Zi-Jiang Chen, M.D., Ph.D.

Address: 157 Jingliu Road, Center for Reproductive Medicine, Shandong University, Jinan 250001, China
Tel: 0086-531-85651188, 87068226
Fax: 0086-531-87989988/ 87068226
E-mail: chenzijiang@vip.163.com
Secretaries: 0086-531-85651189/ 85651190 (O)

Present Appointment
Vice President, Shandong University
Vice President, Shandong Provincial Hospital
Dean, Shandong University Qilu School of Medicine
Vice Dean, School of Medicine, Shandong University
Chair and Professor, Department of Ob & Gyn
Executive Vice President, Shandong Institute of Clinical Medicine
Director, Center for Reproductive Medicine
Director, Institute of Stem Cell, Shandong University, P. R. China.
Director, Center for Reproductive Medicine
Vice President, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Adjunct Professor, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China
Director, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, China, 2011-
Director, The Key laboratory for Reproductive Endocrinology of Ministry of Education, China, 2011-
Director, The Key laboratory for Assisted Reproductive Technology and Reproductive Genetics, Shanghai, 2012-

Education
1979-1984 Bachelor of Medicine, Shandong Medical University (Major in Medicine)
1984- 1989 MD-Ph.D. Five‑Year Honors Training Program, Shandong Medical University (Major in Obstetrics and Gynecology), Shandong Provincial Hospital, China
1989-1991 Reproductive Medicine, Department of Obstetrics and Gynecology, Shandong Provincial Hospital, China
1996 International Scholar, Department of Gynecology, The Cleveland Clinic Foundation, USA
1996.12- 1998.12 Postdoc, Department of Medicine, School of Medicine, Case Western Reserve University (CWRU), USA

Board Certification
Recertification, Chinese Board of Medical Examiners, 1997
Certification of Special Qualification in Reproductive Medicine, 1989
Diplomate, Chinese Board of Obstetrics and Gynecology, 1987
Diplomate, Chinese Board of Medical Examiners, 1984

Main Research Area
Assisted Reproductive Technology: IVF-ET, ICSI, IVM.
Genetics in Reproductive Medicine: PCOS, POF, RSA, PGD.
Reproductive Endocrinology
Conservation of Female Fertility
Human Embryonic Stem Cells

Other Experience and Professional Memberships
2008 - Pres: Associate Editor, Gynecologic and Obstetric Investigation
2009 - Pres: Chair, Gynecological Endocrinology of OB/GYN Professional Committee, Chinese Medical Association
2009 - Pres: Associate President, Chinese Society of Reproductive Medicine, Chinese Medical Association
2009 - Pres: Associate President, Medical Developmental Biology Branch of Chinese Society for Anatomical Sciences
2010 - Pres: Deputy Chief Editor, Chinese Journal of Gynecology and Obstetrics
2010 - Pres: External Expert, the International Olympics Committee (IOC) Medical Commission
2011 - Pres: Member, Androgen Excess and PCOS Society
2012 - Pres: Expert, consultation expert working group (EWG), Geneva Foundation for Medical Education and Research (GFMER) in collaboration with WHO
2013 - Pres: Member, Preimplantation Genetic Diagnosis International Society
2013 - Pres: Assistant Secretary General, International Federation of Fertility Societies (IFFS)
2014 - Pres: Executive Board Member, Asia Pacific Initiative on Reproduction (ASPIRE)

Honors
1993: Excellent Teachers, Fok Ying Tung Education Foundation, Hong Kong;
1996: The Outstanding Young Medical Scientist Award, the Ministry of Health;
1996: Wu Jie-Ping Medical Awards, the National Ministry of Health;
2002: The Outstanding Young Scientists, awarded by the Ministry of Health;
2005: The National Excellent Scientists, Chinese Society of Science & Technology;
2008: Taishan Scholar, Shandong Province People's Government;
2009: Medical Leading Personnel in Shandong Province;
2009: Outstanding Doctoral Dissertation Guidance Award, the National Ministry of Education;
2012: Ho Leung Ho Lee Foundation Award, MOST

Selected peer-reviewed publications (Publications selected from 166 peer-reviewed publications)

