Wai-Yee Chan, Ph.D.

 

Professor, Department of Pediatrics,

Georgetown University Children's Medical Center,

3800 Reservoir Road, NW,

                                    Washington, DC 20007.

Tel: (202) 687-7068

                                    E-mail: chanw@georgetown.edu

 

Adjunct Investigator,

Laboratory of Clinical Genomics

National Institute of Child Health and Human Development,

National Institutes of Health

Tel: (301) 451-8821

Fax: (301) 480-4700

Email: chanwy@mail.nih.gov

 

NATIONALITY:            Naturalized US Citizen, 1984.

 

EDUCATION:

1970-74       B. Sc., Hon., 1st Class (Major: Chemistry; Minor: Biochemis­try), the Chinese University of Hong Kong, Hong Kong.

1974-77       Ph.D. (Biochemistry), University of Florida, Gainesville, FL. Advisor: Dr. Owen M. Rennert.

1977-79       Fellow, Division of Genetics, Endocrinology & Metabolism, Depart­ment of Pediatrics, University

                     of Oklahoma, Oklaho­ma City, OK. Director: Owen M. Rennert, MD.

1982            Visiting Scientist, Department of Biochemistry, University of Washingto­n, Seattle, WA. Supervisor: Earl W. Davie, Ph.D. 

 

APPOINTMENTS:

1979-82                      Director, Clinical Trace Metals Diagnostic Lab, Department of Pediatrics, University of             Oklaho­ma, Oklahoma City, OK.

1979-89           Assistant to Associate Professor, Department of Pediatrics (Tenured 1983) and Department of Biochemistry & Molecular Biology (Adjunct), University of Oklahoma, Oklahoma City, OK.

1980-87           Scientific Director, Biochemical Genetics Lab, Oklahoma Children's Hospital, Okla City, OK.

1981-87           Consultant, Medical Service, Veteran's Administration Medical Center, Oklahoma City, OK.

1982-88                       Scientific Director, Trace Metals Diagnostic Lab, State of Oklahoma Teaching Hospi­tals, Oklahoma City, OK.

1987-89           Associate Member, Oklahoma Medical Research Foundation, Oklahoma City, OK.

1989-Present   Affiliate Member, Oklahoma Medical Research Founda­tion, Oklahoma City, OK.

1989-Present   Professor, Department of Pediatrics (Tenured 1990), Departments of Biochemist­ry & Molecular Biology and Cell Biology (Sec­ondary), Georgetown University, Washington, DC.

1990-Present   Member, Vincent T. Lombardi Cancer Center, Georgetown University, Washington, DC.

1993-2000       Director, Molecular Genetic Diagnostic Lab, Georgetown Universi­ty Children's Medical Center, Washington­, DC.

1998-2000       Chief, Division of Genetics and Metabolic Diseases, Department of Pediatrics, Georgetown University, Washington, DC.

2001-Present   Adjunct Investigator, Laboratory of Clinical Genomics, NICHD, NIH, Bethesda, MD.

 

BOARD CERTIFICATION:

1. Certified Nutrition Specialist, Certificate # 00049,

    The Certification Board for Nutrition Specialists, August 1993.

2. Director, Molecular Genetic Diagnostic Laboratory, CLIA ID#: 09D0903844, Health Care Financing

    Administration, DHHS, 1995-2000.

 

PATENT:

1. Pregnancy Specific Proteins Applications

    Sole Inventor

    US Patent No. 5,169,835; Issue date: December 8, 1992.

    Australian Patent No. 645965; Issue date: December 6, 1993.

    Canadian Patent No. 805-105; European Patent No. 90902488.7; Japanese Patent No. 4-504655.

2. Retinoic Acid Inducible DNA Sequences and Polypeptides Expressed Thereby and Their Use in Promoting 

    Alveolar Development

    U.S.S.N. 09/330,004, European Patent No. 99930221.9-2107; Japanese Patent No. 2000-553125

    Inventor: 60%.  Co-Inventors: Donald Massaro 20%, Gloria Massaro 20%

3. In Vivo Assay for Identifying Nucleic Acid Sequences Involved in Alveolar Loss, Development and Nucleic

    Acid Sequences Identified Thereby

Inventors: Donald Massaro 40%, Gloria Massaro 40%, Wai-Yee Chan 20%.

