David John Grignon

DAVID JOHN GRIGNON

Current Address

Department of Pathology

Harper University Hospital

3990 John R

Detroit, MI 48201

Telephone: (313) 745-2520

FAX: (313) 745-8673

email: dgrignon@med.wayne.edu

Current Position

Professor and Chairman, Department of Pathology, Wayne State University,

Adjunct Professor, School of Pharmacy and Allied Health

Specialist-in-Chief, Detroit Medical Center

Detroit, MI

Other Professional Activities

Chairperson, Pathology Committee, Radiation Therapy Oncology Group (R.T.O.G.), Philadelphia, PA. (1992 - 2001)

Member, Pathology Committee (Central reviewer, prostate cancer protocols), Radiation Therapy Oncology Group (R.T.O.G.), Philadelphia, PA. (1989 - present)

RTOG Protocol No. 8531 (Closed). "A phase III study of Zoladex adjuvant to radiotherapy in unfavorable prognosis carcinoma of the prostate." (Study chairman: MV Pilepich; Co-chairmen: GE Hanks, M Al-Sarraf; Pathology: DJ Grignon, accrual 931 cases)

RTOG Protocol No. 8610 (Closed). "A phase III study of Zoladex and Flutamide used as cytoreductive agents in locally advanced carcinoma of the prostate treated with definitive radiotherapy." (Study chairmen: MV Pilepich, M Al-Sarraf, MJ John, DJ Grignon, DG McGowen; accrual 471 cases)

RTOG Protocol No. 90-20 (Closed). "A phase II trial of external beam radiation with Etanidazole (SR-2508) for the treatment of locally advanced prostate cancer." (Study Chairmen: CN Coleman, C Lawton, J Heaney, D Grignon, T Wasserman; accrual 38 cases)

RTOG Protocol No. 91-17 (Closed). "An observational clinical study of the significance of positive prostatic biopsies following full dose external beam irradiation of patients with bulky locally advanced adenocarcinoma of the prostate, stages T2b and T3, NX or N0 or N1, M0, previously treated on RTOG 86-10. (Study chairmen: MD Hafermann, RH Bard, DJ Grignon, E Hammond)

RTOG Protocol No. 92-02 (Closed). "A phase III trial of long term total androgen suppression following neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate." (Study chairmen: GE Hanks, AT Porter, H Lepor, DJ Grignon; accrual 1554 cases)

RTOG Protocol No. 94-08 (Open). "A phase III trial of the study of endocrine therapy as a cytoreductive and cytostatic agent prior to radiation therapy in good prognosis locally confined adenocarcinoma of the prostate." (Study chairmen: DG McGowen, CU Jones, M Chetner, DJ Grignon; planned accrual 510 cases)

RTOG Protocol 96-01 (Open). "A phase III trial of radiation therapy with or without Casodex in patients with PSA elevation following radical prostatectomy for pT3NO carcinoma of the prostate." (Study chairmen: WU Shipley, D Raghavan, NM Heney and DJ Grignon; planned accrual 1220 patients).

RTOG Protocol 96-08 (Closed). "A phase III trial of total androgen suppression versus total androgen suppression plus definitive external beam radiation therapy for pathologic lymph node positive (pN+) adenocarcinoma of the prostate." (Study chairmen: CA Lawton, B. Donnelly and DJ Grignon, planned accrual 750 patients).

RTOG protocol 98-05 (Open). “Phase II Trial of transrectal ultrasound guided permanent radioactive implantation of the prostate for definitive management of localized adenocarcinoma of the prostate.” (Study Chairmen CA Lawton, M Gillin, LG Gomella and DJ Grignon, planned accrual 95 patients).

RTOG protocol 99-02 (Open). “A phase III protocol of androgen suppression and radiation therapy vs. AS and RT followed by chemotherapy with poclitaxel estramustine and etoposide for localized, high risk prostate cancer.” (Study chairs: H Sandler, S Posenthal, K Pienta, L Gomella and D Grignon, planned accrual 1,440 patients).

