Yi-xun Liu

Member of Chinese Academy of Sciences

Address:               State Key Laboratory of Reproductive Biology,

                                Institute of Zoology, Chinese Academy of

                                    Sciences, Beijing 100080  P.R. China

 

Telephone:             0086-10-62588461,(O)     0086-10-62610283 (O)

Fax:                       0086-10-62588461;       0086-10-62565689

E-mail:                 Liuyx@ioz.ac.cn

 

Citizenship:            Chinese

 

Education and Scientific Research:

 

1958.4-1963.9:    Undergraduate Student, Department of Physiology, Fudan

                University, Shanghai. Graduated in 1963

1963.8-1967.8: Graduate student of reproductive endocrinology in Institute of

                Zoology, Chinese Academy of Sciences, Beijing, and graduated in

                1967 (advisor: Prof. Chang, C.Y.)

1967.8-1972.9:    Reproductive Biology, Institute of Zoology, Chinese Academy of

                Sciences, Beijing

1972.9-1974.3:    Beijing Language College: English training

1974.4-1975.12:   Biochemistry, Department of Biochemistry, Imperial Cancer

                Research Fund, London, England

1976.1-1984.2:    Assistant Professor, Research group leader, Department of

                Endocrinology, Institute of Zoology, Chinese Academy of Sciences, Beijing

1984.3-1986.12:   Biochemistry and Physiology, Dept. of Reproductive Medicine.

                University of California, San Diego, CA, USA

1987.1-1988.9:    Associate Professor of reproductive biology, Institute of Zoology,

                Chinese Academy of Sciences, Beijing, Vice Chairman of 

                Department of Endocrinology

1988.9-1989.5:    Visiting Scientist, Molecular Biology, Unit for Applied Cell and

              Molecular Biology, Umeå University, Umea, Sweden.

1989.6-1990.2:    Professor and Director, Department of Endocrinology; State Key Lab of

Reproductive Biology, Institute of Zoology, CAS

1990.3-1991.4:   Visiting Professor. Molecular Biology, Unit for Applied Cell and

                Molecular Biology, Umea University, Umeå, Sweden.

1992.7-1992.10:  Visiting Professor, Molecular Biology, Unit for Applied Cell and

                Molecular Biology, Umeå University

1995.11-1997.9:  Visiting professor (3 monthes per year), Anatomy Research

                Laboratory in Department of Pre-Clinical Sciences, Leicester

                University,UK.

1999.1-2001.12: Visiting professor , Department of Pre-Clinical Sciences, Leicester University, UK

Present Position:

 

Member (Fellow) of Chinese Academy of Sciences,

Chairman of Academic Committee of State Key Lab of Reproductive Biology, Institute of Zoology,

Chinese Academy of Sciences

Chairman of Academic Committee of State Key Lab of Nanjing Medical University

Director of WHO / Rockefeller Foundation International Implantation Collaboration Research

China Center 

Chairman of Chinese Society for Reproductive Biology

Deputy Director of National Society for Endocrinology, Reproductive Biology and Metabolism,

Member of National Science and Technology of Family Planning Commission

 

Editorial Boards:

Frontiers in Bioscience  Managing Editor/Editor (2005- )

“Human Reproduction” (Cambridge, 1995-2001))

  “Archieves of Andrology” (USA, 2001- )

  “Reproductive Biology & Endocrinology”(USA, 2005- )

  “ Science in China C” ( 2000- )

  “ Developmental and Reproductive Biology” (China, 1995-)

  “Acta Physiologica Sinica" (China, 1985- )

“Acta Zoologica Sinica” ( China, 2000-)

 

International Scientific Activities:

 

  1.  9th International Symposium on Comparative Endocrinology, Hong Kong,  1981

  2.  15th International Symposium on Physiological Sciences, Sydney, Australia, 1983

  3.  Endocrine Society 67th Annual Meeting Baltimore, MD, USA,           1985

  4.  Society for the Study of Reproduction 18th Annual Meeting, Canada,      1985

Endocrine Society 68th Annual Meeting, Anahei, CA, USA,             1986

6.  Society for the study of Reproduction 28th Annual Meeting, Davis, CA, USA

                                                                 1995

  7.  British Fertility Society Winter Meeting, Oxford                       1995

8.      International Conference on Endocrinology,Reproduction, Digestion and

Metabolism,Hong Kong                                          1996.

  9.  British Fertility Society Summer Meeting. Nottigham                   1996

 10.  Anual Meeting of Anatomical Society Great Britain and Ireland. Edinburgh

                                                                   1997

 11.  Hong University Medical Faculty 110 Anniversary Celebration Scientific

      Congress                                                     1997

 12.  International Meeting on Reproductive Biology for Chinese young scientists,

      Beijing                                                       1997.

 13.  Workshop on “the Potential Involvement of Pharmaceutical Industry in Contraceptive Research in China. Beijing                                               1998

 14.  3rd International Symposium of AOSCE Kwangju, Korea,               1998

15.  Rockeffeller Foundation/WHO Implantation Iniative Project Meeting Geneva, Switzerland 1999

16.        Rockefeller Foundation/ WHO Implantation Iniative Meeting, Oregon USA,

2000

 

 

 

Memberships:,

    

   Member of Society for the Study of Reproduction, USA,

   Member of American Association for the Advancement of Science.

   Member of New York Academy of Sciences

   Chairman of: "Chinese Society for Reproductive Biology",

   Member of: "Chinese Society for Physiology",

   Member of: Chinese Society for Cell Biology

   Standing Member of: Chinese Society for Comparative Endocrinology

   Standing Member of Committee of Chinese Society for Physiology,

                      

Awards:

  

    1.  Natural Science Award of Academia Sinica         1982 ( 2rd grade )

        Preparation of Estrogen, Progesterone and Testosterone RIA kits for

        commercial use in China

2.  Beijing Award of Science and Technology          1983 ( 3rd grade )

        Studies on the Effect of Gossypol on anti-endometrisis 

       3.  Natural Science Award of Academia Sinica         1984 ( 2rd grade )

        Reproductive Physiology of Amphioxus

    4.  Natural Science Award of Academia Sinica         1985 ( 2rd grade )

        Regulation and Extrapituitory Function of LH-RH and its  Angonist

    5.  Natural Science Award of Academia Sinica         1991 ( 2rd grade )

        Interaction and Regulation of Ovarian Granulosa and Theca-interstitial

        Cells           

    6.  Natural Science Award of Academia Sinica         1993 ( 3rd grade )

        The Role of Steroid and Steroid Receptors in the Precess of Implantation

    7.  Natioal Science Award of Academia. Sinica         1996 (2rd grade)

          Studies on the Role of tPA and PAI-1 in Regulation of Luteal Regression

           and Spermatogenesis

  8．Science and Technology Award of State Family Planning Commi-ssion             

1996 ( 2rd grade )

        Studies on the Regulation of Follicle Development and Luteal Regression

9. Science and Technology Award of State Family Planning Commission               

1996 ( 2rd grade)

       Studies on Epididymis factors Related to Sperm Maturation

    10.  Natural Science Award of Academia Sinica         1997 (First grade)

        Studies on the Mechanism of Ovulation

11    ostdoctoral Fellowship and Research Fund from Rockfeller Foundation

                                                  1984-1986, 1987-1989

12 Visiting Professorial Fellowship from Swedish Medical Research Council

                                             1991-1992                                       

13 Visiting Professorship Sponsored by the Royal Society of UK and Academia

       Sinica (3 months per year)                     1995- 1997

14 Visiting Program sponsored by Swedish Medical Research Foundation and

       NNFC                                     1998

15    Visiting professorship sponsored by the Royal Society of UK and NNSFC (3

months per year)                             1999-2002

 

 

Publications

1. Xuan Jin, Chun-Sheng Han, Xue-Sen Zhang, Fu-Qing Yu, Shu-Hua Guo, Zhao-Yuan Hu and Yi-Xun Liu (2005): Stem cell factor modulates the expression of steroidogenesis related proteins and FSHR during ovarian follicular development  Frontiers in Biosciences 10:

2. Fu-Qing Yu, Chun-Sheng Han, Wei Yang, Xuan Jin, Zhao-Yuan Hu, and Yi-Xun Liu* (2005) ROLE OF ERK1/2 IN FSH-INDUCED PCNA EXPRESSION AND STEROIDOGENESIS IN GRANULOSA CELLS  Frontiers in Biosciences 10:896-904

3. Fu-Qing Yu, Chun-Sheng Han, Wei Yang, Xuan Jin, Zhao-Yuan Hu, and Yi-Xun Liu* (2005) Activation of p38 MAPK pathway by FSH regulates steroidogenesis in granulosa cells differentially  J. Endocrinol

4. Jin X, Yu FQ, Wei P, Hu ZY, Han CS, Liu YX(2005): Signal transduction of stem cell factor in promoting early follicle development  Mol Cell Endocrinil 229 (1-2): 3-10

5. Liu Yi-Xun (2004): Endometrium implantation and ectopic pregnancy  Sciences in China C 47(4): 293-302

6.刘以训(2004): 我国男性避孕研究的发展前景 自然科学进展 14 (3):249-255

                                                                   

7. Jin X, Yu FQ, Wei P, Hu ZY, Han CS, Liu YX(2004): Anti-apoptotic action of stem cell factor on oocytes in primordial follicles and its signal transduction. Mol Reprod Dev. 2004 Oct 28;70(1):82-90 [Epub ahead of print]

