Asian Journal of Andrology Current issuewww.asiaandro.com陔恓www.asiaandro.comzh-CNwww.asiaandro.comAre men aware of normal penile length and sexual function? A narrative review of the literaturehttps://journals.lww.com/ajandrology/fulltext/9900/are_men_aware_of_normal_penile_length_and_sexual.377.aspx
Keywords: adult; awareness; erectile dysfunction; male; normal; penile length; premature ejaculation
]]>Faizal, Yoonus1; Wu, Winston2; Chan, Vincent3; Duns, Glenn3; Schubach, Kathryn M3; Katz, Darren J3,4,5![CDATE[Received: 18 February 2025; Accepted: 20 August 2025; published online: 20 January 2026]]Phytochemical-based nanomedicine as a promising therapeutic strategy for erectile dysfunctionhttps://journals.lww.com/ajandrology/fulltext/9900/phytochemical_based_nanomedicine_as_a_promising.405.aspx
Keywords: bioactive compounds; erectile dysfunction; nanomedicine; PDE5 signaling; phytochemicals]]>Bhaskar, Rakesh1,2; Han, Sung Soo1,2![CDATE[Received: 30 April 2025; Accepted: 12 September 2025; published online: 24 March 2026]]Exploring better methods for treating urethral stricture caused by lichen sclerosushttps://journals.lww.com/ajandrology/fulltext/9900/exploring_better_methods_for_treating_urethral.380.aspx
Keywords: lichen sclerosus; tissue engineering; urethral stricture]]>An, Jia-Qi; Wang, Jian-Wei![CDATE[Received: 30 June 2025; Accepted: 15 October 2025; published online: 27 January 2026]]Impact of semen quality and maternal age on blastocyst chromosomal abnormalities: a retrospective cohort study based on 1091 PGT-A cycleshttps://journals.lww.com/ajandrology/fulltext/9900/impact_of_semen_quality_and_maternal_age_on.361.aspxZou, Yang1,2,3,4,5,6,7,*; Xu, Xin8,9,*; Xie, Hong-Qiang1,2,3,4,5,6,7; Gao, Ming1,2,3,4,5,6,7; Liu, Xiao-Wei1,2,3,4,5,6,7; Wang, Li-Juan1,2,3,4,5,6,7; Li, Cheng1,2,3,4,5,6,7; Jing, Tao8,9; Gao, Xuan1,2,3,4,5,6,7; Yan, Jun-Hao1,2,3,4,5,6,7; Chen, Zi-Jiang1,2,3,4,5,6,7,10,11; Gao, Yuan1,2,3,4,5,6,7![CDATE[Received: 05 March 2025; Accepted: 23 June 2025; published online: 13 January 2026]]Urinary isoflavone concentrations and semen parameters of Japanese men seeking fertility treatmenthttps://journals.lww.com/ajandrology/fulltext/9900/urinary_isoflavone_concentrations_and_semen.368.aspx 0.05). No associations were observed between urinary isoflavones and total sperm motility. A higher isoflavone intake may be associated with reduced sperm concentration and count. The effect of these alterations in semen parameters on the fecundity of couples trying to conceive remains unknown.

