Steven M. Schrader

STEVEN M. SCHRADER, Ph.D.

MAILING ADDRESS:

Chief, Reproductive Health Section, C-23

National Institute for Occupational Safety and Health

4676 Columbia Parkway

Cincinnati, Ohio 45226

TELEPHONE NO.: Office (513) 533-8210

FAX (513) 533-8138

COUNTRY OF CITIZENSHIP: United States

HIGHEST FEDERAL CIVILIAN GRADE HELD: GS-15

EDUCATION:

Postdoctoral Training 1979-1981

Institute for Molecular and Cellular Evolution

University of Miami

Coral Gables, Florida

NIH Postdoctoral Training Program in Reproductive Biology

Ph.D. Reproductive Physiology, 1978.

Department of Dairy Husbandry

University of Missouri

Columbia, Missouri

M.S. Animal Breeding, Genetics, 1975

Department of Animal Science

University of Missouri,

Columbia, Missouri

B.S. Animal Science, 1974

University of Missouri

Columbia, Missouri

Zoology Major, 1969-1971

Northern Illinois University

DeKalb, Illinois

High School Diploma, 1969

Belvidere High School

Belvidere, Illinois 61008

PROFESSIONAL EXPERIENCE:

August 1989-Present:

Federal Job Title: Supervisory Research Biologist

Federal Job Grade: GS-15

Chief

Reproductive Health Assessment Section

National Institute for Occupational Safety and Health

Supervisory responsibilities include chairing the Division’s Reproductive Hazards Focus Area and the general operation of a Reproductive Hazards Research section. The mission of the section is to assess the effects of occupational hazards on the fecundity of workers.

Primary personal research is the development, evaluation, and implementation of methodologies for assessing the reproductive health of working men. This includes basic laboratory research as well occupational field studies.

Employer Address:

National Institute for Occupational Safety and Health

4676 Columbia Parkway

Cincinnati, Ohio 45226

Supervisor: Dr. Gayle Debord, 513 533 8212

January 1983 - August 1989

Federal Job Title: Research Biologist

Federal Job Grade: GS-11 (1983) to GS-13 (1989)

Andrologist

Acute and Subchronic Toxicology Section

National Institute for Occupational Safety and Health

The research initiated in this position has been extended into the current position described above.

Employer Address:

National Institute for Occupational Safety and Health

4676 Columbia Parkway

Cincinnati, Ohio 45226

Supervisor: Dennis Lynch (513) 533-8213 (may be contacted)

January 1981 - January 1983:

Title: Assistant Professor

Administrative responsibilities involved the supervision of the electron microscope facilities and the advising of graduate students. Teaching duties included both graduate and undergraduate courses in biology, reproductive physiology, and electron microscopy. Research emphasis was on Sperm Physiology. This included the evaluation of the new viability assay, the hypoosmotic stress test (HOS test), which evaluates the functional integrity of the human sperm membrane.

Employer Address:

Department of Biology

Roosevelt University

Chicago, Illinois

Supervisor: Jonathan Greene (Phone unknown)

June 1979 - January 1981:

Title: Postdoctoral Research Fellow

Research project was the production and analysis of antisperm antibodies and their effect on sperm and fertility. This included the development an immunoferritin labeling procedure to identify and elucidate the events surrounding fertilization

Employer Address:

Institute for Molecular and Cellular Evolution

University of Miami

Coral Gables, Florida

Supervisor: Dr. Charles Metz (Phone unknown)

August 1978 - June 1979

Title: Science Instructor

Employer Address:

Higbee High School

Higbee, Missouri

Supervisor: Larry Twellman (Phone unknown)

August 1975 - August 1978:

Title: Ph.D. Graduate Student (Research Assistant)

University of Missouri, Columbia

Advisors: Dr. C.P. Merilan (deceased)

Doctoral Research effort was to identify the site and determine the effects of chemical messengers that govern spermatozoan motility. Other research involved a unique study on the development of methods for semen collection of wildlife (including some endangered species).

Title: Masters Graduate Student (Research Assistant)

University of Missouri, Columbia

Advisor: Dr. John Lasley (deceased)

The Master of Science Research focused on the development and comparison of methods for measuring the rate of proliferation of blood lymphocytes. For this, various types of colorimetric and radio-isotope assays were employed.

