Moira Kathleen O¡¯BRYAN, Ph.D.

 

 

Current Address:               Monash Institute of Reproduction and Development,

                                                27-31 Wright St.,

                                                Clayton 3168.  Australia.

Telephone:                            61 3 9594 7127

Fax:                                       61 3 9594 7111

e.mail:                                  moira.obryan@med.monash.edu.au

 

 

Citizenship:  Australian

 

Employment & Education:

¡¤     2001 - present:  NH&MRC R.D. Wright Fellow and Senior Scientist.

Monash Institute of Reproduction and Development (MIRD), Monash University, 27-31 Wright St., Clayton 3168.

¡¤     2000 (Aug) ¨C 2001:  Senior Scientist and NH&MRC Senior Research Officer.

Monash Institute of Reproduction and Development (MIRD), Monash University, 27-31 Wright St., Clayton 3168.

¡¤     2000 (Jan.) ¨C 2000 (Aug):  NH&MRC Senior Research Officer

Monash Institute of Reproduction and Development (MIRD), Monash University, 27-31 Wright St., Clayton 3168.

¡¤     1996 ¨C 2000:  Peter Doherty Postdoctoral Fellowship (NH&MRC #967135).

Monash Institute of Reproduction and Development (IRD), 27-31 Wright St., Clayton 3168.  Australia. 

¡¤     1993-1995:  Post-doctoral Research Fellow.

The Population Council, Center for Biomedical Research, 1230 York Ave., New York, N.Y.  10021.  U.S.A. 

¡¤     1990-1993:  Ph.D. (Medicine), The University of Melbourne, awarded April 1994.  Supervisors:  Drs. B.F. Murphy1 and H.W.G. Baker2.  1The Department of Nephology, St Vincent¡¯s Hospital, Victoria Pde., Fitzroy, 3065 and 2The Department of Obstetrics and Gynaecology, The Royal Women¡¯s Hospital, Grattan St., Carlton, 3053.  Australia.  Dissertation title:  Clusterin in the male reproductive tract and in cell death - awarded April 1994.

¡¤     1988:  Bachelor of Science with first class honours - pathology. 

The University of Melbourne, Parkville, 3052.  Australia.

¡¤     1985-1987:  Bachelor of Science.

The University of Melbourne, Parkville, 3052.  Australia.

 

Awards and Distinctions:

2004:           ¡®Best Project¡¯ award from The Rebecca Cooper Medical Research Foundation. Co-held with Gerard Gibbs (post-doc in my group).

 

2004:           Monash University Research Fund Travel Award ($1000)

 

2001-2004: NHMRC R.D. Wright Career Development Award. Award #143781.

 

2001:             Monash University Research Fund Travel Award ($1000).

 

2001:             Australian Academy of Science, Career Development Award, Presented at the Australian Academy of Science ¨C Science at the Shine Dome Symposium, May 2001.

 

1999:           European Society for Reproduction and Endocrinology ¨C Fertility Society of Australian Young Scientist lecture, Tour, France, July.

 

1998:           Best Presentation by a Young Scientist, The Fertility Society of Australia.  Presented at the annual meeting in Hobart, October.

 

1997:                    Serono Post-graduate Travel Award, Endocrine Society of Australia.

 

1997:           Junior Scientist Nomination, Australian Society for Reproductive Biology - unable to compete due to family illness.

 

1996-2000: NHMRC Peter Doherty Post-doctoral Fellowship. Award #967135.

 

1996-1998: ARC Australian Post-doctoral Fellowship ¨C never activated due to concurrent NHMRC Fellowship.

 

1993-1995: Mellon Foundation Post-doctoral Fellowship to work at The Population Council Centre for Biomedical Research, Rockefeller University, New York.

 

1994:           Ph.D. (Medicine), The University of Melbourne.  Australia. 

 

1990-1993: Australian Post-graduate Research Award, The Commonwealth Government of Australia.

 

1985-1988: Bachelor of Science with first class honours. The University of Melbourne.  Australia.

 

1985-1987:        Donovan Faculty Scholarship - Newman College, The University of Melbourne.

