Asian Journal of Andrology Current issuewww.asiaandro.com陔恓www.asiaandro.comzh-CNwww.asiaandro.comThe emerging role of exosomes in the development of testicularhttps://journals.lww.com/ajandrology/fulltext/2023/25050/the_emerging_role_of_exosomes_in_the_development.1.aspx
Keywords: exosomes; miRNA; Sertoli cells; sperm; testis]]>Li, Chun-Yang1,2; Liu, Song-Po1,2; Dai, Xiao-Fang1,2; Lan, Dong-Feng1,2; Song, Tao1,2,3; Wang, Xian-Yao1,2,3; Kong, Qing-Hong4; Tan, Jun5,; Zhang, Ji-Dong1,2,3![CDATE[Originally published: April 11, 2023 Received: October 6, 2022 Accepted: February 4, 2023]]Clinical implications of endogenous testosterone density on prostate cancer progression in patients with very favorable low and intermediate risk treated with radical prostatectomyhttps://journals.lww.com/ajandrology/fulltext/2023/25050/clinical_implications_of_endogenous_testosterone.2.aspx2, and progression as recurrence (biochemical and/or local and/or distant). Risk associations were evaluated by multivariable Cox and logistic regression models. Of 320 patients, 151 (47.2%) had intermediate-risk PCa. ET (median: 402.3 ng dl#8722;1) resulted abnormal in 111 (34.7%) cases (median ETD: 9.8 ng dl#8722;1 ml#8722;1). Upgrading and progression occurred in 109 (34.1%) and 32 (10.6%) cases, respectively. Progression was predicted by ISUP grade group 2 (hazard ratio [HR]: 2.290; P = 0.029) and upgrading (HR: 3.098; P = 0.003), which was associated with ISUP grade group 2 (odds ratio [OR]: 1.785; P = 0.017) and TLD above the median (OR: 2.261; P = 0.001). After adjustment for PSA density and body mass index (BMI), ETD above the median was positively associated with BPCD (OR: 3.404; P2, and progression as recurrence (biochemical and/or local and/or distant). Risk associations were evaluated by multivariable Cox and logistic regression models. Of 320 patients, 151 (47.2%) had intermediate-risk PCa. ET (median: 402.3 ng dl#8722;1) resulted abnormal in 111 (34.7%) cases (median ETD: 9.8 ng dl#8722;1 ml#8722;1). Upgrading and progression occurred in 109 (34.1%) and 32 (10.6%) cases, respectively. Progression was predicted by ISUP grade group 2 (hazard ratio [HR]: 2.290; P = 0.029) and upgrading (HR: 3.098; P = 0.003), which was associated with ISUP grade group 2 (odds ratio [OR]: 1.785; P = 0.017) and TLD above the median (OR: 2.261; P = 0.001). After adjustment for PSA density and body mass index (BMI), ETD above the median was positively associated with BPCD (OR: 3.404; P]]>Porcaro, Antonio Benito1,*,; Tafuri, Alessandro1,2,*; Panunzio, Andrea1; Cerrato, Clara1; Bianchi, Alberto1; Gallina, Sebastian1; Vidiri, Stefano1; D＊Aietti, Damiano1; Serafin, Emanuele1; Mazzucato, Giovanni1; Princiotta, Alessandro1; Brusa, Davide1; Brunelli, Matteo3; Pagliarulo, Vincenzo2; Cerruto, Maria Angela1; Antonelli, Alessandro1![CDATE[Received: 03 August 2022; Accepted: 31 October 2022; published online: 06 January 2023]]Patients with MMAF induced by novel biallelic CFAP43 mutations have good fertility outcomes after intracytoplasmic sperm injectionhttps://journals.lww.com/ajandrology/fulltext/2023/25050/patients_with_mmaf_induced_by_novel_biallelic.3.aspx
