CHAWNSHANG CHANG; (U.S.A. Citizen)

Office Address: 601 Elmwood Ave. Box 626, University of Rochester, Rochester, NY 14642

           (Tel:585-2759994; Fax:585-7564133; E-Mail: chang@urmc.rochester.edu)

 

Education: 

 

1974-1978      National Taiwan University  (B.S.)       Agriculture Chemistry

1978-1980      Army Chemical School  (R.O.T.C.)      Nuclear Chemistry & Biology

1980-1985      University of Chicago  (Ph.D.)      Biochemistry & Molecular Biology

1985-1988      University of Chicago  (Post Dr.)      Molecular Endocrinology

 

Academic Experience:

 

1988-90  Assistant Professor and Director, Urology Research Labs, Dept. of Surgery/Urology and Ben May Institute for Cancer Research, University of Chicago, Chicago, IL

1990-00  Assistant Professor (90-93), Associate Professor (93-96), Professor (96-97). Visiting Professor (97-00), Director, Tissue & Blood Bank (90-97). Departments of Human Oncology and Medicine and UW Comprehensive Cancer Center, UW-Madison, WI

1998-  Visiting Professor, Osaka University, Yokohama University, Japan; Peking University and Xiamen Univ. ,Wuhan Univ., Tianjin Medical Univ, China

1999-  Visiting Prof., Chang Gung Univ./National Taiwan Univ./Taipei Medical Univ.

1997-02  Director, Molecular Oncology Graduate Program. Univ. of Rochester, Rochester, NY

1997-  Director, George Whipple Laboratory for Cancer Research, Univ. of Rochester,

1997-  Director, Urology Research Center, University of Rochester, Rochester, NY

George Whipple Distinguished Professor, Departments of Pathology, Urology and Radiation Oncology, and The Cancer Center, University of Rochester, Rochester, NY

2000-            Founder, AndroScience Corporation. San Diego, CA.

 

Honors:

 

1988       The Ayerst Award for Outstanding Young Endocrinologist from the Endocrine Society

1989  Andrew Melon Award for Outstanding Young Faculty in USA from Andrew Melon Foundation

1990  Outstanding Young Investigator Award from Cancer Research Foundation

2003                   The Milheim Award for Excellence in Cancer Research from Milheim Foundation

1992               Tokyo Society of Medical Science and University of Tokyo Lecturer

1991-94  American Cancer Society Junior Professorship in Cancer Research

1995-97  Blowity-Ridgeway Award in Andrology from Blowity-Ridgeway Foundation

1991-97  CapCure Award (6 times) for Excellence in Prostate Cancer Research

1996  Award with Honorary Fellow from The Japan Society of Andrology (The 2nd Non-Japanese ever awarded such honor)

1998         Scholar of the Year, The highest honor from The Taiwanese Osteoporosis Association for Outstanding Contribution in Sex hormones and Osteoporosis.

1998               George Hoyt Whipple Lecture, University of Rochester, Rochester, NY

1998  Jiepimg Wu Award, for Outstanding Achievement in Urology (The highest honor for Chinese-Urology Researcher). Beijing, China.

1999  President Award for Outstanding Urology Research, The highest honor from The Urology Association of Taiwan for the Contribution in Androgen Receptor and Prostate Cancer.

1999       Davey Memorial Award for Outstanding Cancer Research, University of Rochester.

2000  President Award for Outstanding Andrology Research, The highest honor from The Taiwanese Andrology Association for the studies of Androgens and Androgen Receptor.

2001       Who’s Who in America

2001       Dr. S.T.Huang-Chan memorial Lecture/Award, University of Hong Kong.

2001-     President Award for Outstanding Andrology Research, The highest honor from The

               Chinese Andrology Association for the studies of Androgens and Androgen Receptor.

