male Infertility in the Era of ICSI.” American Urological Association Bruce Stewart Memorial Lecture, Presented at the 59^th Annual Meeting of the American Society for Reproductive Medicine, San Antonio, TX, October 13, 2003. Society for Male Reproduction and Urology Newsletter, Summer 2004, p 2.

III. TEACHING INFORMATION

A. Didactic Course Work:

1. Courses Taught at BCM Within the Primary Department:

1. Summer Research Training Program (Cell Biology) – Program Director, 1985. (Organized entire summer course for advanced college students.)

2. Cell Biology Graduate Student Seminar in Reproductive Biology (Cell Biology Course #320-455), 1985. (Mandatory attendance for all first- and second-year cell biology students. Assigned study topics; helped students prepare and critique their seminars.)

2. Courses Taught at BCM External to Primary Department:

1. University of Texas Graduate School of Biomedical Science Research Rotation - Candace Thrash, 1993. (Laboratory supervision of third-quarter graduate student Ph.D. project.)

2. Research in Urology (Medical Student Rotations).

3. Cell Biology Reading Rotation – Rebecca Prince and Trina Knotts, Fall 1993. (Cell Biology Course #320-548) (Assigned 2-3 articles weekly for review with Dr. Lamb on male reproductive biology.)

4. Cell Biology Graduate Student Seminar (Course #320-455) – First Quarter, 1994. (Mandatory attendance for all first- and second-year cell biology students. Assigned study topics; helped students prepare and critique their seminars.)

5. Cell Biology Laboratory Research, Rotation (Course #320-549), Brad Talcott, 1998. (Gene Expression in the Testis.)

6. Molecular and Cellular Biology Laboratory Research, Rotation (Course #320-549), Maria Rosa Maduro. (Gene Expression in the Testis.)

7. Molecular and Cellular Biology Laboratory Research Rotation (Course #320-549), Yinan Lin. (Enrichment of Spermatogonial Stem Cells by Flow Cytometry.)

8. Cell Biology Thesis Examination Committee, 1997-1998

9. Medical School Integrated Problem Solving Blocks I and II – Facilitated, 1997-1999, Substitute 2002.

10. Cell Biology Graduate Student Seminar (3^rd Quarter) (Course #320-466), Winter 1998.

11. Cell Biology Standing Qualifying Examination Committee, 1998-2000.

12. Lamb DJ, McCullough L: Assisted Reproductive Technologies and Reproductive Decisions for Couples: Clinical Correlations in Reproduction (3 hours) (GIMNER). First-year medical students, 2001.

13. Maria Rosa Maduro; Dissertation (#320-550), 2000-present.

14. Gastrointestinal/Metabolism/Nutrition/Endocrine/Reproduction (GIMNER) Endocrine/Reproduction Module for first-year medical students) (6 hours), 2002.

3. Courses Taught at Other Institutions While at BCM: Not Applicable

B. Curriculum Development Work: GastroIntestinal/Metabolism/Nutrition/Endocrine/Reproduction (GIMNER)

C. Non-Didactic Teaching While at BCM:

1. Resident Training

1. Responsible for Urology Grand Rounds (3-6 times/year). (30-minute research update to urology faculty, residents, and fellows.)

2. Educational Programs:

1. Testis Biopsy Conference. (Weekly or monthly review of testis pathology with Dr. Lipshultz, male infertility fellows, residents, and pathologist; teaching human spermatogenesis concepts.)

2. Laboratory for Male Reproductive Research and Testing Journal Club. (Weekly review of two journal articles. Attended by Dr. Lamb’s laboratory fellows, residents, clinical and research technicians.)

3. Laboratory for Male Reproductive Research and Testing Research Conference. (Weekly in-depth review of one ongoing project in laboratory.)

4. Resident Laboratory Training: Jennifer M. Abidari (1993-1994). (Dr. Abidari worked full-time in the laboratory on immediate early gene expression during normal and compensatory renal growth.)

5. Dino DeConcini (1995-1996). (Dr. DeConcini worked full-time on androgen receptor mutations in prostate cancer metastatic to the bone.)

6. John T.B. Houston (1996-1997). (Dr. Houston worked full-time on Y chromosome genes and male infertility.)

7. William W. Lin (1996-1997). (Dr. Lin worked full-time on the molecular control of apoptosis in human testis.)

8. Michael Lewitton (1997-1998). (Dr. Lewitton worked full-time on the molecular analysis of hox genes in cryptorchidism.)

9. Edward C. Schatte (1998-1999). (Dr. Schatte worked full-time on a mouse model of asthenozoospermia, the VDAC3 mouse.)

2. Clinical Fellow Training:

Reproductive Endocrinology/OB/GYN Andrology Laboratory Rotation 1991-1994

3. Research Fellow Training:

(All research fellows work closely with Dr. Lamb on their chosen project. They participate in the weekly Journal Club and Research Conference run by Dr. Lamb as well as specialty conferences [Testis Biopsy Conference, Pediatric Urology Conference, and Cell Biology Conferences]. The fellows meet weekly with Dr. Lamb to discuss their experiments, review new findings in the literature, and to be trained in scientific thinking. During their training period, they spend 80%-100% of their time studying under Dr. Lamb’s direct supervision.

The terms of some of the fellowship awards stipulate that for some fellows, 20% of their time [i.e., 1 day per week] must be spent in the clinic or operating room with the M.D. sponsor.)

1. Jeffrey Buch, M.D., American Foundation for Urologic Disease Scholar (1986-1987). Present Position – Assistant Professor of Urology, University of Connecticut, Farmington School of Medicine. (Full-time [80%] laboratory research on secretion of Sertoli cell secreted growth factor by human Sertoli cells.)

2. Mark Sigman M.D., American Foundation for Urologic Disease Scholar (1987-1989). Present Position – Associate Professor of Urology, Brown University School of Medicine. (Full-time [80%] laboratory research on restriction fragment length polymorphism analysis of the TCP-1 gene in idiopathic male infertility.)

