Department
of Obstetrics and Gynecology
University
of Michigan Medical School
11/1/73-
4/30/76 Postdoctoral
Fellow
Department
of Obstetrics and Gynecology
University
of Michigan Medical School
Ann
Arbor, Michigan
7/1/72 –
10/15/73 Senior
Research Scholar
Council
of Scientific and Industrial Research
Division
of Biochemistry
Central
Drug Research Institute
Lucknow,
India
1990-Present Research
Career Scientist award, Medical Research Service, Department of Veterans
Affairs
1974 -
1976 Postdoctoral
Fellowship
Population
Council, New York
1973 -
1974 Postdoctoral
Fellowship
University
of Michigan, Ann Arbor, Michigan
1972 -
1973 Senior
Research Fellowship
Council
of Scientific and Industrial Research, New Delhi, India
1968 -
1971 Junior
Research Fellowship
Council
of Scientific and Industrial Research, New Delhi, India
1964 - 1968 University
Merit Scholarship, Lucknow University, Lucknow, India
The
Endocrine Society
The
Society for the Study of Reproduction
The
American Association for the Advancement of Science
American
Federation for Clinical Research
American
Diabetes Association
The
American Society for Cell Biology
The
American Society for Biochemistry and Molecular Biology
The
American Chemical Society
The
Protein Society
The
Oxygen Society
Home Address 2021
Orestes way
Campbell,
CA 95008
Telephone: (408)
374-5294 or (408) 374-8199
E-mail: sitapur@aol.com
Publications
1.
Azhar,
S. and Krishna Murti, C.R. Effect of indole-3-acetic acid on
the synthesis of cyclic 3-5'-adenosine phosphate by Bengal gram seeds. Biochem.
Biophys. Res. Comm. 43:58-64, 1971.
2.
Azhar,
S. and Krishna Murti, C.R. Induction of tryptophan oxygenase
in Cicer arietinum seedlings by
indole-3-acetic acid and cyclic 3', 5'-adenosine monophos-phate. Indian J. Biochem. Biophys.
8:210-213,1971.
3.
Azhar,
S., Srivastava, A.K., and Krishna Murti, C.R. Compositional changes during the
germination of Cicer arietinum.
Phytochemistry 11:3173-3179,
1972.
4.
Srivastava, A.K., Azhar, S., and Krishna Murti, C.R. Inhibition of germination
in Cicer arietinum. Phytochemistry
11:3181-3185, 1972.
5.
Balasaraswathi, K., Azhar, S., and Krishna Murti, C.R. Changes in catalase, fructo-sediphosphate aldolase,
aspartate and alanine aminotransferase and acid phosphatase activities and
amino acid uptake by rabbit erythrocytes during experimental reticulocytosis. Indian J. Biochem. Biophys. 10:18-22, 1973.
6.
Babu, C.R., Azhar,
S., and Krishna Murti, C.R. A
possible involvement of cyclic 3:5'-adenosine monophosphate in the maturation
of mammalian reticulocytes. Curr. Sci.42: 463-464, 1973.
7.
Srivastava, A.K., Azhar, S., and Krishna Murti, C.R. Stimulation of RNA synthesis in Cicer arietinum seedings
by cyclic 3',5'-adenosine monophosphate. FEBS
Lett. 33:239-240, 1973.
8.
Azhar,
S. and Mohan Rao, V.K.
Deoxyribonuclease activity of Entamoeba
histolytica Zbl. Bakt. Hyg., I. Abt. Orig. A.
225:553-561, 1973.
9.
Srivastava, A.K., Azhar, S., and Krishna Murti, C.R. Action of indole-3-acetic acid
on the in vitro synthesis of tryptophan oxygenase by Cicer arietinum seedlings. Indian J. Biochem. Biophys.
10:191-194,1973.
10. Azhar, S.,
Mukhtar, H., Dutta, G.P., and Mohan Rao, V.K. Changes in the level of hydrolytic enzymes in the caecum and
the intestine of rats infected with a virulent strain of Entamoeba histolytica intracaecally. Indian J. Med. Res.
62:573-580, 1974.
11. Srivastava,
A.K., Azhar, S., and Krishna Murti,
C.R. Activation of adenyalte cyclase in the early phase of germination. FEBS Lett. 47:330-332, 1974.
12. Srivastava,
A.K., Azhar, S., and Krishna Murti,
C.R. A possible role of cyclic 3', 5'-adenosine monophosphate in the
germination of Cicer arietinum seeds. Phytochemistry
14:903-907, 1975.
13. Azhar, S.
and Mohan Rao, V.K. Ribonuclease activity of Entamoeba histolytica.
Zbl. Bakt. Hyg. I. Abt. Orig. A. 230:270-278, 1975.
