Yeung, Ching-Hei
Date of
birth: 20.02.1951
Place of
birth: Hong
Kong
Nationality: British
Marital
status: Married
with one child
1970-1974 Undergraduate
in Biology (major) and chemistry (minor),
Chinese
University of Hong Kong
(1974
B.Sc. awarded with first class honours)
1975-1977 Research
in epididymal function, Department of Physiology,
University
of Hong Kong
(M.Phil.
thesis "Absorptive and secretory functions of the rat
cauda
epididymidis") Supervisor Prof. PYD Wong
1978 M.
Phil. degree conferred
1977-1980 Research
in physiology and morphology of the epididymis,
Dept.
Physiology & Biochemistry, University of Reading, UK.
(PhD
thesis "Physiological and morphological studies of the
perfused
epididymis") Supervisor Prof.G.M.H. Waites
1980 Ph.
D. degree conferred
1981-1983 Research
in sperm movement, Dept. Physiology, University
of
Bristol Medical School (ARC Postdoctoral Research
Assistant)
1983-1984 National
Research Institute for Family Planning, Beijing,
China. (Visiting scientist)
1985-1987 Max
Planck Society Clinical Research Unit for Reproductive
Medicine,
Münster, Germany (Max Planck Fellow)
1988-1989 Max
Planck Society Clinical Research Unit for Reproductive
Medicine,
Münster, Germany
1989 to
present Institute
of Reproductive Medicine of the University,
Münster, Germany (Research Scientist)
Scientific
Interests
Sperm
function and maturation, epididymal function, contraception and infertility.
Society
for the Study of Reproduction
New York
Academy of Science
Research
Defence Society
Journals:
Human
Reproduction Journals, J Cell Science, J. Androl., Int. Androl., Mol. Reprod.
Dev., Eur. J. Biol.
Grants:
DFG,
National Science Foundation USA, University of Sienna, Italy.
in
Scientific journals -- 120 (50 as first authors)
as book
chapters -- 13 (3 as first authors)
Invited lectures and presentations
Development of sperm motility.
Symposium
on the Epididymis - role and importance in male infertility treatment
Deauville,
France. 1994
Effects of epididymal secretions on male rat fertility
National
Research Institute of Family Planning, Beijing, China, 1995
Characterisation of the kinematics of maturing spermatozoa.
British
Andrology Society, CASA (Computer Assisted Semen Analysis) Workshop, Castleton,
England, 1996
A CASA technique for standardisation and quality control of
subjective sperm motility assessment in conventional semen analysis.
European
Society of Human Reproduction and Embryology (ESHRE) Campus Course, San
Miniato, Italy, 1997
Computer-Assisted Semen Analysis.
The Finish
Andrology Society, Turku, Finland, 1997
Receptor tyrosine kinase c-ros knockout mice as a model for
the study of epididymal regulation of sperm function
Boden
Conference, Robertson, Australia, 1998
Epididymis as the Target for Post-testicular Male
Contraception
ESHRE
Annual Conference, Götterburg, Sweden, 1998
Computer-assisted
sperm anaylsis (CASA) and its application.
German Andrology Society, Giessen, Germany, 1999
The CD52-like
epididymal secretory glycoprotein on sperm.
British Andrology Society, London, England , 1999
Modulation of sperm proteins
during maturation.
The
Epididymis Symposium, 4.Dies Andrologicus, Marburg, Germany, 2000
2nd
Italian-German-Italian Symposium: Frontiers in Reproductive Medicine, Modena,
Italy, 2000
c-ros receptor tyrosine kinase knockout mouse as a
model of epididymal involvement in sperm maturation.
Pre-congress
Andrology Course, European Society of Human Reproduction and Embryology
(ESHRE), Lusanne, Switzerland, 2001
Plenary
Lecture, 9th International Symposium on Spermatology, Cape Town,
South Africa, 2002
Hong
Kong Society of Endocrinology, Metabolism and Reproduction, and Department of
Physiology, The Chinese University of Hong Kong. Hong Kong, Jan. 2003
Publications
Kong, Y.
C.; Yeung, H. W.; Cheung, Y. M.; Hwang, J. C.; Chan, Y. W.; Law, Y. P.; Ng, K.
H., and Yeung, C. H. Isolation of the uterotonic principle from Leonurus
artemisia, the Chinese motherwort. Am J Chin
Med. 4, 373-82 (1976)
Wong,
P.Y.D, Huang, J.C, Yeung, C.H.
Interaction between lanthanum and calcium in isolated guinea-pig heart. Eur. J. Pharmacol. 36,
253-256 (1976)
Wong,
P.Y.D., Yeung, C.H.
Inhibition by amiloride of the sodium dependent fluid reabsorption in
isolated rat cauda epididymidis. Brit. J.
Pharmacol. 58, 529-532 (1976)
Wong, P.Y.D,
Yeung, C.H. Fluid
reabsorption in isolated rat cauda epididymidis. J. Reprod. Fert, 49,
77-81 (1977)
Wong,
P.Y.D., Yeung, C.H.
