GAIL S. PRINS, Ph.D.

 

PRESENT ADDRESS:Department of Urology

University of Illinois at Chicago

820 South Wood Street, M/C 955

Chicago, IL  60612

312-413-9766 (phone); 312-996-1291 (FAX)

gprins@uic.edu

 

EDUCATIONAL BACKGROUND:

1970 - 1974               B.A. in Biology/Chemistry, summa cum laude

Trinity Christian College, Palos Heights, IL

 

1974 - 1979               Ph.D. in Physiology

Department of Physiology and Biophysics

University of Illinois Medical Center, Chicago, IL

 

1979-83         Postgraduate: NIH  Postdoctoral Fellow

Depart­ment of Urology and Center for Reproduc­tive Science

Northwes­te­rn University Medical School, Chicago, IL

 

ACADEMIC AND PROFESSIONAL POSITIONS:

2001-present Professor of Physiology (tenured), Departments of Urology and Physiol­ogy & Biophysics, College of Medicine, University of Illinois at Chicago

1996-2001     Associate Professor of Physiology (tenured), Departments of Urology, Obstetrics & Gynecology, Physiology & Biophysics, University of Illinois

1996-present Director, University Andrology Laboratory, Department of Urology;

IVF Laboratory Consultant, Department of Obstetrics & Gynecology, University of Illinois

1997-present Full Member, Graduate Faculty, University of Illinois Graduate College

1990-1995     Research Associate Professor, Department of Obstetrics & Gynecol­ogy, University of Illinois at Chicago

1983-1990     Assistant Professor, Department of Obstetrics and Gyneco­logy,

Pritzker School of Medicine, University of Chicago

1983-1995     Attending Scientific Staff, Michael Reese Hospital, Department of Obstetrics & Gyne­cology, Division of Repro­ductive Endocrinolo­gy

1987-1995     Director, Reproductive Biology Laboratory,

Michael Reese Hospital & Medical Center

1983-87         Director, University of Chicago-Michael Reese Hospital

In Vitro Fertilization Laboratory and Andrology Laboratory

 

AWARDS:

2001   Distinguished Service Award, American Society of Andrology

1985   Martin R. Rosenthal Memorial Research Award, Michael Reese Hospital Research and Education Foundation

1980-82 NIH  Individual Research Fellowship Award (NRSA)     

1975   Graduate Research Program Award, Argonne National Laboratory

1973   VanderVelde Award for Academic Achievement, Trinity Chris­tian College

 

GRANTS:

1989-05 National Institutes of Health, NIDDK,  Principal Investigator  “Developmental Estrogenizati­on of the Rat Prostate Gland",  R01 DK40890-15

2003-06                  National Institutes of Health, NIEHS,  Principal Investigator, “Estrogen imprinting of the prostate gland via gene methylation”, R21 ES12282

2004-08 National Institutes of Health, NCI, Co-Investigator (PI: A. Diamond, Ph.D.), “Selenoproteins and Prostate Cancer”  R01 CA101053

2003-06 Department of Defense, Co-Investigator  (PI: S. Swanson, PhD), “Role of Growth Hormone in Prostate Cancer”

2002-07 National Institute of Health, NIEHS, Co-Investigator (PI: F. vom Saal, PhD),

“Developmental Toxicity of Environmental Chemicals”, R01 ES11283 

2004-06 American Foundation of Urologic Disease Research Fellowship (on behalf of Dr. Liwei Huang), “ The Role of Growth Hormone in Prostate Cancer”

2004-05 American Cancer Society,   Co-PI (PI: D. Hales, PhD), “CYP1B1 and oxidative stress: markers for prostate disease”

2002-03 National Institute of Health, NIA,  Co-Investigator (PI: S. Swanson, PhD), “Role of Growth Hormone in Prostate Cancer: Rodent Models”, R03 AG 20820

1998-01 Environmental Protection Agency, STAR Award,  Principal Investigator,  “Effects of early exposure to xenoestrogens on the prostate gland”, R826299

1999-01 National Institutes of Health, NCI, “Preclinical Toxicology of Chemopreventive Agents: Evaluation of Hydrogen Ion Concentration in Prostates from Rats and Dogs”, Co-Investigator (PI: A. Levine, Ph.D.), N01-CN-95055

1997-01 NRSA Predoctoral Research Fellowship (on behalf of Carl A Woodham), “Mechanism of prostatic androgen receptor regulation by neonatal estrogens”

1998-00 American Foundation of Urologic Disease Research Fellowship (on behalf of Dr. William Chang), “Retinoic acid  receptors in estrogenized rat prostate”

1998-00 NRSA Postdoctoral Research Fellowship, NIH  (on behalf of Dr. William Chang), “Retinoic acid receptors in estrogenized rat prostate” F32 DK09873