3. Michael Coburn, M.D., American Foundation for Urologic Disease Scholar (1988-1990). Present Position – Associate Professor of Urology, Baylor College of Medicine. (Full-time [80%] laboratory research on the development of a new immunochemical test for obstruction of the male genital tract using 2-D gel electrophoresis to identify proteins of the proximal genital tract in semen.)

4. Glenn Weitzman, M.D., Reproductive Endocrinology Fellow (1988-1989). Present Position – Associate Professor of Obstetrics and Gynecology, University of Arkansas School of Medicine. (Full-time [80%] laboratory research on alternative forms of the estrogen receptor in the uterus during the human menstrual cycle [i.e., 2-affinity forms, activation of a non-binding form of receptor].)

5. Els Berns, Ph.D. (1988-1990). Present Position – Staff Scientist, Dr. Daniel den Hoed Cancer Center, The Netherlands. (Full-time [100%] laboratory research on the role of acidic fibroblast growth factor in androgen regulated growth of DDT₁MF-2 cells.)

6. Shubhada Sankararaman, Ph.D. (1989-1991). Present Position – Pool Scientist at the Indian Institute of Technology, Madras, India. (Full-time [100%] laboratory research on the role of polyamines in the inhibition of DDT₁MF-2 cell growth by glucocorticoids; on the purification and characterization of Sertoli cell secreted growth factor; on the purification of activin and a GnRH-like peptide secreted by rat Sertoli cells in vitro.)

7. Susan Marengo, Ph.D. (1989-1990). Present Position – Associate Professor of Urology, Cleveland Clinic, Cleveland, OH. (Full-time [100%] laboratory research on the culture factors influencing androgen regulated growth of DDT₁MF-2 cells.)

8. Liang Ming Lee, M.D. (1989-1990). Present Position – Faculty of the Division of Urology, Department of Surgery, Veterans General Hospital, Taipei, Taiwan, Republic of China. (Full-time [100%] laboratory research on 2-dimensional gel analysis of sperm membrane proteins involved in capacitation and sperm binding to the zona pellucida.)

9. Mohamed Salama, M.D., Egyptian Peace Scholar (1990-1991). Present Position – Medical Faculty of the Urology Department of Alexandria University, Alexandria, Egypt. [Full-time [100%] laboratory research on 2-dimensional gel analysis of sperm membrane proteins involved in capacitation and sperm binding to the zona pellucida.)

10. Julius Lynn Teague, M.D. (1990-1991). Present Position – Associate Professor of Urology, University of Missouri School of Medicine, Columbia, MO. (Full-time [100%] laboratory research on analysis of androgen receptor function in hypospadias using foreskin fibroblasts and reporter gene transfection; analysis of the physiochemical characteristics of the androgen receptor in hypospadias.)

11. Maurus Glinz M.D., Postdoctoral Fellow (1990-1992). Present Position – Staff of the Clinic for Urology at the University of Berne, Inselspital, Berne, Switzerland. (Full-time [100%] laboratory research on purification of Sertoli cell secreted peptides; Sertoli cell culture.)

12. Sang Kon Lee, M.D., Postdoctoral Fellow (1991-1992). Present Position – Staff of the Department of Urology, Sacred Heart Hospital College of Medicine, Hallym University, Chunchon, Dang Won-Do, Republic of Korea. (Full-time [100%] laboratory research on the role of the low molecular weight substance which influences nucleoside transport secreted by cultured rat Sertoli cells.)

13. Madelyn Holzman, M.D. (1991-1992). Pediatric Urology Fellow; Present Position – Private Practice, Brownsville, TX. (Full-time [100%] laboratory research on the androgen receptor during mouse urogenital development using immunocytochemistry.)

14. Craig S. Niederberger, M.D. (1991-1993). American Foundation for Urologic Disease Scholar, American Fertility Society/Serono Scholar; Present Position – Associate Professor of Urology and Molecular Physiology, University of Illinois at Chicago School of Medicine, Chicago, IL. (Full-time [100%] laboratory research on the development of a method for in situ hybridization in testis; on the development of an artificial intelligence system for the prediction of fertility potential; on immediate early gene expression during spermatogenesis.)

15. Se Joong Kim M.D. (1992-1993). Postdoctoral Fellow; Present Position – Assistant Professor of Urology, Sungdong-Ku, Seoul, Korea. (Full-time [100%] laboratory research on the development of a method for in situ hybridization.)

16. Patrick O’Hollaren, M.D. (1992-1993). Pediatric Urology Fellow; Present Position – Pediatric Urologist, Legacy Hospital, Portland, OR. (Full-time [100%] laboratory research on immediate early gene expression during urogenital development.)

17. Natan Bar-Chama, M.D. (1993-1994). Valentine Fellow (New York Academy of Medicine); Present Position – Associate Professor of Urology, Mount Sinai Medical Center, New York, NY. (Full-time [100%] laboratory research on electroejaculation of spinal cord injured men.)

18. Semih Ozkan, M.D. (1993-1994). DeBakey Exchange Scholar (Turkey); Present Position – Associate Professor, University Hospital, Department of Urology, Inönü University, Arastirma Hastanesi, Malatya, Turkey. (Full-time [100%] laboratory research on the development of a sperm-zona binding competition assay using vital dyes.)

19. Joseph Hicks, M.D. (1993-1994). Pediatric Urology Fellow. Present Position – Private Practice, Huntsville, Alabama. (Full-time [100%] laboratory research on immediate early gene expression during urogenital development in the mouse; polymerase chain reaction of the androgen receptor from the foreskin fibroblasts obtained from hypospadias repair.)

20. Stefania Mariana, M.D. (1993-1994). Reproductive Endocrine Fellow (University of Rome School of Medicine). (Full-time [100%] laboratory research on androgen receptor mutations in advanced prostate cancer using polymerase chain reaction and single-strand conformational polymorphism analysis.)

