December 10, 2004

 

Junichi Fujii

 

Citizenship:     Japan

 

Title:             Ph. D., Professor

 

Address:          Department of Biomolecular Function

                 Major of Environmental Life Science

                 Graduate School of Medical Science

                 Yamagata University

                 2-2-2 Iidanishi, Yamagata 990-9585

                 JAPAN

                 Tel:       +81-23-628-5227

                 FAX:      +81-23-628-5230

                 e-mail: jfujii@med.id.yamagata-u.ac.jp

 

Education:

   1982         B. S., Shizuoka University, Shizuoka, Japan

   1984         M. S., Shizuoka University, Shizuoka, Japan

   1988         Ph. D., Osaka University Medical School, Osaka, Japan

 

Research Experience:

   1987-1988  Research fellow, at the Banting and Best Department of

              Medical Research, University of Toronto, Toronto, Canada

   1988-1990  Postdoctoral fellow, at the above Department

   1990-1991  Postdoctoral fellow of Japan Society for the Promotion of

Science,

  Department of Biochemistry, Osaka University Medical School, Japan

   1991-1992   Research Associate in the same Department

   1992-1996   Assistant Professor in the same Department

   1996-1999   Associate Professor in the same Department

   1999-2004   Professor, Department of Biochemistry

                                    Yamagata University School of Medicine

   2004-present Professor, Department of Biomolecular Function

                  Major of Environmental Life Science

                  Graduate School of Medical Science, Yamagata University

 

 

Junichi FUJII---Original Papers--- December 10, 2004

 (IF; Impact Factor total 104, CI; Citation Index)

 

1.          Shinpei Yamada, Junichi Fujii, and Hajime Katayama

Sarcoplasmic Reticulum Ca-ATPase: Distinction of Phosphoenzyme Formed from Mg ATP and Ca ATP as Substrates and Interconversion of the Phosphoenzymes by Mg2+ and Ca2+.

J. Biochem. 100: 1329-1342 (1986)  (IF=2.191, CI=18)

 

2.          Junichi Fujii, Masaaki Kadoma, Michihiko Tada, Hiroko Toda, and Fumio Sakiyama.

Characterizaion of Structural Unit of Phospholamban by Amino Acid Sequencing and Electrophoretic Analysis

Biochem. Biophys. Res. Commun. 138: 1044-1050 (1986)  (IF=3.161, CI=45)

 

3.          Junichi Fujii, Atsuko Ueno, Katsuhiko Kitano, Shoji Tanaka, Masaaki Kadoma, and Michihiko Tada.

Complete Complementary DNA-derived Amino Acid Sequence of Canine Cardiac Phospholamban.

J. Clin. Invest. 79: 301-304 (1987)  (IF=10.921, CI=135)

 

4.          Atsuko Uyeda, Katsuhiko Kitano, Junichi Fujii, Masaaki Kadoma, Michihiko Tada, and Shoji Tanaka. 

The cDNA sequence of the Major Phospholamban mRNA in Canine Cardiac Muscle

Nucleic Acids Res. 15: 6738 (1987)  (IF=5.748, CI=7)

 

5.          Junichi Fujii, Jonathan Lytton, Michihiko Tada, and David H. MacLennan

Rabbit Cardiac and Slow-twitch Muscle Express the Same Phospholamban Gene.

FEBS Lett. 227: 51-55 (1988)  (IF=3.720, CI=63)

 

6.          Ryozo Nagai, Angel Zarain-Herzberg, Christopher J. Brandl, Junichi Fujii, Michihiko Tada, David H. MacLennan, Norman R. Alpert, and Muthu Periasamy

Regulation of Myocardial Ca-ATPase and Phospholamban mRNA Expression in Response to Pressure Overload and Thyroid Hormone.

Proc. Natl. Acad. Sci. USA. 86: 2966-2970 (1989)  (IF=10.260, CI=251)

 

7.          Ekkehard Leberer, Kar-Thomas Hartner, Christopher, J. Brandl, Junichi Fujii, Michihiko Tada, David H. MacLennan, and Dirk Pette

Slow/cardiac Sarcoplasmic Reticulum Ca2+-ATPase and Phospholamban mRNAs are Expressed in Chronically Stimulated Rabbit Fast-twitch Muscle.