HONORS:

Dean's Honor Roll, 1973 and 1974, University of Missouri

Honorable Mention, Alice Hamilton Science Award for Occupational Safety and Health, 1989

Awarded the Alice Hamilton Science Award for Occupational Safety and Health, 1990, 1991, 1999

Nominated for the Charles C. Shepard Science Award, 1991

Outstanding Work Performance Award, 1989, 1991, 1996, 1997, 1998, 1999, 2000, 2001,2002

Nominated for the Supervisor-of-the-Year 1995

NATIONAL COMMITTEES AND ACTIVITIES:

Served on the National Toxicology Program (NTP), Reproductive and Developmental Biology Subcommittee, 1983 - 1992

Served as a consultant to Centers for Disease Control, Vietnam Experience Study, 1985 - 1988

Served as a NIOSH Grants Office Advisor. 1986 - Present

Invited member to the Workshop on Risk Assessment in Reproductive and Developmental Toxicology, National Center for Toxicologic Research. September 1987

Served as a National Academy of Sciences, National Research Council Research Advisor. 1987 - present

Served on the Review Panel for the Office of Technology Assessment, United States Congress, Report on Infertility Prevention and Treatment. 1987

Served as a March of Dimes Grants Reviewer. 1987 - 1992

Invited member on the Task Force on Environmental Cancer and Heart and Lung Disease, Workshop on the Effects of Pesticides on Human Health, Working Group on Reproductive Toxicology, 1988

Chairman of the Symposium on Assessing Reproductive Hazards in the Workplace, June 16 and 17, 1988

Served on the Editorial Board, Reproductive Sciences, 1989 - 1992

Served on the Hill Air Force Base, Reproductive Hazard Study Advisory Board. 1989 - 1995t

Invited member to U.S. Environmental Protection Agency Superfund Sperm Motility Workgroup, September 6 and 7, 1989.

Invited member to EPA/NIOSH Workshop on Methods for Semen Studies in Humans. October 18 - 20, 1989.

Invited Speaker to Reproductive Issues in Aging Male, National Institute for Child Health and Human Development, November 1990.

Served on the Organizational Committee, and was an invited member to NTP Rat Sperm Motility Workshop, 1990

Chair, Organizational Committee and the NTP Human Semen Workshop, 1990

Served on the Committee on Environmental Epidemiology. National Academy of Sciences, National Research Council. 1991-1992

Invited member to Research Needs Working Group for Occupational and Environmental Reproductive Hazards: A Working Conference. November 1991. Woods Hole, MA

Invited speaker to the Federally Employed Women: 23rd National Training Program, Cincinnati, Ohio. July 23, 1992

Invited speaker to Environment, Safety, and Occupational Health Conference, School of Aerospace Medicine, Brooks Air Force Base, Texas. September 21-25, 1992

Served as member of Laboratory Science Committee of the American Society of Andrology. 1993 to 1996

Invited panel member for American Society of Andrology, Sperm Morphology and Morphometry Workshop. April 1993.

Co-chair for Workgroup of Field Study Applications of Biologic Markers for Male Reproductive Disorders, Agency for Toxic Substances and Disease Registry, May 1993.

Grant Reviewer, National Cancer Institute, NIH. Interdisciplinary Collaborative Studies in the Genetic Epidemiology of Cancer, 1993.

Invited Expert to the Science Advisory Panel of the US EPA FIFRA Reproductive Testing Guidelines. Washington, D.C., December 1993.

Course Instructor for "Statistical Processing Control" at the Post-Graduate Course of American Society of Andrology. March 1994.

Technical Advisor to the “Persian Gulf Expert Scientific Charter Committee”, Department of Veterans Affairs. Washington, DC. February 1995

Course Director for "Managing the Andrology Laboratory" at the Laboratory quality Workshop of the American Society of Andrology. March 1995.

Course Instructor for "Creating Policies that Encourage Participation" at the Laboratory quality Workshop of American Society of Andrology. March 1995.

Course Instructor for "Review of General QC/QA Procedures" at the Reproductive Cryotechnology Specialist Review Course of the American Association of Tissue Banks. March 1995.

Elected member of the Executive Council of the American Society of Andrology 1995-1998.

Course Instructor for “Laboratory Management” at 28th Annual Postgraduate Program of the American Society for Reproductive Medicine, October 1995

Workshop Instructor for “Statistical Methods and Experimental Design in the Reproductive Biology Laboratory” at 51st Annual meeting of the American Society for Reproductive Medicine, October 1995

Invited Speaker to the American College of Epidemiology, St. Louis. September, 1995.

Invited Expert to the Risk Science Institute/EPA Working Group in assessing sperm in toxicology studies. September 1995

Course Director, “Semen Analysis--Challenges of Quality Control and New Technology” Andrology Laboratory Committee Workshop, American Society of Andrology. January 1996

Ad Hoc Member of Scientific Advisory Committee for EPA, FIFRA - Reproductive Guidelines. November 1996, Washington D.C.