 

Grants and research contracts:

2005-2006: Andrology Australia (The Australian Centre of Excellence in Male Reproductive Health). National DNA repository for the identification of genetic causes of male infertility. CIs:  Moira O¡¯Bryan and Rob McLachlan. $75,000 per annum.

 

 

2005-2010: NHMRC Program Grant. CIs: David de Kretser, Gail Risbridger, Milton Hearn, Graham Jenkin, Mark Hedger, Euan Wallace, Kate Loveland, David Phillips, Moira O¡¯Bryan. ~$1.56M/year. Award #334011.

 

2004-2008: NHMRC Enabling Grant. ¡®The Australian Phenome Bank¡¯. Chief investigators: Chris Goodnow, David de Kretser, Moira O'Bryan. $300K per year for 5 years. Award #268084.

 

2004: NHMRC Large Equipment Grant for a gel documentation system. CIs: Loveland, Moran, O¡¯Bryan et al $61,200.

 

2004: Rebecca Cooper Medical Research Foundation. Identificaton of genes essential for male fertility ¨C equipment grant. CIs: Gerard Gibbs, Moira O¡¯Bryan. $15,000. Prize for highest ranking application

 

2003-2005: Schering AG research contract to identify novel contraceptive targets and mechanisms and regulators of prostate disease. CIs:  David de Kretser, Evan Simpson, Gail Risbridger, Rob McLachlan, Moira O'Bryan, Lisa O¡¯Donnell. €600,000 per year.

 

2003: NHMRC Large Equipment Grant for a denaturing high performance liquid chromatography system. CIs: Moira O¡¯Bryan, David de Kretser, David Cram, Rob McLachlan, Colin Clyne, Ed Stanley, Peter Fuller, Andrew Elefanty, Vincent Harley, Evan Simpson and Andrew Perkins. $71,000.

 

2003-2007: The Australian Research Council, Centre for Excellence. $9,458,900. Biotechnology and Development. CIs: John Aitken (Director), David de Kretser, Gary Hime, Michael Holland, David Jans, Peter Koopman, Kate Loveland, Eileen McLaughlin, Moira O¡¯Bryan, Andrew Sinclair, Sean Roman. Award #CE0348239.

 

2003: Monash University. $20,000. A proteomic analysis of the rat sperm tail. CI: Moira O¡¯Bryan, Co-investigator: Gerard Gibbs.

 

2002: Monash IVF. The Genetics of Male infertility. $48,000. CIs Moira O'Bryan, David Cram, David de Kretser and Rob McLachlan.

 

2001-2004: Andrology Australia (The Australian Centre of Excellence in Male Reproductive Health). National DNA repository for the identification of genetic causes of male infertility. CI:  Moira O¡¯Bryan. Co-investigator:  David de Kretser. $267,602.

 

2001: NHMRC Equipment Grant for a high performance liquid chromatography system.  CIs:  Drs David de Kretser, David Phillips, Mark Hedger, Kate Loveland, Moira O¡¯Bryan, John Morrison, Gail Risbridger, Martin Pera, Paul Hertzog.  $86,000.

 

2001-2006:       NHMRC program grant ¡®Reproductive Processes¡¯. Award #143786.  CIs:  Drs. David de Kretser, Milton Hearn, Mark Hedger, Graham Jenkin, Kate Loveland, John Morrison, Moira O¡¯Bryan, David Phillips and Gail Risbridger.  $1.7M / year.

 

2001: Rebecca Cooper Medical Research Foundation. The genetics of male infertility ¨C gene discovery and mutation detection.  $10,000.

 

1999:  Monash IVF Research Grant, Monash IVF, Victoria CIs David Cram, Moira O'Bryan, David de Kretser and Rob McLachlan $28,000.

 

Community Service, Committees:

2005: Deputy convener. ASMR National Scientific Conference. Couran Cove, QLD. November, 2005.

 

2004: Program organizing committee. Inaugural mammalian phenomics workshop, November 18-20, 2004, The Australian National University, Canberra.

 

2003-present: National Director, The Australian Society of Medical Research.

 

2002-3: Convener, The Victorian branch of the Australian Society for Medical Research ¡®Medical Research Week¡¯, 2003

 

2002-3: Convener, The Victorian branch of the Australian Society for Medical Research ¡®Medical Research Week¡¯, 2003

 

2002: Organization committee, Australian Health and Medical Research Congress 2002 (AHMRC 2002) 25-29 November 2002 in Melbourne

 

2002:  Post-graduate course work degrees committee, Monash University.

