Toshiaki Noce

Updated: Oct 29, 2004

CITIZENSHIP: Japanese

WORK ADDRESS: Mitsubishi Kagaku Institute of Life Sciences (MITILS)

Minamiooya 11, Machida-shi, Tokyo 194-8511, Japan

Tel: +81-042-724-6246

Fax: +81- 042-724-6314

e-mail: noce @libra.ls.m-kagaku.co.jp

EDUCATION:

Faculty of Science, Kyoto University, Kyoto, Japan 1974 - 1979

B. Sc. degree (Major in Biology, 1979)

Faculty of Science, Kyoto University, Kyoto, Japan 1979 - 1981

M.D. degree (Major in Developmental Biology, 1981)

Supervisor: Prof. Ikuo Takeuchi

Faculty of Science, Kyoto University, Kyoto, Japan 1981 - 1984

Ph.D. degree (Major in Developmental Biology, 1984)

Thesis Supervisor: Prof. Ikuo Takeuchi

CAREER:

Post-doctoral Fellow 1985 - 1986

Department of Biology, McGill University, Montreal, Canada

Supervisor: Dr. Adrian Tsang

Post-doctoral Fellow 1986 - 1987

(granted by fund for Promoting Science and Technonogy, Japan)

Department of Developmental Biology, National Institute of Basic Biology,

Okazaki, Japan.

Supervisor: Prof. Ikuo Takeuchi

Researcher 1987 - 1989

Department of Developmental Biology, Mitsubishi Kasei Institute of Life Sciences

Senior Researcher 1989 - present

Mitsubishi Kasei Institute of Life Sciences

Present : Mitsubishi Kagaku Institute of Life Sciences

Project Leader of Regenerative and Developmental Biology

Group Leader of Pluripotency and Initialization

CURRENT INTERESTS:

Using mouse vasa (Mvh) gene expression as a visualizing marker for germ cell differentiation, we have first succeeded in developing a culture system for producing germ cells from ES cells (PNAS, 100, 11457-11462, 2003). Specific interest is currently focused on understanding the molecular mechanism regulating the germ / somatic cell segregation and the maintenance of totipotency in germ cell lineage. Furthermore, as an attempt to understand the totipotency, we are trying to investigate the reprogramming event that is occurred in the process of nuclear transfer of somatic nuclei into egg cytoplasm.

PUBLICATIONS (RECENT 4 YEARS):

1) T. Nakamura, R. Yao, T. Ogawa, T. Suzuki1, C. Ito, N. Tsunekawa, K. Inoue, R.　Ajima, T. Miyasaka, Y. Yoshida, A. Ogura, K.Toshimori, T. Noce, T. Yamamoto and T. Noda. Oligo-astheno-teratozoospermia in mice lacking CCR4-associated factor 1, a novel regulator of RXRb. Nature Genetics, 36, 528-533, 2004.

2) T. Hiruma, A. Togayashi, K. Okamura, T. Sato, N. Kikuti, Y-D. Kwon, A. Nakamura, K. Fujimura, M. Gotoh, K. Tachibana, Y. Ishizuka, T. Noce, H. Nakanishi and H. Narimatsu. A novel human ß1,3N-acethygalactosaminy-ltransferase that synthesizes a unique carbohydrate structure, GalNAcß1-3GlcNAc. J Bio. Chem. 279, 14087-14095, 2004.

3) Y. Sakai, T. Noce and S. Yamashina. Cleavage-like cell division and explosive increase in cell number of neonatal gonocytes. Develop. Growth Differ, 46, 15-21, 2004.

4) Y. Toyooka, N. Tsunekawa, R. Akasu, and T. Noce. ES cell can form germ cell in culture. Proc. Natl. Acad. Sci.,USA, 100, 11457-11462, 2003.

5) T.Noce Germ cell differentiation in culture. J Mamm. Ova. Res., 20, 69-73, 2003.

6) N. Shibata, N. Tsunekawa, S. Okamoto-Ito, R. Akasu, A. Tokumasu and T. Noce. Mouse Ran-BPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein. Mol. Repro. Biol. 67, 1-7, 2004.

7) S. Ina, N. Tsunekawa, A. Nakamura and T. Noce. Expression of the mouse Aven gene during spermatogenesis, analyzed by subtraction screening using Mvh-knock-out mice. Gene Exp. Patterns., 3, 635-638, 2003.

8)T. Noce, S. Okamoto, and N. Tsunekawa. Vasa homolog genes in mammalian germ cell development. Cell Struc. & Func. 26, 131-136, 2001.1) T. Noce, S. Okamoto, and N. Tsunekawa. Vasa homolog genes in mammalian germ cell development. Cell Struc. & Func. 26, 131-136, 2001.

9) N. Tsunekawa, M. Naito, Y. Sakai, T. Nishiada and T. Noce. Isolation of chicken vasa homolog and tracing the origin of primordial germ cells. Development, 127, 2741-2750, 2000.

10) Y. Toyooka, N. Tsunekawa, Y. Takahashi, Y. Matsui, M. Satoh and T. Noce. Expression and intracellular localization of mouse Vasa-homolog protein during germ cell development. Mechanism of Development, 93, 139-149, 2000.

11) S.S.Tanaka, Y. Toyooka, R. Akasu, Y. Katoh-Fukui, Y. Nakahara, R. Suzuki, M. Yokoyama and T. Noce. Mouse homolog gene to Drosophila Vasa is required for the development of male germ cells. Genes & Development, 14, 841-853, 2000.