Eur. J. Biochem. 185: 51-54 (1989)  (IF=3.307, CI=64)

 

8.          Junichi Fujii, Kei Maruyama, Michihiko Tada, and David H. MacLennan

Expression and Site-specific Mutagenesis of Phospholamban: Studies of Residues Involved in Phosphorylation and Pentamer Formation.

J. Biol. Chem. 264: 12950-12955 (1989)  (IF=7.666, CI=74)

 

9.          Kei Maruyama, David M. Clarke, Junichi Fujii, Giuseppe Inesi, Tip W. Loo, and David H. MacLennan

Functional Consequences of Alterations to Amino Acids Located in the Catalytic (Isolucine 348 to Threonine 357) and Nucleotide-binding Domain of the Ca2+-ATPase of Sarcoplasmic Reticulum.

J. Biol. Chem. 264: 13038-13042 (1989)  (IF=7.666, CI=89)

10.      Francesco Zorzato, Junichi Fujii, Kinya Otsu, Michael Phillips, N. Michael Green, F. Anthony Lai, Gerhard Meissner, and David H. MacLennan. 

Molecular Cloning of cDNA Encoding Human and Rabbit Forms of the Ca2+ Release Channel (Ryanodine Receptor) of Skeletal Muscle Sarcoplasmic Reticulum.

J. Biol. Chem. 265: 2244-2256 (1990)  (IF=7.666, CI=429)

 

11.      David H. MacLennan, Chatherine Duff, Francesco Zorzato, Junichi Fujii, Michael

Phillips, Robert G. Korneluk, Wanda Frodis, Beverley A. Britt, and Ronald G. Worton.

The Ryanodine Receptor Gene is a Candidate Gene for the Predisposition to Malignant Hyperthermia.

Nature 343: 559-561 (1990)  (IF=29.491 CI=331)

 

12.      Junichi Fujii, Huntington F. Willard, and David H. MacLennan

Characterization and Localization to Human Chromosome 1 of the Human Fast- twitch Skeletal Muscle Calsequestrin Gene.

Somat. Cell Mol. Genet. 16: 185-189 (1990)  (IF=0.835, CI=13)

 

13.      Alex E. MacKenzie, Robert G. Korneluk, Francesco Zorzato, Junichi Fujii, Michael Phillips, David Iles, Be Wieringa, Suzanne Leblond, Jane Bailly, Huntington F. Willard, Cathenine Duff, Ronald G. Worton, and David H. MacLennan

The Human Ryanodine Receptor Gene: Its Mapping to 19q13.1, Placement in a Chromosome 19 Linkage Group and Exclusion as the Gene Causing Myotonic Dystrophy.

Am. J. Hum. Genet. 46: 1082-1089 (1990)  (IF=10.426, CI=78)

 

14.      Junichi Fujii, Kei Maruyama, Michihiko Tada, and David H. MacLennan

Co-expression of Cardiac/slow-twitch Ca2+-ATPase (SERCA2) and Phospholamban.

FEBS Lett. 273: 232-234 (1990)  (IF=3.720, CI=35)

 

15.      Junichi Fujii, Angel Zarain-Herzberg, Huntington, F. Willard, Michihiko Tada, and David H. MacLennan 

Structure of the Rabbit Phospholamban Gene, Cloning of the Human cDNA and Assignment of the Gene to Human Chromosome 6.

J. Biol. Chem. 266: 11669-11675 (1991)  (IF=7.666, CI=44)

 

16.      Junichi Fujii, Kinya Otsu, Francesco Zorzato, Stella de Leon, Vijay K. Khanna, Janice E. Weiler, Peter J. O'Brien, and David H. MacLennan

Identification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant Hyperthermia.

Science 253: 448-451 (1991)  (IF=24.595, CI=572)

 

17.      Elizabeth F. Gillard, Kinya Otsu, Junichi Fujii, Vijay K. Khanna, Stella de Leon, Jeanette Derdemezi, Beverley A. Britt, Catherine L. Duff, Ronald G. Worton, and David H. MacLennan

A Substitution of Cysteine for Arginine 614 in the Ryanodine Receptor is Potentially Causative of Human Malignant Hyperthermia.