Alternate Member of the Endocrine Disruptors Screening and Testing Advisory Committee, EDSTAC US EPA 1996.

Invited participant to “Workshop on the Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment”. Washington, D.C. November 12-14, 1997

Co-Chair of “Effects of Toxicant Exposure on Sperm and Oocyte Quality” Postgraduate Program of the American Society of Reproductive Medicine, October 18, 1997.

Organizing Committee “Gender Differences in Reproductive Biology and Toxicology” Tucson, Arizona November 9-11, 2000

National Children’s Study. Fertility and Early Pregnancy Working Group. 2001 - present

Invited Speaker, Student Colloquium. American Society of Andrology. Seattle, Washington April 2002

Invited Faculty, Post Graduate Course, “Male Reproductive Genetics and Toxicology – Nature and Nurture. October 12-13, 2002. American Society of Reproductive Medicine.

Invited Speaker, “Symposium on Environmental Influences on Human Semen Quality” American Society of Andrology. Phoenix, AZ. April 1, 2003.

Chair, Andrology Laboratory Workshop. 2004 Annual Meeting of the American Society of Andrology, Baltimore, MD. April 17, 2004.

Organizing Committee, American Society of Andrology, Annual Meetings 1986, 2003, 2004, 2005.

Secretary, American Society of Andrology 2004-2007

INTERNATIONAL ACTIVITIES:

Participant in the NIOSH-Finnish Institute for Occupational Health Symposium(s). October 1986, June 1992.

Invited Speaker to the VI International Congress on Spermatology, Siena, Italy. September 1990.

Instructor for the Nordic Institute for Advanced Training in Occupational Health, course title: "The Effect of Chemical, Physical and Biological Workplace Factors on Male and Female Fertility. Copenhagen, Denmark. May 27-31, 1991.

Invited Speaker to the Reproductive Epidemiology Workshop at the Ninth International Symposium, "Epidemiology in Occupational Health", Cincinnati, Ohio. September 1992.

Invited Participant to the International Conference on Male-Mediated Developmental Toxicity: Father's Exposures and Their Children’s Health, Pittsburgh, Pennsylvania, September 1992.

Invited Speaker to the conference "Medical, Social, and Legal Aspects of Health Protection of Motherhood and Childhood. Ekaterinburng, Russia, October 1992.

Scientific Advisor to the INDO-US Subcommission on Science and Technology, the National Institute for Occupational Health, Government of India and the US EPA in the research program "The Effects of Lead Exposure on Parameters of Male and Female Reproduction and Parameters of Adolescent Development”. 1993 to Present.

Invited Speaker to the International Symposium on Health Hazards of Glycol Ethers. Nancy-Port-A-Mousson, France. April 19-21, 1994.

Invited Faculty to the British Andrology Society workshop on Quality Control and Morphology in the Andrology Laboratory, November 17,1994. Bristol England.

Expert Advisor Panel, Health Canada study of the Farm Family - Health effects of pesticides. Ottawa, Canada 1995-Present.

Panel on “Endocrine Disrupting Chemicals: Can We Wait to Take Action” for the United Nations Commission on Sustainable Development. New York, NY April 30, 1996.

Invited Speaker. Reproductive Health and the Environment Symposium. McMaster University and Ontario Ministry of Health. Toronto, Ontario, May 13, 1996

Invited participant to INSERM “Environmental Impact on Male Reproductive Function”, November 10-14, France 1996

Invited speaker to the European Concerted Action Occupational Hazards to Male Reproductive Capability Symposium entitled “Environment, Lifestyle and Fertility” Arhus, Denmark, December 7-10, 1997

Invited speaker to “Environmental Influences on Spermatogenesis and Sperm Quality Symposium”, Genk, Belgium. April 1998.

Organizing Committee “Hazardous Substances and Male Reproductive Health - An International Conference” New York, May 14-15, 1998

Invited Speaker to a symposium on "Molecular aspects of male reproductive toxicology" in Giessen

Germany, November 13-14, 1999

Invited speaker to the “International Workshop on Endocrine Disrupting Chemicals and Their Toxicological Evaluation. in Tsukuba, Japan. February 28 to March 3, 2001.