 

2001-2002:       Secretary, The Victorian branch of The Australian Society for Medical Research.

 

2001: Convener, The Prince Henry¡¯s Institute of Medical Research and Monash Institute of Reproduction and Development joint symposium on ¡°Reproductive Genomics¡±, December 5-6, 2001.  Monash Medical Centre, Clayton 3168.

 

2001: The subject of a documentary made by The Australian Academy of Science. This documentary consisted of a half hour interview about my life and science towards the purpose of attracting secondary school students to continue science at University. The project was funded by the ARC and videos will eventually be distributed to every secondary school in Australia.

 

1999-present:  Committee member, The Victorian branch of The Australian Society for Medical Research.

 

1999-present:  Post-graduate students committee ¨C Monash Institute of Reproduction and Development.

 

1999-2000:       Mentor, Masters of Reproductive Biology Masters Programme, Monash University.

 

1999-2001:       Mentor, Department of Neurosciences, Monash University.

 

1999-2002:       Deputy Radiation Safety Office, Monash Institute of Reproduction and Development.

 

1997-2001:       Senior honours year examiner, Department of Anatomy, Monash University.

 

1996-1998:       Radiation Safety Officer, Monash Institute of Reproduction and Development.

 

Editorial Boards

2004-present: The Biology of Reproduction (Official journal of the American Society for the Study of Reproduction).

 

Executive positions:

2004-present: The access and advisory committee, The Australian Phenome Bank, The Australian Phenomics Facility, Canberra.

 

2003-present: National Director, The Australian Society of Medical Research.

 

2001-present: Male infertility advisory group, Andrology Australia (The Centre for Excellence in Men¡¯s Reproductive Health).

 

University appointments

2004:               Assessment Panel for the Strategic Grant Scheme, Monash University
 

2001:            Monash University Post-graduate students course work committee

 

Teaching:

2004-presents: BMS3011 male reproductive biology lectures.

 

1997-present:  Guest lecturer, 3rd year anatomy, Department of Anatomy, Monash University.

 

BSc honours students:   8

 

Graduate student supervision:

PhD students

Orapin Gerdprasert (BScVetSci), co-supervisor. Completed April 2002. Scholarship: Thai Government. Thesis title: Cellular and cytokine responses to inflammation in the rat testis. Current Position Assistant Professor, Faculty of Medicine, Khon-Kaen University, Thailand.

 

Deborah Hickox BSc(U. Melb) BSc(Hons)(Monash): Main supervisor. Completed October 2003. Scholarship: APA. Thesis title: The yeast two hybrid analysis of tpx-1 binding partners.  Currently working as a post-doctoral Fellow in my group before going overseas for a post-doctoral position.

            *2001 Monash IRD student prize for Best Student Ph.D. presentation.

 

Claire Kennedy BSc(Hons)(Monash): Main supervisor. Enrolled March 2001. Scholarship: APA.

            *2002 Monash University prize for post-graduate research.

            *2003 Monash IRD student prize for Best Student Ph.D. presentation.

            *2004 ASA Lalor Foundation Travel Award ¨C to attend the ASA meeting, Baltimore, April.

 

Leanne Cotton BSc(Monash) BSc(Hons)(U. Melb.): Main supervisor. Enrolled March 2001. Scholarship: Monash University.

            *2004 ASA Travel Award ¨C to attend the ASA meeting in Baltimore, April.

 

Dean Whelan BAppS (Hons)(Swinburne U.I.T.): Main supervisor. Enrolled March, 2003. Scholarship: Monash University.

 

Luke Swain BSc(Hons)(Monash): Main supervisor. Will start March 2004. Scholarship: APA.

 

Society Membership:

The Endocrine Society of Australia

The Australian Society of Medical Research

The Australian Society for Reproductive Biology

Andrology Society of America

 

Invited speaker:

1997: Hormones and Men¡¯s Health.  Prince Henry¡¯s Institute of Medical Research in conjunction with the Institute of Reproduction and Development, Monash University.  Sperm tail proteins and motility.  Melbourne, Australia, February 1997.