Keywords: CFAP43; MMAF; asthenoteratozoospermia; intracytoplasmic sperm injection.]]>Ma, Jing1,2,*; Long, Shun-Hua1,2,*; Yu, Hai-Bing1,2; Xiang, Ye-Zhou1,2; Tang, Xiang-Rong1,2; Li, Jia-Xun1,2; Liu, Wei-Wei1,2; Han, Wei1,2; Jin, Rong1,2; Huang, Guo-Ning1,2,3,; Lin, Ting-Ting1,2,3![CDATE[Originally published: March 21, 2023 Received: September 8, 2022 Accepted: January 30, 2023]]A decade of WHO 2010: total sperm number temporal trend and role of lifestyle factorshttps://journals.lww.com/ajandrology/fulltext/2023/25050/a_decade_of_who_2010__total_sperm_number_temporal.4.aspxCargnelutti, Francesco1; Pallotti, Francesco1; Carlini, Tania1; Faja, Fabiana1; Vestri, Anna Rita2; Fegatelli, Danilo Alunni2; Lenzi, Andrea1; Lombardo, Francesco1; Paoli, Donatella1![CDATE[Received: 18 May 2022; Accepted: 06 November 2022; published online: 17 January 2023]]Comparison of sperm parameters and DNA fragmentation index between infertile men with infection and vaccines of COVID-19https://journals.lww.com/ajandrology/fulltext/2023/25050/comparison_of_sperm_parameters_and_dna.5.aspx
Keywords: COVID-19; semen parameter; sperm DNA fragmentation; sperm quality; vaccines]]>Lestari, Silvia W1,; Restiansyah, Gito1; Yunihastuti, Evy2; Pratama, Gita3![CDATE[Originally published: April 21, 2023 Received: January 26, 2023 Accepted: March 1, 2023]]Modified onlay island flap versus tubularized incised plate urethroplasty for hypospadias reoperationhttps://journals.lww.com/ajandrology/fulltext/2023/25050/modified_onlay_island_flap_versus_tubularized.6.aspx
Keywords: children; hypospadias; reoperation; urethroplasty]]>Zhu, Xiao-Jiang; Deng, Yong-Ji; Wang, Jun; Guo, Yun-Fei; Ge, Zheng![CDATE[Originally published: March 14, 2023 Received: November 7, 2022 Accepted: February 2, 2023]]Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men: a preliminary reporthttps://journals.lww.com/ajandrology/fulltext/2023/25050/predictive_factors_for_efficacy_of_testosterone.7.aspxNobuyuki Kondoh 1, Yohei Kaizuka 1, Seiji Nagasawa 1, Yoshikazu Togo 1, Shingo Yamamoto 2![CDATE[Originally published: April 28, 2023 Received: September 7, 2022 Accepted: March 22, 2023]]Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosishttps://journals.lww.com/ajandrology/fulltext/2023/25050/comprehensive_semen_examination_in_patients_with.8.aspx
Keywords: congenital bilateral agenesia/aplasia of vas deferens; cystic fibrosis; cystic fibrosis transmembrane conductance regulator
gene; semen; spermatozoa]]>Sedova, Anna O; Shtaut, Maria I; Bragina, Elizaveta E; Sorokina, Tatyana M; Shmarina, Galina V; Andreeva, Marina V; Kurilo, Lyubov F; Krasovskiy, Stanislav A; Polyakov, Aleksander V; Chernykh, Vyacheslav B![CDATE[Originally published: March 03, 2023 Received: May 21, 2022 Accepted: December 15, 2022]]Development of a predictive model for increasing sperm retrieval success by microdissection testicular sperm extraction in patients with nonobstructive azoospermiahttps://journals.lww.com/ajandrology/fulltext/2023/25050/development_of_a_predictive_model_for_increasing.9.aspx