Inhibition of alpha-chlorohydrin of fluid reabsorption in the rat cauda
epididymidis. J. Reprod. Fert., 51, 469-471 (1977)
Wong,
P.Y.D., Yeung, C.H.
Hormonal regulation of fluid reabsorption in isolated rat cauda
epididymidis. Endocrinol, 101, 1391-1397 (1977)
Wong,
P.Y.D., Yeung, C.H. Effect
of _-chlorohydrin on transport processes in perfused rat cauda epididymidis. Contraception,
16, 637-644 (1977)
Wong,
P.Y.D., Yeung, C.H. Effect
of catecholamines and adrenergic blockade on fluid reabsorption in isolated rat
cauda epididymidis. Jap. J. Pharmacol. 28,
115-123 (1978)
Wong,
P.Y.D., Yeung, C.H.
Absorptive and secretory functions of the perfused rat cauda epididymis.
J. Physiol. 275, 13-26 (1978)
Wong,
Y.C., Wong, P.Y.D., Yeung, C.H.
Ultrastructural correlation for water reabsorption in isolated rat cauda
epididymidis. Experientia 34, 485-487 (1978)
Au, C.L.,
Ngai, H.K., Yeung, C.H., Wong, P.Y.D. Effect of adrenalectomy and hormone replacement on sodium
and water transport in the perfused rat cauda epididymidis. J. Endocrin. 77,
265-266 (1978)
Cooper,
T.G., Yeung, C.H.
Epithelial structure of the rat cauda epididymidis after luminal
perfusion. Int. J. Androl. 3, 367-374 (1980)
Yeung,
C . H., Cooper, T. G., Waites, G.M.H.
Carnitine transport into the perfused epididymis of the rat: regional
differences, stereospecificity, stimulation by choline, and the effect of other
luminal factors. Biol. Reprod. 23, 294-304 (1980)
Yeung,
C.H., Cooper, T.G., Ultrastructure
of the perfused rat epididymis: the effect of luminal sodium ion concentration.
Cell Tissue Res. 226, 407-425 (1982)
Yeung,
C.H., Woolley, D.W. Localised reactivation
of the principal piece of demembranated hamster sperm by ionophoretic
application of ATP. J.
Submicroscop. Cytol. 15, 327-331 (1983)
Yeung,
C.H., Woolley, D.W. A study of
bend formation in locally reactivated hamster sperm flagella. J. Muscle
Res. Cell Motil. 4, 625-645 (1983)
Yeung,
C.H., Woolley, D.W.
Three-dimensional bend propagation in hamster sperm models and the
direction of roll in free-swimming cells. Cell Motility 4, 215-226
(1984)
Yeung,
C.H. Effect of cyclic AMP on
the motility of mature and immature hamster epididymal spermatozoa studied by
local reactivation of the demembranated cells. Gamete Res. 9, 99-114 (1984)
Cooper, T.
G., Yeung, C.H., Liu, W., Yang, C. Z. Luminal secretion of myo-inositol by the rat epididymis perfused
in vitro. J. Reprod. Fert. 74, 135-144 (1985).
Cooper, T. G., Yeung, C. H., Weinbauer, G. F. Transport
of carnitine by the epididymis of the cynomolgus macaque (Macaca fascicularis). J.
Reprod. Fert. 77, 297-301 (1986).
Cooper, T.
G., Gudermann, T. W., Yeung, C.-H.
Characteristics of the transport of carnitine into the cauda
epididymidis of the rat as ascertained by luminal perfusion in vitro. Int. J.
Androl. 9, 348-358 (1986).
Yeung,
C. H. Temporary inhibition of the
initiation of motility of demembranated hamster sperm by high concentrations of
ATP. Int. J. Androl. 9, 359-370 (1986).
Cooper, T.
G., Yeung, C. H., Bergmann, M.
Protein transport to the epididymal lumen. Cell Tiss. Res. 248,
527-530 (1987).
Cooper, T.
G., Yeung, C. H., Bergmann, M.
Ultrastructural evidence for transport of protein across the epithelium
of the rat caput epididymidis. in “Cell Biology of the Testis and Epididymis”.
Annals New York Acad Sci, 513, 538-540 (1987)
Knuth, U.
A., Yeung, C. H., Nieschlag, E. Computerized
semen analysis: objective measurement of semen characteristics is biased by
subjective parameter setting. Fertil Steril 48, 118-124. (1987)
Yeung, C. H. Inhibition
of the ATP-induced reactivation of demembranated hamster spermatozoa by the
action of free ATP4- and ATP2-. J. Reprod. Fertil. 81,
195-203 (1987)
Cooper, T.
G., Yeung, C. H., Bergmann, M.
Transcytosis in the epididymis studied by local arterial perfusion. Cell
Tiss. Res. 253, 631-637 (1988).
Cooper, T.