4. Method Evolved for Recognition of Thrombophilia (MERT)

    Inventors: Cigdem Dogulu, Owen M. Rennert, Wai-Yee Chan

    US patent application filed: January 15, 2004. DHHS reference no. E-282-2003/0-us-01

 

 

SOCIETY MEMBERSHIPS:

American Society of Human Genetics, 1977

Society for Pediatric Research, 1980

American College of Nutrition, 1981

American Society for Biochemistry and Molecular Biology, 1982

Society of Chinese Bioscientists in America, (Oklahoma Representative, 1985-89), 1985

American Institute of Immunology, 1987

Endocrine Society, 1990

Association of Chinese Geneticists in America, (President-elect 2002-03, President 2003-04) 1999

 

CONSULTANTSHIP:

1.   Mitsubishi Kasei Corporation, Yokohama, Japan. 1993-1994.

2.   Bayer Corporation, Pharmaceutical Division, Berkeley, California. 1998-2000.

3.   AstraZeneca Pharmaceuticals LP, Wilmington, Delaware. 2000-2004.

 

HONORS AND AWARDS:

Awards:

1.   Scholarship for Chemistry, the Chinese University of Hong Kong, 1972‑74.

2.   Tak Shing Scholarship for Biochemistry, the Chinese University of Hong Kong, 1973‑74.

3.   Honors, First Class, Chemistry, the Chinese Univer­sity of Hong Kong, 1974.

4.      Listed in : American Men and Women of Science, 1982; Who's Who in the World, 1984, 1998;

      International Who's Who in Medicine, 1986; Who's Who in Science and Engineering, 1991;

      Who's Who in Medicine and Healthcare, 1997.

5.   Merrick Award for Outstanding Biomedical Research, Oklahoma Medical Research Founda­tion, Oklahoma City, Oklahoma, 1988.

6.   Service Award, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, July, 1989.

7.      Honorary Member, Chinese American Medical Association, New York, 1992.

8.      Distinguished Faculty Tutor, School of Medicine, Georgetown University, 1997.

 

Visiting Professorship:

1.      Visiting Professor, Cancer Institute, Chinese Academy of Medical Sciences, and Institute of Basic Clinical

      Sciences, China-Japan Friendship Hospital, Beijing, China, May 12-15, 1987.

2.  Visiting Professor, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, March 18-20, 1991.

3.   Visiting Scholar, Shaw College, Chinese University of Hong Kong, Hong Kong, June 29-July 5, 1993.

 

Invited Participation in Delegations:

1. American Delegate to the First U.S.‑China Bilateral Conference on Protein in Biology and Medicine. Shanghai and Beijing, China, May 24‑June 12, 1981. 

2. American Delegate, the Second U.S.‑China Bilateral Conference on Protein in Biology and Medicine. Oklahoma City, OK, June 11‑13, 1983.  

3. American Delegate, U.S.A.-P.R.C. Tumor Biology Conference. Oklahoma Medical Research Foundation, Oklahoma City, OK, April 21-22, 1986.

4. Delegation from the Oklahoma Medical Research Foundation to SunYet-sen University of Medical Sciences, Guangzhou, Insti­tute of Biochemistry, Academia Sinica, Shanghai, and Chinese Academy of Medical Sciences, and China-Japan Friendship Hospital, Beijing, China, June to August, 1986.

5. US Delegate, Briefing on Medical Application of Modern Biotechnology to Norwe­gian Parliamentary Committee on Health and Social Affairs. Royal Norwegian Embassy, Washington, DC. September 7, 1990.

6. Centennial Reunion Conference of the US-China Bilateral Meeting on Proteins in Biology and Medicine, 

     Maui, Hawaii, June 20-24, 1992.