14. Azhar S.
and Menon, K.M.J. Cyclic adenosine
3', 5'-monophosphate and lutenizing hormone stimulated protein kinase from
bovine corpus luteum: Evidence for
activation through separate mechanisms.
FEBS Lett. 51:25-28, 1975.
15. Azhar, S.
and Menon, K.M.J. Adenosine 3',
5'-monophosphate dependent phosphoryla-tion of ribosomes and ribosomal subunits
from bovine corpus luteum. Biochim. Biophys. Acta 392:64-74, 1975.
16. Srivastava,
A.K., Azhar, S., and Krishna Murti,
C.R. Tryptophan metabolism in Cicer arietinum. Acta
Vitamin. Enzymol. (Milano) 29:275-277, 1975.
17. Azhar, S.,
and Menon, K.M.J. Adenosine 3',
5'-monophosphate dependent and plasma membranes associated protein kinase from
bovine corpus luteum.
Solubilization and properties of solubilized enzyme. Eur.
J. Biochem. 58:105-115,1975.
18. Azhar, S.
and Menon, K.M.J. Solubilization and characterization of phospho protein
posphatase(s) from bovine corpus luteum membranes. Eur. J. Biochem.
55:487-495,1975.
19. Babu,
C.R., Azhar, S., and Krishna Murti,
C.R. Loss of epinephrine
stimulated synthesis of cyclic adenosine 3', 5'-monophosphate during maturation
of rabbit and human reticulocytes.
Med. Biol. 53:148-153, 1975.
20. Azhar, S.
and Menon, K.M.J. Adenosine 3',
5'-cyclic-monophosphate dependent and plasma membrane associated protein
kinase(s) from bovine corpus luteum:
Properties of associated enzyme and phosphorylation of specific plasma -
membrane proteins. Biochem. J. 151:23-36, 1975.
21. Babu,
C.R. and Azhar, S. Changes in membrane
constituents and membrane bound enzymes during the maturation of rabbit
reticulocytes. Indian J. Biochem. Biophys.
13:79-83,1976.
22. Azhar, S.,
Clark, M.R., and Menon, K.M.J.
Regulation of cyclic adenosine 3',5'-monophosphate dependent protein
kinase of rat ovarian cells by lutenizing hormone and human chorionic
gonadotropin. Endocr. Res. Comm. 3:93-104, 1976.
23. Thambyrajah,
V., Azhar, S., and Menon,
K.M.J. Sedimentation behavior of
solubilized gonadotropin receptor from plasma membrane of bovine corpus
luteum. Biochim. Biophys. Acta 428:35-44, 1976.
24. Srivastava,
A.K. and Azhar, S. Cyclic nucleotide
phosphodiesterase activity in Cicer arietinum. Curr. Sci. 45:21,
1976.
25. Clark,
M.R., Azhar, S., and Menon, K.M.J.
Ovarian adenosine 3', 5'-cyclic monophosphate dependent protein kinase(s): Regulation by choriogonadotropin and
lutropin in rat ovarian cells. Biochem. J. 158:175-182, 1976.
26. Azhar, S.
and Menon, K.M. J. Gonadotropin
receptors in plasma membranes of bovine corpus luteum. I. Effect of phospholipases
on the binding of 125I-choriogonadotropin by membrane associated-
and solubilized receptors. J. Biol. Chem. 251:7398-7404, 1976.
27. Azhar, S.,
Hajra, A.K., and Menon, K.M.J.
Gonadotropin receptors in plasma membranes of bovine corpus luteum. II. Role of membrane
phospholipids. J. Biol. Chem. 251:7405-7412, 1976.
28. Azhar, S.
and Menon, K.M.J. Cyclic
nucleotide phosphodiesterase from rat anterior pituitary: characterization of
multiple forms and regulation by protein activator and Ca2+. Eur.
J. Biochem.73:73-82, 1977.
29. Menon,
K.M.J., Gunaga, K.P., and Azhar, S. GnRH action in rat anterior pituitary
gland: Regulation of protein, glycoprotein and LH synthesis. Acta.
Endocrinol. 86:473-488, 1977.
30. Azhar, S,
Reel, J.R., Pastushok, C.A., and Menon, K.M.J. LH biosynthesis and secretion in rat anterior pituitary cell
cultures: Stimulation of LH glycosylation and secretion by GnRH and an
agonistic analogue and blockade by an antagonistic analogue. Biochem.
Biophys. Res. Comm. 80:659-666, 1978.
31. Menon,
K.M.J. and Azhar, S. Adenosine 3', 5'-cyclic-monophosphate
dependent protein kinase(s) of rat ovarian cells: Gonadotropin regulation of adenosine 3', 5'-cyclic
monophosphate receptor activity. Biochem. J. 172:433-442, 1978.
32. Azhar, S.
and Menon, K.M.J. Stimulation of
ribunucleic acid synthesis in luteninized rat ovary by cyclic 3',5'-adenosine
monophosphate. Biol. Reprod. 19:346-357, 1978.