8. Liu Q, Zhao XG, Zhang Y, Shen Y, Liu YX, Yan XY (2004): Melanoma cell adhesion molecule (MCAM/CD146) is a critical molecule in trophoblast invasion. Prog Biochem Biophs 31 (4):309-312

*9 Luu KC, Nie GY, Hampton A, Fu GQ, Liu YX, Salmonsen LA (2004): Endometrial expression of calbindin (CaBP)-d28k but not CaBP-d9k in primates implies evolutionary changes and functional redundancy of calbindins at implantation. Reproduction 128(4): 433-441

*10 Zhang ZH, Song XX, Xiao LJ, Han CS, Zou RJ and Liu YX (2004): Expression of intermediate filaments in the testis of rhesus monkey during heat-stress induced azoospermia or oligozoospermia   International J. Andrology  27(4): 234-239  

*11 Wei P, Chen XL, Song XX, Hu ZY and Liu YX (2004): VEGF, bFGF and their receptors in the endometrium of rhesus monkey during menstrual and early pregnancy  Mol  Reproduction Develoment 68 (4): 456-462                                                

*12 Siler-Khdor TM, Yu FQ, Wei P, Tao SX and Liu YX (2004): Contraceptive action of a GnRH II analog in the rhesus monkey  J Clin Endocrinol and Metab  2004, 89(9): 4513-4520

*13 Wei p, Jin X, Xiao LJ, Liu YX (2004): Expression of Fas,FasL, bcL-2 and Bax in the endometrium of rhesus monkey during the menstrual cycle and pregnancy  Mol Reprod and Develop  68: (5): (in press)

*14 Wei P, Jin X, Zhang XS, Han CS and LiuYX (2004): Expression of bcl-2 and P53 at the fetal-maternal interface of rhesus monkey  Contraception  (In press)

*15 Liu Yi-Xun (2004): PLASMINOGEN ACTIVATOR / PLASMINOGEN ACTIVATOR INHIBITORS IN OVARIAN PHYSIOLOGY  Frontiers in Biosciences (Review paper) 9:3356-3373

*16 Liu Yi-Xun (2004): Involvement of molecules related to angiogenesis, proteolysis and apoptosis in implantation in rhesus monkey and mouse  Contraception  (Review paper, in press)

*17 Liu Yi-Xun (2004): CONTROL OF SPERMATOGENESIS IN PRIMATE AND PROSPECT OF MALE CONTRACEPTION  Arcieves of Andrology  (Review paper,  in press)

*18 Liu YX, Liu K, Feng Q, Liu HZ, Hu ZY, Fu GQ, Li YC and Ny T (2004): Coordination Expression of Tissue-type Plasminogen Activator and Its Inhibitor Plasminogen Activator Inhibitor Type 1 Plays an Important Role in Ovulation in the Rhesus Monkey  Endocrinology 145: 1767-1775                                                           

*19.Wei P, Chen XL, Song XX, Hu ZY< and Liu YX (2004): VEGF, bFGF and their receptors in the endometrium of rhesus monkey during menstrual cycle and early pregnancy Placenta 25: 184-196                                                                      

20 Wei P, Jin X, Tao CS and Liu YX (2004): Apoptosis and P53 expression in the implantation site of rhesus monkey in the normal and drug-induced abortion  Acta Physiol Sinica  56(1):60-65

*21 Liu Y X (2004): Endometrium implantation and ectopic pregnancy Science in China B 34(2): 105-112

*22 Liu YX (2004): Progress in male contraceptive research in China Progress in Nature Science 14:249-255

*23 Liu K, Feng Q, Gao HJ, Hu ZY, Zou RJ, Li YH and Liu YX (2003): Expression and Regulation of Plasminogen Activators (PAs), Plasminogen Activator Inhibitor type-1 (PAI-1) and steroidogenic acute regulatory protein (StAR) in rhesus monkey corpus luteum  Endocrinology, 2003, 144 (8): 3611-3617          

*24 Chen XL , Gao HJ, Wei P, Zhang ZH and Liu YX (2003): Expression of apoptosis-related genes Fas/FasL, Bax/BcL-2 and caspase-3 in rat corpus luteum during luteal regression  Science in China (C)  46(3):273-285                                                

*25 Wei P, Zhang ZH, Chen XL and Liu YX (2003): Expression and function of AA98, a newly found vascular endothelial cell related factor at the maternal-embyyonic boundary of rhesus monkey      Chinese Sci Bulletin 48(9):881-886                                          

*26 Dimitriadis E, Robb L, Liu YX, Enders AC, Martin H, Stoikos C, Wallace and Salamonsen LA (2003): IL-11 and IL-11Ra immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal  development  Reproductive Biology and Endocrinology 2003 1: 34

*27 Chen XL, Gao HJ, Wei p, Song XX, Hu ZY and Liu YX (2003): Regulatory effect of TGF-b1, TbR-II and StAR in corpus luteum of pregnant rhesus monkey   Acta Pharmacol. Sinica 24(5): 435-441                                                               

*28 Zhang ZH, Zhou XC, Wei P, Hu ZY and Liu YX (2003): Expression of BcL-2 and Bax in rhesus monkey testis during germ cell apoptosis induced by testoterone undecanoate Archives of Andrology 49: 439-447                             

*29 Zhang Z.-H,Hu Z-Y, Zou R-J, Jin X, Zhang X-S, Han C-S, Liu Y-X (2003): BCL-2 and BAX is involved in testicular germ cell apoptosis induced by by experimental cryptorchildism in rhesus monkey  Contraception  68:297-301                                      

*30 Jin Xuan and Liu Yi-Xun (2003): Follicular growth, differentiation and atresia Chinese Sci Bulletin: 48(17):1786-1790                                             

*31Wei P, Yuan JX, Jin X Hu ZY and Liu YX (2003): Molsidomine and N omega-nitro-L-arginine methyl ester affect apoptosis in mouse endometrium  Acta Pharmcol Sinica 24: 24(12):1177-1184                                       

*32 Liu YX, Xiao SB (2003): Development of population and reproductive medicine in China 266-283  in Science Progress in China, Eded by Lu Yongxiang, Science press 2003

*33 Nie GY,Hampton AL,Fu GQ, Liu YX, Findlay JK and Salamonsen LA (2002):A potential molecular mechanism for regulating pre-mRNA spling of implantation-related genes through unique uterine expression of spling factor SC35 in wemen and rhesus monkey     Reproduction 124 (2): 209-217

*34 Han XB, Zhou XC, Hu ZY, Zhang ZH and Liu YX (2002): Cloning and characterization of temperature-related gene TRS1   Archives of Andrology   48: 273-280     

*35 Gao F, Wei P, Chen XL, Zhang ZH and Liu YX (2002): Relationship between uterine expression of matrix metalloproteinases and their inhibitors and endometrial receptivity  Scince in China C  45: 406-411                                      

*36 Gao F, Fu GQ, Ma J, Wei P, Feng Q, Hu ZY and Liu YX (2002): Expression of MMP-2,TIMP-1,-3 mRNAs in mouse placenta   Acta Zool. Sinica 48: 227-232

37 Gao F, Fu GQ, Ma J, Feng Q and Liu YX (2002): Apoptosis occurs in early stage of placentation                                Acta Physiol. Sinica 53:409-413

38 Zhou XC, Hu ZY, Li YC, Wei P, Zou RJ and Liu YX (2002): Role of P16 protein and germ cell apoptosis in rhesus monkey azoospermia or aligozoospermia induced by heat stress or testosterone undecanoate   Acta Zool. Sinica   48(3): 363-367.

*39 Liu Yi-Xun (2002): Molecular basis of implantation   Bulletin of the Chinese Academy of Sciences 7 (5): 331-334:

40 Liu YX (2002): Molecular Basis of Folicular development, ovulation and lutenization   J weifang University 2(6): 1-12

*41 Zhou Xin-Chang,Wei Peng, Hu Zhao-Yuan, Gao Fei, Zhou Ru-Jin, LiuYi-Xun

(2001): Role of apoptosis related genes Fas/FasL in azoospermia or oligozoospermia induced by testosterone undecanoate in rhesus monkey Acta Phamacol. Sinica 11: 1028-1033

42. Zhou XC, Wei P, Hu ZY< Han XB, Zhou RJ and Liu YX (2002): Expression of P16 in testis of rhesus monkey during heat stress and testosterone undecanoate induced azoospermia or oligozoospermia  Contraception  65: 251-255       

43. Zhou XC, Zhang ZH, Hu ZY, Zhou RJ and Liu YX (2002):Expression of Hsp 70-2 in rhesus monkey by testosterone undecanoate  Contraception 66: 377-382

44. Zhou XC, Han XB, Hu ZY, Zhou RJ and Liu YX (2001): Expression of Hsp 70-2 in unilateral cryptorchid testis of rhesus monkey during germ cell apoptosis Endocrine 16: 89-95

*45 Guo CX, Jie Ma, Zhou XC, Liu YX (2001): Expression of hSP 70-2 gene during germ cell apoptosis in rat unilateral cryptorchid testes.Archives. of Andrology. 46(2):109-115

*46.Gao Fei, Xu Fu-Hua, Zhou Xin-Chang, Han Xiao-Bin and Liu Yi-Xun (2001): Mifepristoneregulates expression of apoptosis related genes Fas and FasL in mouse endometrium.   Acta Pharmacol. Sinica 22 (6): 524-529

*47 Gao Fei, Ma Jie, Fu Guo-Qiang and Liu Yi-Xun (2001): Expression of TGF-B in the mouse placenta  Zoological Research  22 (4) : 269-274