G., Gudermann, T. W., Yeung, C. H.
Transport of inositol into the distal cauda epididymidis of the rat. J. Androl. 9, 403-407 (1988).
Cooper, T. G., Yeung, C. H., Nashan, D., Nieschlag, E. Epididymal
markers in human infertility. J. Androl. 9,
91-101 (1988).
De Geyter, C., Bals-Pratsch, M., Doeren, M., Yeung, C. H., Grunert,
J. H., Bordt, J., Schneider, H. P. G., Nieschlag, E. Human and bovine cervical mucus penetration as a test
of sperm function for in-vitro fertilization. Human Reproduction. 3,
948-954 (1988).
Yeung,
C. H., Bals-Pratsch, M., Knuth, U. A., Neischlag, E. Investigation of the cause of low sperm motility in
asthenozoospermic patients by multiple quantitative tests. Int J. Androl. 11,
289-299 (1988).
Cooper, T.
G., Yeung, C. H., Meyer, R.
Immature rat epididymal epithelial cells grown in static primary
monolayer culture on permeable supports. I. Vectorial secretion. Cell Tiss.
Res. 256, 567-572 (1989).
Knuth, U.
A., Yeung, C. H., Nieschlag, E.
Combination of 19-nortesterone-hexyloxyphenylpropionate (Anadur)* and
depot-medroxyprogesterone (Clinovir) for male contraception. Fert. Steril. 51, 1011-1018 (1989).
Yeung, C. H., Weinbauer, G. F.,
Nieschlag, E. Movement
characteristics of ejaculated sperm from Cynomolgus monkeys (Macaca
fascicularis) analyzed by manual and automated computerised image analysis. J.
med. Primatol. 18, 55-68 (1989).
Yeung, C. H., Cooper, T. G.,
Weinbauer, G. F., Bergmann, M., Kleinhans, G., Schulze, H., Nieschlag, E. Fluid-phase
transcytosis in the primate epididymis in vitro and in vivo. Int. J. Androl. 12,
384-394 (1989).
Yeung,
C. H., Cooper, T. G., Meyer, R.
Immature rat epididymal epithelial cells grown in static primary
monolayer culture on permeable supports. II. Histochemistry and ultrastructure. Cell Tissue Res. 256,
573-580 (1989).
Cooper, T. G., Yeung, C. H., Nashan, D., Jockenhövel, F., Nieschlag,
E. Improvement
in the assessment of human epididymal function by the use of inhibitors on the
assay of a-glucosidase
in seminal plasma. Int. J. Androl. 13,
297-305 (1990).
Cooper, T. G., Yeung, C. H., Nashan, D., von Bassewitz, D.-B.,
Nieschlag, E. Nebenhodenfunktion
bei patienten mit Maldescensus testis."Paediatrie aktuell.1. Maldescensus
testis". Zuckschwert Verlag, Muenchen, 1990, 57-60.
Cooper, T.
G., Yeung, C. H., Meyr, R., Schulze, H. Maintenance of human epididymal epithelial cell function
in monolyer culture. J. Reprod.
Fert. 90, 81-91 (1990).
Weinbauer, G. F., Jackwerth, B., Yoon, Y.-D., Behre, H. M., Yeung,
C. H., Nieschlag, E. Pharmacokinetics
and pharmacodynamics of teststerone enanthate in non-human primates. Acta
Endocr. (Copenh). 122, 432-442 (1990).
Yeung,
C. H., Cooper, T. G., Senge, T.
Histochemical localization and quantification of a-glucosidase
in the epididymis of men and
laboratory animals. Biol. Reprod. 42, 669-676
(1990).
Yeung, C. H., Krusemann, C., Bunn,
H., Neuwinger, J., Nieschlag, E. Evaluation
of the semi-automated Autosperm* semen analysis system. I. Accuracy and
comparison with the conventional method and the automated Hamilton-Thorn
system. Fert. Steril. 53, 111-119
(1990).
Yeung, C.H., Bergmann, M., &
Cooper, T.G. Non-specific
uptake of IgG by rat epididymal tubules in vitro. Int J Androl 14, 364-373 (1991)
Yeung, C.H., Cooper, T.G., Bergmann,
M., & Schulze, H. Organization
of tubules in the human caput epididymidis and the ultrastructure of their
epithelia. Am J Anat 191, 261-279 (1991).
Cooper, T.G., Raczek, S., Yeung, C.H., Schwab, E., Schulze, H. The
composition of fluid obtained from human epididymal cysts. Urol Research 20,
275-280 (1992).
Yeung,
C.H., Oberländer, G., & Cooper, T.G.