33. Azhar, S.
and Menon, K.M.J. Differential
actions of gangliosides on gonadotropin and cholera enterotoxin stimulated
adenosine 3', 5'-cyclic monophosphate dependent protein kinases in isolated rat
ovarian cells. Biochem. Biophys. Res. Comm. 81:205-211, 1978.
34. Azhar, S.,
Fitzpatrick, P., and Menon, K.M.J.
Role of gangliosides in gonadotropin and cholera entertoxin stimulated
steroidogenesis in isolated rat ovarian cells. Biochem. Biophys. Res.
Comm. 83:493-500, 1978.
35. Azhar, S.,
Fanelli, C., and Menon, K.M.J.
Gonadotropin induced stimulation and desensitization of cyclic 3',
5'-adenosine dependent protein kinase(s) in the rat ovary. Endocr.
Res. Commun. 5:1-19, 1978.
36. Azhar, S.
and Menon, K.M.J. Receptor
mediated gonadotropin action in the ovary: Regulatory role of cyclic nucleotide
phosphodiesterase(s) in intracellular adenosine 3', 5'-cyclic monophosphate
turnover and gonadotropin stimulated progesterone production by rat ovarian
cells. Biochem. J. 180:201-211, 1979.
37. Azhar, S.
and Menon, K.M.J. Receptor
mediated gonadotropin action in ovary: Differential effects of various
gangliosides and cholera enterotoxin on 125I-choriogonadotropin
binding, production of adenosine 3', 5' monophosphate and steroidogenesis in
rat ovarian cells. Eur. J. Biochem. 94:77-85, 1979.
38. Sen,
K.K., Azhar, S., and Menon,
K.M.J. Receptor mediated
gonadotropin action in the ovary.
Desensitization of receptor binding sites, activation of adenosine 3',
5'-cyclic monophosphate dependent protein kinase(s) and regulation of
steroidogenesis in rat ovary. J. Biol.
Chem. 254:5664-5671, 1979.
39. Sen,
K.K., Azhar, S., and Menon,
K.M.J. Evidence for the
involvement of an energy dependent process in gonadotropin releasing hormone
stimulated luteinizing hormone release by rat anterior pituitary. Endocrinology
105:1158-1161, 1979.
40. Menon,
M., Azhar, S., and Menon,
K.M.J. Evidence that Danazol inhibits
gonadotropin induced ovarian steroidogenesis at a point distal to
gonadotropin-receptor interaction and adenosine 3', 5' cyclic monophosphate
formation. Am. J. Obstet. Gynecol. 136: 524-530, 1980.
41. Reddy,
P.V., Azhar, S., and Menon,
K.M.J. Multiple inhibitory actions
of luteinizing hormone releasing hormone agonist on luteinizing hormone/human
choriogonadotropin receptor mediated ovarian responses. Endocrinology
107: 930-936, 1980.
42. Azhar, S.,
Menon, M., and Menon, K.M.J.
Receptor mediated gonadotropin action in the ovary: Modulation of progesterone response in
isolated rat ovarian cells by gonadotropin cholera enterotoxin and cyclic
nucleotides: requirement for RNA
and protein synthesis. Acta Endocrinol. 95: 528-539, 1980.
43. Azhar, S.
and Menon, K.M.J. Receptor mediate
gonadotropin action in the ovary: Effect of cytoskeletal element - disrupting
agents on gonadotropin induced steroidogenesis in rat luteal cells. Biochem.
J. 194: 19-27, 1981.
44. Reaven,
E and Azhar, S. The effect of
various hepatic membrane fractions on microtubule assembly with special
emphasis on the role of membrane phospholipids. J. Cell Biol. 89:
300-308,1981.
45. Azhar, S.
and Menon, K.M.J. Receptor
mediated gonadotropin action in the ovary: Possible regulatory role of cell surface
sialic acid in gonadotropin interaction to gonadotropin receptors from bovine
corpus luteum plasma membranes. Eur. J. Biochem. 118: 25-31, 1981.
46. Azhar, S.,
Menon, M., and Menon, K.M.J.
Receptor mediated gonadotropin action in the ovary: Demonstration of acute dependence of
rat luteal cells on exogenously supplied steroid precursor (sterols) for
gonadotropin induced steroidogenesis.
Biochim. Biophys. Acta 665:
362-375, 1981.
47. Azhar, S.
and Menon, K.M.J. Receptor
mediated gonadotropin action in the ovary: Rat luteal cells preferentially
utilize and acutely dependent upon the plasma lipoprotein supplied sterols in
gonadotropin stimulated steroid production. J. Biol. Chem.
256: 6548-6555, 1981.
48. Azhar, S.
and Menon, K.M.J.