Keywords: Asia; daidzein; equol; genistein; semen]]>Konishi, Shoko1; Mizuno, Yuki1,a; Yamasaki, Kazumitsu2,3; Uchida, Masahiro2,b; Iwamoto, Teruaki3,4,c![CDATE[Received: 12 April 2025; Accepted: 28 July 2025; published online: 13 January 2026]]Development of individualized surgical strategies for pediatric hypospadias: a multicenter penile morphometric analysishttps://journals.lww.com/ajandrology/pages/results.aspx?txtKeywords=aja202571Fang, Yi-Wei1; Song, Hong-Cheng1,2; Tang, Yun-Man3; Huang, Lu-Gang4; Yang, Yi5; Chao, Min6; Ma, Hong7; Zhang, Jing-Ti8; Zhang, Xu-Hui9; Li, Shou-Lin10; Li, Ning11; Chen, Chao12; He, Da-Wei13; Wu, Wen-Bo14; Xie, Hua15; Guan, Yong16; Yang, Yan-Fang17; Zhang, Jian-Guo18![CDATE[Received: 16 February 2025; Accepted: 01 August 2025; published online: 13 January 2026]]Methamphetamine-induced inhibition of Mettl21c in undifferentiated spermatogonia impairs male fertility in micehttps://journals.lww.com/ajandrology/fulltext/9900/methamphetamine_induced_inhibition_of_mettl21c_in.366.aspx
Keywords: male infertility; methamphetamine; Mettl21c; survival; undifferentiated spermatogonia
]]>Zhao, Xue-Heng1,2; Zhou, Dai1,3; Lu, Shuang4; Yan, Wei-Tao4,5; Fan, Li-Qing1,2![CDATE[Received: 17 October 2024; Accepted: 25 June 2025; published online: 13 January 2026]]Identification of gene variants in 30 patients from southeastern China with severe hypospadias by whole-exome sequencinghttps://journals.lww.com/ajandrology/fulltext/9900/identification_of_gene_variants_in_30_patients.384.aspxT and SRY-box 3 [SOX3] c.1273G>C), morphogenetic modulators (GLI family zinc finger 3 [GLI3] c.4731delA and aristaless-related homeobox [mARX] c.644C>G), and syndromic genes (patched domain containing 1 [PTCHD1] c.667G>A and euchromatic histone lysine methyltransferase 1 [EHMT1] c.3081C>T). Additionally, recurrent CNVs at 22q12.3 and a novel CNV exon 18 deletion in myelin regulatory factor (MYRF) and 18q11.2 were identified. Mutation carriers showed a significantly higher frequency of cryptorchidism (40.0% vs 5.0%, PT and SRY-box 3 [SOX3] c.1273G]]>Huang, Wen-Hua1,2; Tan, Qian-Qian3; Zeng, Wei2; Wang, Hai-Gen4; Cui, Xun2; Wang, En-Hui5; Zhou, Yong3,5; Ni, Wen-Hao3; Zhou, Chao-Ming1,2![CDATE[Received: 09 May 2025; Accepted: 28 September 2025; published online: 06 February 2026]]Current risk factors for male infertility and semen parameters: an umbrella review of systematic reviews and meta-analyseshttps://journals.lww.com/ajandrology/fulltext/9900/current_risk_factors_for_male_infertility_and.365.aspx
Keywords: male infertility; risk factors; semen parameter; umbrella review
]]>Wang, Qi-Hao1,2,*; Ye, Jian-Jun1,2,*; Chen, Ze-Yu1; Zhang, Chi-Chen1; Liao, Xin-Yang1; Zheng, Lei1,2; Chen, Kai1,2; Tu, Xiang1; Liu, Liang-Ren1; Wei, Qiang1; Bao, Yi-Ge1![CDATE[Received: 25 December 2024; Accepted: 22 May 2025; published online: 13 January 2026]]Transcriptional and epigenetic changes associated with lead exposure in spermatozoahttps://journals.lww.com/ajandrology/fulltext/9900/transcriptional_and_epigenetic_changes_associated.362.aspx
Keywords: calcium homeostasis pathway; DNA methylomes; lead exposure; sperm motility; transcriptomes
]]>Zhang, Xu*; Shen, Xiao-Rong*; Wu, Bin; Wang, Xue-Mei; Shi, Hui-Juan; Zhang, Tian-Cheng![CDATE[Received: 31 December 2024; Accepted: 27 June 2025; published online: 13 January 2026 ]]The prognostic significance of prostate-specific antigen dynamics during abiraterone therapy in patients with high-risk metastatic hormone-sensitive prostate cancerhttps://journals.lww.com/ajandrology/fulltext/9900/the_prognostic_significance_of_prostate_specific.354.aspxWang, Qian*; Zhang, Ming*; Zhu, Qi-Yu; Zeng, Hong; Dai, Jin-Dong; Huang, Ke; Wan, Si-Cheng; Shi, Yi-Fu; Zhang, Xing-Ming; Zeng, Hao; Shen, Peng-Fei![CDATE[Received: 13 January 2025; Accepted: 27 March 2025; published online: 09 January 2026]]SPACA4 regulates the structure and molecular basis of spermatid maturation and ultimately affects sperm quality in micehttps://journals.lww.com/ajandrology/fulltext/9900/spaca4_regulates_the_structure_and_molecular_basis.364.aspx