Characterization of the motility of rat spermatozoa by computer-aided
objective measurement. J Reprod Fert 96, 427-441 (1992)
Raczek, S,
Yeung, C.H., Hertle, L., Schulze, H., Cooper, T.G. Appearance and endocytic activity of
epitheial cells from human efferent ducts in primary monolayer culture. Cell
Tiss Res 270, 513-519 (1992)
Yeung,
C.H., Cooper, T.G., Oberpenning, F., Schulze, H., Nieschlag, E. Changes in movement characteristics of
human spermatozoa along the length of the epididymis. Biol Reprod 49, 274-280 (1993)
Yeung, C.H., Nieschlag, E. Performance
and comparison of CASA systems equipped with different phase-contrast optics. J
Androl 14, 222-228 (1993)
Meschede,
D., Keck, C., Zander, M., Cooper, T.G., Yeung, C.H., Nieschlag, E. Influence of three different
preparation techniques on the results of human sperm morphology analysis. Int J
Androl, 16, 362-369 (1993)
Oberländer,
G., Yeung C.H., Cooper, T.G.
Effects of ornidazole on fertility, sperm motility and epididymal
secretion of male rats. J Reprod Fert, 100: 551-559 (1994)
Yeung
C.H., Nashan D, Sorg C, Oberpenning F, Schulze H, Nieschlag E, Cooper T.G. Basal cells of the human epididymis -
Antigenic and ultrastructural similarities to tissue fixed macrophages. Biol
Reprod, 50: 917-926 (1994)
Yeung
C.H., Oberländer, G., Cooper, T.G.
Maturation of hamster epididymal sperm motility and influence of the
thiol status of hamster and rat spermatozoa on their motility patterns. Molec
Reprod Develop, 38 347-355 (1994)
Perez-Sanchez,
F., Cooper, T. G., Yeung, C. H., Nieschlag, E., Improvement in
quality of cryopreserved human spermatozoa by swim-up before freezing. International Journal of Andrology.
17, 115-120 (1994).
Soler, C.,
Yeung, C. H., Cooper, T. G., Development of sperm motility patterns in
the murine epididymis. Int J Androl. 17, 271-278 (1994).
Yeung,
C. H., Cooper, T. G., Study of the role of epididymal alpha-glucosidase in
the fertility of male rats by the
administration of the enzyme
inhibitor castanospermine. Journal of Reproduction and Fertility. 102,
401-410 (1994).
Raczek,
S., Yeung, C. H., Wagenfeld, A., Schulze, H., Cooper, T. G., Epithelial
monolayers from human epididymal and efferent duct tubules, testosterone metabolism
and effects of culture conditions on cell height and confluence. Epith cell
Biol. 3, 126-136 (1994).
Pollanen,
P., Saari, T., Yeung, C. H., Cooper, T. G., Regulation of the transport
of immunoglobulin G into the male rat reproductive tract. J Reprod Immunol. 28,
111-135 (1994).
Yeung,
C. H., Development of sperm motility. Hamamah, S., Mieusset, R., Dacheux,
J.-L.(eds) "Epididymis: Role and importance in male infertility treatment.
Frontiers in Endocrinology". Ares-Serono
Symposia Publications, Rome, 1995, 73-86.
Raczek,
S., Yeung, C. H., Hasilik, A., Robenek, H., Hertle, L., Schulze, H.,
Cooper, T. G., Immunocytochemical localisation of some lysosomal hydrolases, by
their presence in luminal fluid and their directional secretion by human
epididymal cells in culture. Cell Tissue Res. 280, 415-425 (1995).
Yeung,
C. H., Oberländer, G., Cooper, T. G., Effects of the male antifertility agent
ornidazole on sperm function in vitro and in the female genital tract. J Reprod
Fertil. 103, 257-264 (1995).
Oberländer,
G., Yeung, C. H., Cooper, T. G., Influence of oral administration of
ornidazole on capacitation and the activity of some glycolytic enzymes of rat
spermatozoa. J Reprod Fertil. 106, 231-239 (1996).
Yeung,
C. H., Morrell, J. M., Cooper, T. G., Weinbauer, G. F., Hodges, J. K.,
Nieschlag, E., Maturation of sperm motility in the epididymis of the common
marmoset (Callithrix jacchus) and the cynomologus monkey (Macaca fascicularis).
Int J Androl. 19, 113-121 (1996).
Yeung,
C. H., De Geyter, C., De Geyter, M., Nieschlag, E., Production of reactive
oxygen species by and hydrogen peroxide scavenging activity of spermatozoa in
an IVF program. J Assisted Reprod Genetics. 13, 495-500 (1996).
Yeung,
C. H., Cooper, T. G., Weinbauer, G. F., Maturation of monkey spermatozoa in the
epididymis with respect to their ability to undergo the acrosome reaction. J
Androl. 17, 427-432 (1996).
Yeung,
C. H., Spier, B., Cooper, T. G., Nieschlag, E. The effect of the bradykinin
antagonist Hoe 140 on kinematic parameters of human spermatozoa. Int J Androl.
19, 143-149 (1996).
Perez-Sanchez,
F., Tablado, L., Yeung, C. H., Cooper, T. G., Soler, C., Changes in the
motility patterns of spermatozoa from the rabbit epididymis as assessed by
computer aided sperm motion analysis. Mol Reprod Devel. 45, 364-371 (1996).