Receptor-mediated gonadotropin action in the ovary. Inhibitory actions
of concanavalin A and wheat-germ agglutinin on gonadotropin-stimulated cyclic
AMP and progesterone responses in ovarian cells. Biochem. J. 200:
153-159, 1981.
49. Verschoor-Klootwyk,
A.H., Verchoor, L., Azhar, S., and
Reaven, G.M. Role of exogenous cholesterol in regulation of adrenal
steroidogenesis in the rat. J. Biol. Chem. 257: 7666-7671, 1982.
50. Azhar, S.
and Reaven, E.P. Effect of
antimicrotubule agents on microtubules and steroidogenesis in luteal
cells. Amer. J. Physiol. 243: E380-E386, 1982.
51. Azhar, S.,
and Menon, K.M.J. Receptor
mediated gonadotropin action in gonadal tissues: Relationship between blood cholesterol levels and
gonadotropin stimulated steroidogenesis in isolated rat Leydig and luteal cells. J.
Steroid Biochem. 16: 175-184, 1982.
52. Pont,
A., Williams, P.L, Azhar, S., Reitz,
R.E., Bochra, C., Smith, E.R., and Stevens, D.A. Ketoconazole blocks testosterone synthesis. Arch.
Int. Med. 142: 2137-2140, 1982.
53. Reaven,
E., Solomon, R., Azhar, S., and
Reaven, G. Functional homogeneity
of pancreatic islets of aging rats. Metabolism
31: 859-860, 1982.
54. Azhar, S.,
Chen, Y-D.I., and Reaven, G.M.
Stimulation of lipoprotein receptors and role of lipoprotein and
cellular cholesterol during gonadotropin induced desensitization of
steroidogenic response in luteinized rat ovary. J. Biol. Chem.
258: 3735-3740, 1983.
55. Azhar, S.,
Hwang, S.F., and Reaven, E. Effect
of antimicrotubule agents on terminal glycosyltransferases and other enzymes
associated with rat liver subcellular fractions. Biochem. J. 212: 721-731, 1983.
56. Reaven,
E., Jensen, C.G., Spicher, M., and Azhar,
S. Unique microtubules in
luteal cells from superovulated rats. J.
Ultrastruc. Res. 83: 284-295, 1983.
57. Azhar, S.,
Ho, H., Reaven, E.P., and Reaven, G.M.
Evidence of an age-related decline in mitochondral glycerophosphate
dehydrogenase activity of isolated rat islets. Metabolism 32: 1019-1021, 1983.
58. Bogardus,
C., Thuillez, P., Ravussin E., Vasquez, B., Narimiya, M., and Azhar, S. Effect of muscle glycogen depletion on in vivo insulin
action in man. J. Clin. Invest. 72: 1605-1610, 1983.
59. Gibori,
G., Chen, Y-D.I., Kahn, I., Azhar, S.,
and Reaven, G.M. Regulation of luteal cell lipoprotein receptors, sterol
contents and steroidogenesis by estradiol in the pregnant rat. Endocrinology
114: 609-617, 1984.
60. Narimiya,
M., Azhar, S., Dolkas, C.B., Mondon,
C.E., Sims, S., Wright, D.W., and Reaven, G.M. Insulin resistance in older rats. Am. J. Physiol.
246 (Endocrinol. Metab. 9): E397-E404, 1984.
61. Khan,
I., Azhar, S., Chen, Y-D.I., and
Gibori, G. Steroid effects on HMG-CoA reductase and side- chain cleavage enzyme
activities in luteal cells. Proceedings of the 5th Ovarian Workshop.
(Toft, D.O., and Ryan, R.J., Eds.,) pp 369-374, 1984.
62. Azhar, S.,
Chen, Y-D.I., and Reaven, G.M.
Gonadotropin modulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG
CoA) reductase activity in lutenized rat ovary. Biochemistry 23:
4533-4538, 1984.
63. Reaven,
E., Chen, Y-D.I., Spicher, M., and Azhar,
S., Morphological evidence that high density lipoproteins are not
internalized by steroid-producing cells during in situ organ profusion. J.
Clin. Invest. 74: 1384-1397,
1984.
64. Gibori,
G., Khan, M.I., Sridaran, R., Chen, Y-D.I., Azhar, S., Rao, M.C., Jayatilak, P., and Gruber, J.R. Secretion and
action of steroids in the luteal cell.
In Hormonal Control of the
Hypothalamo-Pituitary Gonadal Axis, (McKerns, K. W., Ed.) New York, Plenum
Publishing, pp. 289-307, 1984.
65. Narimiya,
M., Chang, H., Azhar, S., and
Reaven, G.M. Amelioration of
streptozotocin-induced diabetes in the rat by exercise training: Role of muscle
glycogenolytic enzyme activity. Horm.
Metab. Res. 16 (Supple.): 67-70, 1984.
66. Azhar, S.