Conference Organizer, Session Chair, and Invited Presentation in Symposia:

 

1.   Scientific Working Conference on Cystic Fibrosis.  Cystic Fibrosis Foundation and National Institutes of Health, Padre Island, TX, March 4-7, 1979. 

2.   Ross Clinical Research Conference on Meeting Nutritional Goals for Low-Birth-Weight Infants. Ross Laboratories, Tarpon Springs, FL, October 2‑4, 1980.

3.   Manganese in Metabolism and Enzyme Function Confer­ence. Pennsylvania State Universi­ty, University Park, PA, October 7-10, 1984.

4.   Symposium on Manganese Nutrition. American Chemical Society, Anaheim, CA. September 7-12, 1986.

5.   The First International CEA Workshop.  McGill Cancer Center, McGill University, Montreal, Canada, June 11-14, 1990.

6.   The Second International PSG/CEA Workshop (Co-Organizer). NIH/Georgetown University, Washington, DC, June 17-20, 1991.

7.   The Third International PSG/CEA Workshop. University of Umea, Umea, Sweden, June 14-17, 1992.

8.   The Fourth International PSG/CEA Workshop, Deaconess Hospital, Harvard Medical School, Boston, August 22-25, 1993.

9.   The Fifth International PSG/CEA Workshop, Freiburg University, Freiburg, Germany, July 18-21, 1994.

10. The Sixth International PSG/CEA Workshop, McGill Cancer Center, McGill University, Montreal, Canada, September 6-8, 1995.

11. Symposium on the Chemistry and Molecular Biology of Blood Coagulation, Battelle Conference Center,    Seattle, WA, October 24, 1997.

12. Molecular abnormalities of LH action. Symposium on Disorders of Gonadotropin Secretion and Action, 80th Annual Meeting of the Endocrine Society, June 24, 1998.

13. The Impact of Culture on Health Seeking Behavior Panel. (Panelist) Washington DC Area Geriatric Education Center Consortium Spring 1999 Enrichment Series: Multicultural Issues in Aging.  Howard University, Washington, DC, May 27, 1999.

14. Spirituality of Aging for Minority Population (Panelist).  Washington DC Area Geriatric Education Center

      Consortium Spring 2000 Enrichment Series: Multicultural Issues in Aging.  Howard University,

      Washington, DC.  June 2, 2000.

15. TWGH-CUHK Eddie Wang Symposium on Complementary Chinese and Western Medicine Symposium – Integrated Approach, Hong Kong, Feb 27-28, 2004.

16. International Conference on Medical Genetics, Advances on Birth Defect: Diagnosis, Prevention, and

      Intervention. (Scientific Committee); Session on Molecular Basis of Genetic Disorders (Chair), Beijing, China, July 15-17, 2004.

17. Session on Y Chromosome Evolution, Population and Molecular Genetics (Co-Chair), 10th SCBA International Conference, Beijing, China, July 18-23, 2004.

18. Wuhan Frontier of Biomedical Science Satellite Workshop of SCBA, Wuhan, China, July 25-26, 2004.

 

SERVICE ACTIVITIES:

 

Professional Service

I. Grant Review and Study Sections:

A. International:

1. Research Grants Council, University Grants Committee (Formerly University and Polytech­nic Grants  

    Committee), Hong Kong, Overseas Reviewer, 1991-93, 1995-98.

     2. Lottery Health Research, New Zealand Lottery Grants Board, Department of Internal Affairs, New

         Zealand, Reviewer, 1993.

     3. Health Research Council of New Zealand, Reviewer, 1996-present.

     4. USDA Research & Scientific Exchanges/Portuguese Ministry of Science and Technology/European Community, USDA, Reviewer, 1997.

     5. The Wellcome Trust and Health Research Board, United Kingdom, Reviewer, 1999.

B. National:

    1. Site Visit Committee, National Institute of Arthritis, Diabet­es, Digestive and Kidney Diseases, NIH, for            Hepatobiliary Center in Denver, Colorado, August, 1984.