Yeung,
C. H., Majumder, G. C., Rolf, C., Behre, H., Cooper, T. G., The role of
phosphocreatine kinase in the motility of human spermatozoa supported by
different metabolic substrates. Mol Human Reprod. 2, 591-596 (1996).
Cooper, T. G., Yeung, C. H.,
Physiologie der Spermienreifung und Fertilisation. In "Andrologie:
Grundlagen und Klinik der Reproduktiven Gesundheit des Mannes" Chapter 4,
Eds E. Neischlag, H.M. Behre, pp 65-84, Springer, Berlin, 1996
Behre, H. M., Yeung, C. H, Nieschlag, E, Diagnostik der Infertilitat und des Hypogonadismus. In
"Andrologie: Grundlagen und Klinik der Reproduktiven Gesundheit des
Mannes" Chapter 6, Eds E. Neischlag, H.M. Behre, pp 91-120, Springer,
Berlin, 1996
Cooper, T.
G., Wang, X. S., Yeung, C. H., Lewin, L. M., Successful
lowering of epididymal carnitine by administration of privalate to rats.
Int J Androl 20, 180-188. (1997)
Yeung,
C. H., Perez-Sanchez, F., Soler, C., Poser, D., Kliesch, S., Cooper, T. G.,
Maturation of human spermatozoa (from selected epididymides of prostatic
carcinoma patients) with respect to their morphology and ability to undergo the
acrosome reaction. Human Reprod Update 3, 205-213. (1997)
Yeung,
C. H., Cooper, T. G., Nieschlag, E.,
A technique for standardization and quality control of subjective sperm
motility assessments in semen analysis. Fert Steril. 67, 1156-1158 (1997)
Yeung,
C. H., Schröter, S., Wagenfeld, A., Kirchhoff, C., Kliesch, S., Poser, D,
Weinbauer, G. F., Nieschlag, E., Cooper, T. G., Interaction of the human epididymal protein CD52 (HE5)
with epididymal spermatozoa from men and cynomolgus monkeys. Mol Reprod Devel, 48, 267-275 (1997)
Yeung,
C. H., Cooper, T. G., Nieschlag, E.,
Human epididymal secreted protein CD52 on ejaculated sperm: correlation
with semen characteristics and the effect of its antibody. Mol Human Reprod, 3, 1045-1051 (1997)
Cooper, T.
G., Yeung, C. H.,
Physiology of Sperm Maturation and Fertilisation. In "Andrology:
male reproductive health and dysfunction" Chapter 4, Eds E. Nieschlag,
H.M. Behre, pp 61-80, Springer, Berlin, 1997
Behre, H.
M., Yeung, C. H, Nieschlag, E,
Diagnosis of Infertility and Hypogonadism. In "Andrology: male
reproductive health and dysfunction" Chapter 6, Eds E. Nieschlag, H.M.
Behre, pp 97-114, Springer, Berlin, 1997
Bone, W., Yeung, C-H, Skupin, R., Haufe, G.,
Cooper, T. G., Toxicity of ornidazole and its analogues towards rat sperm as
reflected in motility parameters. Int J
Androl. 20, 347-355. (1997)
Pera, I., Derr, P., Yeung, C-H.,
Cooper, T,G., Kirchhoff,.C., Regionalized expression of CD52 in rat epididymis
is related to mRNA ploy(A) tail length.
Mol Reprod Dev. 48, 433-441.
(1997)
Kirchhoff, C., Pera, I., Derr, P., Yeung,
C-H., Cooper, T. The molecular biology of the sperm surface. Post-testicular
membrane remodelling. Adv Exp Med Biol 424, 221-232. (1997)
Schröter, S., Kirchhoff, C., Yeung,
C-H., Cooper, T., Meyer, B. Purification and structureal analysis of sperm
CD52, a GPI-anchored membrane protein. Adv
Exp Med Biol 424, 233-234.
(1997)
Cooper, T. G., Yeung, C-H., Skupin, R., Haufe,
G., Antifertility potential of ornidazole analogues in rats. J Androl. 18, 431-438 (1997).
Yeung,
C. H., Cooper, T. G., Schröter, S., Kirchhoff, C., Nieschlag, E., Epididymal secretion of CD52 as measured in human seminal
plasma by a fluorescence immunoassay. Mol Human Reprod 4, 447-451 (1998).
Wagenfeld,.A., Yeung, C-H.,
Strupat, K., Cooper, T. G.,
Shedding of a rat epididymal sperm protein associated with infertility
induced by ornidazole and a-chlorohydrin. Biol Reprod 58, 1257-1265 (1998).
Gago, C., Perez-Sanchez, P., Yeung, C.H.,
Tablado, L., Cooper, T.G., Soler, C. Standardization of sampling and staining
methods for the morphometric evaluation of sperm heads in the Cynomolgous
monkey (Macaca fascicularis) using computer-assisted image analysis. Int J Androl 21, 169-176 (1998).