*48.Fei Gao,Xin-Lei Chen,Peng Wei, Hong-Juan Gao, Yi-Xun Liu (2001): Expression of

matrix metalloproteinase-2, tissue inhibitors of metaloproteinase-1,-3 at the implantation site of rhesus monkey during the early stage of pregnancy.   Endocrine 15(2): 5-12

*49 Zhou Xin-Chang,Wei Peng, Hu Zhao-Yuan, Gao Fei, Zhou Ru-Jin, Liu Yi-Xun (2001): Role of apoptosis related genes Fas/FasL in azoospermia or oligozoospermia induced by testosterone undecanoate in rhesus monkey  Acta Phamacol. Sinica 11: 1028-1033

*50 Feng Q, Liu K, Liu YX, Byrne S and Ocklefed CD (2001): Plasminogen activators and inhibitors are transcribed during early mataque implantation  Placenta 22:186-199

*51 Guo CX, Jie Ma, Zhou XC, Liu YX (2001): Expression of hSP 70-2 gene during germ cell apoptosis in rat unilateral cryptorchid testes. Archives. of Andrology. 46(2):109-115

*52 Zheng Ping, Zou Ru-Jin, Liu Yi-Xun (2001): Source of plasminogen activator in

   rhesus monkey and its possible role in sperm capacitation  Acta Physiol. Sinica

3(1):45-50

*53.Feng Q, Liu YX, Liu K, Byrne S, Liu GZ, Wang XL, Li ZX and Ockleford CD. (2000): Expression of urokinase plasminogen activitor, inhibitor and urokinase receptor in pregnant rhesus monkey uterus during early placentation. Placenta. 21(2):184-193.

*54. Mu XM, Liu YX, Cllins LL and Chang C (2000): The P53/Rb-mediated

 repression of testicular orptan receptor-2 in the Rhesus monkey with

 cryptorchichidism J. Biol. Chem (31): 23877-23883

*55. Liu HZ and Liu YX (2000): Study on the role EGF on primordial follicle initiation and devolopment. Science in China C  43 (5): 535-543.

柳海珍, 刘以训 (2000): EGF在新生大鼠原始卵泡生长启动中的作用 中国科学C 30 (3): 322-329

*56 Liu YX, Hu ZY, Feng Q, Cao HJ, Liu K and Ockleford C. D (2000): Studies on expression and function of MT1-MMP and TIMP, in Human early placentation  Chinese  Sci.  Bulletin ,45(16): 1483-1488

刘以训, 胡召元, 冯强, 高洪娟, 刘奎, Ockleford C.D (2000): 膜基质金属蛋白酶和金属蛋白酶抑制因子1在早期胎盘中的表达及其功能的研究 .科学通报45 (6): 607－611

*57 Guo CX,Hu ZY, Zou RJ, Mu XM and Liu YX (2000): Expression and regulation of orphan receptor TR2 mRNA in germ cells of cryptorchild testis in rat and rhesus monkey. Chinese .Sci. Bualletin  45 (8): 720-725.

郭彩霞，胡召元，邹如金，穆小民，刘以训（2000）：孤儿受体TR2 mRN在大鼠和恒河猴隐睾内生精细胞凋亡过程中的表达。科学通报44（23）2533－2544

*58. Liu HZ, Zhang XD and Liu YX (2000): Expression and localization of orphan

receptor TR3 mRNA in rat follicles  Chinese. Sci. Bulletin 45(12):1122-1126

  柳海珍, 张晓东, 刘以训 (2000): 孤儿受体在大鼠卵泡中的表达和定位.科学通报45 (3):277-281.

*59. Hu ZY, Feng Q, Gao HJ, Ockleford CD Liu YX (2000) : Studies on localization and passible role of plasminogen activator and inhibitors in early stage of placentation. Chin .Sci. Bulletin  45 (22) : 2056-2061

胡召元, 冯强, 高洪娟, Ockleford C.D, 刘以训(2000): 纤溶酶原激活因子和抑制因子在早期胎盘中的表达及其功能的研究  .科学通报45 (12): 1297-1302

*60. Gao H.J. Cheng XL, Shi L and Liu YX (2000):  Expression of steroidogenic acute regulatory protein And its reguloation by interferon-gamma in rat corpus luteum Chinese Science Bulletin 45 (23): 2152-2157 .

高洪娟, 陈鑫磊，石磊, 刘以训(2000):甾体激素合成灵敏调节蛋白在大鼠黄体中的表达及其调节. 科学通报 45(11): 1179-1184

61 郭彩霞, 唐铁山, 刘以训(2000): 睾丸生殖细胞的凋亡及其调控. 生理科学进展 31 (4) : 299-304.

62.许复华, 徐晶, 刘以训(2000): 利用国际互联网络获得最新科研资料. 生殖与避孕20(1):58-61

*63 Liu YX, Hu ZY, Feng Q, Gao HJ Liu and Ockleford CD (2000): In site hybridization and immunofluorescence localization of tPA, uPA, PAI-1 and PAI-2 in human and rhesus monkey placenta. Dev. Reprod. Biol  9(1): 1-9

*64. Yan JL, Feng Q. Liu HZ, Fu GQ and Liu YX (2000): Expression of tPA, LH receptor and inhibin a, BA subunits during follicular atresia in rat Science in China C 42: 583-590

 严军丽, 冯强, 柳海珍, 傅国强, 刘以训 (1999): 卵泡闭锁与其tPA, LH受体及抑制素a, βA亚基基因表达的关系. 中国科学C 29(6) 592-599

*65. Guo CX, Tang TS, Mu XM, Li SH, Fu GQ, Liu H and Liu YX (1999) : Cloning of novel

temperature-related expressed sequence Tags in rat testis during spermatogenesis Biochem.

Biophs. Res. Comm. 258, 401-406

*66. He SP, Lin YL and Liu YX (1999): Functionally inactive protein C inhibitor in seminal plasma

may be associated with infertility.  Mol. Human Reprod. 5:513-427

*67. Chen YJ, Feng Q and Liu YX (1999): Expression of the Steroidogenic acute

regulatory protein and LH receptor and their regulation by TNF-a in rat corpus lutea    Biol. Reprod.  60: 419-427.

*68. Hu ZY, Liu YX, Zou RJ and Ockleford C (1999): Expression of tissue type and urokinase type

plasminogen activators as well as their inhibitors type 1 and type 2 in the placentea of human and

rhesus monkey. J. Anatomy ( London ) 194:183-195

*69. Chen YJ, Gao HJ and Liu YX (1999): Follicles in pregnant rat ovary ncapable of  steroidogenesis.   Chin. Sci. Bull.  44: 1797-1800

陈毅军，高洪娟，刘以训（1999）：妊娠大鼠卵泡没有甾体合成能力。科学通报44（9）968

－971。

*70. Liu YX (1999): Role of plasminogen activators and inhibitors in reproduction

Chinese Sci. Bull. 44: 673-685

刘以训（1999）：纤溶酶原激活因子和抑制因子在生殖中作用（综合评述）

科学通报44：242－252。

*71. Liu YX (1999): Regulation of plasminogen activator system in the ovary.

Biological Signals and Receptors  8: 160-177

 *72. Chen YJ ,Feng Q and Liu YX (1999): Expression of steroidogenic acute

regulatory protein (StAR) and its regulation by TNF-a in rat corpus lutea Recent Progress in Molecular.Comparative Endocrinology P63-70 eds by H.B. Kwon, JMP Joss and SI Shii, Kwanggju, Republic of Korea 1999

*73. Liu YX, Feng Q and Liu K (1999): Comparative studies on the role of plasminogen

    activators and plasminogen activator inhibitor type 1 in luteal regression in rhesus monkey,rat

    and mouse .Recent Progress in Molecular Comparative Endocrinology P57-62 , 1999, eds

    by HB Kwon, JMP Joss and SI Shii

*74. Mu XM and Liu YX (1999): Expression of orphen receptor TR2 mRNA in rhesus monkey testis. Chinese Sci. Bulletin 44 (10): 927-930

穆小民，刘以训（1999）：孤儿受体TR2在恒河猴睾丸中的表达 科学通报44：292－295

75. 朱艳,陈贵安,冯强刘以训 (1999) : 人正常胚胎和葡萄胎绒毛中纤蛋白酶原激活因子及其尿激酶受体的表达. 生殖医学杂志:8(1):24-27

 76. 刘以训、柳海珍 (1999): 促卵泡素和促黄体素的生理功能和调节I：下丘脑－垂体－卵巢系统。第14章P239-275 现代神经内分泌学 谢启文主编 上海医科大学出版社

77 .刘以训、郭彩霞 (1999): 促卵泡素和促黄体素的生理功能和调节II：下丘脑－垂体－睾丸系统。第15章 P276-301现代神经内分泌学 谢启文主编

上海医科大学出版社

*78. Liu Yi-xun,Peng Xiao-rong,Carrico Whitney,Hsueh AJW and Ny Tor (1998): Prolactin delays gonadotropin-induced ovulation and down-regulates expression of the plasminogen activator system in the ovary. Human Reproduction 12: 2748-2755.

*79. Liu Yi-xun,Hu Zhao-yuan,Liu Kui,Zou Ru-jin and Ockleford Colin (1998): Localization and

distribution of tissue type and urokinase type plasminogen activators and their inhibitors type-1

and type-2 in fetal membranes of human and rhesus monkey.   Placenta 19(1): 171-180

*80. Liu Yi-xun,Peng Xiao-rong,Carrico Whitney,Hsueh AJW and Ny Tor (1998): Prolactin delays gonadotropin-induced ovulation and down-regulates expression of the plasminogen activator system in the ovary. Human Reproduction 12: 2748-2755.