 2. Special Study Section, Physiology of Lactation and Biology of Human Milk, National Institute of Child

        Health and Human Development, NIH, July, 1985.

 3. Biochemistry Subcommittee, Drug Abuse Biomedical Re­search Review Committee, National Institute of

        Drug Abuse, NIH, Ad Hoc Reviewer, October, 1993, 1994.

    4. Reproductive Biology Study Section, National Institutes of Health, Ad Hoc Reviewer, October, 1994.

5. Special Emphasis Panel, National Institutes of Child Health and Human Development, NIH, April 23,

   1998.

6. Endocrinology, Metabolism, Nutritional and Reproductive Sciences Study Section, ZRG1 F06-20, NIH,

October, 2001 - present.

7. Ad Hoc Reviewer, Neonatal Research Network, National Institute of Child Health and Human

    Development, NIH, April, 2004.

 

II. Journal Editorial Activities:

 A. Editorial Boards:

      1. Journal of the American College of Nutrition, 1982 ‑ Present.

      2. Journal of Endocrine Genetics, 1999 - present.

      3. Journal of Current Molecular Medicine, 1999 - present.

      4. Annals of Traditional Chinese Medicine, 2004 – present.

 B. Reviewer:

     Science, Proceedings of the National Academy of Sciences, USA, Biochemistry, New England Journal of

     Medicine, American Journal of Medical Genetics, Journal of Immunology, Journal of Clinical

     Endocrinology and Metabolism, Gene, Human Genetics,  European Journal of Biochemistry, Biochimica et

     Biophysica Acta, Pediatrics, Life Sciences,  American Journal of Clinical Nutrition, DNA and Cell Biology,

     Journal of Nutritional Biochemistry, Proceedings for the Society of Experimental Biology and Medicine,

     DNA Sequences, Molecular Reproduction and Development, Asian Journal of Andrology.

 

III. Other Review Activities:

1. Literature Selection Technical Review Committee, National Library of Medicine, Guest Reviewer, 1996.

2. Selection Committee, Japanese Society for the Promotion of Science (JSPS) Fellowship Program, Fogarty

    International Center, National Institutes of Health, December 2, 1996.

3. Selection Committee, Asia Pacific Economic Council (APEC) Youth Science Festival, International

    Directorate, American Association for the Advancement of Sciences, 2000, 2003.

4. Review Panel, the Korea-U.S. Science and Engineering Summer Camp in Seoul, South Korea, American

Association for the Advancement of Science, April, 2002.

 

IV. Activities at Foreign Academic Institutes:

1. Dissertation/Thesis External Reviewer, Master of Philosophy and Doctor of Philosophy, Division of

    Biochemistry, the Chinese University of Hong Kong, 1984, 1989-1994, 1998, 2001-present.

2. External/Visiting Examiner, Undergraduate Program of Biochemistry, Undergraduate Examination Board,   

    the Chinese University of Hong Kong, Hong Kong, 1994-97.

3. External Assessor, Personnel Department, the Chinese University of Hong Kong, Hong Kong S.A.R., China,

    1995, 1997, 1999-2002, 2004.

4. External Examiner, First Professional Degree, the Chinese University of Hong Kong School of Medicine,         Hong Kong S.A.R., China, 2001-present.

5. Special Advisor to the Chancellor (2001-present) and Member, College Council (2002-present), the Macau       Millennium College, Macau S.A.R., China.

6. Member, Scientific Advisory Board, Area of Excellence in Chinese Medicine Research and Further Development, Hong Kong S.A.R., China, 2002-2007.