Seiler, P., Wenzel, I., Wagenfeld, A., Yeung,
C-H., Nieschlag, E., Cooper, T.G. The appearance of basal cells in the
developing murine epididymis and their temporal expression of macrophage
antigens. Int J Androl. 21, 217-226
(1998).
Weinbauer, G.F., Schubert, J., Yeung, C.H.,
Rosiepen, G., Nieschlag, E. Gonadotrophin-releasing hormone antagonist arrests
premeiotic germ cell proliferation but does not inhibit meiosis in the male
monkey: a quantitative analysis using 5-bromodeoxyuridine and dual parameter
flow cytometry. J Endocrin. 156,
23-34 (1998).
Yeung, C.H., Cooper, T.G.,
DeGeyter, M., DeGeyter, C., Rolf, C., Kamischke, A.,
Nieschlag, E. Studies on the origin of redox enzymes in seminal plasma
and their relationship with results of in-vitro fertilization. Mol Human Reprod. 4, 835-839 (1998).
Yeung,
C.H., Sonnenberg-Riethmacher, E., Cooper, T.G. Receptor tyrosine kinase c-ros
knockout mice as a model for the study of epididymal regulation of sperm. J Reprod Fertil Suppl. 53, 137-147
(1998)
Cooper, T.G., Yeung, C-H. A
flow cytometric technique using peanut agglutinin for evaluating acrosomal loss
from human spermatozoa. J Androl. 19,
542-550 (1998).
Krishnamurthy, H., Weinbauer,
G.F., Aslam, H., Yeung, C-H., Nieschlag, E. Quantification of apoptotic
testicular germ cells in normal and methoxyacetic acid-treated mice as
determined by flow cytometry. J Androl.19,
710-717 (1998).
Cooper, T.G., Yeung, C.H.
Approaches to post-testicular contraception. Asian J Androl. 1, 29-36.(1999).
Cooper, T.G., Yeung, C.H. Recent
biochemical approaches to post-testicular, epididymal contraception. Human Reprod Update. 5, 141-152.(1999).
Cooper TG and Yeung C-H Sperm maturation in the primate epididymis. In: Reproduction in nonhuman primate. Ed. GF Weinbauer, R Korte. Waxmann Verlag, Münster. pp
61-78 (1999).
Gago, C., Tablado, L., Yeung,
C.-H., Cooper, T.G., Soler, C. Morphological characterization of ejaculated
monkey (Macaca fascicularis) spermatozoa. Am
J Primatol. 47, 105-115.(1999).
Rolf, C., Cooper, T.G., Yeung,
C.H., Nieschlag, E. Antioxidant treatment of patients with asthenozoospermia or
moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a
randomized, placebo-controlled, double-blind study. Human Reprod. 14, 1028-1033.(1999).
Yeung, C.H.,
Sonnenberg-Riethmacher, E., Cooper, T.G. Infertile Spermatozoa of c-ros
tyrosine kinase receptor knockout mice show flagellar angulation and maturational
defects in cell volume regulatory mechanisms. Biol Reprod. 61, 1062-1069.(1999).
Yeung, C.-H.,
Weinbauer, G.F., Cooper, T.G. Effect of acute androgen withdrawal by GnRH
antagonist on epididymal sperm motility and morphology in the cynomolgus monkey.
J Androl. 20, 72-79.(1999).
Yeung, C.-H., Weinbauer, G.F.,
Cooper, T.G. Responses of monkey epididymal sperm of different maturational
status to second messengers mediating protein tyrosine phosphorylation,
acrosome reaction, and motility. Mol
Reprod Devel. 54, 194-202.(1999).
Seiler, P., Cooper, T.G., Yeung, C.H., Nieschlag, E. Regional
variation in macrophage antigen expression by murine epididymal basal cells and
their regulation by testicular factors. J
Androl 20, 738-746. (1999)
Bone, W.,
Jones, N.G., Kamp, G., Yeung, C.H., Cooper, T.G. The antifertility effect of
ornidazole in male rats: inhibition of a glycolysis-related motility pattern
and zona binding required for fertilisation in vitro. J Reprod Fert, 118, 127-137 (2000).
Cooper,
T.G., Weydert, S., Yeung, C.-H., Künzl, C., Nieschlag, E., Sachser, N.
Maturation of epididymal spermatozoa in the non-domesticated guinea pigs Cavia aperea and Galea musteloides, J
Androl, 21, 154-163 (2000).
Soler, C.,
Perez-Sanchez, F., Schulze, H., Bergmann, M., Oberpenning, F., Yeung, C.H.,
Cooper, T.G. Objective evaluation
of the morphology of human epididymal sperm heads. Int J Androl, 23, 77-84 (2000).
Gago, C.,
Soler, C., Perez-Sanchez, P., Yeung, C.H., and Cooper, T.G. Effect of
cetrorelix on sperm morphology during migration through the epididymis in the
Cynomolgous Macaque (Macaca fascicularis) . Am
J Primatol, 51:103-117 (2000).