*81. 穆小民, 刘以训 (1998): 核受体及其转录活化机制的新突破-辅活化和辅阻遏子. 生物化学

和生物物理学进展. 25(3):222-226

*82. Liu Yi-xun, Peng Xiao-rong, Liu Hai-zhen, Chen Yi-jun and Ny Tor (1998): Prolactin 

regulation of tPA and PAI-1 gene expression in PMSG-primed rat granulosa cells in culture. Biol.

Reprod. 59(8):409-416 

*83. Mu XM, Young WJ, Liu YX, Uemura H and Chang CS (1998): Induction of an intronic enhancer

of the human ciliary neurotropic factor receptor (NTRFa) Gene by the TR3 orphan receptor.   Endocrine 9 (1): 27-32.

84. 穆小民，刘以训（1998）：孤儿受体TR3与人CNTF受体基因中顺式元件作

用机制的研究. 中国生物化学与分子生物学报15（5）：485-491

*85.Liu Yi-xun, Peng Xiao-rong, Liu Hai-zhen, Chen Yi-jun and Ny Tor (1998): Prolactin  regulation

of tPA and PAI-1 gene expression in PMSG-primed rat granulosa cells in culture. Biol. Reprod.

59(8):409-416 

*86. Mu XM, Young WJ, Liu YX, Uemura H and Chang CS (1998): Induction of an intronic enhancer

of the human ciliary neurotropic factor receptor (NTRFa) Gene by the TR3 orphan receptor.  

Endocrine 9 (1): 27-32.

*87. Liu YX, Peng XR, Liu HZ, Chen YJ and Ny T (1998): PRL inhibition of FSH-induced tissue

plasminogen activator expression in cultured rat granulosa cells   Acta Physiol. Sinica  50 (1): 11-18

88. 穆小民，刘以训（1998）：孤儿受体TR3在小鼠睾丸中的定位和表达.

生理学报50（4）：439－443

89. 穆小民，刘以训（1998）：孤儿受体TR3与人CNTF受体基因中顺式元件作

用机制的研究. 中国生物化学与分子生物学报15（5）：485-491

90. 陈毅军，冯强，刘以训 (1998)：组织型纤溶酶原激活因子及抑制因子类

型1在受孕第七天大鼠子宫中的表达。基础医学和临床18（1）：51－56

91. 刘以训, 彭晓荣, 陈毅军(1998):催乳素延缓 hCG诱发大鼠排卵和下调纤溶酶原激活系统在卵巢中的表达. 生殖与避孕 18 : 12-16

*92. Liu Kui, Liu Yi-xun,Hu Zhao-yuan, Chen Yi-jun, Mu Xiao-min and Ny Tor

(1997):Temporal  expression of urokinase type plasminogen activator plasminogen

activator inhibitor type-1 and LH receptor mRNA in the corpus luteum of rhesus

monkey during gonadotropin-induced luteolysis. Mol. Cell. Endocrinol.  133:

109-116

*93. Zhang Tong Guo CX, Hu ZY and Liu Yi-xun (1997): Localization of plasminogen activator and inhibitor, LH receptor, androgen receptor and inhibin subunits in monkey epididymis. Mol. Human Reproduction 11:945-952.

*94. Zhou Hong-ming, Zhang Tong and Liu Yi-xun (1997): Regulation and expression of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in rat epididymis. Chinese Science Bulletin, 42:779-783

周红明、张彤、刘以训 (1997) :纤溶酶原激活因子及抑制因子在大鼠附睾中的表达及其激素调节。科学通报42：757－760。

*95 . Zhang T, Zhou HM and Liu YX(1997): Expression of plasminogen activator and inhibitor, urokinase receptor and inhibin subunits in rhesus monkey testes. Mol Human Reprod. 3:223-231

*96. 张春雨, 段恩奎, 曾国庆, 刘以训(1997): 细胞表面半乳糖基转移酶及其生物学功能.  生物化学和生物学进展. 24(6):518-520.

*97. Liu Yi-xun, Peng Xiao-rong, Carrico Whitney and Ny Tor (1997) : Prolactin delays gonadotropin- induced ovu1ation and down-regu1ates expression of the p1asminogen activator system in the ovary. Human Reproduction 12:2748-2755.

*98. Liu YX, Hu ZY, Zou RJ and Ockleford C D. (1997) :Identification of secretion sites of tissue plasminogen activator and plasminogen activator inhibitor type-1 in basal plastes of human and rhesus monkey placentae. Chinese Science Bulletin, 42 : 1030-1033

刘以训、胡召元、邹如金、Ockleford CD (1997):人和恒河猴胎盘分泌tPA和PA

－1部位的鉴定。科学通报42：1324－1326。

*99. Mu X M  and Liu Y X  (1998) ：Localisation and expression of TR3 orphan

receptor protein  and its mRNA in rat testis．Chinese Science Bullutin 43（2）：146－149。

穆小民，刘以训(1997)：孤儿受体TR3蛋白及其mRNA在大鼠睾丸中的定位和表达的研究。科学通报42：2446－2448

100. 朱艳，陈贵安，冯强，武淑英，刘以训 (1997)：米非司酮对早孕蜕膜中纤蛋白溶酶原激活因子及其尿激酶受体的分布与表达的影响 生殖医学杂志 （6）：147－151

101. 朱艳，陈贵安，刘以训 (1997)：纤溶酶原激活抑制系统及其在女性生殖中的

作用。生殖医学杂志9（6）：186－189

102. 胡召元、刘以训、0ckleford (1997)：纤溶酶原激活因子及抑制因子在胎盘膜组织中免疫定位的研究。 “生殖与避孕”17(4)：245－246

103. 陈贵安，张彤，朱艳，冯强，刘以训(1997)：RU486对人早孕绒毛中纤维蛋白溶酶原激活与抑制系统的影响。现代妇产科学6（4）：307－316。

*104. Liu K, Brandstrom A, Liu Y X, Ny T and Selstram G(1996): Coordinated expression of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 during corpus luteum formation and luteolysis in the adult pseudopregnent rat.  Endocrinology 137: 2126-2133

*105. Liu K, Liu YX, Du Q, Zhou an, Lin X, Hu ZY, Zhang GY and Zhang GH (1996) : Preliminary studies on the role of plasminogen activator in seminal plasma of human and rhesus monkey. Mol. Human Reprod. 2: 99-104

*106. Zhou HM, and Liu YX (1997) : Localization of tPA and PAI-1 in rat testes. Chinese Science Bulletin. 42 : 588-591.

周红明、刘以训(1996): 组织型纤溶酶原激活因子及抑制因子的信使核糖核酸在大鼠睾丸中的定位。科学通报41：455－458。

*107. Zhou HM, Zhang T and Liu YX (1997) :Localisation of LH receptor in rat epidydimis. Chinese Science Bulletin 42: 121-125.

周红明、张彤、刘以训 (1996) : 促黄体生成素受体(LHR)在大鼠附睾中的定位。科学通报 41 :1 608- 1 6 1 0

108. 刘以训 (1996): 哺乳动物排卵机制的新假说. 中国生理学会七十周年纪念学术论文集. 生理通讯增刊 15:243-249.

*109. Liu YX, Du Q, Zhong HM, Liu K, and Hu ZY(1996): Regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in cutured rat sertoli and leydig cells. Science in China (Series C), 39:37-44

     刘以训, 杜群, 刘奎, 周红明, 胡召元 (1995): Sertoli和Leydig 细胞的相互作用及其表达的调节。中国科学B，25：852－857

*110. Liu YX, Du Q, Liu K and Fu GQ (1995): Hormonal regulation of

plasminogen activator in rat and mouse seminiferous epithelium. Biological Signals 4 : 232-240

*111. Liu YX, Liu K, Zhou HM, Du Q, Hu ZY and Zou RJ (1995) :Hormonal regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in cultured monkey Sertoli cell. Human Reproduction 10 (3) :719-727

*112. Liu YX, Chen YX, Shi F W and Feng Q (1995) : Studies on the role of plasminogen activators and plasminogen activator inhibitor type-1 in rat corpus luteum of pregnancy. Biol. Reprod. 53 : 1 131-1 138

*113. Liu YX, Du Q, Zhong HM, Liu K, and Hu ZY(1996): Regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in cutured rat sertoli and leydig cells. Science in China(Series C), 39:37-44

刘以训、杜群、刘奎、周红明、胡召元(1995): Sertoli和Leydig细胞的相互作用及其PA/PAI-1表达的调节。中国科学B, 25 : 852-857

114. 杜群、刘以训、刘奎、刘德谕、张桂元(1995) : 激素对大鼠和小鼠生精上皮纤溶酶原激活因子分泌的影响。自然科学进展6： 983-987

115. 胡召元、刘以训  (1995) : 促乳素对促性腺激素诱导小鼠卵巢雌激素和孕酮形成的影响。生理学报,47 : l-7

116. Liu YX (1995)  Role of tissue plasminogen activator and plasminogen activator inhibitor in mechanism of ovulation. Progress in Natural Science, 5:316-324.

刘以训 (1995) : 纤溶酶原激活因子在排卵中功能的研究 (综述) 自然科学进展5:410-416

*117. Liu YX, Feng Q, Liu K and Hu ZY(1994): Identification and possible function of tissue-type plasminogen activator and plasminogen activator inhibitor in corpus luteum of rhesus monkey. Chinese Science Bulletin, 39:1735-1738.  