Genomics 11: 751-755 (1991)  (IF=3.386, CI=190)

 

 

 

18.      Junichi Fujii and Naoyuki Taniguchi

Phorbol Ester Induces Manganese-superoxide Dismutase in Tumor Necrosis Factor-resistant Cells

J. Biol. Chem. 266: 23142-23146 (1991)  (IF=7.666, CI=78)

 

19.      Elizabeth F. Gillard, Kinya Otsu, Junichi Fujii, Catherine Duff, Stella de Leon,Vijay K. Khanna, Beverley A. Britt, Ronald G. Worton, and David H. MacLennan

Polymorphisms and Deduced Amino Acid Substitutions in the Coding Sequence of the Ryanodine Receptor (RYR1) Gene in Individuals with Malignant Hyperthermia.

Genomics 13: 1247-1254 (1992)  (IF=3.386, CI=109)

 

20.      Eiji Miyoshi, Junichi Fujii, Norio Hayashi, Keiji Ueda, Takehiro Towata, Hideyuki Fusamoto, Takenobu Kamada, and Naoyuki Taniguchi

Enhancement of Hepatitis B Surface Antigen Expression by 5-Azacytidine in a

Hepatitis B Virus-transfected Cell Line. 

Int. J. Cancer 52: 137-140 (1992)  (IF=3.545, CI=1)

 

21.      Toshiyuki Nakata, Keiichiro Suzuki, Junichi Fujii, Mutsuo Ishikawa, Haruyuki Tatsumi, Toru Sugiyama, Takashi Nishida, Tetsuya Shimizu, Michiaki Yakushiji, and Naoyuki Taniguchi

High Expression of Mn-superoxide Dismutase in 7,12-Dimethylbenz(a)anthracene-

induced Ovarian Cancer and Increased Serum Levels in the Tumor-bearing Rats

Carcinogenesis 13: 1941-1943 (1992)  (IF=4.118, CI=9)

 

22.      Yoshitaka Ikeda, Junichi Fujii, and Naoyuki Taniguchi.

Significance of Arg-107 and Glu-108 in the Catalytic Mechanism of Human g-Glutamyl Transpeptidase: Identification by Site-directed Mutagenesis

J. Biol. Chem. 268: 3980-3985 (1993)  (IF=7.666, CI=26)

 

23.      Motoko Takahashi, Junichi Fujii, Tadashi Teshima, Keiichiro Suzuki, Tetsuo Shiba, and Naoyuki Taniguchi

Identity of a Major 3-Deoxyglucosone Reducing Enzyme with Aldehyde Reductase in Rat Liver Established by Protein Sequencing and cDNA Expression

Gene 127: 249-253 (1993)  (IF=2.258, CI=45)

 

24.      Toshiyuki Nakata, Keiichiro Suzuki, Junichi Fujii, Mutsuo Ishikawa, and Naoyuki Taniguchi

Induction and Release of Manganese Superoxide Dismutase from Mitochondria from Human Umbilical Vein Endothelial Cells by Tumor Necrosis Factor-a and Interleukin-1a

Int. J. Cancer 55: 646-650 (1993)  (IF=3.545, CI=16)

 

25.      Eiji Miyoshi, Suresh K. Jain, Toshihiro Sugiyama, Junichi Fujii, Norio Hayashi,

Hideyuki Fusamoto, Takenobu Kamada, and Naoyuki Taniguchi

Expression of DNA Methyltransferase in LEC Rats during Hepatocarcinogenesis

Carcinogenesis 14: 603-605 (1993)  (IF=4.118, CI=11)

 

26.      Kinya Otsu, Junichi Fujii, Muthu Periasamy, Michael Difilippantonio, Madhvi Uppender, David C. Ward, and David H. MacLennan

Chromosome Mapping of Five Human Cardiac and Skeletal Muscle Sarcoplasmic   

Reticulum Protein Genes

Genomics 17: 507-509 (1993)  (IF=3.386, CI=46)

27.      Keiichiro Suzuki, Haruyuki Tatsumi, Shoji Satoh, Takao Senda, Toshiyuki Nakata, Junichi Fujii, and Naoyuki Taniguchi

Manganese-superoxide Dismutase in Endothelial Cells: Localization and Mechanism of Induction.