1. Yongyong Shi, Han Zhao, Yuhua Shi, Yunxia Cao, Dongzi Yang, Zhiqiang Li, Bo Zhang, Xiaoyan Liang, Tao L, Jianhua Chen, Jiawei Shen, Junzhao Zhao, Li You, Xuan Gao, Dongyi Zhu, Xiaoming Zhao, Ying Yan, Yingying Qin, Wenjin Li, Junhao Yan, Qingzhong Wang, Junli Zhao, Ling Geng, Jinlong Ma, Yueran Zhao,Guang He, Aiping Zhang, Shuhua Zou, Aijun Yang, Jiayin Liu, Weidong Li, Baojie Li, Chunling Wan, Ying Qin, Juanzi Shi, Jing Yang, Hong Jiang, Jin-e Xu, Xiujuan Qi, Yun Sun,Yajie Zhang, Cuifang Hao, Xiuqing Ju, Dongni Zhao, Chun-e Ren, Xiuqing Li, Wei Zhang, Yiwen Zhang, Jiangtao Zhang, Di Wu, Changming Zhang, Lin He*, and Zi-Jiang Chen*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nature Genetics. 2012; 44(9): 1020-5.
2. Zi-Jiang Chen*, Han Zhao, Lin He, Yuhua Shi, Yingying Qin, Yongyong Shi*, Zhiqiang Li, Li You, Junli Zhao, Jiayin Liu, Xiaoyan Liang, Xiaoming Zhao, Junzhao Zhao, Yingpu Sun, Bo Zhang, Hong Jiang, Dongni Zhao, Yuehong Bian, Xuan Gao, Ling Geng, Yiran Li, Dongyi Zhu, Xiuqin Sun, Jin-e Xu, Cuifang Hao, Chun-e Ren, Yajie Zhang, Shiling Chen, Wei Zhang, Aijun Yang, Junhao Yan, Yuan Li, Jinlong Ma, Yueran Zhao. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nature Genetics. 2011; 43(1): 55–59.
3. Zhibin Hu, Zheng Li, Jun Yu, Chao Tong, Yuan Lin, Xuejiang Guo, Feng Lu, Jing Dong, Yankai Xia, Yang Wen, Hao Wu, Honggang Li, Yong Zhu, Ping Ping, Xiangfeng Chen, Juncheng Dai, Yue Jiang, Shandong Pan, Peng Xu, Kailing Luo, Qiang Du, Bing Yao, Ming Liang, Yaoting Gui, Ning Weng, Hui Lu, Zhuqing Wang, Fengbin Zhang, Xiaobin Zhu, Xiaoyu Yang, Zhou Zhang, Han Zhao, Chenliang Xiong, Hongxia Ma, Guangfu Jin, Feng Chen, Jianfeng Xu, Xinru Wang, Zuomin Zhou, Zi-Jiang Chen*, Jiayin Liu*, Hongbing Shen* & Jiahao Sha*. Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nature Communication. 2014; 5:3857.
4. Han Zhao, Jianfeng Xu, Haobo Zhang, Yingpu Sun, Jielin Sun, Zhong Wang, Jiayin Liu, Qiang Ding, Shaoming Lu, Rong Shi, Li You, Yingying Qin, Xiaoming Zhao, Xiaoling Lin, Xiao Li, Junjie Feng, Li Wang, Jeffrey M. Trent, Chengyan Xu, Ying Gao, Bo Zhang, Xuan Gao, Jingmei Hu, Hong Chen, Guangyu Li, Junzhao Zhao, Shuhua Zou, Hong Jiang, Cuifang Hao, Yueran Zhao, Jinglong Ma, S. Lilly Zheng, and Zi-Jiang Chen*. A Genome-wide Association Study Reveals Variants within the HLA Region Are Associated with Risk for Nonobstructive Azoospermia. Am J Hum Genet. 2012; 90(5): 900-906.
5. Han Zhao, Zi-Jiang Chen(Co-first authors), Yingying Qin, Yuhua Shi, Shan Wang, Youngsok Choi, Joe Leigh Simpson, Aleksandar Rajkovic*. Transcription Factor FIGLA is Mutated in Patients with Premature Ovarian Failure. American Journal of Human Genetics. 2008; 82(6):1342-1348.
6. Yingying Qin, Youngsok Choi, Han Zhao, Joe Leigh Simpson, Zi-Jiang Chen, Aleksandar Rajkovic*. NOBOX Homeobox Mutation Causes Premature Ovarian Failure. American Journal of Human Genetics. 2007; 81(3): 576-581.
7. Yingying Qin, Han Zhao, Jianfeng Xu, Yongyong Shi, Zhiqiang Li, Jie Qiao, Jiayin Liu, Chunrong Qin, Chune Ren, Jie Li, Shiling Chen, Yunxia Cao, China POF Study Group, Joe Leigh Simpson, Zi-Jiang Chen*. Association of 8q22.3 locus in Chinese Han with idiopathic premature ovarian failure (POF). Hum Mol Genet. 2012 Jan 15;21(2):430-6.
8. Li T, Zhao H, Zhao X, Zhang B, Cui L, Shi Y, Li G, Wang P, and Chen ZJ*. Identification of YAP1 as a Novel Susceptibility Gene for Polycystic Ovary Syndrome. J Med Genet. 2012; 49(4): 254-7.