刘以训、冯强、胡召元、邹如金(1994) : 恒河猴黄体PA和 PAI-1活性的鉴定及生理功能的研究。科学通报，39 : 1332-1335

*118. Liu YX, Feng Q, Liu K and Hu ZY (1994): Identification and possible function of tissue-type plasminogen activator and plasminogen activator inhibitor in corpus luteum of rhesus monkey. Chinese Science Bulletin, 39:1735-1738.

    刘以训、冯强、胡召元、邹如金 (1994) : 恒河猴黄体PA和 PAI-1活性的鉴定及生理功能的研究。科学通报，39 : 1332-1335

*119. Liu Yi-xun (1994) : tPA involvement in ovulation - studies on mechanism of ovulation. Devel. Reprod. Biol. 3: 70-78

*120. 陈贵安、郭滨、高荣莲、刘以训 (1994) : 米非司酮及R2323对离体培养人子宫内膜细胞PA和PAI－1生成的影响。生殖与避孕, 328-331

*121. Feng Q,Liu K,Zou RJ and Liu YX (1993) : The possible involvement of tissue type plasminogen activator in luteolysis of rhesus monkey. Human  Reproduction 8 : 1640-1644   2.917 (1995)

*122. Liu YX, Peng XR, Liu K and Ny T (1994) ： Hormonal regulation of tissue type plasminogen activator and plasminogen activator inhibitor type-1 gene expression in cultured rat granulosa cells. Science in China B, 37:271-279

刘以训、彭晓蓉、刘奎 (1993)：大鼠颗粒细胞tPA和PAI－1基因表达的激素调节。中国科学B,23 : 702-706

*123. Liu YX, Feng Q, Peng XR and Ny T (1994) : Secretion of plasminogen activator inhibitor type-1 in cultured ovarian cells obtained from  gonadotropin-treated immature rats. Science in China B, 37:940-947

刘以训、冯强、彭晓蓉、Ny T（1993）：促性腺激素对幼鼠卵巢细胞PAI-l分泌的调节。中国科学B,23：1042－1047

*124. Liu YX, Peng XR and Liu K (1994) :Coordinated regulation of tissue type plasminogen activator and p1asminogen activator inhibitor type-1 gene expression in hypophysectomized rat ovaries during GnRH~induced ovulation. Science in China B, 37: 820-829.

   刘以训、彭晓蓉、刘奎 （1993）：GnRHa诱导去垂体大鼠排卵过程中tPA和PAI-1基因在卵巢中的协调表达。中国科学B, 23：841－847

*125. Liu YX, Peng XR and Ny T (1993): Comparative study of tPA and PAI-1 gene expression in ovarian granulosa and theca-interstitial cells during hCG and GnRHa-induced ovulation in hypophysectomixed rat. Chinese Science Bulletin, 38(9) :843-845.

刘以训、彭晓蓉、Ny T (1993)：hCG和GnRH诱发大鼠卵巢tPA和PAI-1基因表达的比较研究。科学通报，38：843－845

*126. Chen YX, Chen YF and Liu YX (1993) : The role of tissue-type plasminogen activator in rat corpus luteum. Devel. Reprod. Biol.  2(1) : 28-32

*127. Hu ZY and Liu YX (1993) : Effect of prolactin on gonadotropin regulation of mouse ovarian function. Devel. Reprod. Biol. 2(2) : 26-32

128. 胡召元、刘以训 (1993)：促乳素抑制促性腺激素诱导小鼠卵巢纤蛋白溶酶原激活因子增加和排卵。生理学报，45：510－516

*129. Liu YX, Du Q, Hu ZY (1992) : Hormonal regulation of tissue type plasminogen activator and plasminogen acativator inhibitor type-1 gene expression in cultured mouse Sertoli cells. Science in China B, 35:1161-1167

 刘以训、杜群、胡召元（1992）：小鼠Sertoli细胞tPA和PAI－1基因表达的激素调节。中国科学B，22：1161－1167

*130. Liu YX and Feng Q (1992): Tissue type plasminogen activator in rat oocytes and preimplantation embryos. Chinese J. Physiol. Sci, 8(2): 158-166

*131. Chen GA, Feng Q, Zhang LZ and Liu YX (1992): Plasminogen activator and plasminogen activator inhibitor type-1 in human endometrium. Chinese J. Physiol. Sci, 8(2) :1 50-1 57

*132. Liu YX, Feng Q and Hu ZY (1992): Plasminogen activator and plasminogen .activator inhibitor in mouse ovaries during periovulatory periods. Devel. Reprod. Biol. 1(1): 1-9

*133. Liu YX, Feng Q, Zou RJ, Peng XR, Hsueh AJW and Ny T (1992) : Hormone regulation of tissue type plasminogen activator (tPA) and plasminogen activator inhibitor type-1(PAI-1)gene expression in the ovaries during gonadotropin-induced ovulation. Reproduction and Contraception, 4(1) : 97-102

134. 陈贵安、冯强、张丽珠、刘以训 (1992)：人子宫内膜PA和PAI－1活性的激素调节。生理学报，44(5)：502－509

135. 刘以训、冯强、彭晓蓉、Ny T (1992)：大鼠排卵周期中卵巢颗粒细胞和膜间质细胞纤溶酶原激活因子抑制因子(PAI-1)分泌功能的激素调节。生理学报，44(37)：282－289

*136. Liu YX, Peng XR and Ny T (1991) : Tissue-specific and time-coordinated hormone regulation of plasminogen-activator-inhibitor type 1 and tissue-type plasminogen activator in the rat ovary during gonadotropin-induced ovulation. Eur. J. Biochem. 195 : 549-555

*137. Liu YX，Feng Q and Cajander S（1991）：A comparative study on involvement of tPA activity in ovulation induced by hCG and GnRH agonist in hypophysectomized rats． Science in China B, 34（10）：1215－1224

   刘以训、冯强Cajander S（1991）：hCG和GnRHa诱发去垂体大鼠排卵及卵巢PA活性变化的比较研究。中国科学B, 21：54－61

*138. Ohlsson M, Peng XR, Liu YX, Jia XC, Hsueh AJW and Ny T ( 1991 ) : Hormone regulation of tissue-type plasminogen activator gene expression and plasminogen activator-mediated proteolysis. Seminars in Thrombosis and Hemostasis. 17(3) : 286-290

139. 刘以训、冯强、邹如金 (1991)：促性腺激素诱导猕猴排卵周期中纤溶酶原激活因子与抑制因子的变化。生理学报，43(5)：472-479

140. 石磊, 许复华, 刘以训(2000): 激素合成快速调节蛋白在卵泡发育和闭缩过程中的表达 动物学报 46 (3): 324-329

141.  韩晓彬,刘以训 (2000):生殖(第十二章),现代生理学.

142. 薛爱玲, 陈贵安, 刘以训(1999): 月经周期子宫内膜凋亡与 BcL-2, Fas 及FasL基因表达产物的相关研究. 生殖医学杂志 8(2):92-97

143.张春雨, 段恩奎, 曾国庆, 刘以训(1997): 白血病抑制因子及其在胚泡发育着床中的生理功能. 生理科学进展 28(3):1-4

*144. Ny T, Liu YX, Ohlsson M, Peng XR, Jia XC and Hsueh AJW (1990): Hormone regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type 1 gene expression in ovary. In Major Advances in Female Reproduction. eds by Adashi E Y and Mancusos. 77-84

*145. Liu YX, Hu ZY, Feng Q and Zou RJ (1991) :Paradoxical effect of a GnRH agonist on steroidogenesis in cultured monkey granulosa cells. Science in China B, 34（12）：1452－1460

 刘以训、胡召元、冯强、邹如金（1990）: GnRHa对恒河猴颗粒细胞离体下甾体激素形成的双向作用。中国科学B，20：1145－1151

*146. Liu YX, Peng X R and Ny T (1990) : Prolactin inhibits gonadotropin-induced ovulation in rat by decreasing tissue type plasminogen activator activity and increasing plasminogen activator inhibitor type-l expression in granulosa cells. Advances in Reproductive Biology ed. by Cao Y Q and Zhu Ch. 1990, pp48-62

*147. Liu YX and Stephen C.(1988) :Indomethacin inhibits hCG and GnRH agonist-inducd secretion of plasminogen activator by granulosa and theca-interstitial cells of hypophysectomized rats. Scientia Sinica B 31:807-817.

 刘以训，Stephen C．（1989）：消炎痛抑制由hCG和GnRH类似物诱发的大鼠颗粒细胞和膜-间质细胞PA的分泌。中国科学B，19：603一610

*148. Liu YX(1989) :A factor(s) produced by rat granulosa cells stimulated oocyte tissue plasminogen activator activities in vitro. Scientia Sinica B 32(10) :42-49 .