Am. J. Physiol. 265: H1173-H1178 (1993)  (IF=2.747, CI=42)

 

28.      Han Geuk Seo, Haruyuki Tatsumi, Junichi Fujii, Atsushi Nishikawa, Keiichiro Suzuki, Kenji Kangawa, and Naoyuki Taniguchi.

Nitric Oxide Synthase from Rat Colorectum: Purification, Peptide Sequencing, Partial PCR, and Immunohistochemistry 

J. Biochem. 115: 602-607 (1994)  (IF=2.191, CI=19)

 

29.      Junichi Fujii, Toshiyuki Nakata, Yoshitaka Ikeda, Eiji Miyoshi, and Naoyuki Taniguchi

Induction of Manganese Superoxide Dismutase mRNA by Okadaic Acid and Protein Synthesis Inhibitors.

Biochem. J. 301: 31-34 (1994)  (IF=4.349, CI=13)

 

30.      Ryoichi Nakano, Shuzo Sato, Takashi Inuzuka, Kenji Sakimura, Masayoshi Mishina, Hitoshi Takahashi, Fusahiro, Ikuta, Yoshiaki Honma, Junichi Fujii, Naoyuki Taniguchi, and Shoji Tsuji

A Novel Mutation in Cu/Zn Superoxide Dismutase Gene in a Japanese Familial Amyotrophic Lateral Sclerosis. 

Biochem. Biophys. Res. Commun. 200: 695-703 (1994)  (IF=3.161, CI=75)

 

31.      Yoshiro Kayanoki, Junichi Fujii, Keiichiro Suzuki, Sumio Kawata, Yuji Matsuzawa, and Naoyuki Taniguchi.

Suppression of Antioxidative Enzyme Expression by Transforming Growth Factor-b1 in Rat Hepatocytes.

J. Biol. Chem. 269: 15488-15492 (1994)  (IF=7.666, CI=99)

 

32.      Hideaki Kaneto, Junichi Fujii, Keiichiro Suzuki, Hiroshi Kasai, Ryuzo Kawamori, Takenobu Kamada, and Naoyuki Taniguchi.

DNA Cleavage Induced by Glycation of Cu,Zn-superoxide Dismutase.

Biochem. J. 304: 219-225 (1994)  (IF=4.349, CI=28)

 

33.      Makito Hirano, Junichi Fujii, Yoshitaka Nagai, Masanobu Sonobe, Koichi Okamoto, Heihachi Araki, Naoyuki Taniguchi, and Satoshi Ueno

A New Variant Cu/Zn Superoxide Dismutase (Val7→Glu) Deduced from Lymphocyte mRNA Sequences from Japanese Patients with Familial Amyotrophic Lateral Screlosis. 

Biochem. Biophys. Res. Commun. 204: 572-577 (1994)  (IF=3.161, CI=40)

 

34.      Yoshitaka Ikeda, Junichi Fujii, Naoyuki Taniguchi, and Alton Meister.

Expression of an Active Glycosylated Human g-Glutamyl Transpeptidase Mutant

That Lacks a Membrane Anchor Domain.

Proc. Natl. Acad. Sci. USA. 92: 126-130 (1995)  (IF=10.260, CI=16)

 

35.      Motoko Takahashi, Lu Ya-bin, Theingi Myint, Junichi Fujii, Yoshinao Wada, and Naoyuki Taniguchi.

In Vivo Glycation of Aldehyde Reductase, a Major 3-Deoxyglucosone Reducing Enzyme: Identification of Glycation Sites. 

Biochemistry 34: 1433-1438 (1995)  (IF=4.493, CI=37)

 

36.      Junichi Fujii, Theingi Myint, Han Geuk Seo, Yoshiro Kayanoki, Yoshitaka Ikeda, and Naoyuki Taniguchi.

Characterization of Wild-type and Amyotrophic Lateral Sclerosis-related Mutant Cu,Zn-superoxide Dismutase Overprodued in Baculovirus-infected Insect Cells.