7. Liaison, Montgomery College-Millennium College Faculty/Student Exchange Program, 2003-present.

NIH/University Service:

I. National Institutes of Health:

1. Coordinator, Graduate Supervisory Committee, NICHD-CUHK Graduate Partnership Program, NICHD,       2003-present.

II. Georgetown University:

  1. Genetics Graduate Program Committee, 1989-95.

  2. Genetics Clinical Fellowship Committee, 1989-95.

  3. Neuroscience Task Force, 1990-93.

  4. Subcommittee on Reproductive Failure/Genetics, Perinatal Task Force, 1990-93.

  5. Georgetown University Hospital Molecular Diagnostic Laboratory Committee, 1993-97.

  6. Institutional Biosafety Committee, 1996–2002.

  7. Medical Center Research Committee, 1998-2001.

  8. Sub-committee on Pre-Clinical Education of the Committee on Medical Education, 1998-present.

  9. Executive Committee, Department of Biochemistry & Molecular Biology, 2003-present.

10. Committee on Appointment and Promotion, Georgetown University Medical Center, 2003-present.

11. Development and Child Health Research Initiative Task Force, Georgetown University, 2004.

 III. Oklahoma Medical Research Foundation:

  1. Recombinant DNA subcommittee, 1987-88.

  2. Library Advisory committee, 1988-89.

III. University of Oklahoma:

  1.Graduate Curriculum Committee (1981-83), Graduate Admissions and Student Recruitment Committee

     (1986-89), and Faculty Advisory Committee (1988-89), Department of Biochemistry & Molecu­lar                      Biology.

 2.  Research and Education Computer Advisory Committee, 1983‑86.

 3.  Affirmative Action Committee, 1984‑87.

 4.  Planning Committee, Mid‑American Molecular Biology Colloquium, 1986‑87.

 5.  Medical Alumni Association Research Award Committee, 1989.

 

Public Service:

I. National and International Scientific Organizations:

1.  American Biographical Institute, Inc., Honorary Educational Advisory Board, 1984‑89.

2.  Society of Sigma Xi, University of Oklahoma Chapter, Award Committee, 1984‑85; Treasurer, 1985‑88.

3.  Society of Chinese Bioscientist in Ameri­ca, Oklahoma Representative, 1985‑89.

4.  American Association for the Advancement of Science, Advisory Committee, Pacific Rim Initiative,             1997-2003.

5.  Association of Chinese Geneticists in America, Board of Directors, 2000-2002, President-Elect, 2002-2003,      President 2003-2004,.

 

SCHOLARSHIP AND RESEARCH:

 

A. RESEARCH SUPPORT:

 

Past Support from NIH (Foundation and Industrial Support Not Listed):

1.   Identification and Quantitation of Cystic Fibrosis Factors. (Co-Investigator) RFP‑NHLBI‑HR‑77‑3, NIH. 1977 – 1981.

2.   Human Milk Peptide, Metallo‑Peptides and Trace Metals (Co-PI). RO1 HD 12465, NIH. 1978 – 1981.     

3.   Nutritional Role of Manganese Binding Molecules in Milk (PI). RO1 HD 16730, NIH. 1983 – 1986.           

4.   Genetic Studies of Pregnancy Specific b1 Glycoprotein (PI). RO1 HD 21793, NIH. 1986 – 1993. 

5.     Project 1: Role of PSG Proteins in the Testis (PI). Program Project: Cell Biology of Testis. PO1HD24633,   NIH, 1992 - 1996          

6.      Molecular Genetics of Pregnancy Specific Glycoproteins (PI). IPA, NCHGRI, NIH. 1995.  

7.   The Promonocyte Receptor for PSG11s. (PI) RO1 HD31553, NIH. 1995 - 1998                

8.   Experimental Emphysema: Studies on Remediation. (Co-Investigator)  RO1 HL59432, NIH. 1997 - 1999.

9.   Research Training in Developmental Immunology.T32 HD07185-11. NIH. 1994 – 1999.             

10. Remediation of Emphysema: Mechanism, Characterization. (Co-Investigator) 1RO1 HL60115-01A, NIH, 1998 – 2002.

 

Current Support:

 

1.  Establishment of a developmental genomics program in NICHD. IPA, NICHD, NIH. 100%,

     01/01/2001 – 09/30/2005.   $ 942,143.00, current year $ 228,652.50.     

2.  Section on Developmental Genomics, NICHD intramural support for the laboratory, 100%,