9. Yunfang Zhang, Ying Zhang, Junchao Shi, He Zhang, Zhonghong Cao, Xuan Gao, Wanhua Ren, Yunna Ning, Lina Ning, Yujing Cao, Yongchang Chen, Weizhi Ji, Zi-jiang Chen*, Qi Chen*, Enkui Duan*. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. J Mol Cell Biol. 2014;6(2):172-4.
10. Yingying Qin, Mei Sun, Li You, Deying Wei, Jielin Sun, Xiaoyan Liang, Bo Zhang, Hong Jiang, Jianfeng Xu and Zi-Jiang Chen*. ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure. Orphanet Journal of Rare Diseases. 2012;7(1):5.
11. Peng Wang, Han Zhao, Tao Li, Wei Zhang, Keliang Wu, Mei Li, Yuehong Bian, Hongbin Liu, Yunna Ning, Guangyu Li and Zi-Jiang Chen*. Hypomethylation of the LH/Choriogonadotropin Receptor Promoter Region Is a Potential Mechanism Underlying Susceptibility to Polycystic Ovary Syndrome. Endocrinology. 2014;155(4):1445-52.
12. Linlin Cui, Han Zhao, Bo Zhang, Zhongyu Qu, Jiayin Liu, Xiaoyan Liang, Xiaoming Zhao, Junli Zhao, Yingpu Sun,Peng Wang, Tao Li, Yuhua Shi, Zi-Jiang Chen*. Genotype–phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women. Human Reproduction. 2013;28(2):538-44.
13. Hongyan Wang, Yunhong Li, Lei Sun, Xuan Gao, Li You, Yin Wang, Jinglong Ma, Zijiang Chen*. Allotransplantation of cryopreserved prepubertal mouse ovaries restored puberty and fertility without affecting methylation profile of Snrpn-DMR. Fertil Steril. 2013; 99(1):241-247.e4.
14. Han Zhao, Xinghua Xu, Xiuye Xing, Jianfeng Wang, Lin He, Yongyong Shi, Yuhua Shi, Yueran Zhao, Zi-Jiang Chen*. Family-Based Analysis of Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3, 2p21 and 9q33.3. Human Reproduction. 2012; 27(1): 294-8.
15. M. Guo, Z.J. Chen*, M.J.E. Eijkemans, A.J. Goverde1, B.C.J.M. Fauser, and N.S. Macklon. Comparison of the phenotype of Chinese versus Dutch Caucasian women presenting with polycystic ovary syndrome and oligo/amenorrhoea. Human Reproduction.2012; 27(5): 1481-8.
16. Xue Jiao, Chunrong Qin, Jie Li, Yingying Qin, Xuan Gao, Bo Zhang, Xiumei Zhen, Yun Feng, Joe Leigh Simpson, Zijiang Chen*. Cytogenetic analysis of 531 Chinese women with premature ovarian failure. Hum Reprod. 2012; 27(7): 2201-7.
17. S. Lu*, Y. Cui, X. Li, H Zhang, J Hu, J. Liu, ZJ Chen*. Sperm retrieval in anejaculatory diabetic men who failed in drug treatment and penile vibratory stimulation during blood sugar under control. Andrologia. 2014; 46(4): 370-3.
18. Xinghua Xu, Yuhua Shi, Yuqian Cui, Jinlong Ma, Li Che, Zijiang Chen*. Endocrine and Metabolic Characteristics of Polycystic Ovary Syndrome in Chinese Women with Different Phenotypes. Clin Endocrinol. 2012;76(3): 425-30.
19. Yujie Dang, Yingying Qin, Rong Tang, Yulan Mu, Guangyu Li, Mingdi Xia, Zi-Jiang Chen*. Variants of the WNT7A gene in Chinese patients with m€ullerian duct abnormalities. Fertil and Steril. 2012; 97(2): 391-394.
20. Mingdi Xia, Han Zhao, Yingying Qin, Yulan Mu, Jia Wang, Jinglong Ma, Zi-Jiang Chen*. LHX1 Mutation Screening in 96 Patients with Müllerian Duct Abnormalities. Fertil and Steril. 2012; 97(3):682-5.
21. Peng Wang, Han Zhao, Mei Sun, Yuan Li, Zi-Jiang Chen*. PAX2 in 192 Chinese women with Müllerian duct abnormalities: mutation analysis. Reprod Biomed Online. 2012; 25(2): 219-22.
22. Junhao Yan, Guoning Huang, Yingpu Sun, Xiaoming Zhao, Shiling Chen, Shuhua Zou, Cuifang Hao, Song Quan, Zi-Jiang Chen*. Birth defects after assisted reproductive technologies in China: analysis of 15,405 offspring in seven centers (2004 to 2008). Fertility and Sterility. 2011; 95(1): 458-460.