21. Tatiana Sheiko, Ph.D. (1993-Present). American Foundation of Urologic Disease Scholar (Institute of Biochemistry, Russian Academy of Sciences); Currently in Dr. Joseph Byrant’s Laboratory. (Full-time [100%] laboratory research on analysis of the molecular mechanism of androgen regulation of immediate early gene expression, analysis of promoter regulatory regions by transfection of reporter gene constructs.)

22. Marina Gvakharia, M.D., Ph.D, (1993-1997). Present Position – IVF Laboratory Director, San Jose, CA. Research Associate (Medical Academy of Georgia, Tbilisi, Georgia). (Full-time [100%] laboratory research on the development of new tests for the diagnosis of sperm fertilizing capacity using the assisted reproductive techniques.)

23. Richard W. Sutherland, M.D., Pediatric Urology Fellow (1994-1995). Present Position – Director, Pediatric Urology, Associate Professor of Urology, University of North Carolina, Chapel Hill, NC. (Full-time [100%] laboratory research on androgen receptor mutations in hypospadias and on androgen receptor gene expression during urogenital development.)

24. Adel Essen, M.D., DeBakey Exchange Scholar (Turkey) (1994-1995). (Full-time [100%] laboratory research on androgen receptor mutations in advanced prostate cancer.)

25. Benjamin Tripp, M.D., Canadian Kidney Foundation Fellow (1995-1997). Present Position – Private practice, Boca Raton, FL. (Full-time laboratory research on male reproductive function of the progesterone receptor “knock-out” mouse.)

26. Margaret Vereb, M.D., Infertility Fellow (1995-1996). Present Position – Assistant Professor of Urology, Lahey Clinic, MA. (Full-time [80%] research on defining azoospermia Gensan human male infertility.)

27. John S. Wiener, M.D., Pediatric Urology Fellow (1995-1996). Present Position – Associate Professor of Urology, Duke University School of Medicine. (Full-time [100%] laboratory research on androgen receptor mutations and genitourinary development.)

28. Thomas F. Kolon, M.D., Pediatric Urology Fellow (1996-1997). Present Position – Assistant Professor, University of Pennsylvania School of Medicine. (Full-time [100%] laboratory research on hox genes and genitourinary development.)

29. William Huang, M.D., Infertility Fellow (1997-1998). Assistant Professor, Taipei Veterans General Hospital, Taipei, Taiwan. (Full-time [100%] laboratory research on FISH analysis of chromosome non-disjunction in testicular pathologies.)

30. Edward D. Kim, M.D., AFUD Scholar (1997-1999). Present Position – Associate Professor of Urology, Department of Surgery/Division of Urology, University of Knoxville, Knoxville, TN. (Full-time [100%] laboratory research on genetic defects in male infertility.)

31. Chang Os Kim, M.D., Urology Research Fellow (1999). (Full-time [100%] involved in laboratory research on androgen receptor mutations in prostate cancer.)

32. David J. Cozzolino, M.D., AFUD Scholar (1999-2000). Present Position – Brandywine Urology Consultants, Wilmington, DE. (Full-time [100%] laboratory research on germ cell transplantation and stem cells.)

33. Sergio G. Moreira, Jr., M.D., Infertility Fellow (1999). Present Position – Urology Resident, University of South Florida School of Medicine. (Full-time [100%] involved in correlates of fertility in spinal cord injured men.)

34. Roberto Casella, M.D., Swiss Research Foundation and Roche Research Scholar (1999-2001). Assistant Professor of Urology, University of Bern, Switzerland. (Full-time [100%] research on triplet disease transmission and genomic instability in male infertility.)

35. Rodrigo Pagani, M.D., Urology Research Fellow (2000-2001). Assistant Professor of Urology, University of São Paulo School of Medicine, São Paulo, Brazil. (Full-time [100%] research on the purification and identification of testicular stem cells.)

36. Eric A. Jones, M.D., Pediatric Urology Fellow (2000-2001). Assistant Professor of Urology, Scott Department of Urology, Baylor College of Medicine. (Full-time [100%] research involved in research on the genetic basis of VACTERL [VATER] syndrome and cryptorchidism.)

37. Steven King, Ph.D., NIDDK Postdoctoral Trainee (2000-present). (Full-time [100%] involved in the regulation of neurosteroid production and libido.)

38. Victor M. “Trey” Brugh, III, M.D., AFUD Scholarship (2001-2002). (Full-time [100%] involved in spermatogonial stem cell identification and transplantation.)

39. Kirk C. Lo, M.D., AFUD Scholarship (2002-2004). (Full-time [100%] research involved in the purification of spermatogonial stem cells.)

40. Weber W. Chuang, M.D., 2002 NIH K12 Training Grant Fellow (2002-2003). (Full-time [100%] research on the development of a male-mediated approach to the production of transgenic rats.)

41. Lixin Zhang, M.D., Ph.D., NIH T32 Training Grant Urology Research Fellow (2002-2005). (Full-time [100%] research on androgen receptor mutations in advanced prostate cancer and their significance to tumor progression.)

42. Laura Chelu, M.D., Urology Research Fellow (2002-2005). (Full-time [100%] research on the safety and efficacy of intracytoplasmic sperm injection [ICSI].)

43. Joan Blanco, Ph.D., Research Associate (2003-Present). (Full-time [100% research] research on chromosomal genomic instability in non-obstructive azoospermia.)

4. Graduate Student Training: (As Above, As Major Advisor, Committee Member)

1. Off-Campus Doctoral Thesis Committee Member for Candidate Lei Chen, University of Texas Medical Branch at Galveston, Department of Human Biological Chemistry and Genetics. (1993-1995). (Androgen Receptor Mutations in Hypospadias – Activation by Progesterone.)

2. Off-Campus Doctoral Thesis Committee Member for Candidate Victor MAK, M.D., University of Toronto (1995-1997). (Cystic Fibrosis Gene Mutations in Congenital Bilateral Absence of the Vas Deferens.)

3. Doctoral Thesis Committee Member for Candidate Sarah Blatt, Baylor College of Medicine, Department of Cell Biology, (1995-1999). (Regulation of Prostate Cell Growth by Vitamin D.)