1992-95 Research and Education Foundation Grant, Michael Reese Hospital,   Principal Investigator, "Prostate cancer androgen receptor by immunocytochemistry",

1991-92 Medical Research Institute Council, Michael Reese Hospital, Principal Investigator,  "Neonatal and prepubertal imprinting of the adult prostate gland",

1988-90 American Cancer Society,   Principal Investigator, "Hormonal regulation of prostate steroid receptors",  Grant # PDT-358

1985-87 Michael Reese Medical Research Institute, Principal Investigator, "Prolactin testoster­one synergism in regulating growth of the prostate: prolactin's effect on the androgen receptor system",  BRSG S07 RR 054476

1980-82 NRSA Individual Research Fellowship, National Institutes of Health, "Prolactin-testosterone synergism in the rat prostate gland", F32 HD06175

 

 

PROFESSIONAL SOCIETY MEMBERSHIPS:

Endocrine Society, American Society of Andrology, Society for the Study of Reproduction,

Society for Basic Urologic Research, Society for Developmental Biology,

American Association of Anatomists, American Society of Reproductive Medicine

American Urologic Association, American Association of Bioanalysts

American Association of Tissue Banks, American Association for the Advancement of Science

 

COMMITTEES:

INTRAMURAL:

2002-04 Academic Freedom and Tenure Committee, UIC Senate

2000-05 CME Committee, College of Medicine

2000-05 Academic Affairs Committee, College of Medicine

1999-02            Faculty Senate, UIC

2000-02 Senate Faculty Affairs Committee

2000-02 Senate Research Committee

1998-03 Admissions Committee, MD/PhD Training Program, UIC

2001-04 Teaching Awards Selection Committee, University of Illinois College of Medicine

1998-02            Committee on Research, University of Illinois College of Medicine

1998-99            Search Committee, Head of Biochemistry & Molecular Biology, UIC

1997-98            Search Committee, Head of Obstetrics & Gynecology, UIC

1995-98 Steering Committee, Prostate Cancer Program, University of Chicago

1990-96 Institutional Animal Care and Use Committee, MRH

1988-96 Institutional Research Committee, MRH

1995-96 Research Radioisotope Committee, MRH

1990-92 Committee on Re­search, University of Illinois College of Medicine

1988-92 Institutional Review Board, MRH

EXTRAMURAL:

2003-05 Chair, Development Committee, American Society of Andrology

2000-03 Chair, Membership Committee, Society for Basic Urologic Research

2003-04 Development Committee, Society for the Study of Reproduction

1999-03            Chair, Finance Committee, American Society of Andrology

2000-03 Associates Committee, The Endocrine Society

2001-02 Awards Committee, Society for the Study of Reproduction

1998-01            By-Laws Committee, American Association of Tissue Banks

1999-03 Program Committee, American Society of Andrology

1997-02 Steering Committee, Chicago Prostate Consortium

1997-00            Membership Committee, Society for Basic Urologic Research

1996-97            Liaison Committee for Male Reproduction and Sexual Function

1996-97            Chair, Liaison Committee,  Society for Basic Urologic Research

1990-93 Executive Council, American Society of Andrology

1992-93            Nominating Committee, American Society of Andrology

1992-93            Andrology Laboratory Committee, American Society of Andrology

1991-93 Nominating Committee, RBPG, American Fertility Society

1993               Prize Presentation Committee, American Fertility Society

1987-90 Chair, Student Affairs Committee, American Society of Andrology

1988-90 Membership Committee, American Society of Andrology

 

 

 

PROFESSIONAL ACTIVITIES:

1.                  President, American Society of Andrology (2003-2004)

2.                  Treasurer, American Society of Andrology (1994-1998)

3.            Editorial Board, Endocrinology (1998-2002)

4.            Associate Editor, Journal of Andrology (1992-1997)

5.            Journal Reviewer (ad hoc): Molecular Endocrinology, Proceedings of the National Academy of Science, Nature,  Cancer Research,  Oncogene, Prostate, Biology of Reproduction, Journ­al of Endocri­nology, Endocrine, Neuroendocrinolog­y, American Journal of Physiology, Differentiation,  American Journal of Pathology, Environmental Health Perspectives, J Toxicology,  Fertility and Sterility, Journal of Reproduction & Fertili­ty, Urology, J Urology, Inter­nation­al Jour­nal of Andro­logy, Molecular Reproduction & Development, J Assisted Reproduction, Journal of Histochemistry and Cytochemistry,