2002       Dr. Chien-Tien Hsu Memorial Lecture/Award at 2002 Annual Meeting of OBGYN      

 

Grant and Publication Review:

 

1.Member of Editorial Board, Endocrine (2000-)

2.Member of Editorial Board, The Prostate Journal(2002)

3.Member of Editorial Board, The Prostate(2003-)

4.Member of Editorial Board, Neuroimmune biology (2002)

5.Reviewer in PNAS/JBC/Mol Endo/Cancer Research and 16 other peer-reviewed journals

6.NIH Study Section: Ad Hoc & Regular Member at Biochemical Endocrinology & Other  Study Section (1995-2001)

7.NIH Study Section: Ad Hoc & Regular Member at Reproductive Endocrinology (2003)

8.VA Merit Grant Oncology Study Section (1996-2002)

9.NIH Prostate SPORE P50 Center Grant; and NIH PO1 Core Grant, NIH Research Centers in Minority Institutes Core Grant, NIH P19 Orphan Receptor Center Grant.

10.ARMY Breast and Prostate Cancer Grant Study Section (1999-)

11.Air Force TCDD Grant (reviewer) (2001)

12.Medical Research Council of Canada and Dutch Cancer Society Grant;

13.Taiwan CRC Biomedical Sciences Project and Taiwan National Science Council Grant

14.Hong Kong Earmarked Research Grant; Italian Association for Cancer Research

 

Teaching: (all in University of Rochester)

 

1.Cancer Biology (3 credit, course director)

2.Biochemistry of Steroid Hormones

3.Current Topic in Pathology and Oncology

4.Signal Transduction (2 hours lecture)

5.Toxicology (2 hours lecture)

6.Epidemiology (2 hours lecture)

7. Hormones and Cancer

7.Graduate Independent Study (current 15 Ph.D. students)

                                  

Current Research Grants: direct cost only (59% extra indirect cost for U of R)

 

2003-2006DOD-ARMY Grant, Years 1-3 ($375,000), P.I.

Knockout AR in Prostate

2003-2007NIH RO1 Grant DK61222, Years 1-4 ($900,000), P.I.

TR2 & TR4 knock-out mice

2002-2007NIH RO1 Grant DK60948, Years 1-5 ($875,000), P.I.

PTEN in prostate cancer

1993-2000NIH RO1 Grant CA103006, Years 1-3 ($600,000), P.I.

AR in prostate -bone

2002-2006NIH RO1 Grant DK60905, Years 1-4 ($700,000), P.I.

Induction of AR transactivation by DHT vs E2.

2001-2005NIH RO1 Grant DK56984, Years 1-4 ($700,000), P.I.

                                          TR4 orphan receptor in testis & prostate

2001-2004    ARMY Prostate Research Grant ($375,000), P.I.

                                          suppression of AKT signal in prostate cancer.

2002-2004ARMY Research Grant ($300,000), P.I.

PTEN in breast cancer.

1997-2022    George Whipple Professorship Endowment for 25 years

 

Previous Research Grants: direct cost only (59% extra indirect cost for U of R)

 

1995-2003NIH RO1 Grant DK47258, Year 1-8 ($1,517,400), P.I.

                     TR2 & TR3 orphan receptors in prostate cancer.

1997-2002NIH RO1 Grant CA71570, Years 1-5 ($806,592), P.I.

                     Title: AR coregulators in prostate carcinogenesis.

1993-2001NIH RO1 Grant CA55639, Years 1-9 ($569,349), P.I

                     Title: T vs DHT effects in prostate cancer.

1995-97Hollis-Eden Research Award ($60,000).

                     Title: DHEA-derivatives receptor.

1998-2000NIH-NCI Research Grant Contract ($180,000), P.I.

                     Title: ARA-A1B1 CAG repeat polymorphism

1998-2001ARMY Prostate Research Grant ($486,000), Co-P.I. (PI:Harrison.

                     Title: Androgen effects on LNCaP prostate cancer cell growth

1997-2001Rhone-Poulenc Rorer Research Award ($50,000)

Title:  AR Coregulators

1995-2000NIH RO1 Grant DK51346, Years 1-5($950,815), P.I.

AR CAG polymorphism

1998-2000    NIH Training Grant ($60,000 for Drs. Young & Yeh to study in P.I.’ lab)

1999-2002CaP CURE Research Award ($600,000), P.I.

The roles of AR in prostate

1995-1998    NIH Research Grant  CA 23563 ($465,433) Co P.I.(P.I.:Verma)

1993-1997    NIH Research Grant P30 CA 14520 ($210,000), P.I.(Tissue Bank Project) 

1992-1997    NIH Research Grant  CA 10536 ($607,331) Co P.I.(P.I.:Weindruch)

1996-1997    The Blowity-Ridgeway Foundation Award ($120,000), P.I.