Invited speaker to the Sixth International Nickel Conference on Ecologic, Toxicologic and Human Health Issues Associated with the Mining, Refining and Production of Nickel and Companion Elements. September 1-6, 2002, Murmansk, Russia

International Expert Panel on Reproductive Health Issues Associated with Exposure to the Port Colborne Chemicals of Concern (i.e. Cobalt, Nickel, Copper and Arsenic) 2002-2003

Invited Speaker to International Congress “Prevention of Reproductive Health from Occupational & Environmental Risk Factors” (PROERF) Volgograd, Russia, July 2004

TEACHING:

University of Cincinnati

Lecture in the following courses:

Survey of Environmental Toxicology

Fundamentals of Environmental Toxicology Course

Occupational Medicine Training Course

Basics of Occupational Medicine II

ABSTRACTS AND PRESENTATIONS

1. Schrader, S.M. and C.P. Merilan, 1977. X-ray Microanalysis of Bovine Spermatozoa. J. Dairy Sci. 60:86.

2. Schrader, S.M. and C.P. Merilan, 1979. Ultrastructure of Springbuck Antiodorcas marsuialis Spermatozoa. Proceedings of 145th national Meeting of the American Association for the Advancement of Science, Houston, Texas.

3. Schrader, S.M. and C.P. Merilan, 1979. Calcium Localization in Bovine Spermatozoa. J. Dairy Sci. 62:174.

4. Gharib, E. and S.M. Schrader, 1982. An Immunoferritin Study of Antisperm Antibodies on the Sperm Surface During Events Proceeding Fertilization. Proceedings of the seventh International Conference of Defined Immunofluorescence, Immunoenzyme studies and related labeling techniques.

5. Schrader, S.M., R.S. Jeyendran, M., Perez-Pelaez, and L.J.D. Zaneveld, 1983. Evaluation of the Physical and Functional Integrity of the Human Sperm Membrane. J. of Andrology 4:48.

6. Bruns, E.S., S.M. Schrader and L.A. Eng 1984. A Sperm Agglutinin in Rabbit Saliva. J of Andrology, 5:P25.

7. Schrader, S.M., T.W. Turner, B.D. Hardin, R.W. Niemeier, J.R. Burg. 1984. Morphometric Analysis of Human Spermatozoa. J of Andrology 5:P22.

8. Oluka, I.S., S.M. Schrader, M. Perez-Pelaez, A.J. Sobrero and R.S. Jeyendran. 1984. Filtration with Silica Wool to Improve Human Semen Quality. J Andrology, 5:P21.

9. Ratcliffe, J.M., S. Schrader, T. Meinhart and K. Steenland. 1984. Semen analysis as an indicator of occupational hazards to reproduction, with particular reference to ethylene dibromide. Presented at the 112 annual meeting of the Am. Public Health Assoc. Nov 13, 1984

10. Schrader, S.M., T.W. Turner, D.E. Clapp and J.M. Ratcliffe. 1985. Sperm velocity as a measure of toxic effects of acute EDB exposure. J Andrology 6:38P.

11. Schrader, S.M., R.S. Jeyendran, K.J. Loseth and B.G. Crabo. 1985. Morphometric parameters of boar sperm heads are not correlated to fertility. J. Animal Sci. 61:411 (supplement 1).

12. Schrader, S.M., R.S. Jeyendran, J.R. Burg, H.H. Van der Ven, M. Perez-Pelaez, and L.J.D. Zaneveld, 1985. Association of sperm morphology with in vitro fertilizing capacity of human spermatozoa as assessed by different classification systems. Presented at the American Congress of Obstetricians and Gynecologist District VI annual meeting September 27, 1985 Milwaukee WI.

13. Turner, T.W. and S.M. Schrader. 1986. Relationship of sperm velocity to semen viscosity. J. of Andrology 7:26p

14. Schrader, S.M., R.E. Chapin, T.W. Turner, J.M. Ratcliffe, J.R. Burg, M.D. Ross and J.C. Lamb IV. 1986. The effect of ethylene dibromide on sperm characteristics. J of Andrology 7:27p

15. Ratcliffe, J.M., S.M. Schrader, T.W. Turner, R.W. Hornung. 1986. The use of new field methods of semen analysis in the study of occupational hazards to reproduction: The example of ethylene dibromide. Presented at the Third Joint U.S. - Finnish Science Symposium. October 24, 1986.

16. DeStefano, F., J.L. Annest, M.J. Kresnow, M.L. Flock and S.M. Schrader. 1987. Automated semen analysis in large epidemiologic studies. J Andrology 8:24P

17. Turner T., S. Schrader, R.S. Jeyendran, M. Perez-Pelaez, R.F. Karuhn, and H.H. Van der Ven. 1987. A comparison of morphometry and volume of human spermatozoa. J Andrology 8:36P.