6.         Grant Reviewer (ad hoc):

National Science Foundation, March of Dimes Foundation, Veterans Administration

7.         Study Sections:

NIH Site Reviewer, Oregon Regional Primate Research Center, 1988

            NIH Special Emphasis Panel: Regulation of Prostatic Growth, 06/93

NIH Biochemical Endocrinology Study Section, 10/95

NIH Reproductive Endocrinology Study Section, 10/96

NIH Special Emphasis Panels: Pediatric Urology Centers, 1996; Urology Centers, 03/99; Pathology B, 08/99; Urology,11/02; Reproductive Endocrinology, 10/01; 03/02; 03/03; 10/03

NIH Cooperative Specialized Infertility Research Centers, 05/02

NIH/NIDDK Program Project Site Reviewer, 12/99

NIH/NIEHS Program Project Site Reviewer, 03/01;  01/03 (Chair); 11/03 (Chair)

DOD Prostate Cancer Research Program, Molecular Biology Panel, 1998

8.                  Scientific Advisory Panels:

Department of Defense Prostate Cancer Research Program, Integration Panel (IP) Member, 2000-2005 (Executive Committee Member, 2002-2004)

NIH – National Institute of Environmental Health External Scientific Review Committee, 2004-2008

Center for Cancer Research and Therapeutic Development, External Advisory Committee, Clark-Atlanta University,

National Assessors Panel for Cancer Research, Victoria,  Australia, 2001

NTP/NIEHS Endocrine Disruptors Low-Dose Peer Review Panel, October, 2000

9.                  Scientific Session/Symposium Moderator:

AUA/SBUR Summer Research Conference Organizing Committee, 2005

Gordon Research Conference: Hormonal Carcinogenesis, 1997, 2001

Gordon Research Conference: Reproductive Tract Biology, 1998, 2004

Endocrine Society Annual Meeting, 1999, 2001

Society for Basic Urologic Research/Fourth World Congress in Urologic Research,2001

American Society of Reproductive Medicine­, 1990-1992, 1997, 2000

American Society of Andrology Meet­ing, 1989-1991, 1995, 1997, 2000, 2002-2004

Ameri­can Association for Can­cer Research, 1994

10.            Certification:

High Complexity Clinical Laboratory Director, American Association of Bioanalysts, (1994)

 

 

 

TEACHING:

Human Physiology & Pathophysiology 302: Male Reproduction Lectures

Graduate College Integrative Lecture Series 510:  Hormones & Cancer Lectures

 

LABORATORY TRAINEES:  

Postdoctoral Fellows:

William Chang, DVM, PhD, 1997-2000 (AFUD Scholar; NRSA Fellow)

Oliver Putz, PhD, 1998-2002

Yong Bing Pu, MD, PhD, 2001-present

Liwei Huang, MD, PhD, 2001-present (AFUD Scholar)

 

Visiting Scientists:

Shu-Hua Ye, MD, 1990-96, Research Associate, University of Illinois

Helga Habermann, MD, 1998-2000, Assistant Professor, University of Gratz, Austria

 

Graduate Students:       

Carl Woodham, PhD, 1998-2004 (NRSA recipient)

 

Medical Students:

Suresh Vedantham, MD, 1985-87, University of Chicago

Kenneth Gordon, MD, 1984-85, Columbia University

Christina Dothinger, 2003-2004

 

Research Residents:

Roger Lalich, DO, 1987-88, University of Wisconsin    

C. Sawetawan, MD, 1991-92, University of Texas

Brijesh Kapoor, MD, 1995

Michael Marmar, MD, 1996-97

Steven Kim, MD, 1997-98

Christopher Schwartz, MD, 1998-99

Vibha Sabharwal MD, 1999-00

Patrick Springhart, MD, 2000-01

Jason Gilleran, MD, 2001-2002, University of Texas Southwestern

Shumyle Alam, MD, 2002-2003, University of Kentucky

David Hepps, MD, 2004-2005

 

Dissertation Committee:

Jennifer McCafferty, PhD, 1999, Univ of Miami School of Medicine

Jason Derry, PhD, 2001, Department of Genetics, UIC

Dubravka Markovic, PhD, 2001, Dept of Microbiology & Immunology, UIC

Yan Wang, PhD, 2002, College of Pharmacy, UIC

Natasa D. Pajkovic, 2003-, College of Pharmacy, UIC

 

 

INVITED LECTURES (past 6 years):

“Signaling mechanisms regulating proliferation and programmed cell death during prostate development” Society for Basic Urologic Research annual Meeting, Savannah, Georgia, December 9-12, 2004.

 

“Hormonally mediated immune responses in the prostate gland”, International Inflammation Symposium, Monash University, Melbourne, Australia, November 28-30, 2004.

 

“The role of estrogens in prostate development and carcinogenesis”, Clark-Atlanta University, November 12, 2004.