4. Doctoral Thesis Committee Member for Candidate Trina Knotts, Baylor College of Medicine, Department of Cell Biology (1995-2001). (Role of Phosphorylation of the Function of the Human Progesterone Receptor.)

5. Doctoral Thesis Committee Member for Candidate Mac Johnson, Baylor College of Medicine, Department of Cell Biology (1995-2001). (Role of Androgen Regulation of Cadherin on Catenins.)

6. Doctoral Thesis Committee Member for Candidate Michael J. Girds, Baylor College of Medicine, Department of Cell Biology (1997-1999). (Androgen Regulation of Prostate Function.)

7. Doctoral Thesis Committee Member for Candidate Tara Polk, Baylor College of Medicine, Department of Cell Biology (1997-2001). (Molecular Basis Inhibition of Prostate Cancer Growth by Vitamin D.)

8. Doctoral Thesis Committee Member for Candidate Shalini Murthy, Baylor College of Medicine, Department of Cell Biology (1998-2002). (Vitamin D Regulation of Prostate Growth.)

9. Doctoral Thesis Committee Member for Candidate Jennifer Truxhorn, Department of Molecular and Cellular Biology (1998-2002). (Growth Factor Regulation of Prostate Development and Function.)

10. Doctoral Thesis Committee Member for Candidate Kevin Scholars, Department of Molecular and Cellular Biology, (2000-Present). (Identification of the Ligand for the Type II Estrogen Receptor.)

11. Off-Campus Doctoral Thesis Committee Member for Candidate, Joyce Lim Po I, University of Singapore, Department of Obstetrics and Gynecology (2002). (Molecular Pathogenesis in Complete and Minimal Androgen Insensitivity Syndromes.)

12. Doctoral Thesis Committee Member for Candidate Cindy Shirley, Department of Radiotherapy, M.D. Anderson Tumor Center, University of Texas Graduate School for Biomedical Sciences (1999-Present). (Targeted Deletion of Non-Histone Basic Proteins During Spermatogenesis.)

13. Off-Campus Doctoral Thesis Committee Member for Candidate, Joyce Lim Po I, University of Singapore, Department of Obstetrics and Gynecology (2002). (Molecular Pathogenesis in Complete and Minimal Androgen Insensitivity Syndromes.)

14. Doctoral Thesis Committee Member for Candidate Kevin Shoulars, Department of Molecular and Cellular Biology (2000-Present). (Identification and Purification of the Ligand for the Type II Estrogen Receptor.)

15. Doctoral Thesis Committee Member for Candidate Yi-Nan Lin, Department of Molecular and Cellular Biology (2002-Present). (Targeted Deletion of Male Fertility Genes in the Mouse.)

16. Doctoral Thesis Committee Member for Candidate Ashrumroy, Department of Molecular and Cellular Biology (2003-Present).

17. Doctoral Thesis Committee Member for Candidate Allison Fallander, Department of Molecular and Cellular Biology (2003-Present).

Doctoral Thesis Advisor

1. Doctoral Thesis Advisor for Maria Rosa Maduro (Course #320-550), Baylor College of Medicine, Department of Molecular and Cellular Biology, (1999-Present). (The Molecular Basis of Genomic Instability in Male Infertility.)

5. Medical Student Mentoring:

SMART and Summer Students. (Each SMART student in Dr. Lamb’s laboratory participates in a series of readings with Dr. Lamb, the Research Conference, and Journal Club, as well as laboratory experience.)

1. Cheryl Gonzales, 1988-1989; University of Texas School of Medicine at San Antonio, V.A. Hospital – Psychology and Internal Medicine, San Antonio, TX.

2. Suki Chandra (SMART Program 1989); New York University, New York, NY.

3. Nancy Williamson, 1990; Baylor College of Medicine, Houston, TX.

4. Ramie Kalish (SMART Program 1991); University of Texas Medical School, Houston, TX.

5. Steven Maislos (SMART Program 1992); University of Illinois at Chicago School of Medicine, Urology Residency.

6. Jamie Brandsma (SMART Program 1992); University of Georgia School of Medicine, Augusta, GA.

7. Cynthia Furlong (SMART Program 1993); Louisiana Tech University, LA (U.S. News Top 20 Students of the Year, 1993).

8. Daniel Venanske, 1995; American Cancer Society Student Trainee, Medical Student at Baylor College of Medicine, Houston, TX.

9. Carolyn Sufrin (SMART Program 1996); Johns Hopkins School of Medicine, Baltimore, MD.

10. Aarti Shah (SMART Program 1997; University of Houston School of Pharmacy, Houston, TX.

11. Theresa Nell (SMART Program 1997); Southwest Missouri State University, Springfield, MO.

12. Melissa Smith (SMART Program 1998); Louisiana State University, LA.

13. Jenny Yiee (SMART Program 1999); Yale University School of Medicine, New Haven, CT.

14. Anthony Joseph Herrera (SMART Program 2000); Harvard University, Cambridge, MA.

15. Sharon P. Fernandez, 2000; Honors Premedical Academy, Baylor College of Medicine/Rice University, Houston, TX.

16. Gretchen Wischweh (SMART Program 2001); NIH Trainee.

17. James D. Wolf, May 21–June 30, 2001; Medical student elective.

18. Latonia Botley, June–August 2001; Honors Premedical Academy, Baylor College of Medicine/Rice University.

19. Erica Herndon (SMART Program 2002); Xavier University, New Orleans, LA.

20. Nureen Haq, 2002; Summer Research for High School Students.

21. Leslie M. Pickett (SMART Program 2003; Endocrine Society Summer Fellowship, 2003); Honors Premedical Academy 2002, Baylor College of Medicine/Rice University, Houston, TX.

22. Rukayat Adelagun (SMART Program 2003); Baylor College of Medicine, Houston, TX.

23. Yi-Nan Lin, 2003; Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.

24. Allison Fallander, 2003; Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.

25. Angshumoy Roy, 2003; Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.

26. Heather Aguirre, June 1-24, 2004; Honors Premedical Academy Preceptorship, University of Texas at Austin, Austin, TX.

