Yong-Lian Zhang
Nationality:China
Contact: (Mailing Address, Email, Tel, Fax)
State key Laboratory of
Molecular Biology
Institute of Biochemistry & Cell Biology
Shanghai Institute for Biological Sciences
Chinese Academy of Sciences,
320, Yue-Yang Road, Shanghai, 200031, China
Tel. 8621-54921163; Fax. 8621-54921011
E-mail. yonglz@sunm.shcnc.ac.cn ylzhang@sibs.ac.cn
Main research
interest:
Studies of sperm maturation related epididymis-specific
programmatically expressed novel genes.
Publications:
1.
Zong-Yao Zhou, Chen Xu,
Qiang-Su Guo, Yuan-Xin Hu, Yong-Lian Zhang, Yi-Fei Wang (2004) Spatial and
temporal expression of germ cell nuclear factor in murine epididymis. Asian J. Andrology 6(1):23-28
2.
Chen Xi Zhou,Yong-Lian
Zhang, Liqing Xiao,Min Zheng, Ka Man Leung,Man Yee Chan, Pui Shan Lo1, Lai Ling
Tsang, Hau Yan Wong, Lok Sze Ho,Yiu Wa Chung & Hsiao Chang Chan (2004) An
epididymis-specific β-defensin
is important for the initiation of sperm maturation. Nature Cell Biology 6(5):458-464
3.
Li-Qing Xiao, Ai-Hua Liu
& Yong-Lian Zhang (2004) An Effective Method for Raising Antisera Against β-defensins: Double-copy Protein Expression of
mBin1b in E.coli. Acta
Biochimica et Biophysica Sinica 36(8):571-576
4.
Yuanxin Hu, Zongyao Zhou,
Chen Xu, Quan Shang, You-Duan Zhang & Yong-Lian Zhang (2003) Androgen down-regulated and region-specific expression of
Germ Cell Nuclear Factor in mouse epididymis. Endocrinology
144(4):1612-1619
5.
Genyan Yang, Yong-Lian
Zhang, Gregory M. Buchold, Anton M. Jetton & Deborah A. O’Brien (2003) Analysis
of Germ Cell Nuclear Factor Transcripts and Protein Expression During
Spermatogenesis. Biology of
Reproduction 68:1620-1630
6.
Yuanxin Hu, Juyuan Guo, Lu
Shen, Yan Chen, Zuchuan Zhang & Yong-lian Zhang (2002) Get effective
polyclonal antisera in one month. Cell
Research 12(2):157-160
7.
Zhi-Hong Hu, Qiang Liu,
Qung Shang, Min Zheng, Jun Yang & Yong-Lian Zhang (2002)
Identification and characterization of a new member of Sepin family
HongrES1 in rat epididymis. Cell Research
12(5-6):407-410
8.
Hu Zhi-Hong, Li Bin, Liu
Qiang & Zhang Yong-Lian (2002)
Expression, purification of the recombinant protein fragment of the monkey
epididymis expressed gene Esc-615 and preparation of polyclonal antisera to
it. Cell Research 34(6):753-756
9.
Peng Li, Hsiao Chang Chan,
Bin He, Siu Cheung So, Yiu Wa Chung, Quan Shang, You-Duan Zhang, Yong-Lian
Zhang (2001) An Antimicrobial
Peptide Gene Found in the Male Reproductive System of Rats. Science 291(5509):1783-1785
10.
Gen-Yan Yang, Christopher
W Gregory, Quan Shang, Deborah A O’Brien, Yong-Lian Zhang (2001) Differential Expression of CCAAT/Enhancer-Binding
Protein-delta (C/EBP-delta) in Rat Adrogen-dependen Tissues and Human Prostate
Cancer.
J. Andrology 22:
(3) 471-480
International
Conference:
Editorial
Position:
Cell Research, Member of Editorial Board
Acta Biochimica et Biophysica Sinica, Standing Member of Editorial Board
Asian J. Andrology, Editorial Board
Chinese Science Bulletin, Associate Editor in Life Science
Andrologia, Editorial Board
Other
Important Activities:
EDUCATION
INSTITUTION AND LOCATION DEGREE YEAR CONFERRED FIELD OF STUDY
Fudan University, Shanghai, China
B.S. 1957
Chemistry
Shanghai Institute of Biochemistry, Ph.D. 1978
Biochemistry
Academia Sinica, Shanghai, China
EMPLOYMENT
AND EXPERIENCE
1957-1978 Division of Radiobiology, Shanghai
Institute of Biochemistry, Academia Sinica, Shanghai, China. Basic biological
research in early diagnosis of radiation injury; selection and synthesis of
drugs for preventing and curing
radiation diseases.
1978-1982 Ph. D. (equivalent) Division of Steroid
Hormones Biochemistry, Shanghai Institute of Biochemistry. Estrogen receptor
assays and selection of biochemical markers for studying the actions of sex
hormones.
1983-1985 visiting Scholar, Molecular
Endocrinology Laboratory, Imperial Cancer Research Fund, London, UK.
characterization of rat prostatic steroid binding protein(PSBP) gene
expression.
1985-1986 Assistant Professor, Division of
Steroid Hormones Biochemistry, Shanghai Institute of Biochemistry. Mechanisms
of Androgen Regulation of Gene Transcription.
1986-1991 Associate Professor, Division of
Steroid Hormones Biochemistry. Mechanisms of Androgen Regulation of Gene
Transcription.
1988
& 1989 Visiting Scholar, Molecular Endocrinology Laboratory, Imperial
Cancer Research Fund, London, UK. (July-November 1988 and June-October 1989).
Gene promotor analysis.
1989-present
Head of Sex Hormones Action Laboratory, State Key Laboratory of Molecular
Biology, Shanghai Institute of Biochemistry. Mechanisms of Androgen Regulation
of Gene Transcription. Studies of gene program during spermatogenesis in testis
and sperm maturation in epididymis.
1990-1991
& 1991-1992 Visiting Scholar,
Department of Human Oncology, University of Wisconsin, Madison. (July 1990 to
February 1991 and June 1991 to January 1992.). Androgen responsive elements
searching.
1991-present Professor, Shanghai Institute of
Biochemistry.
1993 Visiting Scholar, Molecular Endocrinology
Laboratory, Imperial Cancer Research Fund, London. (September-November).
Regulation machanism of gene transcription at the chromatin level.
1995
Visiting Scholar, The Laboratory for Reproductive Biology, University of North
Carolina at Chapel Hill. Chapel Hill. NC. U.S.A. Studies of the nuclear orphan
receptor in spermatogenesis.
1997
Jan.- April Visiting Scholar. The Laboratories for Reproductive Biology.
University of North Carolina at Chapel Hill. Chapel Hill NC U.S.A. Cloning and sequencing of a novel
orphan receptor.
1999 Sep.-Oct. Visiting Prof. , Dept. of
Endocrinology, Division of Andrology, Sydney University, Sydney,
Austrilia. Hormone regulation of RTR gene expression in hpg mice and
testing a potential
diagnosis
marker for prostate cancer.