RTOG protocol P-0011-1 (Open). “Phase III randomized study of adjuvant therapy for high-risk pT2-T3NO prostate cancer.” (Study chairs: R. Valicenti, K. Pienta, L. Gomella, D. Grignon and R. Choo; planned accrual 1398 patients).

Invited member, special review committee, Specialized Programs of Research Excellence (SPORE), Prostate Cancer, National Institute of Health, Bethesda, MD (1995)

Ad-hoc reviewer, National Cancer Institute, Bethesda, MD (1992 - present)

Reviewer, Abstracts (Genitourinary), United States - Canadian Academy of Pathology. (1992-1995; 2002-2004)

Invited reviewer: Cancer, Diagnostic Cytopathology, The Prostate, American Journal of Clinical Pathology, International Journal of Radiation Oncology Biology Physics, American Journal of Surgical Pathology, Urology, Journal of Urology, Journal of the National Cancer Institute

Reference Pathologist, "A phase III study of the use of cyproterone acetate as a cytoreductive agent in locally advanced carcinoma of the prostate treated with definitive radiotherapy." Berlex Canada, Lachine, Quebec. (Dr. A. Porter, Study Chairman; Closed accrual 208 cases)

Participant, Special Study Group for review of Specialized Programs of Research Excellence (SPORE) in Prostate Cancer, National Institutes of Health, Bethesda, MD, 1992

Member of Council, Ontario Medical Association Section on Laboratory Medicine, Toronto, Canada. (1989-1992)

Member, Genitourinary Pathology Panel, Canadian Reference Centre for Cancer Pathology, Ottawa, Canada (1988-1992)

Editorial Board Memberships

1. Journal of Genitourinary Pathology (1990-1992, Journal discontinued)

2. Journal of Urologic Pathology (1992-present)

3. Oncology Reports (1993-present)

4. Advances in Anatomic Pathology, Section Editor, Genitourinary Pathology (1994-1999; 2002- present)

5. American Journal of Surgical Pathology (Genitourinary Pathology Editorial Consultant), (1996- present)

6. Modern Pathology (1998-present)

7. Urolgic Oncology, Section Editor – Pathology (2000-present)

8. Korean Journal of Pathology (2002-present)

Professional Appointments

July 1986 - December 1986 Staff Pathologist, Victoria Hospital and Lecturer in

Pathology, The University of Western Ontario, London,

Ontario

Nov 1988 - July 1992 Staff Pathologist, Victoria Hospital, London, Ontario

Nov 1988 - June 1992 Clinical Assistant Professor, Department of Pathology,

The University of Western Ontario, London, Ontario

Jan 1990 - July 1992 Clinical Assistant Professor, Department of Oncology,

The University of Western Ontario

June 1992 - July 1992 Clinical Associate Professor, Department of Pathology,

The University of Western Ontario

August 1992 - July 1997 Associate Professor of Pathology, Department of Pathology, Wayne State University

Administrative Experience

Director of Anatomical Pathology, Harper Hospital (1996-1999)

Member, Surgery Committee, Harper Hospital (1996-1999)

Member, Harper Hospital Q.A. Committee (1996-1999)

Developed and implemented Pathologist Workload Model (1997-present)

Member, Dermatology Chair Search Committee (1998-1999)

Interim Chairman, Department of Pathology (1999-2000)

Medical Director, DMC University Laboratories (1999-present)

Chief of Pathology, Harper Hospital (1999-present)

President, University Pathologists, P.C. (1999-present)

Member, Medical Staff Operating Committee, Harper Hospital (1999-present)

Member, Medical Executive Committee, Detroit Medical Center (1999-present)

Board Member, University Physicians Group (2000-present)

Member, Executive Committee, University Physicians Groups (2000-2001)

Member, Medical Leadership Executive Committee, Karmanos Cancer Institute (2000-2002)

Member, Medical Staff Operating Committee, Karmanos Cancer Hospital (2000-present)

Board Member, University Physicians Services Inc. (2000-present)

Board Member, Fund for Medical Research and Education, Wayne State University School of Medicine (2000-present)

Member, Internal Review Committee, Dept. of Biochemistry (2001)

Chairman, Urology Chair Search Committee (2001-2003)