1996-1997    Glaxo Research Fund ($35,000), P.I.

1992-1997    Taiwan National Science Council ($100,000 for 2 scientists studying in lab )

1990-1997    NIH Research P30 CA 14520. Co Investigator, 30% salary support

1995-1996    UW Comprehensive Cancer Center Award ($14,000), P.I.

1995-1996    UW Graduate School Research Award ($10,000), P.I.

1994-1996    Triton Research Fund ($21,400), P.I.

1994-1996    UW Medical School Merit Award ($65,000), P.I.

1994-1996      Anderson Research Fund($23,000), P.I.

1994-1995    CaP CURE Research Award ($100,000), Co P.I. (P.I.:Messing)

1994-1995    Adria Research Fund ($20,000), P.I.

1993-1994    NIH Training Grant ($40,000 for Dr. Lin to study in my lab)

1992-1994    Uehara Foundation ($20,000 for Dr. Kurada to study in my lab)

1992-1994    Shiseido Research Foundation ($35,000), P.I.

1991-1994    ACS Research Grant  BE-78 and BE-78a ($314,968), P.I.

1991-1994      University of Wisconsin Grants (4 grants for total $106,000), P.I.

1990-1993      American Cancer Society Junior Faculty Award ($90,500)

1989-1991    Cancer Research Foundation Young Investigator Award ($40,000)

1989-1991    Milheim Foundation Young Investigator Award ($20,000)

1988-1991      American Cancer Society (ACS) Research Grants ($81,415), P.I.

1988-1989    Louis Block and Coleman Foundations ($45,000), P.I.

 

Patents:

 

1. Androgen receptor and TR2 orphan receptor.

2. Androgen receptor coregulators ARA70, ARA55, ARA54, ARA24, BRCA1, Rb

3. Using differential length of androgen receptor’ and ARAs’ CAG repeat to predict prostate cancer risk in Chinese population.

4.Cross-talk between androgen receptor and other signal pathways (TGFb, Her2/Neu,MAPK, IL6/PI3K/AKT, PTEN, BRCA1, RB).

5.Using Aortic endothelial cells to screen SERMs.

6.Vitamin E as anti-prostate cancer agent

7.Androgen receptor knock out mice

8.TR2 and TR4 knock out mice

9, Antiandrogen HF avtivates MAPK pathway in prostate cancer.

10.Cucurmin analogs function as antiandrogen

 

Membership:

 

1. The Endocrine Society

2. American Society for Biochemistry and Molecular Biology

3. American Association for Cancer Research

3. American Urology Association

 

Invited Speaker:

 

I. International and National Meetings: (Total 67 since 1988)

 

1.Second International Symposium on "The Steroid/Thyroid Hormone Receptor Family

            and Gene Regulation".Stockholm, Sweden. (1988)

2.Satellite Symposium of the 8th International Congress of Endocrinology on "Steroid

            Antagonists", Kyoto, Japan. (1988)

3.Prostate Cancer National Symposia on "Molecular and Cellular Biology of Prostate

            Cancer", Prouts Neck, Maine. (1989)

4.Terra Symposia on "Androgens & Antiandrogens"  New Paltz, New York. (1991)

5.The First International Symposium on "Steroid Receptor Superfamily" UW-Madison. WI

            (1992) Symposium director.

6.First Asian & Oceanic Congress of Andrology.  Nanjing, China (1992).

7.International Symposium on Tumor Biology. Taipei, Taiwan (1994)

8.International Symposium on Sex Hormones and Antihormones. Milano, Italy (1994)

          Chairman of the Androgen Section.

9.American Urological Association Summer Research Conference. Houston, Texas (1994)

10.The American Association for Cancer Research/Taiwan Conference. Taipei, Taiwan  (1994)

11.The Second International Symposium on "Steroid Receptor Superfamily" UW-Madison. WI

            (1994) Symposium director.