Keywords: anti-M邦llerian hormone; inhibin B; microdissection testicular sperm extraction; predictive model; sperm retrieval]]>Deng, Chen-Yao1,2,*; Liu, De-Feng2,3,*; Zhao, Lian-Ming1,2,4; Lin, Hao-Cheng1,2,4; Mao, Jia-Ming2,3; Zhang, Zhe1,2; Yang, Yu-Zhuo2,3; Zhang, Hai-Tao1,2,4; Hong, Kai1,2,4; Xu, Hui-Yu3; Jiang, Hui1,2,4![CDATE[Received: 20 September 2022; Accepted: 15 December 2022; published online: 07 February 2023]]Bladder calculi concomitant with benign prostatic enlargement: is prostate surgery mandatory in patients who have never received medical therapy?https://journals.lww.com/ajandrology/fulltext/2023/25050/bladder_calculi_concomitant_with_benign_prostatic.10.aspxAnil, Hakan1,; #220;nal, Umut1; Karamik, Kaan2; Ortoglu, Ferhat1; Er#231;il, Hakan1![CDATE[Received: 28 September 2022; Accepted: 15 December 2022; published online: 27 January 2023]]Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motilityhttps://journals.lww.com/ajandrology/fulltext/2023/25050/phosphodiesterase_10a_inhibitor_pf_2545920_as_a.11.aspxYang, Yi-Ting1,*; Yan, Bin2,*; Li, Yu-Hua1; Guo, Li-Na1; Wang, Wei-Wei3; Liu, Li-Jie4; Yu, He-Guo1,; Diao, Hua1![CDATE[Originally published: April 04, 2023 Received: August 19, 2022 Accepted: February 7, 2023]]Comparison of outcomes in three surgical techniques for proximal hypospadias: staged transverse preputial island flap urethroplasty versus single-stage repairshttps://journals.lww.com/ajandrology/fulltext/2023/25050/comparison_of_outcomes_in_three_surgical.12.aspxWang, Yu-Si; Song, Hong-Cheng; Liu, Pei; Fang, Yi-Wei; Zhang, Wei-Ping![CDATE[Originally published: January 03, 2023 Received: June 27, 2022 Accepted: November 24, 2022]]Efficacy of stepwise mini-incision microdissection testicular sperm extraction for nonobstructive azoospermia with varied etiologieshttps://journals.lww.com/ajandrology/fulltext/2023/25050/efficacy_of_stepwise_mini_incision_microdissection.13.aspx
Keywords: etiology; male infertility; nonobstructive azoospermia; standard mTESE; stepwise mini-incision mTESE]]>Zhang, Yu-Xiang*; Yao, Chen-Cheng*; Huang, Yu-Hua; Li, Peng; Zhi, Er-Lei; Zhu, Zi-Jue; Zhang, Jian-Xiong; Zhao, Fu-Jun; Li, Zheng; Tian, Ru-Hui![CDATE[Originally published: February 24, 2023 Received: July 23, 2022 Accepted: January 5, 2023]]Insufficiency of Mrpl40 disrupts testicular structure and semen parameters in a murine modelhttps://journals.lww.com/ajandrology/fulltext/2023/25050/insufficiency_of_mrpl40_disrupts_testicular.14.aspx
Keywords: cryptorchidism; DiGeorge syndrome; semen analysis; spermatozoa]]>Liu, Ying1,*; Fu, Long-Long2,*; Xu, Hui-Zhong3; Zheng, Yi-Ming1; Li, Wei-Xi1; Qian, Guang-Hui1; Lu, Wen-Hong2,; Lv, Hai-Tao1![CDATE[Originally published: March 03, 2023 Received: February 23, 2022 Accepted: January 13, 2023]]Buried penis: a histological and histochemical study of dartos fasciahttps://journals.lww.com/ajandrology/fulltext/2023/25050/buried_penis__a_histological_and_histochemical.15.aspxZhang, Hong-Yi1,2; Zhao, Gang-Gang1,2; Song, Yi-Ting1,2; Xiao, Ke-Bing1,2; Li, Hua-Feng1,2; Cui, Jie2![CDATE[Originally published: March 14, 2023 Received: May 12, 2022 Accepted: January 15, 2023]]Aerobic exercise improves ejaculatory behaviors and complements dapoxetine treatment by upregulating the BDNF-5-HT duo: a pilot study in ratshttps://journals.lww.com/ajandrology/fulltext/2023/25050/aerobic_exercise_improves_ejaculatory_behaviors.16.aspx