 

1998: The Australian Society for Medical Research.  The Emerging Genetic Basis for Male Infertility - Sperm tail proteins and motility.  Hobart, Australia, November 1998.

 

1999: 15th Annual Meeting of the European Society of Human Reproduction and Embryology FSA/ESHRE exchange lecture - Tpx-1 in the testis and sperm function.  Tours, France, June 1999.

 

2000: Department of Anatomy and Cell Biology, Queen¡¯s University, Kingston, Ontario, Canada, July.

 

2001: Secondary Teachers Association of Victoria annual conference. Glen Waverly Secondary College. June.

 

2003: Department of Anatomy and Cell Biology, The University of Melbourne. The outer dense fibres of the sperm tail. Function and fertility. October.

 

2004: School of Biological Sciences, Monash University. Mouse and human approaches to a greater understanding of male fertility, May.

 

2004: Major National Research Facilities Road Show. Walter and Elisa Hall Institute, Parkville, October. ¡®How to crack the nut of male infertility¡¯

 

2004: Prince Henry¡¯s Institute of Medical Research. ¡®Of snakes and sperm: CRISP proteins¡¯ December.

 

2005: The Inaugural Mammalian Phenomics Symposium, The Australian National University, Canberra. February.

 

Publications:

M1.      Murphy B.F., Saunders J.R., O¡¯Bryan M.K., Kirszbaum L., Walker I.D., d¡¯Apice A.J.F., 1989.  SP-40,40 is an inhibitor of C5b-6-initiated haemolysis.  Int. Immunol. 1:  551-554.                       

M2.      O¡¯Bryan M.K., Baker H.W.G., Saunders J.R., Kirszbaum L., Walker I.D., Hudson P., Liu D.Y., Glew M.D., d¡¯Apice A.J.F., Murphy B.F., 1990.  Human seminal clusterin (SP-40,40).  Isolation and characterization.  J. Clin. Invest. 85L  1477-1486.                              

M3.      Pearse M.J., O¡¯Bryan M., Fisicaro N., Murphy B., and d¡¯Apice A.J., 1992. Differential expression of clusterin in inducible models of apoptosis.  Int. Immunol. 4:  1225-1231.                     

M4.      O¡¯Bryan M.K., Cheema S.S., Bartlett P.F., Murphy B.F., and Pearse M.J., 1992.  Clusterin levels increase during neuronal development.  J. Neurobiol. 24:  421-432.                                  

M5.      Polihronis M., Machet D., Saunders J., O¡¯Bryan M., McRae J., and Murphy B., 1992.  Immunohistological detection of C5b-9 complement complexes in normal and pathological human livers.  Pathology 25:  20-23.        

M6.      O¡¯Bryan M.K., Mallidis C., Murphy B.F., and Baker H.W.G., 1994.  The immunohistological localization of clusterin in the male genital tract in humans and marmosets.  Biol. Reprod. 50:  502-509.           

M7.      O¡¯Bryan M.K.., Murphy B.F., Liu D.Y., Clarke G.N., and Baker H.W.G., 1994.  The use of anticlusterin monoclonal antibodies for the combined assessment of human sperm morphology and acrosome integrity.  Human Reprod. 9:  1490-1496.               

M8.      Zini A., O¡¯Bryan M.K., Magid M.S., and Schlegel P.N., 1996.  The immunohistochemical localization of endothelial nitric oxide synthase in testis, epididymis and vas suggests a possible role for nitric oxide in spermatogenesis and sperm maturation.  Biol. Reprod. 55:  935-941.        

M9.      O¡¯Bryan M.K., and Cheng C.Y., 1997.  Purification and localization of testicular b2-microglobulin.  Life Sciences 61:  487-494.           

M10.  Mathur P.P., Grima J., Mo M.M., Zhu L.J., Arvindan G.R., Calcagno K., O¡¯Bryan M., Chung S., Mruk D., Lee W.M., Silvestrini B., and Cheng C.Y., 1997.  Differential expression of multiple cathepsin mRNAs in the rat testis during development, maturation and following lonidamine induced tissue restructuring.  Biochemistry and Molecular Biology International 42:  217-233.  