Yeung,
C.H., Wagenfeld, A., Nieschlag, E., Cooper, T.G. The Cause of Infertility of
Male c-ros Tyrosine Kinase Receptor Knockout
Mice. Biol Reprod. 63:612-618
(2000)
Yeung,
C.H., Schröter, S., Kirchhoff, C., Cooper, T.G. Maturational changes of the
CD52-like epididymal glycoprotein on cynomolgus monkey sperm and their apparent
reversal in capacitation conditions. Mol
Reprod Dev, 57:280-289 (2000)
Cooper, T. G., Yeung, C. H.,
Physiologie der Spermienreifung und Fertilisation. In "Andrologie:
Grundlagen und Klinik der Reproduktiven Gesundheit des Mannes", 2.
Auflage, Chapter 4, Eds E. Neischlag, H.M. Behre, pp 69-90, Springer, Berlin
(2000)
Behre, H. M., Yeung, C. H, Nieschlag, E, Diagnostik der Infertilitat und des Hypogonadismus. In
"Andrologie: Grundlagen und Klinik der Reproduktiven Gesundheit des
Mannes", 2. Auflage, Chapter 6, Eds E. Neischlag, H.M. Behre, pp 137-157,
Springer, Berlin (2000)
Cooper, T.
G., Yeung, C. H., Physiology of
Sperm Maturation and Fertilisation. In "Andrology: male reproductive
health and dysfunction", 2nd Ed. Chapter 4, Eds E. Nieschlag, H.M. Behre, pp 63-82, Springer, Berlin (2000)
Behre, H.
M., Yeung, C. H, Nieschlag, E,
Diagnosis of Infertility and Hypogonadism. In "Andrology: male
reproductive health and dysfunction", 2nd Ed. Chapter 6, Eds E. Nieschlag, H.M. Behre, pp 90-124,
Springer, Berlin (2000)
Yeung, C.
H. Modulation of sperm proteins
during maturation. Andrologia
32:369-369 (2000)
Derr, P.,
Yeung, C.H., Cooper, T.G., Kirchhoff, C.
Synthesis and glycoslation of CD52, the major ‘maturation-associated’
antigen of rat spermatozoa, in the cauda epididymidis. Reproduction 121:435-446 (2001)
Yeung, C.H. and Cooper, T.G. Effects of the
ion-channel blocker quinine on human sperm volume, kinematics and mucus
penetration, and the involvement of potassium channels. Molecular
Human Reproduction 7:819-828 (2001)
Yeung, C.H., Perez-Sanchez, F., Schroter, S.,
Kirchhoff, C. and Cooper, T.G. Changes of the major sperm maturation-associated
epididymal protein HE5 (CD52) on human ejaculated spermatozoa during
incubation. Mol Hum Reprod 7:617-24 (2001)
Cooper,
T.G., Yeung, C.H., Jones, R., Orgebin-Crist, M.-C. and Robaire, B. Rebuttal of
a role for the epididymis in sperm quality control by phagocytosis of defective
sperm. J Cell Sci 115:5 (2002)
Sipila, P.,
Cooper, T.G., Yeung, C.H., Mustonen, M., Penttinen, J., Drevet, J., Huhtaniemi,
I. and Poutanen, M. Epididymal dysfunction initiated by the expression of
Simian Virus 40 T-antigen leads to angulated sperm flagella and infertility in
transgenic mice. Mol Endocrin,
16:2603-2617 (2002)
Wagenfeld,
A., Yeung, C.H., Lehnert, W., Nieschlag, E. and Cooper, T.G. Lack of glutamate
transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. J
Androl 23:772-782 (2002)
Yeung, C.H.,
Anapolski, M., Sipilä, P., Wagenfeld, A., Poutanen, M., Huhtaniemi, I., Nieschlag,
E. and Cooper, T.G. Sperm volume regulation - Maturational changes in fertile
and infertile transgenic mice and association with kinematics and tail
angulation. Biol Reprod 67:269-275 (2002)
Yeung, C.H.,
Anapolski, M., and Cooper, T.G. Measurement of volume changes in mouse
spermatozoa using an electronic sizing analyser and a flow cytometer -
validation and application to an infertile mouse model. J
Androl 23:522-528 (2002)
Yeung, C.H.
and Cooper, T.G. Acquisition and development of sperm motility upon maturation
in the epididymis. In The Epididymis: From Molecular to Clinical Practice. Eds.