President, University Pathology Research Services (2002-present)

Vice-Chair, Council of Clinical Chairs, Wayne State University (2002-2003)

Chair, Council of Clinical Chairs, Wayne State University (2004-2005)

Postgraduate Training Record

Dates

July 1987 – October 1988

January 1987 - June 1987

July 1982 – June 1986

June 1981 – June 1982

Institution

The University of Texas MD Anderson Cancer Center, Houston, Texas

The University of Western Ontario

St. Joseph's Hospital, London, Ontario

Position

Chief Fellow in Surgical Pathology

Fellow in Surgical Path-ology

Resident in Anatomic Path-ology

Rotating Intern

Academic Record

Dates

September 1977 -

June 1981

September 1974 -

June 1977

September 1969 -

June 1974

Institution

The University of Western Ontario, London, Ontario

Haileybury High School, Haileybury, Ontario

Degree

M.D.

B.Sc.

(Dean's Honor List)

Secondary School Diploma

Professional Associations

United States-Canadian Academy of Pathology

Arthur Purdy Stout Society of Surgical Pathologists

International Society of Urologic Pathology

Canadian Association of Pathologists

Ontario Association of Pathologists

Southwestern Ontario Pathologists Society

Ontario Medical Association

License

Fellow, Royal College of Physicians and Surgeons of Canada FRCP(C), Anatomic Pathology

Diplomate, American Board of Pathology, Anatomic Pathology

Ontario Medical License, Ontario College of Physicians and Surgeons - #33516

State of Michigan, General License, #4301059153

Licentiate of the Medical Council of Canada (LMCC) - #53131

Diplomate, National Board of Medical Examiners - #245452

Publications

1. Grignon DJ, Troster M. Changes in immunohistochemical staining of prostatic adenocarcinoma following diethylstilbestrol therapy. Prostate 7:195-202, 1985.

2. Grignon DJ, Kirk ME, Haines DSM. Cholesterol granulomas in lymph nodes draining a benign ovarian neoplasm. Arch Pathol Lab Med 109:1124-1126, 1985.

3. Grignon DJ, Shum DT, Hayman WP. Metastatic tumors of the testis. Can J Surg 29:359-361, 1986.

4. Grignon DJ, Turnbull DI, Lohmann RC. Carcinoma of the prostate presenting as acute disseminated intravascular coagulation. Can Med Assoc J 135:775-776, 1986.

5. Grignon DJ, Carey MR, Kirk ME, Robinson ML. Diffuse uterine leiomyomatosis: A case study with pregnancy complicated by intra-partum hemorrhage. Obstet Gynecol 69:477-480, 1987.

6. Grignon DJ, Banerjee D. Cross reactivity of a monoclonal pan-T cell antibody (anti-Leu 4) with prostatic epithelium. J Urol 137:330-332, 1987.

7. Grignon DJ. Endometrioid carcinoma of the prostatic utricle (letter). Br J Urol 59:368-369, 1987.

8. Grignon DJ, Shum DT, Bruckschwaiger O. Transitional cell carcinoma in the Muir-Torre syndrome. J Urol 138:406-408, 1987.

9. Johnson DE, Wishnow KI, von Eschenbach AC, Grignon DJ, Ayala AG. Partial nephrectomy using the ND:Yag laser: Comparison of the 1.06u and the 1.32u lasers employing different delivery systems. Lasers Surg Med 8:241-247, 1988.

10. Grignon DJ, Ro JY, Ayala AG. Primary mucin secreting adenocarcinoma of the kidney. Arch Pathol Lab Med 112:847-849, 1988.

11. Ro JY, Grignon DJ, Troncoso P, Ayala AG. Mucin in prostatic adenocarcinoma. Sem Diag Pathol 5:273-283, 1988.

12. Grignon DJ, Ro JY, Ordonez AG, Ayala AG. Extratesticular interstitial cells (letter). Am J Surg Pathol 12:735-736, 1988.

13. Grignon DJ, McIsaac GP, Armstrong RF, Wyatt JK. Primary rhabdomyosarcoma of the kidney: A light-microscopic, immunohistochemical, and electron-microscopic study. Cancer 62:2027-2032, 1988.