J. Neurochem. 64: 1456-1461 (1995)  (IF=4.906, CI=24)

 

37.      Han Geuk Seo, Junichi Fujii, Hidenobu Soejima, Norio Niikawa, and Naoyuki Taniguchi.

Heme Requirement for Production of Active Endothelial Nitric Oxide Synthase in

Baculovirus-infected Insect Cells.

Biochem. Biophys. Res. Commun. 208: 10-18 (1995)  (IF=3.161, CI=21)

 

38.      Terry K. Smith, Yoshitaka Ikeda, Junichi Fujii, Naoyuki Taniguchi, and Alton Meister. 

Different Sites of Acivicin Binding and Inactivation of g-Glutamyl Transpeptidase.

Proc. Natl. Acad. Sci. USA. 92: 2360-2364 (1995)  (IF=10.260, CI=21)

 

39.      Yoshitaka Ikeda, Junichi Fujii, Naoyuki Taniguchi, and Alton Meister. 

Human g-Glutamyl Transpeptidase Mutants Involving Conserved Aspartate Residues and the Unique Cysteine Residues of the Light Subunit.

J. Biol. Chem. 270: 12471-12475 (1995)  (IF=7.666, CI=19)

 

40.      Hideaki Kaneto, Junichi Fujii, Han Geuk Seo, Keiichiro Suzuki, Taka-aki Matsuoka, Masahiro Nakamura, Haruyuki Tatsumi, Yoshimitsu Yamasaki, Takenobu Kamada, and Naoyuki Taniguchi.

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic b-cells.

Diabetes 44: 733-738 (1995)  (IF=9.019, CI=218)

 

41.      Michio Asahi, Junichi Fujii, Keiichiro Suzuki, Han Geuk Seo, Tsunehiko Kuzuya, Masatsugu Hori, Michihiko Tada, Shigeru Fujii, and  Naoyuki Taniguchi

Inactivation of Glutathione Peroxidase by Nitric Oxide: Implication for Cyototoxicity.

J. Biol. Chem. 270: 21035-21039 (1995)  (IF=7.666, CI=147)

 

42.      Yoshitaka Ikeda, Junichi Fujii, Mary E. Anderson, Naoyuki Taniguchi, and Alton Meister. 

Involvement of Ser-451 and Ser-452 in the Catalysis of Human g-Glutamyl Transpeptidase.

J. Biol. Chem. 270: 22223-22228 (1995)  (IF=7.666, CI=23)

 

43.      Motoko Takahashi, Junichi Fujii, Eiji Miyoshi, Ayumu Hoshi, and Naoyuki Taniguchi.

Elevation of Aldose Reductase Gene Expression in Rat Primary Hepatoma and Hepatoma Cell Lines: Implication in Detoxification of Cytotoxic Aldehydes. 

Int. J. Cancer 62: 749-754 (1995)  (IF=3.545, CI=29)

 

44.      Hiroyuki Saito, Jianguo Gu, Atsushi Nishikawa, Yoshito Ihara, Junichi Fujii, Yutaka Kohgo, and Naoyuki Taniguchi.

Organization of the Human N-Acetylglucosaminyltransferase V Gene.

Eur. J. Biochem. 233: 18-26 (1995)  (IF=3.307, CI=31)

 

 

 

 

45.      Han Geuk Seo, Ikuya Takata, Masahiro Nakamura, Haruyuki Tatsumi, Keiichiro Suzuki, Junichi Fujii, and Naoyuki Taniguchi

Induction of Nitric Oxide Synthase and Concomitant Suppression of Superoxide Dismutases in Experimental Colitis in Rats

Arch. Biochem. Biophys. 324: 41-47 (1995)  (IF=2.386, CI=51)

 

46.      Yilin Zhang, Junichi Fujii, Michael S. Phillips, Hai-Shiene Chen, George Karpati, Won-Chee Yee, Bertold Schrank, David R. Cornblath, Kevin B. Boylan, and David H. MacLennan.

Characterization of cDNA and Genomic DNA Encoding SERCA1, the Ca2+-ATPase of Human Fast-Twitch Skeletal Muscle Sarcoplasmic Reticulum, and Its Elimination as a Candidate Gene for Brody Disease

Genomics 30: 415-424 (1995)  (IF=3.386, CI=33)

 

47.      Han Geuk Seo, Noriko Fujiwara, Hideaki Kaneto, Michio Asahi, Junichi Fujii, and Naoyuki Taniguchi.

Effect of a Nitric Oxide Synthase Inhibitor, S-Ethylisothiourea, on Cultured Cells and Cardiovascular Functions of Normal and Lipopolysaccharide-treated Rabbits.