23. Chao Li, Yuhua Shi, Li You, Laicheng Wang, Zijiang Chen*. Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Molecular Human Reproduction. 2011 Mar;17(3):193-198.
24. Xiuye Xing, Junhao Yan, Yueran Zhao, Li You, Yuehong Bian, Zi-Jiang Chen*. Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Recurrent Spontaneous Abortion in Chinese Han Women. American Journal of Reproductive Immunology. 2011; 65(5): 521-525.
25. Xing X, Zhao H, Li M, Sun M, Li Y, Chen ZJ*. Morphologically abnormal oocytes not capable of fertilization despite repeated strategies. Fertil Steril. 2011; 95(7): 2435.e5-7.
26. Jinlong Ma, Yingying Qin, Wen Liu, Hua Duan, Zi-Jiang Chen*. Analysis of PBX1 mutations in 192 Chinese women with Müllerian duct abnormalities. Fertility and Sterility. 2011; 95(8): 2615-7.
27. Zijiang Chen. Barriers to conducting clinical research in reproductive medicine: China. Fertility and Sterility. 2011; 96(4): 811-2.
28. Y Cui, J Ma, Y Shi, Q Huan, H Guo, Y Zhao*, ZJ Chen*. Positive and Negative Feedback Regulation in the Production and Secretion of Insulin from INS-1 Cells by Testosterone. Hormone and Metabolic Research. 2011; 43(13): 911–8.
29. Shan Liu, Yuan Li, Xuan Gao, Jun-Hao Yan, Zi-Jiang Chen*. Changes in the distribution of mitochondria before and after in vitro maturation of human oocytes and the effect of in vitro maturation on mitochondria distribution. Fertility and Sterility. 2010; 93(5): 1550-1555.
30. Kehua Wang, Leiguang Wang, Yueran Zhao, Yuhua Shi, Laicheng Wang, Zi-Jiang Chen*. No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene and polycystic ovary syndrome. Human Reproduction. 2009; 24(2): 485-490.
31. Shaoming Lu, Yueran Zhao, Jingmei Hu, Xiao Li, Haobo Zhang, Li You, Zi-jiang Chen*. Combined use of phosphodiesterase-5 inhibitors and selective serotonin reuptake inhibitors for temporary ejaculation failure in couple undergoing assisted reproductive technologies. Fertility and Sterility. 2009; 91 (5): 1806-1808.
32. LH Wang, SF Mullen, Y Li, JQ Zhong, JK Crister, ZJ Chen*. Morphological and Apoptotic Comparison of Primordial and Primary Follicles in Cryopreserved Human Ovarian Tissue. Reproduction in Domestic Animals. 2009; 44: 879-883.
33. Hao-Bo Zhang, Shao-Ming Lu, Chun-Yan Ma, Li Wang, Xiao Li, Zi-Jiang Chen*. Early apoptotic changes in human spermatozoa and their relationships with conventional semen parameters and sperm DNA fragmentation. Asian Journal of Andrology. 2008; 10(2): 227-235.
34. Ying-Ying Qin, Han Zhao, Ertug Kovanci, Joe Leigh Simpson, Zi-Jiang Chen*, Aleksandar Rajkovic. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. Fertility and Sterility. 2007; 88(5): 1465-1467.
35. Han Zhao, Yingying Qin, Ertug Kovanci, Joe Leigh Simpson, Zi-Jiang Chen*, Aleksandar Rajkovic. Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure. Fertility and Sterility. 2007; 88(5):1474-1476.
36. Yuan Li, Huai-Liang Feng, Yi-Juan Cao, Guang-Juan Zheng, Yong Yang, Steve Mullen, John K. Critser, Zi-Jiang Chen*. Confocal microscopy analysis of the spindle and chromosome configurations of human oocytes matured in vitro. Fertility and Sterility. 2006; 85(4): 827-832.
37. Zi-Jiang Chen, Michael Vetter, Geen-Dong Chang, Shiguo Liu, Danian Che, Yaxian Ding, Sung Soo Kim, Chung-Ho Chang*. Cyclophilin A Functions as an Endogenous Inhibitor for Membrane-Bound Guanylate Cyclase-A. Hypertension. 2004; 44: 963-968.