M11.  O¡¯Bryan M.K., Grima J., Zini A., and Cheng C.Y., 1997.  Haptoglobin is a Sertoli cell product in the rat seminiferous epithelium:  its purification and regulation. J. Androl. 18:  637-645.

M12.  Thomas T.Z., Wang H., Niclasen P., O¡¯Bryan M.K., Evans L.W., Groome N., Pederson J., and Risbridger G.P., 1997.  Expression and localization of activin and follistatins in tissues from men with high grade prostate cancer. J. Clin. Endocrinology Metabolism 82:  3851-3858.  

M13.  Zini A., O¡¯Bryan M.K., Israel L., and Schlegel P.N., 1998.  Human sperm NADH and NADPH diaphorase cytochemistry:  correlation with sperm motility.  Urology 51:  464-468.                    

M14.  Meinhardt A., O¡¯Bryan M.K., McFarlane J.R., Loveland K.L., Mallidis C., Foulds L.M., Phillips D.J., and de Kretser D.M., 1998.  Localization of follistatin in the rat testis.  J. Reprod. Fert. 112:  233-241.           

M15.  O¡¯Bryan M.K., Loveland K.A., Herszfeld D., McFarlane J.F., Hearn M.T.W., and de Kretser D.M., 1998.  Identification of a rat testis-specific gene encoding a putative rat outer dense fibre protein.  Mol. Reprod. Dev. 50:  313-322.  

M16.  O¡¯Bryan M.K., Zini A., Cheng C.Y., and Schlegel P.N., 1998.  Human sperm endothelial nitric oxide synthase expression:  correlation with motility.  Fert. Steril. 70:  1143-147.           

M17.  Meinhardt M., Bacher M., O¡¯Bryan M.K., McFarlane J.R., Mallidis C., Lehmann C., Metz C.N., de Kretser D.M., Bucala R., and Hedger M.P., 1999.  A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment.  J. Cell Sci. 112:  1337-1344.  

M18.  Kim Y.H., McFarlane J.R., O¡¯Bryan M.K., Almahbobi G., Temple-Smith P.D., and de Kretser D.M., 1999.  Isolation and partial characterization of rat outer dense fibres and comparison with rabbit and human spermatozoa using a polyclonal antiserum.  J. Reprod. Fert. 116:  345-353.           

M19.  O¡¯Bryan M.K., Schlatt S., Phillips D.J., de Kretser D.M., and Hedger M.P., 2000. Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels.  Endocrinology 141:  238-246.        

M20.  Buzzard J.J., Morrison J.R., O¡¯Bryan M.K., Song Q., and Wreford N.G., 2000.  The developmental expression of thyroid hormone receptors in the rat testis.  Evidence for a novel thyroid hormone receptor transcript.  Biol. Reprod. 62:  664-669.  

M21.  Meehan T., Schlatt S., O¡¯Bryan M.K., de Kretser D.M., and Lakoski Loveland, 2000.  Regulation of Sertoli and germ cell development by activin and FSH. Dev. Biol., 220:  225-237.           

M22.  O¡¯Bryan M.K., Sebire S.L., Gerdprasert O., Hedger M.P., Hearn M.T.W., and de Kretser D.M., 2000.  Cloning and regulation of the rat activin bE subunit.  J. Mol. Endo. 24:  409-418.           

M23.  O¡¯Bryan M.K., Schlatt S., Gerdprasert G., Phillips D.J., de Kretser D.M., and Hedger M.P., 2000.  Inducible nitric oxide synthase in normal testis function and in inflammation-induced infertility. Biol. Reprod. 63:  1285-1293.

M24.  Gow R.M., O¡¯Bryan M.K., Canny B.J., Ooi G.T., and Hedger M.P., 2001.  Dexamethazone ameliorates the inhibitory effects of lipopolysaccharide on luteinizing hormone secretion and testicular steroidogenesis, but does not prevent testicular inflammation in the male rat. J. Endo.168:  193-201.

M25.  O¡¯Bryan M.K., Sebire K.L., Meinhardt A., Edgar K.A., Keah H.-H., Hearn M.T.W., and de Kretser D.M., 2001.  Tpx-1 is a component of the outer dense fibers and acrosome of rat spermatozoa. Mol. Reprod. Dev., 58:  116-125.