27. Emily Deanna Salman, June 8 – August 6, 2004 (SMART Program 2004); Mercer University, Atlanta, GA.

28. Shannon Whirledge, July 2004; Graduate Student, Scott Department of Urology, Baylor College of Medicine, Houston, TX.

29. Francesca Gordon, August 2004; Graduate Student, Scott Department of Urology, Baylor College of Medicine, Houston, TX.

30. Lei Chu, August 15-31, 2005; Medical Student, Awarded Howard Hughes Medical Institute Research Training Fellowship, Baylor College of Medicine, Houston, TX.

D Lectures:

1. International:

1. “Reproductive Rescue of Male Infertility in the Mouse Using Gamete Micromanipulation.” International Meeting on Basic and Clinical Aspects of Human Reproduction, Cartagena, Columbia, South America, November 1992.

2. “Growth Factors and Spermatogenesis.” International Meeting on Basic and Clinical Aspects of Human Reproduction, Cartagena, Columbia, South America, November 1992.

3. “Genetic Aspects of Male Infertility.” International Meeting on Human Reproduction, São Paulo, Brazil, South America, April 1996.

4. “Hormonal Disruptors and Male Infertility: Are Men at Serious Risk?” International Society for Regulatory Toxicology and Pharmacology, Raleigh, NC, January 1997.

5. Smithsonian, WHO, UN Sponsored International Workshop on Endocrine Disruptors, Washington, DC, January 23-24, 1997.

6. “Endocrine Disruptors and Male Infertility.” World Chlorine Conference, Washington, DC, September 22, 1998.

7. “Overview of Current Issues in Male Reproductive Health.” World Chlorine Chemistry Council’s Science Research Forum, Washington, DC, September 1998.

8. “Male Infertility Panel: Role of the Y Chromosome.” American Urological Association, San Diego, CA, May 4, 1999.

9. “Androgen Receptor Mutations in Advanced Prostate Cancer.” European Society of Oncology, Urology and Endocrinology, Paris, France, October 1999.

10. “Endocrine Disruptors and Male Infertility.” International Congress of Endocrinology, Sydney, Australia, October 30, 2000.

11. “Genetic Basis of Male Infertility”. “Causes of Male Reproductive Failure”. New Approaches in the Diagnosis and Treatment of Male Infertility, Istanbul, Turkey, April 20, 2002.

2. National:

1. “Tests of Sperm Function: Tru-Trax, Penetrak and the Sperm Capacitation Index – When are they Indicated? What do the Results Mean?” Endocrine Forum, American Urological Association, Annual Meeting, New Orleans, LA, May 1990.

2. “Growth Factors in the Testis.” American Academy of Pediatrics, Annual Meeting, San Francisco, CA, October 1992.

3. “Genes Involved in Spermatogenesis and Fertility.” American Urological Association, Molecular Approaches to Urologic Diseases, August 1992.

4. Director – Molecular Studies of Fertility and Spermatogenesis Session. American Urological Association, Molecular Approaches to Urologic Diseases Workshop (Attendance by Invitation Only), Houston, TX, August 1992.

5. “Rat Sertoli Cell Secretions Influence Nucleoside Biosynthetic Pathways In Vitro.” American Fertility Society, 48^th Annual Meeting, Male Reproduction/Urology Prize Paper, Plenary Session, 1992.

6. “Genetic Basis for Male Reproductive Disorders.” American Fertility Society, San Antonio, TX, 1994.

7. “Animal Models that Mimic Human Male Reproductive Defects.” American Urological Association, Office of Continuing Education, Houston, TX, 1994.

8. “Androgen Receptor Mutations in Advanced Prostate Cancer.” American Urological Association, Endocrine Forum, Orlando, FL, May 5, 1996.

9. “Environmental Estrogens and Male Infertility: Are Men at Serious Risk?” Women’s Health Initiative, Washington, DC, June 1996.

10. “Androgen Receptor Mutations and How They Affect Receptor Function.” National Institutes of Health, NICHD, Bethesda, MD, July 1996.

11. Endocrine Disruptor Workshop, Stakeholder Presentation, Environmental Protection Agency, Washington, DC, 1996.

12. “Genetics of Male Infertility” Society for the Study of Male Reproduction, American Urological Society, New Orleans, LA, 1997.

13. “Is ICSI Safe”? National Institutes of Child Health and NABER Consensus Conference on ICSI and Ethics, June 20-21, 1997.

14. “Does ICSI Transmit Dominant Genetic Disease? What Should We Do? The Debate Continues.” American Society for Reproductive Medicine, Cincinnati, 1997.

15. “Male Reproductive Effects and Mechanisms of Action.” NIEHS Conference on Estrogens in the Environment, Arlington, VA, 1997.

16. “Molecular Changes Involved in Progression of Hormone-Dependent Prostate Cancer.” Gordon Research Conference on Hormonal Changes, Tilton, NH, 1997.

17. “Is ICSI a Genetic Time Bomb? Yes.” The Pharmacia Upjohn Clinical Debate, American Society of Andrology, San Diego, CA, March 1998.

18. “Endocrine Disruptors.” Society for the Study of Male Reproduction, American Urological Association, May 30, 1998.

19. “Genetic Control of Sexual Differentiation.” American Society of Andrology, Long Beach, CA, 1998.

20. “A Look Towards the Future: New Technologies that May Influence Sperm Banking.” American Association of Tissue Banks, Miami, FL, (Syllabus), September 2000.

21. “Update on Male Infertility.” Serono Symposia, Washington, DC, March 29-31, 2001.

22. “Microassisted Fertilization and Genetic Defects.” Reproductive Genetics Genomics and Functional Proteomics, Boston, MA, June 28-July 1, 2001.