Keywords: aerobic exercise; animal model; brain-derived neurotrophic factor; premature ejaculation; raphe nucleus; serotonin]]>Huang, Yuan-Yuan1,*; Peng, Dang-Wei1,*; Liu, Qiu-Shi1; Jiang, Hui2,3,4,; Zhang, Xian-Sheng1![CDATE[Originally published: March 03, 2023 Received: September 12, 2022 Accepted: January 12, 2023]]A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertilityhttps://journals.lww.com/ajandrology/fulltext/2023/25050/a_novel_loss_of_function_variant_in_pnldc1.17.aspxT, p.Gln48Ter) in PNLDC1. Hematoxylin and eosin staining revealed that the spermatozoa of the patient with OAT had an irregular head phenotype, including microcephaly, head tapering, and globozoospermia. Consistently, peanut agglutinin staining of the spermatozoa revealed a complete or partial loss of the acrosome. Furthermore, the disomy rate of chromosomes in the patient＊s spermatozoa was significantly increased compared with that of a fertile control sample. We reported an LOF variant of the PNLDC1 gene responsible for OAT.

Keywords: loss-of-function variant; male infertility; oligo-astheno-teratozoospermia; PARN-like ribonuclease domain-containing
exonuclease 1]]>Zhao, Si-Yi1; Meng, Lan-Lan2,3; Du, Zhao-Li4; Tan, Yue-Qiu2,3; He, Wen-Bin2,3,; Wang, Xiong5![CDATE[Originally published: March 21, 2023 Received: October 6, 2022 Accepted: February 1, 2023]]Commentary on ※Clinical implications of endogenous testosterone density in prostate cancer progression in patients with favorable low and intermediate risk treated with radical prostatectomy§https://journals.lww.com/ajandrology/fulltext/2023/25050/commentary_on__clinical_implications_of_endogenous.18.aspxBusetto, Gian Maria; Falagario, Ugo Giovanni; Carrieri, Giuseppe![CDATE[Received: 29 Nov 2022; Accepted: 06 Dec 2022; published online: 10 January 2023]]Who are the fair candidates for testosterone replacement therapy in patients with late-onset hypogonadism symptoms?https://journals.lww.com/ajandrology/fulltext/2023/25050/who_are_the_fair_candidates_for_testosterone.19.aspxToshiyasu Amano ![CDATE[Received: 14 March 2023; Accepted: 26 March 2023; published online: 09 May 2023]]ZMYM3: a new candidate gene in nonobstructive azoospermia?https://journals.lww.com/ajandrology/fulltext/2023/25050/zmym3__a_new_candidate_gene_in_nonobstructive.20.aspxLe Beulze, Morgane1,2; Swierkowski-Blanchard, Nelly1,2,3; Ghieh, Farah1,2; Fortemps, Joanne4; Gerault, Carole5; Serazin, Val谷rie1,2,5; Louboutin-Sanchez, Anne4; Bailly, Marc3; Vialard, Fran#231;ois1,2,5![CDATE[Received: 22 July 2022; Accepted: 06 December 2022; published online: 03 February 2023]]Pudendal nerve lesions in young men with erectile dysfunction: imaging with 3T magnetic resonance neurographyhttps://journals.lww.com/ajandrology/fulltext/2023/25050/pudendal_nerve_lesions_in_young_men_with_erectile.21.aspxHuang, Guo-Quan1,2,*; Gong, Tao3,*; Wang, Shan-Shan3; Xia, Qin-Hua4; Lin, Liang-Jie5; Wang, Guang-Bin3![CDATE[Received: 09 July 2022; Accepted: 15 November 2022; published online: 10 January 2023]]