M26.  Keah H.-H., O¡¯Bryan M.K., de Kretser D.M., and Hearn M.T.W., 2001.  Synthesis and application of peptide immunogens related to the sperm tail protein tpx-1, a member of the CRISP superfamily of proteins.  J. Pept. Res., 57:  1-10.

M27.  Zini A., O¡¯Bryan M.K., and Schlegel P.N., 2001.  Nitric oxide synthase activity in human seminal plasma.  Urology 58:  85-89.  

M28.  Dickins R.A., Frew I.J., House C.M., O¡¯Bryan M.K., Holloway A.J., Haviv I., Traficant N., de Kretser D.M., and Bowtell D.D.L., 2002.  Meiosis I chromosome segregation in male mice requires the RING domain ubiquitin ligase component Siah1a.  Mol. Cell Biol., 22:2294-303.     

M29.  Gerdprasert O., O¡¯Bryan M.K., Nikolic-Paterson D., Sebire K., de Kretser D.M., and Hedger M.P., 2002.  Expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage colony-stimulating factor (M-CSF) in the rat testis:  possible roles in monocyte recruitment.  Mol. Hum. Reprod. 8:  518-524..  

M30.  Gerdprasert O., O¡¯Bryan M.K., Muir J.A., Caldwell A.M., Schlatt S., de Kretser D.M., and Hedger M.P., 2002.  The response of testicular leukocytes to lipopolysaccharide-induced inflammation: evidence for functional heterogeneity of the testicular macrophage population. Cell Tissue Research, 308:  277-285.

M31.  McManamny P., Chy H.S., Finkelstein D.H., Craythorn R.G., Crack P.J., Kola I., Cheema S.S., Horne M.K., Wreford N., O¡¯Bryan M.K., de Kretser D.M., and Morrison J.R., 2002. A mouse model of spinal and bulbar muscular atrophy. Hum. Mol. Genet. 11:  2103-2111     

M32.  Hickox D., Gibbs G., Morrison J.R., Sebire K., Edgar K., Keah H.-H., Alter K., Loveland K.A., Hearn M.T.W., de Kretser D.M., and O¡¯Bryan M.K., 2002.  Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2.  Biol Reprod 67:  917-927.

M33.  Kennedy C., Sebire K., de Kretser D.M. and O¡¯Bryan M.K. 2003. Human sperm associated antigen-4 (SPAG-4) is a cancer/testis antigen. Cell Tissue Res. 315(2):279-83. Epub 2003 Nov 12.  

M34.  Buzzard J.J., Loveland K.L., O¡¯Bryan M.K., Anne E. O¡¯Connor, Wreford N.G., Morrison J.R., de Kretser D.M., 2004. Changes in circulating and testicular levels of inhibin A and B and activin A during postnatal development in the rat. Endocrinology 145(7): 3532-3541     

M35.  Gold E.J., O¡¯Bryan M.K., Mellor S.L., Cranfield M., Risbridger G., Groome P., and Flemming J.S., 2004. bC-activin shows cell-specific expression in rat ovary, testis, pituitary, uterus and adrenal, as well as in rat liver. Mol Cell Endocrinol. 2004 Jul 30;222(1-2):61-9.                

M36.  Douglas G.C., O¡¯Bryan M.K., Hedger M.P., Lee D., Yarski M.A., Smith A.I., and Lew R.A., 2004. The novel angiotensin converting enzyme homologue, ACE2, is selectively expressed in mature Leydig cells of the testis. Endocrinology, 145(10): 4703-11. Published on line ahead of print July 1, 2004.

M37.  O¡¯Bryan M.K., Foulds L.M., Cannon J.F., Winnall W., Muir J.A., Sebire K., Smith A.I., Keah H.H., Hearn M.T.W., de Kretser D.M., de Kretser D.M., and Hedger M.P. 2004. Identification of a novel gonadal apolipoprotein, ApoN. Endocinology, Jul 15 145(11):5231-42. Epub 2004 Jul 15.  