23. NICHD Reproductive Genetics Genomes and Functional Proteomics, Chairman, Boston, MA, June 28-July 1, 2001.

24. “Genetic Basis of Male Infertility.” Frontiers in Reproduction, Woods Hole, MA, June 27, 2001.

25. “Genetic Basis of Male Infertility.” American Association of Bioanalysts, Waikoloa, HI, August 3-7, 2001.

26. “Challenges and Strategies in Assisted Reproductive Technology.” 2001: An ART Odyssey, Waikoloa, HI, August 4-7, 2001.

27. “New Technologies: Freeze Dried Sperm, Spermatogonial Stem Cell Transplantation and Cloning.” American Urological Association, Office of Continuing Education: Molecular Approaches to Therapy in Urologic Disease, Houston, TX, August 10-12, 2001.

28. “Aging, Fertility and Contraception.” Panel Discussion, 57^th Annual Meeting of the ASRM, Orlando, FL, October 20-25, 2001.

29. “Regenerative Stem Cells and Male Infertility.” NIH Conference on Apoptosis in the Male Reproductive System, Bethesda, MD, March 21-22, 2002.

30. “The Genetics of Male Infertility,” American Urological Association Plenary Speaker, Orlando, Florida, May 29, 2002.

31. “Types of Abnormalities in ART: Consent/Follow-up Issues. Evidenced Based Assisted Reproductive Technologies.” National Institutes of Health, September 18-19, 2002.

32. “Exploring the Genetic Basis of Male Infertility.” American Association of Clinical Medical Geneticists, San Diego, CA, March 16, 2003.

33. “Case Studies in Male Infertility: Azoospermic Men.” Panelist, Panel Discussion, Plenary Session II, 99^th Annual Meeting of the American Urological Association, San Francisco, CA, May 10, 2004. J Urol (suppl) 171(4):XXXVIII, 2004.

3. Regional:

1. “Sertoli Cell Secreted Growth Factor.” Advances in Reproductive Medicine and Surgery, Postgraduate Course, February 1990.

2. “The Use of Artificial Intelligence for Predicting Clinical Outcomes in Urology.” Texas Association of Genitourinary Surgeons, Houston, TX, April 1994.

3. “Male Infertility Panel.” Innovations in Urologic Practice, Postgraduate Course, Houston, TX, February 1996.

4. “Are Sperm Counts Declining? The Debate Continues.” Annual Innovations in Urologic Practice, Postgraduate Course, Houston, TX, January 31 – February 2, 1997.

5. “Endocrine Disruptors and Male Infertility.” National Institute of Environmental Health Science, Raleigh, NC, May 11, 1998.

6. “Progesterone Receptor Knockout Mouse and the Non-Genomic Sperm Membrane Receptor.” National Institute of Environmental Health Science, Raleigh, NC, May 11, 1998.

7. “Diagnosing Male Infertility: The New Genetics.” 8^th Innovations in Urologic Practice, Santa Fe, NM, October 5-7, 2000.

8. “New Technologies That May Alter Sperm Banking in the Future.” California Reproductive Endocrine Society, San Diego, CA, August 22, 2001.

4. Local:

1. “Prostate Growth in Benign and Malignant Diseases.” AUA/SBUR Summer Research Conference, Houston, TX, August 1-3, 2003.

2. Chair, Session on Prostate and Growth Control. AUA/SBUR Summer Research Conference, Houston, TX, August 1, 2003.

E. Visiting Professorships:

1. University of Texas, M.D. Anderson Tumor Center, Department of Urology, Houston, TX, 1990. “Growth Factors and Oncogenes in Genitourinary Tumors” and “Steroid Regulated Growth of Male Reproductive Tumors.”

2. Mount Sinai School of Medicine, Department of Urology, New York, NY, 1994. “Growth Factors, Oncogenes, and Testicular Development and Function.”

3. University of Iowa School of Medicine, Department of Urology, Iowa City, IA, 1996. “Reproductive Rescue of Human Male Infertility Using Gamete Micromanipulation.” and “Androgen Receptor Mutations in Advanced Prostate Cancer.”

4. Sloan-Kettering Cancer Center, Genitourinary/Head and Neck Oncology Service Research Conference, New York, NY, 1996. “Androgen Receptor Mutations in Advanced Prostate Cancer.”

5. University of South Florida, Department of Pathology, Tampa, FL, November 1999. “Androgen Receptor Mutations in Advanced Prostate Cancer.”

6. The Population Council, Rockefeller University, New York, NY, 2002. “Microassisted Fertilization and Genetic Defects.”

7. North Shore University Hospital, New York University School of Medicine, Manhasset, NY, 2002. “Microassisted Fertilization and Genetic Defects.”

IV. MEDICAL AND SERVICE INFORMATION

A. Patient Care Responsibilities:

1. Department-wide: Not Applicable

2. Section or Subspecialty: Not Applicable

B. Clinical Laboratory Responsibilities:

1. Director of the Laboratory for Male Reproductive Research and Testing, Scott Department of Urology, Baylor College of Medicine, Houston, TX (1987-Present), Director of the Special Procedures Laboratory, Scott Department of Urology, Baylor College of Medicine, Houston, TX (2002-present) (Clinical Chemist, Specialty: Endocrinology) (High Complexity Clinical Laboratory Director, HCLD). (Dr. Lamb’s laboratory, one of the largest andrology laboratories in the country, performs state-of-the-art andrology testing. Current procedures in the laboratory include tests of sperm function [the optimized sperm penetration assay and the competitive zona binding assay]; testing for free radicals [ROS], and DNA damage in sperm, tests for immunological causes of infertility [the immunobead assay for antisperm antibodies and an immunocytochemical assay for the presence of white blood cells in semen]; tests for sexually transmitted diseases [chlamydia, mycoplasma, HIV, and gonorrhea] and other infectious diseases [cytomegalovirus, hepatitis A, hepatitis B, hepatitis C, and HTLV-1,], semen and urine cultures with sensitivities; hormone profiles [testosterone, prolactin, follicle-stimulating hormone, luteinizing hormone, free testosterone, progesterone, DHEA-sulfate, IGF-I, and estradio], genetic testing for Y chromosome microdeletions; fluorescent in situ hybridization for sex chromosome non-disjunction, semen analysis and sperm processing for insemination; and sperm cryopreservation; testing for tumor markers [PSA, free PSA, BTA, BTA-STAT, TGF beta, IGFBP-3, and IL-6SR, IL-2]. The laboratory is also the only andrology laboratory in a urology department in the country that performs gamete micromanipulation for the treatment of male infertility.