J. Biochem. 119: 553-558 (1996)  (IF=2.191, CI=5)

 

48.      Motoko Takahashi, Ayumu Hoshi, Junichi Fujii, Eiji Miyoshi, Takehiro Kasahara, Keiichiro Suzuki, Katsuyuki Aozasa, and Naoyuki Taniguchi. 

Induction of Aldose Reductase Gene Expression in LEC Rats during Development of the Hereditary Hepatitis and Hepatoma. 

Jpn. J. Cancer Res. 87: 337-341 (1996)  (IF=2.117, CI=17)

 

49.      Yoshiro Kayanoki, Junichi Fujii, Kazi Nazrul Islam, Keiichiro Suzuki, Sumio Kawata, Yuji Matsuzawa, and Naoyuki Taniguchi.

The Protective Role of Glutathione Peroxidase in Apoptosis Induced by Reactive Oxygen Species.   

J. Biochem. 119: 817-822 (1996)  (IF=2.191, CI=62)

 

50.      Yoshitaka Ikeda, Junichi Fujii, and Naoyuki Taniguchi. 

Effect of Substitutions of Conserved Histidine Residues in Human g-Glutamyl Transpeptidase.

J. Biochem. 119: 1166-1170 (1996)  (IF=2.191, CI=4)

 

51.      Ayumu Hoshi, Motoko Takahashi, Junichi Fujii, Theingi Myint, Hideaki Kaneto,  Keiichiro Suzuki, Yoshimitu Yamasaki, Takenobu Kamada, and Naoyuki Taniguchi.

Glycation and Inactivation of Sorbitol Dehydrogenase in Normal and Diabetic Rats. Biochem. J. 318: 119-123 (1996)  (IF=4.349, CI=19)

 

52.      Ryoichi Nakano, Takashi Inuzuka, Koki Kikugawa, Hitoshi Takahashi, Kenji Sakimura, Junichi Fujii, Naoyuki Taniguchi, and Shoji Tsuji

Instability of Mutant Cu/Zn Superoxide Disumutase (Ala4Thr) Associated with Familial Amyotrophic Lateral Sclerosis. 

Neurosci. Lett. 211: 129-131 (1996)  (IF=2.085, CI=11)

 

53.      Ayako Okado, Yoshimi Kawasaki, Yukiko Hasuike, Motoko Takahashi, Tadashi Teshima, Junichi Fujii, and Naoyuki Taniguchi

Induction of Apoptotic Cell Death by Methylglyoxal and 3-Deoxyglucosone in Macrophage-Derived Cell Lines. 

Biochem. Biophys. Res. Commun. 225: 219-224 (1996)  (IF=3.161, CI=57)

54.      Michael S. Phillips, Junichi Fujii, Vijay K. Khanna, Stella DeLeon, Kathy Yokobata, Pieter J. de Jong, and David H. MacLennan

The Structural Organization of the Human Skeletal Muscle Ryanodine Receptor (RYR1) Gene. 

Genomics 34: 24-41 (1996)  (IF=3.386, CI=67)

 

55.      Noriko Fujiwara, Ayako Okado, Han Geuk Seo, Junichi Fujii, Kigen Kondo, and Naoyuki Taniguchi

Quinazoline Derivatives Suppress Nitric Oxide Production by Macrophages through Inhibition of NOS II Gene Expression

FEBS Lett. 395:299-303 (1996)  (IF=3.720, CI=3)

 

56.      Hideaki Kaneto, Junichi Fujii, Theingi Myint, Kazi Nazrul Islam, Nobuko Miyazawa, Keiichiro Suzuki, Yoshimi Kawasaki, Masahiro Nakamura, Haruyuki Tatsumi, Yoshimitsu Yamasaki, and Naoyuki Taniguchi.

Reducing Sugar Triggers Oxidative Modification and Apoptosis in Pancreatic b-cells by Provoking Oxidative Stres