M38.  Krebs DL, Metcalf D, Merson TD, Voss AK, Thomas T, Zhang J-G, Rakar S, O¡¯Bryan MK, Wilson TA, Winey E, Mielke L, Nicola NA, Hilton DJ, Alexander WS, 2004. Hydrocephalus in mice lacking Socs7. Proc Natl Acad Sci U S A. 2004 Oct 19 [Epub ahead of print]    

M39.  Webster K., O¡¯Bryan M.K., Aapola U., Lyle R., Meachem S., Antonarakis S, Hedger M., Peterson P, de Kretser D, and Scott HS. 2004. Meiotic and epigenetic modification defects in Dnmt3L knockout mouse spermatogenesis. Submitted for publication. *Equal First Author (Aug. Proc. Natl. Acad. Sci. USA)

M40.  O¡¯Bryan M.K., Gerdprasert O., Nikolic-Paterson D.P., Meinhardt A., Muir J.A., Foulds L.M., Phillips D.J., and Hedger M.P. 2004. Cytokine profiles in the rat testis during lipopolysaccharide-induced inflammation indicate local regulation of immune responses. Submitted for publication. (Am J Physiol, Sept.)

 

Reviews in refereed journals

R1.       de Kretser D.M., Meinhardt A., Meehan T., Phillips D.J., O¡¯Bryan M.K., and Loveland K.A, 2000.  The role of inhibin and related peptides on gonadal function.  Mol. Cell. Endocrinol. 61:43-46.  

R2.       de Kretser D.M., O¡¯Bryan M.K., Cram D., and McLachlan R.I., 2000.  Expanding our understanding of spermatogenesis:  the future genetic test for infertility. Int. J. Andrology 23 (Suppl.):  30-33.     

R3.       de Kretser D.M., Loveland K.L., Meehan T., O¡¯Bryan M.K., and Wreford N.G., 2001.  Inhibins, activins and follistatin:  actions on the testis.  Mol. Cell. Endocrinol. 180:  87-92.        

R4.       Cram D.S., O¡¯Bryan M.K., and de Kretser D.M., 2001.  Male infertility genetics ¨C the future.  J. Androl. 22:  738-746.        

R5.       Gibbs G. and O¡¯Bryan M.K., 2002. Joint Prince Henry¡¯s Institute of Medical Research and Monash Institute of Reproduction and Development Symposium ¨C Reproductive Genomics. Comparative & Functional Genomics 3:  205-208.

R6.       Cram D, Lynch M, O¡¯Bryan M., Salvado C., McLachlan R. and de Kretser D, 2004. Genetic screening of infertile men. Reprod. Fertility, Development, 16: 573-580. 

 

Commentaries and other publications

Aitken R.J., Baker M.A., and O¡¯Bryan M.K. 2004. Shedding light on chemiluminescence. The application of chemiluminescence in diagnostic andrology. J Androl. 2004 Jul-Aug;25(4):455-65.

 

Chapters in books (by invitation)

B1.       de Kretser DM, Meehan T., O¡¯Bryan M.K., Wreford N.G., McLachlan R.I., and Loveland K.L.  Regulatory mechanism in mammalian spermatogenesis.  In ¡®Testis, epididymis and technologies in the year 2000¡¯.  Jegou, Pineau and Siaz (Editors), Springer, 2000.  pp. 87-106.

B2.       de Kretser, O¡¯Bryan M.K., Cram D.S., and McLachlan R.I., 2004. Genetics of male infertility: clinical applications. In press.

B3.       de Kretser D.M., Loveland K., O¡¯Bryan M.K. and Kerr J. ¡®The Cytology of the Testis and Intrinsic Control Mechanisms¡¯ in ¡®The Physiology of Reproduction, Third Edition. Submitted for publication

 

International Patent Application:

P1.       A cell regulation factor, and uses thereof.  Holders:  M.K. O¡¯Bryan, D.M. Hickox, M.T.W. Hearn, D.M de Kretser.  Patent Number:  PCT/AU00/01177.  Filing date:  September 22, 2000.

P2.       A sperm polypeptide: M.K. O¡¯Bryan, D.M. Hickox and D.M. de Kretser.  Patent Number: PS1604. Filing date: April 8, 2002. PCT.

 

Conference papers:            94

 

Granting bodies Reviewed for\

NHMRC

ARC

Telethon (Italy)

Monash University