Dr. Lamb’s laboratory provides its services to the Departments of Urology and Obstetrics and Gynecology at Baylor College of Medicine, as well as to numerous urology and in vitro fertilization laboratories in the United States, Canada, and Mexico.)

2. Technical Consultant, The In Vitro Fertilization Program, The Department of OB/GYN, Baylor College of Medicine and The Methodist Hospital Center for Reproductive Medicine and Surgery. (1992-Present).

c. National Education or Voluntary Health Organization Participation:

1. Technological Advances in the Diagnosis and Management of Male Infertility. Faculty, American Fertility Society, 26^th Annual Postgraduate Program, Montreal, QC, Canada, October, 1993.

2. Molecular Approaches to the Study of Human Male Infertility: Basic Concepts. Faculty, American Fertility Society, 27^th Annual Postgraduate Program, San Antonio, TX, 1994.

3. American Urological Association Office of Continuing Education, Summer Research Conference, Program Chair, 1997.

4. Germ Cell Transplantation. American Society of Reproductive Medicine, Toronto, Ontario, Canada, September 1999.

5. Laboratory Evaluation of the Infertile Couple: A Look Towards the Future. American Society of Reproductive Medicine, Program Chair, Toronto, ON, Canada, September 1999.

6. Gene Therapy.” American Society of Reproductive Medicine, Toronto, ON, Canada, September 1999.

7. Immunologic Infertility. American Society of Reproductive Medicine, Toronto, ON, Canada, September 1999.

8. Laboratory Evaluation of the Infertile Male: Current Strategies and a Look Towards the Future. American Association of Reproductive Medicine, Toronto, ON, Canada, September 1999.

9. Computer-Assisted and Automated Techniques for Genetic Analysis. American Association of Reproductive Medicine, Toronto, ON, Canada, September 1999.

10. Y Chromosome Microdeletions. American Society of Reproductive Medicine, Toronto, ON, Canada, September 1999.

11. Basic Overview of Molecular Techniques. American Society of Reproductive Medicine, Toronto, ON, Canada, September 1999.

12. American Urological Association Office of Continuing Education, Summer Research Conference: Molecular Approaches to Therapy in Urologic Disease. Faculty, August 12, 2001.

13. Round Spermatid Nucleus Injection (ROSNI) Should not be Offered to Male Infertility Patients at this Time.” 34^th Annual Postgraduate Program, American Society for Reproductive Medicine, Orlando, FL, October 20-21, 2001.

14. Male Infertility and the New Genetics. 34^th Annual Postgraduate Program, American Society for Reproductive Medicine, Orlando, FL, October 20-21, 2001.

15. Libido. 34^th Annual Postgraduate Program, American Society for Reproductive Medicine, Orlando, FL, October 20-21, 2001.

16. Male Infertility and the New Genetics. American Society of Reproductive Medicine Orlando, FL, October 20-21, 2001.

17. Finding the Best Ph.D. Mentor. AUA Summer Research Program, Renal Cell Carcinogenesis, Houston, TX, August 4, 2002

18. Animal Models of Male Reproductive Defects. American Society of Reproductive Medicine, Seattle, WA, October 12-13, 2002

19. New Research Advances in Genetic Male Infertility—What Does the Future Hold? American Society for Reproductive Medicine, Seattle, WA, October 12-13, 2002.

20. Primer on Molecular Biology Techniques in the Evaluation of Genetic Aberrations, American Society for Reproductive Medicine, WA, October 12-13, 2002.

D. Administrative Assignments at BCM:

1. Department Administration, Committees, etc.:

1. Committees:

1988-1990 Residency Committee

1989-1992 Postgraduate Education Committee

1989-Present Research Committee

1990-1992 Marketing Committee

2003-Present Fellowship Committee, Scott Department of Urology, Baylor College of Medicine

2. Committee Chairmanships:

1989-1991 Research Committee, Chairman

1992-1994 Management Information System Committee, Scott Department of Urology, Baylor College of Medicine

2. College Administration, Committees, Etc.:

1. Committees:

1985-1995 Animal Research Committee, Baylor College of Medicine, Houston, TX

1990-Present Summer Medical and Research Training Program Committee, Baylor College of Medicine Graduate School, Houston, TX

1992-1993 Student Affairs Committee, Baylor College of Medicine Graduate School, Houston, TX

2000-2001 Association of Women Faculty, Subcommittee on Sexual Harassment, Baylor College of Medicine

2000-2001 American Cancer Society, New Investigator Grant Review Panel, Baylor College of Medicine

2000-2002 Faculty Appointments & Promotions Committee, Baylor College of Medicine

2001-2003 Endocrine/Reproduction Module Oversight Committee, Fall I Curriculum, Baylor College of Medicine

2001-2003 University of Texas Graduate School of Biomedical Sciences Alumni Association Steering Committee

2003-Present Basic Science Representative to the Academic Council, Baylor College of Medicine, Houston, TX

2003-Present Curriculum Committee, Baylor College of Medicine, Houston, TX

2003-2004 Chair, Nominating Committee for Academic Council Faculty-At-Large Positions, Baylor College of Medicine, Houston, TX

2004-2007 Standing Examination Committee of the Graduate Program, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX

2004-2005 Curriculum Committee, Baylor College of Medicine, Houston, TX

2. Committee Chairmanships: Not Applicable

E. Other Pertinent Information Not Given Above:

1. Previous Faculty Positions:

Research Instructor, Department of Cell Biology, Baylor College of 1984-1985

Medicine, Houston, TX

Assistant Professor of Urology, The Scott Department of Urology, Baylor 1986-1995

