Shahriar Koochekpour, M.D., Ph.D.

 

Personal Information

Bussiness Address:

Department of Microbiology, Immunology, and Parasitology

Stanley S. Scott Cancer Center

Louisiana State University-Health Sciences Center

533 Bolivar Street, CSRB 4-17

New Orleans, LA 70112

Tell: 504-568-7261 (office)

        504-568-4382 (laboratory)

Fax: 504-568-6888

 

 

Education and Qualifications:

 

-Doctor of Medicine (M.D), Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran (1983-1990).

 

-Elective Medical Rotation at Hemato-Oncology, Radiotherapy and Chemotherapy wards at University Teaching Hospital, Shiraz Medical School, Shiraz, Iran (1989).

 

-Doctor of Philosophy (Ph.D) in Experimental Neuro-Oncology Group, Department of Pathology, Institute of Psychiatry/Maudsley Hospital, King’s Colledge School of Medicine, University of London, London, U.K (1993-1996).

 

-Training in Research Applications of Scanning and Transmission Electron Microscopy (SEM and TEM). Department of Neuropathology, Institute of Psychiatry / Maudsley Hospital; King,s Colledge School of Medicine, University of London, U.K (1994).

Academic Positions:

-Lecturer in Medical Terminology. Shiraz Medical School, Zanjan Medical School, Zandjan Nursing college, Shiraz Nursing and Midwife College, Kazaroon Open University, Kazaroon, Iran (1989-1990).

-Lecturer in Medical Immunology. Kazaroun Open University, Iran (1989-1990).

 

-Lecturer in Prenatal Diagnosis of Genetic Disease. Shiraz Medical School, Iran (1987-1990).

 

-Head, University Burn Centre, Zandjan University of Medical Sciences, and Medical School, Zandjan, Iran. (1991-1992)

 

- Scientific Chief Editor of Medical Journal of Zandjan University of Medical Sciences. (1992)

-General Medical Practice in Beheshti Hospital, Zandjan Medical  School  (1990-1992).

 

-Postdoctoral Scientist, Molecular Oncology Section, ABL-Basic Research Program, National cancer Institute (1996-1999). NCI-FCRDC, Frederick, MD.

 

 

-Postdoctoral Scientist, Department of Biochemistry and Molecular Biology, LSU-Health Sciences Center (11/13/1999-6/30/00).

 

-Assistant Professor, Department of Biochemistry and Molecular Biology, LSU-Health Sciences Center (7/01/00-5/19/01).

 

-Assistant Professor/Principal Investigator, Department of Biochemistry and Molecular Biology, LSU-Health Sciences Center (5/19/01-10/1/2003).

 

-Assistant Professor/Principal Investigator, Department of Microbiology, Immunology, and Parasitology, LSU-Health Sciences Center (10/1/2003-pres).

 

 

Ongoing Research:

 

Bio-functional Characterization of Saposin C (Prosaposin) In Prostate Cancer and Its Role In Prostate Carcinogenesis and Progression From Androgen-Dependent (AD) to Androgen-Independent stage (AI).

 

Fields of Interest:

 

-Cross-talk between androgen receptor (AR) and other signalling pathways (e.g., G-protein coupled receptor, MAPK, PI3K/Akt) and its role in prostate cancer progression to an androgen-independent state.

 

-Role of prostate cancer and stromal interactions in carcinogenesis events of primary and metastatic prostate cancer.

 

-The role of AR-expressing stromal cells in prostate cancer progression and bone metastatic phenotype.

 

 

Other professional/academic activities:

 

-Supervisor for undergraduate students (National Cancer Institute/Hood College, Fredereick, Maryland)

 

-Supervisor for postgraduate summer students / National Cancer Institute-Research Training Program, Louisiana State University-Health Sciences Center/Stanley S. Scott Cancer Center, New Orleans, LA)

 

-Reviewer for peer-reviewed journals (Cancer Research, Clinical Cancer Research, Oncogene, Clinical Prostate Cancer) 

 

 

 

 

Memberships:                  

 

-European Association for Cancer Research (UACR)

-American Association for Cancer Research (AACR)

-American Association for Advancement of Science (AAAS)

-New York Academy of Science (NYAS)

-Society for Basic Urologic Research (SBUR)

-British Neuro-Oncology Group (BNOG)

 

 

 

Research Experiences:

 

 