Research Support

Ongoing Research Projects
2012CB944700, Zi-Jiang Chen (PI), 01/01/2012 - 08/31/2016
National Basic Research Program of China (973 Program)/MOST
Mechanisms of anovulation-related diseases
The programme aims to clarify the mechanism of ovulation disorders. We attempt to process a multiple layers, systematic and translational researches by closely combining clinical problems of anovulation related diseases with reproductive biological research together. We also attempt to establish a bio-bank of ovulation disorders and create a risk prediction model for the establishment of early warning and intervention measures.
Role: Principal Investigator (The chief scientist)

81490743, Zi-Jiang Chen (PI), 01/01/2015 - 12/31/2019
NSFC
The Screening and Identifying of Genetic Markers for the Recurrent Spontaneous Abortion and Preeclampsia, So we plan to conduct intensive investigations on the associate genes and sites discovered during our former study; take advantage of the abundant clinical resources of our country, built adequate depository, then to excavate the potential susceptible loci, so to establish the genetic and epigenetic markers for PE and RSA.
Role: Principal Investigator

81430029, Zi-Jiang Chen (PI), 01/01/2015 - 12/31/2019
NSFC
Translational Study of TOX3 Function in Follicle Development of Polycystic Ovary Syndrome
The grant is to study the function of TOX3 signaling pathway in follicle development, utilizing in vitro(high concentration of androgen/insulin stimulating cells, up/down regulation TOX3 gene) and in vivo(knockout/knockin Tox3 of granulosa cells in mouse models) research technique, and the relationship with PCOS. This study will illustrate the mechanism of abnormal TOX3 pathway in PCOS pathogenesis, and enrich fundamental reproductive biological theories
Role: Principal Investigator

348-2011-7319, Kui Liu (PI), 01/01/2012 – 12/31/2014
Swedish Research Links programme
Generation of patient-specific stem cells from large amount of human oocytes from China
This programme aims to generate patient-specific pluripotent human embryonic stem (ES) cells by oocyte somatic cell nuclear transfer (SCNT).
Role: Co-Investigator

Completed Research Support
39300136, Zi-Jiang Chen (PI), 01/01/1994 - 12/31/2009
NSFC
The Biological Effects of the Cryopreservation on Human Oocytes
The grant is to study the effects of the cryopreservation on human oocytes, including oocytes spindle morphology, mitochondrial morphology and so on.
Role: Principal Investigator

(2006CB944004), Zi-Jiang Chen (PI), 01/01/2006 – 08/31/2012
National Basic Research Program of China (973 Program) /MOST
In vitro Manipulation of Reproductive Stem Cell and New Technology in Assisted Reproduction
Role: Principal Investigator

2006AA02Z4A4, Zi-Jiang Chen (PI), 01/06/2006 - 12/31/2008
National High-tech R&D Program of China (863 Program)/MOST
Oocyte Cryopreservation
The projiect is to establish new protocol for Oocyte Cryopreservation.
Role: Principal Investigator

30670777, Zi-Jiang Chen (PI), 01/01/2007 - 12/31/2009
NSFC
Molecular Mechanisms of Activation of Membrane-bound Guanylate Cyclase GC-A by 17-beta estradiol
The grant is to study the role and the mechanisms of 17-beta estradiol in activation of Membrane-bound Guanylate Cyclase GC-A.
Role: Principal Investigator

30973170, Zi-Jiang Chen (PI), 01/01/2010 - 12/31/2014
NSFC
Characterization of PTEN-PI3K-Akt sinal pathway and FOXO3A in Premature Ovarian Failure
The grant is to study the contributions of PTEN- PI3K- Akt pathway and FOXO3A gene to POF in Chinese population.
Role: Principal Investigator

201002013, Zi-Jiang Chen (PI), 07/01/2011 - 06/31/2014
Science research foundation item of no-earnings health vocation/MOH
Normalization and generalization of the diagnosis and therapy of reproductive major diseases
The program aims to establish Chinese Diagnosis criteria of Infertility and PCOS
Role: Principal Investigator

2010CB945000, Jiangang Gao (PI), 01/01/2010 - 08/31/2014
National Basic Research Program of China (973 Program)/MOST
Basic research on ovarian aging mechanism and related major diseases
The goal of this project is to evaluate the role of genes in the POF
Role: Co-Investigator