12.The Second International Conference on Androgens. Long Beach, CA (1995)

13.Mary Lasker Symposium on Frontiers of Cancer Research. San Diego, CA (1995)

14.The Second Annual CaP CURE Scientific Meeting. Santa Barbara, CA (1995)

15.The Second Symposium of Severtance Institute of Andrology, Seoul, Korea (1996)

16.The Third Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1996)

17.The 10th International Congress of Endocrinology. SF, CA (1996)

18.National Prostate Cancer Coalition. Houston, TX (1996)

19.The Third International Symposium on "Steroid Receptor Superfamily" UW-Madison. WI

             (1996), Symposium director.

20.The Fourth Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1997)

21.Golden Conference. New England (1997)

22.The VIth International Congress of Andrology. Salzburg, Austria (1997), Plenary Lecture

23.Cambridge Symposium on ”Gene Transcription and Therapeutic Interaction”. Washington

             D.C. (1997)

24.The 7th SCBA International Symposium on Hormone Action, Toronto, Canada (1997)

25.International Symposium of “Molecular Basis of Sex Hormone Receptor Function-New

             Targets for Intervention” Berlin, Germany (1997)

26.The International Symposium for 50th Year Urology in Yokohama City University, Japan.

       (1997), Keynote speaker.

27.The Japan Annual Andrology Meeting. Yokohama, Japan. (1997), Keynote speaker

28.The China Andrology Meeting, Yichong, China (1997), Keynote speaker.

29.The Annual Endocrine Society Meeting, Minneapolis, (1997)

30.The Fifth Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1998)

31.The China-Japan International Urology Symposium, Shanghai, China, Keynote speaker (1998)

32.The Annual China Urology Meeting, Shanghai, China, Keynote speaker (1998)

33.Keystone Symposium on “Nuclear Receptor Gene Family” (1998)

34.The First International Chinese Urology Symposium, Shanghai, China, Keynote speaker (1998)

35.The Annual Taiwan Urology Meeting, Hualein, Taiwan, Keynote speaker (1999)

36.AACR Conference on “The Steroid Receptor Superfamily” Palm Springs, CA (1999)

37.The 8th SCBA International Symposium on Hormone Action, Hong Hong (1999)

38.The Annual Taiwanese Osteoporosis Association Meeting, Kaohsiung, Taiwan,          

             Keynote speaker (1999)

39. International Conferences on Gene Therapy and Mol. Biology & Medicine, Grete, Greece (1999)

40.The Sixth Annual CaP CURE Scientific Meeting. Lake Tahoe, CA (1999)

41.The Annual Endocrine Society Meeting, San Diego, (1999)

42.The 92nd Annual Meeting of Formosan Medical Association, Taipei, (1999)

43.Golden Conference. New England (1999)

44.North American Taiwanese Professor Association-Southern California Chapter, Irvine, CA (1999)

45.The Asia-Pacific International Urology Meeting, Beijing, China, Keynote speaker (2000)

46.17th Meeting of the International Academy of Tumor Marker Oncology, Hong Kong (2000)

47.The Second International Chinese Urology Symposium, Beijing, China, Keynote speaker (2000)

48.The Annual China Urology Meeting, Beijing, China, Keynote speaker (2000)

49.The 4th International Spinal and Muscular Atrophy Research & Clinical Meeting. St Louis (2000)

50.The Steroid Receptors and Cell Signal Pathways Symposium. Cincinnati, Ohio (2000)

51.The International Scientific Summit Conference On Current Gynecology, Taipei, Taiwan (2000)

52. The Annual Chinese Andrology Meeting, Han-Chou, China, Keynote speaker (2001)         

53. The Annual Taiwanese Andrology Meeting, Taichung, Taiwan. Keynote speaker (2001)

54.US-Taiwan Global Bio/Pharm Conference. Newark, NJ (2001)

55.Annual Meeting of Taiwanese Association of OBGYN, Taipei, Taiwan (2002)

56.The 2002 Annual Meeting of Chinese Medical Association, Taipei, Taiwan (2002)

57.The 2002 Annual Meeting of Taiwanese Urology Association, Taipei, Taiwan (2002)

58.the 3rd Conference of the Pacific Rim Society for Fertility and Sterility, Taipei, Taiwan (2002)

59.The 2002 Annual Meeting of Chinese Urology Association, Changsha, China (2002)

60.The 12th Asia-Oceania Congress of Endocrinology, Taipei, Taiwan (2002)

61.Mid