Cellular and Molecular Biology                    

          Tissue culture (monolayer, spheroid and organotypic), 3D-Matrigel Plug (branching morphogenesis) assay, in vitro  assay to determine the inhibitory or stimulatory effects of chemicals or cytotoxic agents on tumor cells proliferation, migration and invasion, proliferation assay, adhesion assay, migration assay, invasion assay, immunocytohistochemistry, immunobloting, ELISA, in vivo and in vitro angiogenesis assays, microscopy (Scanning and Transmission Electron Microscopy, Phase contrast, Fluroescent and Confocal ), MTT/MTS assay, immortalization of normal human astrocytes, soft agar colony formation assay, cytogentics analysis (Chromosome karyotyping, Banding and FISH), gelatin and casein Zymography. Nucleic Acid Extraction, hybridisation, and sequencing, RT-PCR, Transfection, transformation and infection, Gel Shift Assay, RFLP analyses, Differential Expression analyses, In Vitro Transcription / Translation Assay, Site Directed Mutagenesis, Vector Construction, Real Time-PCR.

 

 

In vivo studies:

          Experiences for identification and analyzing gene expression and function, in vivo tumorigenesis experiments (including subcutaneous, peritoneal, intravenous and intracranial  injection of drugs,  tumor cells or viruses) with laboratory animals (rat, mouse), explant  culture, cloning and subcloning of tumor cells, establishment of primary cell line (e.g.,  from human and laboratory animals brain compartments as well as brain tumors), Post-mortem (whole body) dissection of laboratory animals that have been subjected to in vivo tumorigeneis /angiogenesis assay and familiarity with gross diagnostic pathology. 

 

 

Teaching Subjects:

          *Department of Biochemistry and Molecular Biology:

                       

                    -Cancer Invasion and Metastasis

                    -Oncogenes and Tumor Suppressor Genes

         

          *Department of Microbiology, Immunology, and Parasitology:

                  

          -Biology of Cancer Invasion and Metastasis

          -Mechanisms of Functions of Oncogenes and Tumor Suppressor Genes

PUBLICATIONS

                                                         

1. Merzak, A., McCrea, S., Koochekpour, S., Pilkington, G.J.: Control of human brain tumour cell proliferation, migration, and invasion in vitro by Transforming Growth Factor beta 1. Br. J. Cancer. 70: 199-203, 1994.

 

2. Merzak, A., Koochekpour, S., Pilkington, G.J.: CD44 mediates human glioma cell invasion and adhesion in vitro. Cancer Res. 54: 3988-3992, 1994. 

 

3. Merzak, A., Koochekpour, S., Pilkington, G.J.: Cell surface gangliosides are involved in the control of glioma cell invasion in vitro. Neurosci. lett. 177: 44-46, 1994.

 

4. Merzak, A., Parker, C., Koochekpour, S., Sherbet, G., Pilkington, G.J.: Overexpression of the 18/A2mts1 gene and down regulation of the TIMP-2 gene in invasive human glioma cell lines in vitro. Neuropath. Appl. Neurobiol., 20: 614-619, 1994.

 

5. Koochekpour, S., Merzak, A., Pilkington, G.J.: Control of glioma cell proliferation, morphology,    and migration by basement membrane (BM) in vitro. European J. Cancer, 31, 375-380, 1995.

 

6. Koochekpour, S., Merzak, A., Pilkington, G.J.: Growth factors and gangliosides stimulate laminin    production by human glioma cells in vitro. Neurosci. lett., 186, 53-56, 1995.

 

7. Merzak, A., Koochekpour, S., Pilkington, G.J.: Adhesion of human glioma cell lines to fibronectin,  Laminin, vitronectin, and collagen I is modulated by gangliosides in vitro. Cell Adhesion and Communication, 3, 27-43  1995.

 

8. Merzak, A., Koochekpour, S., McCrea, S., Roxanis, I., Pilkington, G.J.: Gangliosides modulate proliferation, migration, and invasion of human brain tumour cells in vitro. Mol. Chem. Neuropathol., 24, 121-135, 1995.

 

9. Merzak, A., Koochekpour, S., Dkhissi, F., Rynal, S., Lawrence, D., Pilkington, G.J.: Synergism between growth factors in the control of glioma cell proliferation, migration, and invasion in vitro. Int. J. Oncol., 6, 1079-1085, 1995.

 

10. Koochekpour, S., Pilkington, G.J and Merzak, A.: Hyaluronic acid / CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro. Int J Cancer: 63, 450-455, 1995.