College of Medicine, Houston, TX

Assistant Professor of Cell Biology, Baylor College of Medicine, 1986-1995

Houston, TX

Director of Research, Scott Department of Urology, Baylor College of 1987-1991

Medicine, Houston, TX

2. Past Research Grants Funded (While at Baylor College of Medicine):

1. “Progesterone Receptor Hormone Action”

(1) National Research Service Award, National Institute of Child Health and Human Development

(2) Principal Investigator

(3) 1982-1984

(4) Annual Direct Costs: $29,532

(5) Total Direct Costs: $88,596

(6) Fellowship Number 1-F32-HD-06336

2. “Progesterone Receptor Structure and Function”

(1) National Institute of Child Health and Human Development, New Investigator Research Award

(2) Principal Investigator

(3) 1984-1986

(4) Annual Direct Costs: $36,228

(5) Total Direct Costs: $108,684

(6) Grant Award Number 1-R23-HD-18301

3. “Sertoli Cell Secreted Growth Factor”

(1) United States Public Health Service

(2) Principal Investigator

(3) 1987-1988

(4) Annual Direct Costs: $10,000

(5) Total Direct Costs: $20,000

(6) Biomedical Research Support Grant Number RR-05425

4. “Androgen Receptor Gene in Growth and Differentiation”

(1) National Institute of Diabetes and Digestive and Kidney Diseases

(2) Co-Principal Investigator (Principal Investigator at Baylor)

(3) 1987-1989

(4) Annual Direct Costs to Baylor College of Medicine: $81,377

(5) Total Direct Costs to Baylor College of Medicine: $244,103

(6) Public Health Service Grant Number R01-DK37691

5. “Steroids in Tumor Growth in the Male Reproductive Tract”

(1) National Cancer Institute

(2) Principal Investigator

(3) 1987-1989

(4) Annual Direct Costs: $99,088

(5) Total Direct Costs: $297,263

(6) Public Health Service Grant Number R01-CA36264

6. “Sertoli Cell Secreted Growth Factor”

(1) National Institute of Diabetes and Digestive and Kidney Diseases

(2) Principal Investigator

(3) 1987-1991

(4) Annual Direct Costs: $78,693

(5) Total Direct Costs: $236,079

(6) Public Health Service Grant Number R01-DK39719

7. “The Methodist Hospital Center for Reproductive Research”

(1) The Methodist Hospital

(2) Scientific Co-Director for Urology

(3) 1987-1992

(4) Annual Direct Costs: $139,319

(5) Direct Costs to Costs: $696,597

8. “The Acrosome Reaction and Infertility”

(1) Humagen

(2) Co-Principal Investigator

(3) 1988-1990

(4) Annual Direct Costs: $102,000

(5) Direct Costs: $204,000

(6) Humagen Research Award

9. “Baylor SPORE – Endocrine Group”

(1) National Institutes of Health — National Cancer Institute

(2) Investigator

(3) 1992-1994

(4) Annual Direct Costs: $32,000

(5) Total Direct Costs: $96,000

(6) Public Health Service Grant 1 P50 CA58204

10. “Correlates of Fertility in Spinal Cord Injured Men”

(1) National Institutes of Health

(2) Co-Principal Investigator

(3) 1992-1997

(4) Annual Direct Costs: $198,000

(5) Total Direct Costs: $990,000

(6) Public Health Service Grant 1R01 HD30155-01

11. “Steroid Regulation of Male Reproductive Tumors”

(1) National Institute of Health — National Cancer Institute

(2) Principal Investigator

(3) 1992-1998

(4) Annual Direct Costs: $83,377

(5) Total Direct Costs: $459,258

(6) Public Health Service Grant Number 1 R01 CA58020-01

12. “Society for Basic Urologic Research Fall Symposium Meeting Grant”

(1) National Institutes of Health — NIA DDK

(2) Program Chairperson (P.I.)

(3) 1993

(4) Annual Direct Costs: $15,000

(5) Total Direct Costs: $15,000

(6) Public Health Service Grant 1R13DK48156-01

13. “Androgen Receptor Mutations in Advanced Prostate Cancer”

(1) CaP Cure Foundation

(2) Principal Investigator

(3) 1994-1995

(4) Annual Direct Costs: $100,000

14. “Androgen Receptor Mutations in Advanced Prostate Cancer”

(1) CaP Cure Foundation

(2) Principal Investigator

(3) 1995-1996

(4) Annual Direct Costs: $100,000

15. “Male Fertility Panel”

(1) Chlorine Council on Behalf of the Chemical Manufacturers Association

(2) Co-Principal Investigator

(3) 1995-2000

(4) Annual Direct Costs: $85,000

16. “Activation of Spermatogenic Recovery After Toxic Insult”

(1) National Institutes of Health

(2) Consortium Principal Investigator at Baylor

(3) 1996-2001

(4) Annual Direct Costs: $17,760; $96,185

(5) Public Health Service Grant 1-R01-ES08075

17. “Androgen Receptor Mutations in Advanced Prostate Cancer” – Competitive Renewal Submitted (2002-2007)

(1) National Institutes of Health

(2) Principal Investigator

(3) 1996-2001

(4) Annual Direct Costs: $243,695

(5) Total Direct Costs: $1,361,838

(5) Public Health Service Grant 1-R01-CA68615

18. Center for the Study of Reproductive Biosciences

(1) National Institutes of Health, National Institute of Child Health and Human Development

(2) Project Co-Leader (Bert W. O'Malley, Director)

(3) 1998-2001

(4) $117,740; $615,636

3. Scientific Advisory Boards:

Humagen Fertility Diagnostics, Inc. – Scientific Advisory Board

Biopore, Inc. – Consultant

The Methodist Hospital, Center for Reproductive Medicine and Surgery, Scientific Steering Committee (1988-1993)

Bioshaf Fertility Diagnostics – Consultant

Complegen – Consultant

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