14. Ro JY, Grignon DJ, Ayala AG, Hogan SF, Tetu B, Ordonez NG. Blue nevus and melanosis of the prostate: Electron-Microscopic and immunohistochemical studies. Am J Clin Pathol 90:530-535, 1988.

15. Grignon DJ, Ro JY, Ordonez NG, Ayala AG, Cleary K. Basal cell hyperplasia, adenoid basal cell tumor, and adenoid cystic carcinoma of the prostate gland: An immunohistochemical study. Hum Pathol 19:1425-1433, 1988.

16. Grignon DJ, Ro JY, Varona AB, Ayala AG. Malignant melanoma with metastasis to a colonic polyp: Report of a case. Am J Gastroenterol 83:1298-1300, 1988.

17. Wishnow KI, Johnson DE, Grignon DJ, Ayala AG, Cromeens D, von Eschenbach AC. Denudation of the entire mucosa of the canine urinary bladder using the neodymium:Yag laser with the 1.5 MTR contact probe. Lasers Surg Med 8:589-595, 1988.

18. Ro JY, Grignon DJ, Troncoso P, Ayala AG. Intraluminal crystalloids in whole organ sections of prostate. Prostate 13:233-239, 1988.

19. Grignon DJ, Ro JY, Ayala AG. Malignant melanoma with metastasis to adenocarcinoma of the prostate. Cancer 63:196-198, 1989.

20. Ayala AG, Ro JY, Babaian R, Troncoso P, Grignon DJ. The prostatic capsule: Does it exist? Its importance in the staging and treatment of prostatic carcinoma. Am J Surg Pathol 13:21-27, 1989.

21. Grignon DJ, Shkrum MJ, Smout MS. Extra-adrenal myelolipoma: Report of 3 cases and literature review. Arch Pathol Lab Med 113:52-54, 1989.

22. Grignon DJ, El-Naggar A, Green LK, Ayala AG, Ro JY, Swanson DA, McLemore D, Giacco GG, Guinee VF. DNA flow cytometry as a predictor of outcome of stage I renal cell carcinoma. Cancer 63:1161-1165, 1989.

23. Grignon DJ, Ro JY, Mackay B, Ordonez NG, Ayala AG. Collagenous spherulosis of the breast: Immunohistochemical and ultrastructural studies. Am J Clin Pathol 91:386-392, 1989.

24. Wishnow KI, Johnson DE, Grignon DJ, Cromeens DM, Ayala AG. Regeneration of the canine urinary bladder mucosa after complete surgical denudation. J Urol 141:1476-1479, 1989.

25. Sahin A, Ro JY, Grignon DJ, Ordonez NG. Basal cell carcinoma with hyaline inclusions. Arch Pathol Lab Med 113:1015-1018, 1989.

26. Grignon DJ, El-Naggar A, Ro JY, Johnson DE, Ayala AG. Deoxyribonucleic acid flow cytometry on primary adenocarcinoma of the bladder: An analysis of 36 cases. J Urol 142:1206-1210, 1989.

27. Grignon DJ, Ayala AG, El-Naggar A, Wishnow KI, Ro JY, Swanson DA, McLemore D, Giacco GG, Guinee VF. Renal cell carcinoma: A clinicopathologic and DNA flow-cytometric analysis of 103 cases. Cancer 64:2133-2140, 1989.

28. Green LK, Ayala AG, Ro JY, Swanson DA, Grignon DJ, Giacco GG, Guinee VF. The role of nuclear grading in stage I renal cell carcinoma. Urology 34:310-315, 1989.

29. Troncoso P, Babaian RJ, Ro JY, Grignon DJ, von Eschenbach AC, Ayala AG. Prostatic intraepithelial neoplasia and invasive prostatic adenocarcinoma in cystoprostatectomy specimens. Urology 34 (Supp):52-56, 1989.

30. Grignon DJ, Ayala AG, Carrasco CH, Ames FC, Meis JM. Extraosseous intra-abdominal osteosarcoma (Case Report 532). Skel Radiol 18:147-151, 1989.