 

11. Koochekpour, S., Pilkington, G.J., Merzak, A.: Vascular endothelial growth factor production is stimulated in response to growth factors in human glioma cells. Oncology Report: 2, 1059-1061, 1995.

 

12. Koochekpour, S., Pilkington, G. J.,  Merzak, A.: Expression of VEGF in human brain tumour    cyst fluids. Oncology Report: 2, 1147-1149, 1995.

 

13. Merzak, A., Koochekpour, S., Marie-Paule Fillion., Gilles Fillion., Pilkinigton, G. J.: Expression of serotonin receptors in human fetal astrocytes and glioma cell lines: a possible role in glioma cell proliferation and migration. Mol Brain Res: 41, 1-7, 1996

 

14. Maidment, S., Merzak, A., Koochekpour, S., Rooprai, H., Rucklidge, G., Pilkington, G.J.: Gangliosides stimulate metalloproteinase expression in human glioma cell lines in vitro. Eur J Cancer: 32A, No.5, 868-871, 1996.

 

15. Koochekpour, S . and Pilkington G.J.: Hyaluronic acid modulates human glioma cells proliferation  through CD44H in vitro. Oncology Reports: 3, 133-135, 1996.

 

16. Koochekpour, S., Merzak, A., Pilkington, G.J.: Vascular endothelial growth factor production is stimulated by gangliosides and TGF-β isoforms in human glioma cells in vitro. Cancer Letters: 102, 209-215, 1996.

 

17. Koochekpour, S. and Pilkington, G. J.: Vascular and perivascular GD3 expression in human glioma. Cancer Letters, 104, 97-102, 1996.

18. Koochekpour, S., Jeffers, M., Rulong, S., Taylor, G., Klineberg, E., Hudson, E.A., Resau,J.H.  and Vande Woude, G.F.: Met and Hepatocyte Growth Factor expression in Human Gliomas. Cancer Research: 57, 5391-5398, 1997.

19. Jeffers, M., Koochekpour, S., Fiscella, M., Sathyanarayana and Vande Woude, G.F.: Signaling Requirements for Oncogenic Forms of the Met Tyrosine Kinase receptor.  Oncogene, 17:2691-2700, 1998.

 

20.  Jeffers, M., Fiscella, M., Webb, C.P., Anver, M., Koochekpour, S., and Vande Woude, G.F.: The mutationally activated Met receptor mediates motility and metastasis.  Proc. Natl. Acad. Sci. USA, 95:14417-14422, 1998.

 

21. Koochekpour, S., Jeffers, M., Wang, P.H., Gong, C., Taylor, G.A., Roessler, L.M., Stearman, R.,  Stetler-Stevenson, W.G., Kaelin Jr., W.G., Linehan, W.M., Klausner, R.D., Gnarra, J.R., and Vande Woude, G.F.: The VHL Tumor Suppressor Gene Inhibits HGF/SF-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells.  Mol. Cell. Biol., 19, 9: 5902-5912, 1999.

 

22. Webb, C. P., Hose, C. D., Koochekpour, S., Jeffers, M., Oskarsson, M., Sausville, E., Monks, A.and Vande Woude, G.F. The geldanamycins are potent inhibitors of the HGF/SF-Met-uPA-Plasmin proteolytic network. Cancer Research, 60, 2: 342-349, 2000.

 

23. Topol, L.Z., Modi, W.S., Koochekpour, S.and Blair, D.G. DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain. J.Cytogenetics & Cell Genetics, 89, 1-2:79-84, 2000.

 

24. Duesbery, N.S., Resau, J., Webb, C. P., Koochekpour, S., Koo, H. M., Leppla, S.H ., Vande Woude, G.F. Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways. Proc. Natl. Acad. Sci. USA, 27: 98 (7):4089-4094, 2001.

 

25. Koochekpour, S., Maresh, G., Katner, A., Parker-Johnson, K., Lee, T-J., Hebert, F. E., Kao, Y., and Rayford, W. Establishment and characterization of a primary African-American prostate cancer cell line, E006AA. Prostate, 60: 141-152, 2004.

                                       

26. Koochekpour, S., Sartor, O., Lee, T-J., Zieske, Arthur., Patten, D. Y., Hiraiwa, M., Sandhoff, K., Remmel, N., Minokadeh, A. Prosaptide TX14A stimulates growth, migration, and invasion and activates the Raf-MEK-ERK-RSK-Elk-1 signaling pathway in prostate cancer cells. Prostate, 61: 114-123, 2004.