B. Robaire and B. Hinton, Kluwer Academic / Plenum Publishers, New York.
417-434 (2002)
Yeung, C.H.,
Anapolski, M., and Cooper, T.G. Cell volume regulation of mammalian
spermatozoa. G. Van de Horst, D. Franken, R. Bornman, R. (eds), Proceedings of 9th International Symposium
on Spermatology. Eds. Monduzzi Editore, Bologna, Italy, pp. 167-172
(2002)
Xu, Y.X., Wagenfeld, A.,
Yeung, C.H., Lehnert, W., Nieschlag, E., Cooper, T.G. Expression and location of
the taurine transporter in the epididymis of infertile c-ros receptor tyrosine kinase-deficient and fertile heterozygous
mice. Mol Reprod Develop 64:144-151
(2003)
Cooper, T.G. and Yeung, C.H. Acquisition of volume
regulatory response of sperm upon maturation in the epididymis and the role of
the cytoplasmic droplet. In Epididymis: Microscopy Reseach and Technique 61:28-38 (2003)
Yeung, C.H., Anapolski, M., Depenbusch, M., Zitzmann, M. and Cooper, T.G. Human sperm volume regulation. Response to physiological changes in osmolality, channel
blockers and potential sperm osmolytes. Human
Reproduction 18:1029-1036 (2003)
Xu, Y., Yeung,
C.H., Setiawan, I., Avram, C., Biber, J, Wagefeld, A., Lang, F. and
Cooper, T.G. Sodium-inorganic phosphate cotransporter
NaPi-IIb in the epididymis and its potential role in male fertility
studied in a transgenic mouse model. Biol
Reprod, in press 69:1135-1141 (2003)
Yeung, C.H. and Cooper,
T.G. Developmental changes in
signalling transduction factors in maturing sperm during epididymal transit. Cell Mol Biol 49:341-349 (2003)
Andersen O.M., Yeung C.H., Vorum H., Wellner
M., Andreassen T.K., Erdmann B., Mueller E.C., Herz J., Otto A., Cooper T.G.,
and Willnow T.E. Essential role of the apolipoprotein E receptor-2 in sperm
development. J Biol Chem. 278:23989-95 (2003)
Cooper T.G., Wagenfeld A., Cornwall G.A., Hsia
N., Chu S.T., Orgebin-Crist M.-C., Drevel J., Vernet P.A.C., Nieschlag E., and
Yeung C.H. Gene and protein expression in the epididymis of infertile c-ros
receptor tyrosine kinase-deficient mice. Biol Reprod 69:1750-1762 (2003)
Kamischke A., Kuhlmann M., Weinbauer G.F.,
Luetjens M., Yeung C.H., Kronholz H.L., Nieschlag, and E Gonadal protection
from radiation by GnRH antagonist or recombinant human FSH: a controlled trial
in a male nonhuman primate (Macaca fascicularis). J Endocrinol
179:183-194 (2003)
Yeung C.H., Anapolski M., Setiawan I., Lang F.,
and Cooper T.G. Effects of putative epididymal osmolytes on sperm volume
regulation of fertile and infertile c-ros transgenic Mice. J Androl
25:216-23 (2004)
Cooper
T. and Yeung C.H. Approaches to post-testicular contraception: Insights from
the infertile c-ros knockout mouse. In The Third International Conference on
the Epididymis (ed. Hinton B.T. and Turner T.T.) The Van Doren Company,
Charlottesville. In press (2004)
Cooper
T.G., Yeung C.H., Wagenfeld A., Nieschlag E., Poutanen M., Huhtaniemi I., and
Sipila P. Mouse models of infertility due to swollen spermatozoa. Mol Cell Endocrin.
216:55-63 (2004)
Yeung, C.H., Breton, S., Setiawan, I. Xu Y., Lang F.and Cooper T.G. Increased
luminal pH in the epididymis of infertile c-ros knockout mice and the
expression of sodium-hydrogen
exchangers and vacuolar proton pump H+-ATPase . Mol Reprod Dev.
68:159-168 (2004)
Avram,
C., Yeung, C.H., Nieschalg, E., Cooper, T.G. Regulation of the initial segment
of the murine epididymis by dihydrotestosterone and testicular exocrine
secretions studied by expression of specific proteins and gene expression. Cell
Tissue Research. 317:13-22 (2004)
Yeung
C.H., Barfield, J., Anapolski M. and Cooper T.G. Volume regulation of mature and immature spermatozoa in a
primate model and possible ion channels involved. Human Reproduction.
19:2587-2593 (2004)
Communications at Conferences
Movement
characteristics of human spermatozoa along the length of the epididymidis.
Annual
Conference of the Society for the Study of Fertility, Cambridge, UK, 1993
Changes in
sperm movement parameters upon maturation in the epididymis of mice and
cynomolgous monkeys.
7th
International Spermatology Symposium, Cairns, Australia, 1994
Study of
the role of epididymal -glucosidase
in the fertility of male rats by the administration of castanospermine.
7th International
Spermatology Symposium, Cairns, Australia, 1994
Response of monkey epididymal sperm of different
maturational status to secondary messengers mediating protein tyrosine kinase
phosphorylation, acrosome reaction and motility.
Society for the Study of Reproduction, Pullman, USA,
1999
Regulation of human sperm volume.
International Congress of Andrology, Montreal, Canada,
2001