 刘以训 (1989)：颗粒细胞分泌一种刺激卵母细胞组织型纤溶酶原激活因子的物质。中国科学 B，19：1050－1053

149. 刘以训、冯强、柳建昌、胡召元(1989)：小鼠排卵前后卵巢纤蛋白溶酶原激活因子活性的变化。生理学报，41(3)：284-290

*150. Liu YX and Dahl K (1988) : A factor(s) produced by Sertoli cells stimulates androgen biosynthesis by Leydig cells in neonatal rats. Scientia Sinica B 31:818-827

    刘以训、DahI KD (1989)：Sertoli细胞分泌一种刺激Leydig细胞合成雄激素的因子。中国科学 B，19：262－268

*151. Liu YX, Hu ZY, Lin X and Zou RJ (1989) : A comparative study on regulation of steroidogenesis in cultured infant and adult rhesus monkey granulosa cells. Science in China B 33 (9) : 1060-1069

    刘以训、胡召元、邹如金 (1989)：幼猴和成年猴颗粒细胞离体下甾体形成激素调节。中国科学8, 19:1272－1280

152. 刘以训、张友端 (1989)：激素<<中国大百科全书>> 生物化学 242－246

*153. Hsueh AJW, Liu YX, Cajander S, Peng XR, Dahl K, Kristensen P and Ny T (1988): Gonadotropin-releasing hormone induces ovulation in hypophysectomized rats : Studies on ovarian tissue-type plasminogen activator activity, messenger ribonucleic acid content and cellular localization. Endocrinology 122 : 1486-1495

*154. Liu YX (1988) : Autocrine role of endogeneously-produced progesterone in FSH-induced steroidogenesis by cultured rat granulosa cells. Chinese J. Physiol. Sci : 4(2): 1 5 5- 1 59

155. 刘以训 (1988)：卵巢纤蛋白溶酶原激活因子及其抑制因子的研究。生理学报，40(5)：421－429

*156. Liu YX, Kasson BG, Dahl KD and Hsueh AJW (1987): Vasoactive interstitial peptide stimulates plasminogen activator activity by  cultured rat granulosa cells and cumulus-oocyte complexes. Peptides 8(1): 29-33

*157. Liu YX and Hsueh AJW (1987) : Plasminogen activator activity in

cumulus-oocyte complexes of gonadotropin-treated rats during periovulatory

periods. Biol. Reprod. 36 : 1055-1062   

*158. Liu YX, Cajander SB, Ny T, Krestensen P and Hsueh AJW (1987) : Gonadotropin regulation of tissue and urokinase types of plasminogen activator in rat granulosa and theca-interstitial cells during periovulatory periods.

Mol. Cell. Endocrinol. 54 : 22 1 –229

*159. Ny T, Liu YX, Ohlsson M. Jones PBC and Hsueh AJW(1987) : Stimulatory effect of GnRH on tissue type plasminogen activator activity in cultured granulosa cells and cumulus-oocyte complexes in hypophysectomized, DES implanted immature rats. J. Biol. Chem.  262 : 11790-11793

*160. Liu YX (1988) : Interaction and regulation of plasminogen activator and their inhibitor in rat follicles during periovulatory periods Scientia Sinica B  31:47-57

      刘以训(1987)：大鼠滤泡纤蛋白溶酶原激活因子及其抑制因子的相互作用和调节。中国科学 B，17：1278－1285

*161. Liu YX and Liu Y (1987): Stimulatory effect of vasoactive interstitial peptide on progesterone production in cultured rat luteal cells. Chinese J. Physiol. Sci., 3: 115-121

*162. Liu YX and Hsueh AJW (1986) : Synergism between granulosa and theca-interstitial cells in estrogen biosynthesis by gonadotropin-treated rat ovaries : Studies on the two-cel1, two-gonadotropin hypothesis using steroid antisera. Biol. Reprod. 35 : 27-36

*163. Liu YX, Ny T, Sarkar D, Loskutoff D and Hsueh AJW(1986): Identification and regulation of tissue plasminogen activator activity in rat cumulus-oocyte complexes. Endocrinology 119 : 1578- 1587

164 Liu YX and Hsueh AJW (1986) Autocrine role of endogenously-produced estrogen in the enhancement of aromatase activity, progesterone production and LH receptor in cultured rat granulosa cells. Chinese J. Physiol. Sci 1(2): 1-9

*165. Liu YX and Hsueh AJW (1986) : Effect of adrogens on progesterone production by long term cultured luteal cells. Chinese J. Physiol. Sci. 1(2): 10-19

166 Kessel Bruce, Liu YX, Jia XC and Hsueh AJW (1985) :  Autocrine role of estrogen in augmentation of luteinizing hormone receptor formation in cultured  rat granulosa cel1s. Biol. Reprod. 32 : 1038-1050

*167. Liu YX, Jia XC, Zhu HH and Chang Chih-ye (1985) : Local effect of blastocyst on the contents of uterine estrogen progesterone and their  receptors. In Current Trends in Comparative Endocrinology. eds B Lofts and Wh Holmes. Hong Kong University Press, 779-780

*168. Chang CY, Liu YX and Zhu HH (1985): The Sex steriod hormones and their function regulationin Amiphioxus (Branchistoma Belcheri Gray) . In current Trends in Comparative Endocrinology, (eds) by B Lofts and WH Holmes, Hong Kong University Press, 205-207

*169. 刘以训、朱洪华、张致一(1984)：促黄体素释放做素类似物（LH－RH－A）对人蜕膜组织核糖核酸和蛋白质合成的抑制作用。动物学报，30(2)：114－120

170. 刘以训、朱拱华、张致一(1984)：促黄体素释放激素类似物（LH－RH－A）对妊娠大鼠子宫代谢的直按作用。动物学报，30(2)：121－130

171. 刘以训、朱洪华、施从柱、张致－(1984)：促黄体素释放激素类似物对人胎盘绒毛组织RNA、蛋白质和DNA合成的作用。生理学报，36(4)：374－380

172. 刘以训 (1984)：促黄体素释放激素(LH－RH)及其类似物(LH－RH－A)对子宫和胎盘直接作用的研究。生殖与避孕，4(3)：3－8

173. 刘以训、张星、庄临之、曹咏清译(1983)：普通内分泌学(General Endocrinology) C.D.纳，J. T. 贝格那尔著，428页，科学出版社，1983年

174. 刘以训、贾晓池、朱洪华、张致一(1982)：胚泡对子宫的局部影响：雌、孕激素受体含量的变化。动物学报，28(2)：106－113

175. 刘以训、贾晓池 (1982)：妊娠大鼠着床期间孕激素及其受体含量的变化。生理学报，  34(2)：197－203

176. 刘以训 (1982)：一种迅速可靠的甾体激素放射免疫测定方法。中国动物学杂志，3：42－46

177. 石其贤、刘以训 (1982)：关于3－Qximinoandrostense抗生育作用的研究：雌激素、孕激素及子宫雌激素受体量的变化。生殖与避孕2：10－15

178. 刘以训、叶良勤 (1982)：普通内分泌讲座(1)。中国动物学杂志， 1：49－56

179．刘以训、叶良勤、张星 (1982)：普通内分泌讲座(1)。中国动物学杂志， 2：47－54

180．刘以训 (1982)：普通内分泌讲座(6)。中国动物学杂志， 5：53－58

181. 刘以训、贾晓池 (1981)：妊娠大鼠胚泡着床期间雌激素及其受体含量的变化。生理学报，33(1)：44一51

182. 刘以训、贾晓池、周素民、赵梅 (1981)：醋酸棉酚对子宫内膜性基体激素受体含量的影响。中华妇产科杂志，16(3)：129－131

183. 刘以训等 (1981)：正常周期中中国奶牛血液LH，雌二醇－17b孕酮和C－AMP水平的变化。动物学集刊，1(12)：147-152

184. 刘以训 (1981)：雌、孕激素受体测定方法。生殖与避孕，1(2):53-56。

185. 刘以训、李树民(1980)： LHRH九肽类似物抑制蜕膜形成机理的研究I：对假孕大鼠的研究。动物学报，26：1-4

186. 赵梅、刘以训 (1980)：正常月经周期和绝经期妇女血清激素水平的测定。中华妇产科杂志，15(3)：161－164

187. 刘以训、贾晓池、唐谨、张秀华、费立民 (1980)：人乳腺组织肿瘤雌激素和孕激素受体含量的测定。肿瘤防治研究，1:11－14

188. 袁福汉，刘以训等 (1980)：中药“催情散”对诱发马、驴排卵作用的初步研究  陕西兽医杂志6(10)：10－13

189. King, RJB and Liu YX (1979) : Studies on the effect of oestrodiol-induced protein on DNA synthesis by cultured cells. Research on Steroid  8 : 19-26

190. Liu YX(1979) :Studies on purification of estrogen-induced protein from rat uterus and its physiological role in cultured cells. Sciencia Sinica 22(2):222-236

刘以训 (1979)：大鼠子宫雌激素诱导蛋白的纯化及其离体下生理功能的研究。中国科学，7：709-719 .