 

27. Sartor, O and  Koochekpour, S. Stem Cells and Prostate Cancer. Clin. Prostate. Cancer, 3: 11-12, 2004.

Scientific Presentations In National and International Conferences

 

1. Merzak, A., Koochekpour, S., Roxanis, I., Pilkington, G.J. Differential effect of growth factors on human glioma cell migration and invasion". J. Neuro-oncol., 15: S18, 1993.

Tenth International Conference on Brain Tumour Research and Therapy, Stalheim-Norway, September 1993.

 

2. Pilkington, G. J., Martin, K., Merzak, A., Hatva, E., Rogers, J., Roxanis, I., Koochekpour, S. Gangliosides and glioma cell motility. J. Neuro-oncol., 15: S20, 1993.          

Tenth International Conference on Brain Tumour Research and Therapy, Stalheim-Norway, September 1993.

 

3. Merzak, A., McCrea, S., Koochekpour, S., Roxanis, I., Pilkington, G.J. Biological effects of gangliosides on human glioma cell lines in vitro. Br. J. Neurosurg., 8: 256-257, 1994.         

Thirteenth Annual Meeting of The British Neuro-Oncology Group, Birmingham-UK, July 1993.

 

4. Merzak, A., McCrea, S., Koochekpour, S., Pilkington, G.J. Regulation of glioma cell growth, migration and invasiveness by Transforming Growth Factor beta 1. Br. J. Neurosurg., 8: 258-259, 1994.

Thirteenth Annual Meeting of The British Neuro-Oncology Group, Birmingham-UK, July 1993.

 

5. Merzak, A., McCrea, S., Koochekpour, S., Pilkington, G.J. Control of proliferation of human glioma cell lines by various growth factors. Neuropath. Appl. Neurobiol. 19: 444, 1993.

Eighty-Sixth Meeting of the British Neuropathological Society, Liverpool-UK, June 1993.

 

6. Merzak, A., Koochekpour, S., Pilkington, G.J. Laminin plays a key role in adhesion, migration, and invasion of human glioma cell lines in vitro. Clinical Exp. Metastasis, 12: 47, 1994.

Fifth International Congress of the Metastasis Research Society, Bethesda-USA, October 1994.

 

7. Merzak, A., Koochekpour, S., Pilkington, G.J. Gangliosides positively regulate human glioma cell invasion in vitro through their control of cell adhesion to extracellular matrix proteins. Brain Pathol., 4: 419, 1994.

XIIth International Congress of Neuropathology, Toronto-Canada, September 1994.

 

8. Merzak, A., Koochekpour, S., Pilkington, G.J. Growth factors control migration and invasion of human glioma cell lines in vitro by regulating their adhesive properties to extracellular matrix proteins. Brain Pathol., 4: 416, 1994.

XIIth International Congress of Neuropathology, Toronto-Canada, September 1994.

 

9. Merzak, A., Koochekpour, S., Pilkington, G.J. CD44 plays a positive role in cell adhesion and invasion of human glioma cell lines in vitro. Brain Pathol., 4: 418, 1994.

XIIth International Congress of Neuropathology, Toronto-Canada, September 1994.

 

10. Merzak, A., Koochekpour, S., Pilkington, G.J. H-ras transfected glioma cell lines exhibit morphological changes and reduced cell adhesiveness, and invasiveness in vitro. J. Neuro-oncol., 21: 50. 1994.

First Congress of the European Association for Neuro-Oncology, Maastricht-Netherlands, October 1994.

 

11. Merzak, A., Koochekpour, S., Pilkington, G.J. CD44 and intrinsic brain tumours: Antibody and antisense mRNA inhibition of invasion. Br. J. Neurosurg., 9: 259. 1995.

XIVth Annual Meeting of the British Neuro-Oncology Group, London-UK, July 1994.

 

12. Martin, K., Merzak, A., Koochekpour, S., Rooprai, H. K., Pilkington, G. J. The role of cluster of differentiation epitopes in brain tumour invasion and metastasis.

Congress of Neurological Surgeons, Chicago-USA, October 1994.

 

13. Koochekpour, S., Merzak, A., Pilkington, G.J. Hyaluronic acid decreases adhesion and enhances motility and invasion of human glioma cell lines in vitro. J. Neuro-oncol., 21: 54. 1994.

First Congress of the European Association for Neuro-Oncology, Maastricht-Netherlands, October 1994.