 

“Influence of estrogen and retinoic acid receptors on regulation of prostate cancer growth” Prouts Neck Prostate Cancer Meeting, Prouts Neck Maine, November 4-7, 2004.

 

“Estrogen imprinting of the prostate gland via methylation”, Joint NIEHS/ACC Developmental Toxicology and Fetal Basis of Adult Disease Grantee Meeting, NIEHS, Research Triangle Park, NC, March 8-9, 2004.

 

“Prolactin regulation of prostate growth and inflammation”, Prolactin Gordon Research Conference, Ventura, CA, Feb 2-5, 2004.

 

“The Role of Estrogens in Prostate Development and Carcinogenesis”, Michigan State University, Lansing, MI, Oct 2-3, 2003.

 

“The Role of Estrogens in Prostate Development and Carcinogenesis”, Department of Medicine, Endocrinology Division, Mt Sinai Hospital, NYC, Sept 24-25, 2003.

 

“Estrogenic Exposures: Potential role in prostate development and carcinogenesis”, The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, June 27, 2003.

 

“Estrogens and Prostate Development and Carcinogenesis”, The Endocrine Society Annual Meeting, Symposium on Steroid Receptors in Prostate Cancer, Philadelphia, June 19, 2003

 

“Estrogenic regulation of steroid receptors, morphogens and signaling pathways during prostate development”, Eppley Institute for Cancer Research, University of Nebraska Medical Center , Omaha, NE, May 1, 2003

 

“Estrogenic Regulation of Homeobox Genes and Signaling Pathways during Prostate Development”, Testis Workshop, Phoenix, AZ, March 26-29, 2003

 

“Differential Gene Expression in Estrogenized Rat Prostate”, Society for Basic Urologic Research Fall Symposium, Tucson, AZ, Dec 5-8, 2002

 

“Postnatal Estrogen Exposure and Prostate Development”, Gordon Research Conference on Reproductive Tract Biology, New London, CT, July1-5, 2002

 

“Reprogramming of prostatic steroid receptor expression by developmental estrogen exposure”, University of Massachusetts, May 13-14, 2002

 

“Estrogens and Prostate Cancer”, American Society of Andrology Postgraduate Course, Seattle, WA, April 27, 2002

 

“Might maternal estrogens predispose prostate disease?”, Department of Medicine, Columbia University, New York City, March 1, 2002

 

“Reprogramming of prostatic steroid receptor expression by developmental estrogen exposure”, National Institute of Environmental Health and Safety, January 11, 2002

 

“Estrogen in Prostate Development”  e.Hormone Conference on Endocrine Disruption, Tulane University, New Orleans, LA, Oct 18-20, 2001

 

“Estrogenic effects on retinoic acid signaling in the rat prostate gland”, Gordon Research Conference on Hormonal Carcinogenesis, Kimball Academy, NH, July 8-13, 2001.

 

“Steroid receptor pathways involved in estrogen imprinting of the prostate gland”, Department of Physiology, University of Wisconsin, Madison, WI, May 9, 2001.

 

“Steroid receptor pathways in estrogen programming of prostate development”, Keynote Lecture, Michigan Prostate Research Consortium, Detroit, MI, April 28, 2001.

 

“Neonatal estrogen programming of prostate growth”, Department of Biochemistry, University of Arizona, Tucson, AZ, Feb 15-17, 2001.

 

“Prenatal  DES:  Impaired  Prostate Development”,  National Institute of Environmental Health and Safety, Division of Extramural Research and Training Science Retreat, Molecular Basis of Environmental Disease, Pine Needles Resort, NC, Dec 4-5, 2000.

 

“Stromal-epithelial steroid receptors in normal and estrogenized rat prostate”, Society for Basic Urologic Research Fall Symposium, Sanibel Island, FL, November 9-12, 2000.

 

“Androgen and estrogen receptors in prostate development”, Hormones and Cancer 2000, Port Douglas, Australia, November 3-7, 2000.

 

“Influence of neonatal estrogens on mature prostate function”, Australian Academy of Science, Boyden Research Conference: Estrogens and Male Health; Sydney, Australia, November 2-3, 2000.

 

“Andrology laboratory issues in the era of ICSI, MESA and TESE”, American Society of Reproductive Medicine Workshop, San Diego, CA, October 24, 2000.

 

“Effects of prenatal and neonatal steroid exposure on prostate development” and “ERαKO and ERßKO transgenic mice as prostate models”, NIH Workshop on Prostate Growth and Aging, Bethesda, MD, September 13-15, 2000.

 

“Effects of estrogenic exposures on prostate development”, American Institute for Cancer Research, 10th Annual Research Conference, Washington DC, August 31-September 1, 2000.