191.刘以训、李树民 (1979)：LHRH九肽类似物抑制蜕膜形成机理的研究II，对妊娠大鼠的研究。动物学报，25：201－204

192. 袁福汉、刘以训、李树民、张惠民、肖莉利、董云香 (1979)：羊红膻对马驴催情作用的初步研究。畜牧兽医学报，10(2)：105－110

193. 彭先忠、刘庚信、刘以训 (1979)：我国正常育龄妇女血清中雌二醇－17（148例）和孕酮（154例）含量的测定。北京医学院学报，3：208

194. Liu YX, King RJB, Kaye AM and Shodell MJ (1977): Co-purification of an oestrogen-induced protein from rat uterus and a factor able to stimulate DNA synthesis in cultured 3T6 cells. Experiment Cell Research 109 : 1-8 2.980 (1996)

195. 刘以训 (1991)：激素测定<<中国大百科全书>> 生物卷 II 668－670

196. 刘以训 (1991)：激素<<中国大百科全书>> 生物卷 I 667－668

197. 刘以训 (1991)：内分泌泌系统<<中国大百科全书>> 生物卷 II 1031-1032

198．刘以训 (1991)：丘脑下部-垂体系统<<中国大百科全书>> 生物卷 II 1851-1855

 

 

International Meeting Abstracts

 

1 Wei P, Jin X. , Hu ZY, Han CB and Liu YX (2004): ANGIOGENESIS AND APOPTOSIS IN THE ENDOMETRIUM AND MATERNO-FETAL BOUNDARY OF IMPLANTATION SITE DURING THE MENSTRUAL CYCLE AND EARLY PREGNANCY IN RHESUS MONKEY SSR International Meeting Abstracts   Reference #: WEI-1076-579121

2 Zhang ZH., Hu ZY, Jin X., Yu FQ. 1, Han CB. and Liu YX (2004) :DISRUPTED EXPRESSION OF INTERMEDIATE FILAMENTS AND ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASES 1 AND 2 IN SERTOLI CELLS AFTER EXPERINENTAL CRYPTORCHIDISM OF RHESUS MONKEY   SSR International Meeting Abstracts   Reference #: ZHA-1076-578057

3 Jin X, Han CB, Yu FQ, Wei P, Hu ZY and Liu YY (2004): INVOLVEMENT OF STEM CELL FACTOR, BCL-2 FAMILY PROTEINS IN OOCYTE APOPTOSIS DURING PRIMORDIAL FOLLICULAR DEVELOPMENT IN VITR1 Reference #: JIN-1076-576425

4 Xiao Li-Juan *, Yuan Jin-Xiang *, Wang Rui§, Li Yin-Chuan *, Hu Zhao-Yuan *, Han Chun-Sheng and Liu Yi-Xun (2004):Expression and regulation of extracellular Ca2+-sensing receptor (CaR), stanniocalcin-1 (STC-1) and stanniocalcin 2 (STC-2) in rat uterus during peri-implantation period  SSR International Meeting Abstracts   Reference #:

5 Liu YX ,Feng Q,  Liu K, Gao HJ, Hu ZY, Fu GQ,  Zou RJ (2002): Plasminogen activators,  plasminogen activator inhibitor type-1,Steroidgenic Acute regulatory protein,LH and FSH receptors in corpus luteum of rhesus monkey .Biol. Reprod.66(Supp l): 123     

6. Feng Q, Liu K, Hu ZY ,Liu HZ, Fu GQ, Zou RJ and Liu YX(2002):Plasminogen activator and plasminogen activator inhibitor-type-1 rhesus monkey ovary Biol Reprod 66(Suppl):128  

7. HanXB,ZhouXC,HuZY,ZhangZHandLiuYX(2002):Characterization of temperature-related gene TRS1  Biol Reprod 66(Suppl):291                              

8. Liu (2002): Role of tissue type plasminogen activator and plasminogen activator inhibitor type-1 in ovulation and luteinization. Symposium on tissue Remomodeling:Growth,  Apoptosis,  and Differentation. October 21-22,2002.   Tainan

9 Gao HJ and Liu YX (2000): Luteolysis in rhesus monkey and rat is related to apoptosis. International Symposium on “Molecular and Clinical Aspects of the Regulation of Ovarian Function ” Oct 6-10 1999. Delhi India.  Mol. Cell. Endocrinol. 164: 261 p-10    

10 Liu HZ and Liu YX (2000): Preliminary study on initiation, growth and differentiation of primordial follicles in rat  Mol. Cell. Endocrinol. 164: 260 P-05           

11 Jie Ma, Hong-juan Gao, Xin-lei Chen and Yi-xun Liu. (2000): Expression of steroidogenic regulatory protein (StAR) and its regulation by TNF and IFN in corpus luteum of rat and rhesus monkey.    Biol. Reprod. 62 (suppl ): 140 p86                   

12. Hong-juan Gao, Zhao-yuan Hu and Yi-xun Liu (2000): Expression of gelatinase A(MMP-2) and Tissue inhibitor of Metalloproteinses type 1(TIMP-1) and theirregulation by TNF and during coring corpus luteum (CL) for mation and    luteal regression in rhesus monkey.  Biol. Reprod. 62 ( suppl. ): 139 p 85                                 

13. Fu-hua Xu, Jing Zheng, Ronald R Magness and Yi-xun Liu (2000): Expression of the angiognic factors, VEGF,bFGF, Ang-1 and Ang-2, in the corpus lutea of rhesus monkey.  Biol. Reprod.  62 ( suppl. ) : 213, P269                              

14. Zhao-yuan Hu, Qiang Feng, Hong-juan Gao, CD Colin and Yi-xun Liu. (2000): Localization of plaminogen activators and inhibitors and inhibitors in first and second trimester human placental tissues.  Biol. Reprod. 62 (suppl.): 313, p 524   

15. Qiang Feng, Yi-xun Liu, Zhao-xun Hu, Hong-jing Gao, Kui Liu and CD Colin. (2000): Studies on localization of membrane type metalloproteinase and tissue inhibirors of metalloproteinase-1 in human placental tissues during early placentation.  Biol. Reprod. 62 (Suppl.) :313, p525                                                

16. Yi-xun Liu, Zhao-yuan Hu, Qiang Feng,and CD Ockleford.(2000): Distribution and  possible role of tPA, uPA, PAI-1 and PAI-2 in human and rhesus monkey placentae.  Biol. Reprod. 62 (Suppl.) : 313, p526.                                     

17. 冯强，刘以训，刘奎，Ockleford CD .(2000): 妊娠早期子宫上皮细胞组织变化的激素调控机制 上皮细胞生物学-初探  主编：陈小章，高杰英 P 18

Feng Q, Liu YX, Liu K. Ockleford CD (2000) : Chorionic gonadotropin ( CG ) is a major regulator of both maternal and fetal epithelial cells during early implantation in rhesus monkey. In Epithelial Cell Biology- A Primer Ed. By Chen Xiao-chang and Gao jia-ying  p 18-29

18. 高飞，陈鑫磊，刘以训（2000）：Fas和 FasL 在恒河猴早期胎盘中的表达。上皮细胞生物学-初探  主编：陈小章，高杰英 P 265

19. 周新昌，韩晓彬，陈鑫磊，胡召元，邹如金，刘以训。（2000）：HSP70-2在超生理计量十一酸睾酮和热压诱导恒河猴睾丸生细胞凋亡中的作用。 上皮细胞生物学-初探  主编：陈小章，高杰英  P 307

20. Chen YJ. Feng Q, Gao HJ and Liu YX (1999): No expression of steroidogenic acute regulatory protein is detected in the follicles of pregnant ovary. Biol. Reprod  60(suppl 1):P50                                                          

21. Feng Q, Liu YX, Liu K,Syrne S et al (1999): Trophoblast invsion during early placentation in rhesus monkey is associated with plasmin-related fibrinolysis. Biol.Reprod. 60 (suppl.1): P259                                                          

 22. Guo CX and Liu YX (1999): Differential display to screen novel temperature-sensitive ESTs during sperematogenesis. Biol. Reprod. 60 (suppl1) :P 335  (SSR meeting Abstract)

 23. Feng Q, Liu YX, Liu K, Byrne S and Ockleford C (1999): Plasminogen activators and an inhibitor are transcribed during early macague implantation Austria International Placental Meeting.

 24. Ockleford C, Feng Q, Liu K ,Ny T , Hu ZY, Byrnes, Lacey CD and Liu YX (1999) . Proteinases and their inhibitors in term human fetal membranes. Austria International Placental Meeting.

 25. Liu Yi-xun, Liu Kui, Zhou Hong-ming, Du Qun and Liu Yi-xun (1995): Studies on the role of plasminogen activators (PA) in seminal plasma of human and rhesus monkey. Biol. Reprod. 52(suppl.) : 84

 26. Feng Qiang, Liu Kui, Hu Zhao-yuan, Zou Ru-jin and Liu Yi-xun (1995): Studies on the expression and localization of plasminogen activator and its inhibitor in corpus luteum of rhesus monkey. Biol. Reprod. 52(suppl.) : 66

 27. Liu YX, Feng Q. , Zou RJ and Ny T (1992) : Gonadotropin regulation of tissue-type and urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in rhesus monkey ovaries during periovulatory period. Biol. Reprod. 46 (suppl.): 164 

 28. Liu YX, Cajander SB and Hsueh AJW (1987) : Ovulation induction in Hypophysectomized rats by gonadotropin releasing hormone agonist involve tissue type plasminogen activator activity. Biol. Reprod. 37(supp): 835

 

Chinese Meeting Abstracts (in Chinese ):

 

(1)   刘以训 (2002)： 排卵的基因调控。      2002. 9  成都 中国科协2002年学术年会

(2) 刘以训 (2002)：纤溶酶原激活因子（tPA）和它的抑制因子（PAI-1）在卵炮破裂和黄体萎缩中功能的研究2002.6 台北市海峡两岸比较内分泌暨生殖生物学术研讨会（大会付主席）

(3). 刘以训(2000):VIP, GnRH和促性腺激素诱发卵泡破裂的分子机理。中国生理学会新世纪学术会议。专题报告 生理通讯录19（增刊登II）P2。

(4).王训立，李志雄，周建华，刘以训（2000）：RU486对早孕恒河猴孕酮和雌激素分泌的影响 中国生理学会新世纪学术会议。论文摘要 生理通讯录19（增刊登II）P28。

(5).胡召元，刘以训，冯强，邹如金（2000）：纤溶酶原激活因子与抑制因子在胎盘中功能的研究。论文摘要 生理通讯录19（增刊登II）P27。

(4).冯强，马捷，许复华，王训立，Oclieford CD,刘以训(1999):uPA及其受体，PAI-1 和 PAI-2在恒河猴胚泡着床点的表达。第七次全国生殖生物学学术研讨会。论文摘要078