Keywords: multiple abnormalities; SPACA4; spermatid maturation; sperm quality; subfertility]]>Chen, Xu1,2; Wu, Hai-Qian1; Wan, Dan-Yang1,3; Zhang, Xiang-Zheng1; Zhou, Xin-Li1; Guo, Xue-Jiang1; Zhu, Hui1![CDATE[Received: 09 January 2025; Accepted: 16 June 2025; published online: 13 January 2026]]No difference in ICSI outcomes from cryopreserved testicular spermatozoa from patients with azoospermia or cryptozoospermiahttps://journals.lww.com/ajandrology/fulltext/9900/no_difference_in_icsi_outcomes_from_cryopreserved.396.aspx 0.05). Sperm utilization in NOA group (60.5%) was significantly higher (both P0.05). Sperm utilization in NOA group (60.5%) was significantly higher (both P0.05). Of 162 couples undergoing ICSI, there were no differences in fertilization, clinical pregnancy, delivery, and miscarriage rates among patients with OA, NOA, and cryptozoospermia (all P]]>Xu, Jin-Yan1,2; Li, Ding-Ming1,2; Liu, Bo1,2; Liu, Sha-Sha1,2; Luo, Xue-Feng1,2; Luo, Chen1,2; Zhao, Wen-Rui1,2; Liu, Yuan1,2; Ying, Li-Juan1,2; Xian, Yang1,2; Li, Fu-Ping1,2![CDATE[Received: 29 June 2025; Accepted: 23 October 2025; published online: 03 March 2026]]Novel biallelic CFAP43 mutations induce MMAF with mitochondrial abnormalities and successful ICSI outcomeshttps://journals.lww.com/ajandrology/fulltext/9900/novel_biallelic_cfap43_mutations_induce_mmaf_with.370.aspxG (p.N1024S), by whole-exome sequencing (WES). The proband had a typical MMAF phenotype; Sanger sequencing confirmed these mutations and showed that they cosegregated within the family. Further analysis of the patient＊s sperm samples indicated that the CFAP43 mutations result in aberrant RNA splicing. Additionally, we observed disturbance and partial deletion of the mitochondrial sheath, along with a significant reduction in translocase of outer mitochondrial membrane 20 (TOM20) expression. This study suggests that infertility associated with CFAP43 loss of function may be linked to mitochondrial dysfunction. Finally, assisted reproductive technology using intracytoplasmic sperm injection (ICSI) resulted in a successful pregnancy and live birth. Our study expands the spectrum of pathogenic CFAP43 mutations and provides valuable insights for genetic counseling and personalized reproductive strategies in patients with MMAF.

Keywords: CFAP43; ICSI; infertility; MMAF; sperm flagella]]>Chen, Qi1,*; Yang, Jie1,*; Shi, Sheng-Jia1; Wu, Shao-Chun1; Ren, Huan1; Xue, Yu1; Ji, Xing-Zhe1; Yu, Man2; Cai, He1; Shi, Juan-Zi1; Qiao, Sen1![CDATE[Received: 18 April 2025; Accepted: 31 July 2025; published online: 16 January 2026]]Clinical features and genetic analysis of androgen receptor gene variants in 30 prepubertal patients with androgen insensitivity syndromehttps://journals.lww.com/ajandrology/fulltext/9900/clinical_features_and_genetic_analysis_of_androgen.375.aspx
Keywords: 46,XY DSD; AIS; AR; disorder of sex development]]>Li, Jia-Nan1,*; Wei, Jiang1,2,*; Hui, Jing1; Wang, Zi-Xuan1; Yang, Ji-Yun1,3![CDATE[Received: 28 June 2025; Accepted: 19 September 2025; published online: 20 January 2026]]Seasonal Gleason scores: compelling observations amid methodological complexityhttps://journals.lww.com/ajandrology/fulltext/9900/seasonal_gleason_scores__compelling_observations.389.aspxIslam, Raeesa; Golombos, David M; Ghodoussipour, Saum![CDATE[Received: 26 July 2025; Accepted: 21 August 2025; published online: 17 February 2026]]Retraction note: The calcium-sensing receptor participates in testicular damage in streptozotocin-induced diabetic ratshttps://journals.lww.com/ajandrology/fulltext/9900/retraction_note__the_calcium_sensing_receptor.398.aspxKong, Wei-Yuan1; Tong, Li-Quan2; Zhang, Hai-Jun3; Cao, Yong-Gang4; Wang, Gong-Chen5; Zhu, Jin-Zhi5; Zhang, Feng2; Sun, Xue-Ying6; Zhang, Tie-Hui5; Zhang, Lin-Lin7![CDATE[published online: 06 March 2026]]