 

14. Koochekpour, S., Merzak, A., Pilkington, G.J. Basement membrane (BM) inhibits growth, stimulates migration, and elicits dramatic morphological changes in glioma cells in vitro. Neuropath. Appl. Neurobiol. 20: 507. 1994.

Eighty-Eighth Meeting of the British Neuropathological Society, Notingham-UK, July 1994.

15. Merzak, A., Parker, C., Koochekpour, S., Sherbet, G., Pilkington, G.J. The 18A2/mts1 metastasis-associated gene and the TIMP-2 gene are expressed and down-regulated, respectively, in invasive human glioma cell lines. J. Neur-oncol., 24 (1): 137, 1995.

XIIth International Congress of Neuropathology, Satellite Meeting on Brain Tumours, Ottawa-Canada, September 1994.

 

16. Maidment, S., Merzak, A., Koochekpour, S., Rooprai, H., Pilkington, G.J. Secretion of metalloproteases by human cell lines in vitro: modulation by exogenous gangliosides. Br. J. Neurosurgery., 9: 260. 1995.

XIIth International Congress of Neuropathology, Satellite Meeting on Brain Tumours, Ottawa-Canada, September 1994.

 

17. Koochekpour, S., P. Bullock., A. Dean and Pilkington, G. J. Differential expression of vascular endothelial growth factor in cyst fluid from patients with high and low-grade gliomas.Neuropathol Appl Neurobiol: 21, 442, 1995.

Nintieth Meeting of the British Neuropathological Society, University of Oxford-UK, July 1995.

 

18. Koochekpour, S., A. Merzak and pilkington, G. J. Growth factors modulate vascular endothelial growth factor secretion in human glioma cell lines. Neuropathol Appl Neurobiol: 21, 442, 1995.

Nintieth Meeting of the British Neuropathological Society, Univerity of Oxford -UK, July 1995.

 

19. Koochekpour, S., Merzak, A and Pilkington, G. J. Gangliosides differentially stimulate Vascular endithelial growth factor production by human glioma cell lines.

XVIth Annual Meeting of the British Neuro-Oncology Group, London-UK, June 1995.

 

20. Koochekpour, S., Merzak, A., Pilkington, G.J. Growth factors and gangliosides control laminin production by human glioma cell lines in vitro. Br. J. Neurosurg., 9: 260. 1995.

XIVth Annual Meeting of the British Neuro-Oncology Group, London-UK, July 1994.  

 

21. Koochekpour, S., Merzak, A., Pilkington, G. J. Vascular endothelial growth factor in glioma cyst fluid and culture supernatant: Influence of growth factors.

11th International conference on brain tumor research and therapy, Napa, California, October 31-November 3, 1995.

 

22. Koochekpour, S., Merzak, A., G. J. Pilkington. Induction of cell detachment, migration and invasion of human glioma cells is mediated by CD44H/Hyaluronic acid interaction.

11th International conference on brain tumor research and therapy, Napa, California, October 31-November 3, 1995.

 

23. Maidment, S. L., Rucklidge, A., Gratsa, A., Merzak, A., Koochekpour, S., Roopri, H. K and Pilkington, G. J. Interdependency of MMPs, gangliosides and N-CAMs in human brain tumour invasion in vitro. Anticancer Research: 15 (5A) September-October 1995

5th International Conference of Anticancer Research, 17-22 October 1995, Corfu, Greece

 

24. Koochekpour, S., E. Pierce, R. Doshi, A. Merzak   and G. J. Pilkington. E-cadherin and human gliomas: a marker of malignancy and dedifferentiation.

14th meeting of the European Association of Cancer Research (EACR) with the British Association of Cancer Research (BACR) and Association of Cancer Physicians (ACP), Edinburgh, UK, 31 March-3 April, 1996.

 

25. Koochekpour, S., Pierce, E., Doshi, R., Merzak, A and Pilkington, G. J. TGF-β isoforms and type II receptor expression  in human gliomas: An evidence for autocrine regulatory pathway in tumour progression.

 14th meeting of the European Association of Cancer Research (EACR) with the British Association of Cancer Research (BACR) and Association of Cancer Physicians (ACP), Edinburgh, UK, 31 March-3 April, 1996.

 

26. Koochekpour, S., Jeffers, M., Rulong, S., Klineberg, E., Hudson, E. A., Resau, J. H  and Vande Woude, G. F. C-Met/HGF-SF expression and involvement in autocrine/paracrine regulatory pathway in primary human brain tumors.