(6).胡召元，邹如金，刘以训(1999):PA/PAI-1系统在人和恒河猴在胎盘中的表达和功能研究。第七次全国生殖生物学学术研讨会。论文摘要072

(7).邹如金，周新昌，胡召元，刘以训，（1999）：纤溶酶激活系统及其他基因在恒河猴附睾中的表达及其功能的研究。第七次全国生殖生物学学术研讨会。论文摘要022

(8).郭彩霞，马捷，周新昌，刘以训（1999）：热激蛋白HSP70.2和热激因子HSF2在大鼠隐睾内生精细胞凋亡中的表达。第七次全国生殖生物学学术研讨会。论文摘要023

(9).郭彩霞，周新昌，胡召元，刘以训（1999）：孤儿受体TR2 mRNA在大鼠和恒河猴隐睾内生精细胞凋亡中的表达。第七次全国生殖生物学学术研讨会。论文摘要024

(10).丁峰，付国强，陈世岭，邢福祺，俞清，刘以训（1999）：RU486对早孕蜕膜Fas/FasL和 Bcl-2/Bax的表达的影响。 第七次全国生殖生物学学术研讨会。论文摘要053

(11).柳海珍,高飞，韩晓彬,刘以训（1999）：卵泡启动,生长和分化分子机理的初步探讨。第七次全国生殖生物学学术研讨会。论文摘要012

(12).高洪娟，俞清，许复华，刘以训（1999）：大鼠黄体萎缩与细胞凋亡有关。第七次全国生殖生物学学术研讨会。论文摘要013

(13).高洪娟，高飞，刘以训（1999）：StAR在大鼠和恒河猴黄体中的表达。第七次全

 

(14).刘以训，柳海珍, 冯强，胡召元，付国强，严军丽，（1998）：卵泡生长、分化、成熟和不排卵黄体化的基因调控。中国生理学会第20届学术研讨会。论文摘要P48

 (15).陈毅军，冯强，刘以训（1998）：甾类激素合成灵敏调控蛋白（StAR）在促性腺激素诱导的假孕和妊娠大鼠黄体中的表达及其受TNFа的调控。中国生理学会第20届学术研讨会。论文摘要P239

 (16).郭彩霞，刘以训（1998）：利用隐睾模型寻找精子发生中温度敏感基因。中国生理学会第20届学术研讨会。论文摘要P242

 

 (17).郑萍，邹如金，刘以训（1998）：恒河猴附睾，前列腺，精囊PA基因表达及其与精子数目的关系。中国生理学会第20届学术研讨会。论文摘要P262

 (18).柳海珍,刘以训（1998）：原始卵泡生长启动、分化机理的初步探讨。中国生理学会第20届学术研讨会。论文摘要P261

 (19).刘以训（1996）: 纤溶酶原激活因子与抑制因子在生殖系统中功能的研究。中国动物学会生殖生物学学术研讨会。论文摘要P015

 (20).严军丽，刘以训（1996）: 大鼠卵泡发育与闭锁过程中FSHR, LH及Inhibinа的表达。中国动物学会生殖生物学学术研讨会。论文摘要P014

 (21).张彤，刘以训（1996）: 纤溶酶原激活-抑制因子、LH受体及抑制素亚基在恒河猴附性器官中的表达。中国动物学会生殖生物学学术研讨会。论文摘要P020

 (22).张彤，周红明，刘以训（1996）: 纤溶酶原激活-抑制因子及抑制素亚基在恒河猴睾丸中的表达。中国动物学会生殖生物学学术研讨会。论文摘要P021

 (23).胡召元，刘以训，邹如金，Oclieford CD,（1996）：组织型纤溶酶原激活因子(tPA)及其抑制因子(PAI-1)在人和恒河猴胎盘基盘定位研究。中国动物学会生殖生物学学术研讨会。论文摘要P068

 (24).胡召元，刘以训，Oclieford CD,（1996）：纤溶酶原激活因子及其抑制因子在人分娩胎膜及蜕膜中定位的研究。中国动物学会生殖生物学学术研讨  会。论文摘要P069

 (25).冯强，刘以训，朱艳，陈贵安 (1996)：人早孕蜕膜中纤溶酶原激活与抑制因子的分布与调节。中国动物学会生殖生物学学术研讨会。论文摘要P 070

(26).胡召元，邹如金，Oclieford CD,刘以训（1998）：纤溶酶激活物-金属蛋白酶系统在人和恒河猴在胎盘中定位和功能研究。中国生理学会第20届学术研讨会。论文摘要P262

   ………

 

Manuscripts

 

1 Fu-Qing Yu, Chun-Sheng Han, Wei Yang, Xuan Jin, Zhao-Yuan Hu and Yi-Xun Liu (2004): Involvement of ERK1/2 in FSH-regulated proliferative activity and steroidogenesis in granulosa cells  Endocrinology (submitted)

2 Mu Xm, Liu YX, Collins LL and Chang C (2004): Androgen-induced orphan receptor TR4 is involved in attachment of round spermatids to Sertoli cells in rhesus monkey and mice   Molecular and Cellular Biology (submitted)

3 FU-QING YU, CHUN-SHENG HAN, WEI YANG, XUAN JIN, ZHAO-YUAN HU AND YI-XUN LIU*(2004): Activation of p38 MAPK pathway by FSH regulates steroidogenesis in granulosa cells differentially Biol Reprod (submitted)

4 Xuan Jin, Chun-Sheng Han, Fu-Qing Yu, Peng Wei, Zhao-Yuan Hu, Yi-Xun Liu*(2004): Anti-apoptotic action of Stem Cell Factor on oocytes in primordial follicles and its signal transduction  Biol Reprod (submitted)

5 Gao Hong-Juan*, Chen Xin-Lei*, Zhang Zhi-Hong, Song Xin-Xin, Hu Zhao-Yuan and Liu Yi-Xun*(2004): IFN-γ and TNFαinhibit expression of TGFβ1, its receptorsTβR-I and TβR-II in rhesus monkey corpus luteum  Contraception (submitted)

6 Zhang ZH, Yu FQ, Jin X, Zou RJ, Han CS and Liu YX (2004): Activation of extracellular signal-regulated kinase 1 & 2 in Sertoli cells of the cryptorchidism of rhesus monkey  

7 Xiao LJ, Yuan JX, Li YC, Hu ZY, Liu YX(2004) : Stanniocalcin-1 is Involved in Implantation and Decidualization in Rat

8 Xiao LJ, Yuan JX, Guo SH, Hu ZY, Liu YX(2004): Localization and Regulation of Stanniocalcin 2 in Rat Uterus During Embryo Implantation and decidualization

9 Xiao LJ, Wang R, Yuan JX, Li YC, Hu ZY, Liu YX(2004): Expression and Regulation of

Extracellular Ca2+-Sensing Receptor in Rat Uterus During Peri-implantation Period

10 Xuan Jin, Chun-Sheng Han, Xue-Sen Zhang, Fu-Qing Yu, Shu-Hua Guo, Zhao-Yuan Hu, Yi-Xun Liu*(2004) Stem Cell Factor Modulates Expression of Steroidogenesis Related Proteins and FSHR During Ovarian Follicular Development

11. Theresa M. Siler-Khodr1, Fu-Qing Yu2, Peng Wei2, Shi-Xin Tao2, Susan Coulhart1,

Shari Mactyszczyk1 and Yi-Xun Liu2 (2004) Contraceptive Action of a GnRH II Analog in the Rhesus Monkey: Dose Response Studies  J Clin Endocrinol Metab

 

刘以训，研究员 院士，博士生导师
学科：生理学
电话：86-10-62588461
电子邮件： liuyx@ioz.ac.cn
1936年10月出生于山东省安丘。中国科学院动物研究所首席研究员、中国科学院院士、博士生导师，生殖生物学国家重点实验室学术委员会主任、WHO/洛氏基金胚胎植入研究中心中国中心主任，中国生殖生物学会理事长。Frontiers in Bioscience, Managing Editor (美国,2005-); Human Reproduction (Cambridge, 1995-2001), Archives of Andrology（美国, 2002- ）, Asia Journal of Andrology (2005-)，中国科学，生理学报，动物学报等八刊编委。
自1974年来刘以训研究员先后赴英、美、瑞典等国留学或长期国际合作。主要从事性腺和胚胎分子生物学研究。80年代初首先发现GnRH对子宫有直接作用；80年代末发现卵巢颗粒细胞(GC)产生的孕酮可被膜细胞(TC)利用转化为雄激素，GC和TC的相互作用是卵巢产生雌激素的前提，为著名的卵巢两种细胞两种促性腺激素学说的建立作出了重要贡献；近年来又发现GC产生tPA，而TC合成其抑制因子PAI-1，tPA和PAI-1在卵巢中的协同表达可诱发卵泡破裂，提出了排卵机制的新学说。发表论文195余篇(其中SCI论文90余篇)，有引文800余篇次，荣获中国科学院自然科学一等奖1项、二等奖5项。由于业绩突出，贡献大，多次受到表彰，被授予多种荣誉称号。2004年他荣获得"中华人口奖科学技术奖"。 已培养博士后、博士和硕士40余名.
性腺分子生物学研究组是从分子和细胞水平上研究精子和卵子发生，成熟和排放的分子机制;筛选和克隆与精子发生相关的特异基因并研究其功能;本研究组还承担多项国际合作课题，研究胚胎植入的分子调控，寻找控制这一过程的关键分子。
主要研究方向：
1． 精子发生的分子机制，筛选和克隆特异的相关基因并研究其功能
2． 原始卵泡（卵子）生长，分化，成熟和排卵的信息和传递机制
3． 胚胎植入的分子基础