18. Peterson, G.E., S.M. Schrader and T.W. Turner. 1987. The effectiveness of an insulated jar in protecting semen quality from temperature extremes. J Andrology 8:36P

19. Schrader, S.M., T.W. Turner, J.R. Burg and J.M. Ratcliffe. 1987. Semen Characteristics of "unexposed workers" - A comparison of five worker populations. J Andrology 8:34P

20. Schrader, S.M.. 1987. Reproductive toxicology of male workers. Presented at Reproductive Endocrine Conference, Bethesda Fertility Center, Cincinnati, Ohio. August 26, 1987.

21 Schrader, S.M.. 1987. Semen quality of male workers exposed to glycol ethers. Keynote Address at the Annual Meeting of the Genetic and Environmental Toxicology Association of Northern California, Oakland California, December 3, 1987.

22. T.W. Turner, S.M. Schrader, and SD Simon. 1988. Sperm Head morphometry as measured by three different computer systems. J Andrology 9:45, 1988.

23. Schrader, S.M.. 1988. Reproductive Toxicology of the Male Worker. Presented at Lehigh University, Bethlehem, Pennsylvania on July 25, 1988

24. Schrader, S.M., T.W. Turner, M.J. Breitenstein, S.D. Simon. 1988. Longitudinal Study of Semen Quality of Unexposed Workers. I. Study Overview. Presented at the Symposium on Assessing Reproductive Hazards in the Workplace in Cincinnati, Ohio on June 17, 1988

25. Schrader, S.M., T.W. Turner, and J.M. Ratcliffe. 1988. The Effects of Ethylene Dibromide on Semen Quality: A Comparison of Short Term and Chronic Exposure. Presented at the Symposium on Assessing Reproductive Hazards in the Workplace in Cincinnati, Ohio on June 17, 1988

26. Turner, T.W., J.L. Franchi, S.M. Schrader, S.D. Simon, and D.W. Lynch. 1989. A Comparison of Monkey Semen Motility Parameters Using Two Collection Methods. J Andrology 10:31P.

27. Fogle T., B. Bean, S. Schrader, T. Turner, and L. Zotter. 1989. Observations on Hamster Ovum Penetration and Chromosome conversion of Cold-Stored Sperm of the Cynomolgus Monkey, Macaca fascicularis. J Andrology 10:29P.

30. Destefano, F., J.L. Annest, M-J. Kresnow, S.M. Schrader, and D.F. Katz. 1989. Semen Characteristics of Vietnam Veterans. J Andrology 10:25P.

31. Schrader, S.M. 1989. Longitudinal Studies of Semen Quality of Unexposed Workers: An Update. Presented at the Institute for Environmental Health, University of Cincinnati, Cincinnati, Ohio. April 26, 1989.

32. Simon, S.D., S.M. Schrader, and Terry W. Turner. 1989. The Use of Tolerance Intervals for Assessing Male Reproductive Potential. Presented to the American Statistical Association, August 7, 1989

33. Williams, J., B.C. Gladen, R.E. Chapin, and S.M. Schrader, Ethylene dibromide (EDB): Comparison of rabbit and human seminal characteristic. Presented to the Society of Toxicology for presentation at the annual meeting, February 1990, Miami Beach, FL.

34. Wright, D.M., J.S. Kesner, S.M. Schrader, N.W. Chin, V. Wells. 1990. Methods to detect Ovulation in Females. Presented at workshop: Designing and Conducting Studies of Early Fetal Loss. NIEHS, Research Triangle Park , NC.

35. Turner, T., S. Schrader, W. Moorman, J Clark, S. Simon. 1990. A Study of Sperm Motion Analysis after Exposing Rats to Ethylene Oxide. Journal of Andrology 11:50-P.

36. Schrader, S.M., T.W. Turner, and S.D. Simon. 1990. Sources of Variation of Sperm Motility Measurements. Journal of Andrology 11:38-P.

37. Evenson, D., L. Jost, R. Baer, T. Turner, S. Schrader. 1990. Longitudinal Study of Sperm Chromatin. Journal of Andrology 11:35P.

38. Schrader, S.M., M. Breitenstein, T.W. Turner, and S.D. Simon. 1990. Longitudinal Study of Semen Quality of Unexposed Workers: Seminal Plasma Characteristics. Presented at the VI International Congress on Spermatology, Siena, Italy, September 1990.

39. Schrader, S.M., T.W. Turner, and S.D. Simon. 1991. Sources of Variation of the Sperm Penetration Assay under Filed Study conditions. Journal of Andrology 12:Supplement P48.

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