13th Annual Meeting on Oncogenes, Hood College, frederick, Maryland, U.S.A, June 18-21, 1997.

 

27. Koochekpour, S., Jeffers, M., Gnarra, J., Edwards, D. F., Stetler-Stevenson, W. G., Klausner, R and Vande Woude, G. F. Hepatocyte growth Factor/Scatter Factor induces von Hippel lindau (VHL) dependent Invasion and branching Morphogenesis in renal Cell Carcinoma cells.

14th Annual Meeting on Oncogenes, The Salk Institute, San Diego, CA, U.S.A, June 24-27, 1998.

 

28.  Koochekpour, S.,Jeffers, M., Wang, P.H., Gong, C., Taylor, G.A., Roessler, L.M., Stearman, R.,  Stetler-Stevenson, W.G., Kaelin Jr., W.G., Linehan, W.M., Klausner, R.D., Gnarra, J.R., and Vande Woude, G.F.:The VHL Tumor Suppressor Gene Inhibits HGF/SF-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells.

15th Annual Meeting on Oncogenes, Hood College, frederick, Maryland, U.S.A,  June 22-27, 1999.

 

29. Koochekpour, S.,Jeffers, M., Wang, P.H., Gong, C., Taylor, G.A., Roessler, L.M., Stearman, R.,  Stetler-Stevenson, W.G., Kaelin Jr., W.G., Linehan, W.M., Klausner, R.D., Gnarra, J.R., and Vande Woude, G.F.The VHL Tumor Suppressor Gene Inhibits HGF/SF-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells.

FASEB Summer Research Conference-Growth factor receptor Tyrosine kinases in mitogenesis, Morphogenesis, and Tumorigenesis, Snowmass Village, CO, July 31-August 5, 1999.

 

30. Koochekpour, S., Lallier, T and Gnarra, J. R. VHL-dependent alterations in fibronectin adhesion and integrin expression and downstream signaling effectors in RCC cells.

92nd Annual Meeting, AACR, New Orleans, March 24-28, 2001.

 

31. Koochekpour, S., Sartor, O, Zieski. A, Lee, T-J, Hebert. F, Remmel, N, Minookadeh. A, Sandhoff. K and Patten. D. Y. Identification, Expression, Function, And Potential Therapeutic Value of an Extracellular Protein (Prosaposin) Expressed In Poorly Differentiated Prostate Cancer.

Prostate Cancer Foundation (CaP CURE), 10th Annual Retreat. New York, November 8-10, 2003

 

32. Koochekpour, S., Sartor, O., Lee, T-J., Sandhoff. K., Remmel, N., Minokadeh, A., and Patten, D. Y. Saposin C stimulates migration and invasion and upregulates uPA/uPAR and cathepsin D expression in human prostate stromal and cancer cells.

95nd Annual Meeting, AACR,  Orlando, March 27-31, 2004. 

 

33. Lee, T-J., Sartor, O., Lee, T-J., Minokadeh, A., Patten, D. Y., Sun. Y., Grabowski, G. A., Koochekpour, S. Differential induction of prosaposin promoter by androgen and serum in human prostate cancer and stromal cells.

95nd Annual Meeting, AACR,  Orlando, March 27-31, 2004.

 

34. Zhihue, X., Ling, J., Edlund, M., Lee, T-J., Koochekpour, S., Marshall, F., and Hsieh, C-L. Involvement of cell adhesion molecule L1 in human prostate cancer bone metastasis.

95nd Annual Meeting, AACR,  Orlando, March 27-31, 2004.

 

35. Mukherjee, P. K., Koochekpour, S., Lee, T-J., Grabowski, G. A., Sartor, O., Bazan, N. G. The prosaposin gene downregulates oxidative strees-induced apoptosis in human retinal pigment epithelial cells: Hammerhead ribozymes and proximal promoter studies.

Association for Research in Vision and Ophthalmology, ARVO 2004, April 25-29, 2004; poster# 4675.

 

36. Koochekpour, S., Sartor, O., Lee, T-J., Hebert, F., Patten, D. Y., and Minokadeh, A. Prosaposin is a novel AR-target gene and upregulates AR/PSA expression in prostate stromal and cancer cells.

Abstract #998 :

American Urological Association, Annual Meeting, San Francisco, May 8-13, 2004.

(Discussed Poster Session)